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ARTICLE 10.1177/8756479304272711 JOURNAL OF DIAGNOSTIC MEDICAL SONOGRAPHY January/February 2005 WHY WE DO THE THINGS WE DO (IN ULTRASOUND) / Milburn JDMS 21:1735 JDMS 21:1735 January/February 2005 January/February 2005 VOL. 21, NO. 1
An Overview:
Why does every ultrasound textbook begin with a physics chapter? Dont you know everything you need to know about ultrasound physics? After all, youve probably been performing echocardiograms or sonograms for years. How will learning more about the physical principles of sound make you a better sonographer? This article will answer these questions in order. You simply cannot be the best if you dont know the physics of sound. Key words: ultrasound, physics, instrumentation, Doppler
Correspondence: Dawn Sanchez, Society for Diagnostic Medical Sonography, 2745 N. Dallas Parkway, Suite 350, Plano, TX 75093; email: dsanchez@sdms.org. Article originally published by the SDMS Educational Foundation within the Integrated Ultrasound Reference Guide, Volume 2. JDMS expresses appreciation to Michelle Bierig, MPH, RDMS, RDCS, for editing and updates. DOI: 10.1177/8756479304272711
Every text begins with physics because everything we do in ultrasound is based on our understanding of how to control this thing called ultrasound. From the beginning to the end of every sonogram, the best sonographers are the ones that not only perform that exam but also understand the nature of sound and how to control it for optimal results. You simply cannot be the best if you dont know the physics of sound. For those of you who have been doing these exams for years and think you know enough physics, are you really being truthful? The manufacturers who design and produce these marvelous systems we work with are constantly pushing the known limits of our technologies. Look around at some of the newer systems. Most offer new capabilities, which let the operator work with different transmit and receive image frequencies and multiple Doppler frequencies all within one probe. Do you know why? How can this remarkable ability help you in your day-to-day life in the lab? Do you really know why there are so many probe types and frequencies available? Do you know the advantages and disad-
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FIG. 1.
FIG. 2.
vantages of all of them? Did you know that each type has certain performance levels and limitations? Why one probe does excellent color Doppler and is more sensitive to detecting slow flow while the other will make clearer 2D near fields and overall better images? If you dont know, then you need ultrasound physics. Finally, the answer to the third question is easy. The more you know about acoustic physics, the more you will understand ultrasound technology. When you can truly control that technology, the better sonographer you become. You graduate from the level of button pushing and rote memory
to being truly competent, highly sought after, and fabulously wealthy. Disclaimer: Be advisedif you are looking for a formal physics chapter, this is not it. There are plenty of those out there; however, if you want a commonsense practical explanation of how ultrasound works, then this is the chapter for you.
Where Do We Begin?
What is sound? Sound waves are mechanically produced longitudinal waves or vibrations that like to travel in straight lines. Just as the audible sound
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we hear every day reacts to certain laws, ultrasound is held to similar laws and constraints. In audible sound (20-20,000 hertz), we can hear the sound from voices or noises reflecting from distant objects. We also know that audible sound has difficulty passing or traveling through certain substances and will be attenuated or not heard at all. We know that different ranges or frequencies of sound affect us differently. The booming bass generated by a neighbors stereo seems to penetrate all the walls in your house. The high frequencies of the lead sopranos voice is piercing to the front-row listener but hardly audible to the rear of the performance hall. We live every day with sound and accept what we hear. In ultrasound, our sound cannot travel through air; it can only exist and travel in a media, which, in our case, is the tissues and blood of our bodies.
chines and no one-button patients, a control that is not used potentially limits acoustic data by restricting proper manipulation of the sound.
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FIG. 3.
FIG. 4.
FDA recommended power settings for 2D, Mmode, and Doppler and allow you to set up your system quickly and efficiently. This does not mean you dont have to learn the system controls because their purpose is to fine-tune the presets. Finally, dont be afraid to ask for help if you dont understand all of the controls on your system. Requesting help lets your coworkers know that you are a true professional and lets you know how much they dont know either.
puters and beam forming technologies to provide us with the beautiful pictures we are used to seeing; however, not everyone uses the same probes. In fact, there are very few transducer manufacturers, and most systems use crystals made by someone else for the production of their probes. Specific information on how transducers are manufactured is proprietary.
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areas, and we are used to seeing linear-array probes as well. In fact, it is becoming quite common for shared service systems to utilize all probe types: phased, flat linear, curved linear, etc. So why do we have all of them? A basic fact we must learn is that an ultrasound exam is a series of trade-offs or compromises. For every advantage a certain technology has, there will also be a disadvantage. These differences directly affect the quality and ease of acquisition of our ultrasound data. We all know from our years of intense study of ultrasound physics that a high frequency will provide better spatial resolution with decreased penetration, while a lower frequency penetrates large patients, but the spatial resolution leaves something to be desired. This is all based on sound wave intervals and other conversation-starting words like period, wavelength, and cycles per second. The modern lab of today requires that we select probes not only on frequency but also for bandwidth, footprint, image quality, and Doppler performance. Modern probes also employ broad bandwidths, which means that there are multiple frequencies available for image and Doppler acquisition within each probe. The listed frequency on the probe is the center frequency. As Figure 4 shows, different transmit and receive frequencies may be selected to optimize image quality and penetration and Doppler penetration, sensitivity, and aliasing limits. Our final types of transducer arrays are linear and curved-linear or switched-array probes. While phased and linear probes are both electronic, linear probes generate their sectors differently from phased arrays. Linear and curved-linear probes are typically larger than phased arrays and are ideally suited for vascular examinations (flat linear) and abdominal, OB/GYN studies (curved linear). Their larger probe face, shape, and overall footprint provide much bigger and better near fields than phased arrays but limit their use in cardiology. Newer transducers also have bandwidths capable of providing harmonics, which enables enhanced imaging capabilities. A harmonic image is created by sending a frequency into tissue (lets say 2 MHz or f 1) and listening to the multiple of that frequency (in this case, 4 MHz or f 2). When ultrasound propagates through tissue, the inherent resistance, along with the time and distance traveled,
produces multiple frequencies in the positive and subharmonic ranges. Signal-processing techniques allow the operator to utilize the 2nd harmonic or the doubled fundamental frequency to our advantage. Harmonic imaging allows us to have the benefit of low-frequency imaging for penetration while displaying the high-frequency multiple, which provides optimal spatial resolution. Harmonics are also being used in conjunction with ultrasound contrast agents in the positive and subharmonic frequency ranges to elicit increased activity and reflectivity in differing agents. Okay, now you know a little about sound, its basic controls, frequencies, and probes, so whats next?
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FIG. 5.
FIG. 6.
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FIG. 7.
pf =
2 foV (cos), c
where f = the detected Doppler frequency shift, fo = fundamental Doppler frequency, V = velocity of the moving blood, c = speed of sound in tissue, and = the angle between the ultrasound beam and the flow direction.
2This indicates that the sound must travel into the body and return to the probe. Since this always has to happen for Doppler detection, this parameter becomes a constant. foThe Doppler frequency that you are using. If this changes, the frequency shift will change. VVelocity of the blood. This will change, and the change is reflected in the frequency shift. cThe speed of sound in tissue. Again, a constant. cosineThe cosine of the angle between the insonation beam and the blood flow. One can now see why you need to understand the relationship of these parameters. Any change in them directly affects the frequency shift. Now you know why proper Doppler frequency selection and angle are so important. The higher the Doppler frequency, the higher the returned frequency shift. The closer to 0 degrees your angle becomes, the higher the frequency shift becomes. To the novice, this becomes confusing but is easily explained. Doppler is an angles game. The best angle for Doppler is 0 degrees. However, this is difficult (and very painful) to obtain on noncardiac studies. We must therefore rely on varying insonation angles to transmit and receive an adequate frequency shift. We have all heard that the worst angle for Doppler detection is 90 degrees, and Figure 8 shows why.
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FIG. 8.
difficult to reproduce patient to patient because as our Doppler equation demonstrated, if you change Doppler probe frequencies or angles, the frequency shift changes as well. In modern labs with multiple Doppler probes, frequencies, and operators, you can see how this becomes difficult to work with. It essentially means that you must have a separate diagnostic reference chart for every Doppler frequency that you use and for different angles as well. It can be done, but who needs the grief?
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FIG. 9.
(PRF), or sometimes it is referred to as scale. Highspeed flows require high sampling rates (PRF) for accurate, unaliased detection, and slow-moving blood requires low PRF for maximum sensitivity to slow flow.
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FIG. 10.
FIG. 11.
seen examples. The forward-moving stagecoach wheel on TV that appears to be turning backwards or an airplane propeller that is rotating one direction but appears to be moving slowly in another are examples of aliasing. Since PRF affects our detection speed, then it would make sense to just in-
crease the PRF to eliminate aliasing. This is why we select high-PRF Doppler, which, through some electronic trickery, utilizes multiple sample volumes along the Doppler cursor. This allows the system to transmit a higher level of PRF to the sample volumes than allowed with single-gate pulsed
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FIG. 12.
Doppler. This works to a point, but even with high PRF selected, some flows, especially cardiac flows, will exceed pulsed Doppler capabilities, and then we employ another tool, continuous-wave Doppler (CW). CW Doppler essentially uses a split crystal or two sets of crystals to continuously transmit and receive Doppler data. Continuous-wave Doppler does not operate with PRF constraints, which provides us the ability to detect and display extremely high velocities without aliasing. The compromise, though (and there always is one), is that we sacrifice range location. Our sample volume in a CW probe is where the two beams intersect and can be quite long depending on probe frequency and configuration. This lack of a precise sample volume limits accurate range location. This does not present a large problem in cardiology but can present confusing spectral signals in the presence of multiple, closely spaced arteries and veins, which will all be detected simultaneously in a CW sample volume.
Color My World
The biggest problem with understanding color Doppler is eliminating all of the myths that exist concerning color Doppler. The most common are:
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FIG. 13.
Color Doppler results are the same from all types of systems. Color Doppler provides quantitative velocity data. Color Doppler provides a real-time accurate assessment of blood flow.
Color Doppler is a pulsed Doppler technology, meaning that to know where to depict the blood, we must know range location. Just as pulsed spectral Doppler uses a sample volume for range location, color does the same but utilizes many sample volumes. In fact, there can be thousands of sample volumes being sampled on a color image. A single sample volume can be corrected for angle and the data converted to a velocity. This is the job that pulsed or CW spectral Doppler does for us. In color, however, since thousands of sample volumes are used throughout a large region of interest (ROI), they cannot be angle corrected. Add to this the processing method color Doppler uses (autocorrelation), and the problem compounds itself. Autocorrelation means that all data from all color sample volumes being utilized in the color region of interest are averaged together to produce a mean frequency estimate. So, multiple sample volumes, uncorrected for angle and averaged together, cannot provide a quantitative velocity. Pretty colors, yes. Quantitation, no. These facts combined with the slow frame rates inherent in color Doppler, all of the various system controls that may be used to increase or decrease sensitivity, and different color maps may limit accurate, real-time displays of flow.
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The existence of blood flow: If its there, moving, and you have your system controls properly adjusted, you see it. Direction: If you can detect blood flow, then you can tell which direction its going. Spatial characteristics: Color will show, again all things being properly adjusted, the quality of flow and the spatial characteristics (i.e., complete filling of vessels, chambers, etc.).
FIG. 14.
Lets Review
It all adds up to this: Existence of flow, direction, and spatial characteristics of flow = a qualitative assessment of blood flow. Color Doppler also provides a rapid assessment of flow abnormalities and general location, so pulsed or CW spectral Doppler can be employed. Spectral Doppler provides a quantitative assessment of flow.
Spectral Doppler can be continuous wave or pulsed wave. CW Doppler detects high frequencies without aliasing but has limited range location. Pulsed Doppler has accurate range location but is a pulsing technique (PRF) and will alias if the speed of the blood exceeds 1/2 of the PRF (Nyquist limit). Both PW and CW Doppler use the Fast Fourier Transform (FFT) process to compute peak frequency data from a single sample volume. CW and PW Doppler frequency shifts can be corrected for angle and converted to velocities. Spectral Doppler data are quantitative data. Color Doppler is a pulsed Doppler technique. Color Doppler must use pulse repetition frequencies. Color Doppler uses the autocorrelation processing technique. Autocorrelation averages the frequency shifts from millions of blood cells moving through thousands of sample volumes. A color Doppler display shows average frequency data. Color Doppler data are qualitative data.
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FIG. 15.
Doppler Displays
You should now understand that Doppler is color and color is Doppler. This becomes apparent when we look at the similarities in the data provided on our spectral and color Doppler displays. As Figure 15 demonstrates, all displays show the difference between positive and negative flows. The spectral Doppler graph describes flow that is either moving towards or away from the transducer. A positive spectral shift will be written above the zero baseline. A positive color shift is written above the zero color baseline as well. Negative Doppler and color shifts are simply written in the opposite direction. As the graph shows, there are different kinds of displays available that all provide the same type of data.
or reversed flow by encoding it blue. Do not ever accept a color display at face value. Arterial flow is not always red, and venous or reversed flow is not always blue. A sound knowledge of anatomy, physiology, and hemodynamics is the best way to avoid mistakes in Doppler diagnosis.
Caution
All Doppler units have spectral and color invert controls, which allow positive and negative shifts to be reversed on their displays. There are times when this is an advantage, such as making arteries appear red regardless of their direction of flow. The invert control can help call attention to venous flow
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you produce and look at displays amplitude. The strongest amplitudes are displayed as the brightest whites, and the weakest amplitudes are displayed as the darkest grays or blacks. Power Doppler simply analyzes the strength or amplitude of the insonated blood cells and displays those ranges in shades of gold or yellow or something close to that. The highest concentrations of blood cells are located in the center of blood vessels, so the power display is brightest there. There are less blood cells at the edges of the vessels, so the returned amplitude signals are smaller, thus the definition of vessel walls. Those signals are displayed in shades of darker colors. Since we are looking at amplitude, not frequency data, PDI is not subject to the common Doppler artifacts such as aliasing, angle of insonation, etc. PDI is not as dependent on angles as color, so the typical signal dropout at 90-degree interfaces is greatly reduced. And an added bonus is that PDI is more sensitive to extreme slow flow than color Doppler is! So, if you need to know the direction of blood flow, use color Doppler and live with the inherent artifacts. If you need extreme sensitivity to slow flow or need to visualize residual lumens better or just hate Doppler artifacts, use power Doppler. As I said way back at the beginning of this article, though, everything has a trade-off, and PDI is much more sensitive to motion artifact, so uncooperative patients will present a problem. Also, PDI does not display hemodynamics very well, so color should be used to evaluate the motion of blood.
PRESETS/ICON Function
Allows rapid optimization of image, Doppler, and color parameters for all clinical applications. Proper use of system icons saves time, reduces button pushing, and ensures diagnostic results.
Recommendations
Presets/icons do many useful things. Many ultrasound manufacturers provide presets as a place to start, but optimizing the presets to lab preferences will be helpful. Their use sets proper gains, powers, PRF, DGC curves, filters, etc. Most important, they provide the FDA-recommended power levels for each application. Different clinical situations require that you intervene with system controls to optimize parameters. Use the preset/icon setting as a stepping-off point and adjust controls accordingly to clinical needs. Dont worry about power settings as the proper preset/icon selection will not let you exceed power levels for that application.
Clinical Situations
Improper use of preset/icons will yield inadequate results. For example, the leg vein preset/icon sets parameters for low-speed venous flow detection. Trying to perform cardiac studies with the leg vein preset/icon will result in sensitivity to slow, phasic flow but no aliasing control for high-speed cardiac flow. Using the renal icon for a carotid study would provide the wrong filters and PRF performance, so a carotid study would be inadequate. Let the preset/icons work for you, not against you. You will save time, avoid frustration, and obtain optimal clinical data.
MASTER OR RECEIVE GAIN: COLOR OR SPECTRAL DOPPLER Function
Increases or decreases the received signal only Does not control insonative energy into tissue
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Recommendation
Dont rely on icon preset adjustments. Always adjust gain for optimal signal display. Sometimes it helps to increase gain until display becomes noisy and then reduce gain to an acceptable level. This ensures you have correct gain settings.
Clinical Situations
blood is faster than 1/2 PRF (Nyquist limit). Normal flow can alias. Scale set too low in color can cause tissue flash to overlie blood signals or show color outside of cardiac chambers.
HIGH-PASS FILTERS (HPF) Function
Not enough Doppler gain = reduced display of low flow. Too much image gain can minimize color display. Too much color gain causes color bleeding onto tissue.
PRF/SCALE Function
Blood signals are high frequency, low amplitude. Tissue signals are low frequency, high amplitude. Low-frequency tissue signals can mask low blood flow signals. Filters help to eliminate low-frequency signals from tissue, thereby increasing the display of slow blood flow.
Scale or PRF controls the sample time or look time that is required to process Doppler information.
Recommendation
Slow flow detection requires low PRF settings. High flow detection requires high PRF settings. PRF also controls aliasing.
Use filters to display low-flow signals and reduce tissue flash. Filters should be set independent of PRF if possible. Caution: Think of filters as electronic erasers. They eliminate all signals from frequency shifts lower than the filter number you select (i.e., a filter setting of 200 Hz will display no frequencies lower than 200 Hz).
Clinical Situations
Recommendation
Do not rely on preset/icon PRF settings. Scale must be adjusted for each patient and different clinical situations. Use the preset as a starting point only. Increase or decrease scale for high or low flows and to control aliasing.
Clinical Situations
Increased PRF may eliminate display of extremely slow flows. When you suspect total occlusion or small areas of reflux, scale must be set at lower levels. Remember, color alone cannot diagnose total occlusion. Only rare cardiac situations require changing color Doppler PRF. Scale set too low will cause Doppler aliasing. Remember: aliasing occurs if the speed of the
Filters set too high will erase slow flow in extremely stenotic lumens and valves. Filters set too high can erase bidirectional flow in dissected vessel lumens. Filters set too low will cause tissue flash to obliterate small vessels. Filters set too high will erase the diastolic component of the waveform and the color profile. Filters set too high will erase small reflux flows. Use caution when comparing Doppler results from different systems. If the filters are not the same, the diastolic or low-flow component of the waveforms and colors can be different.
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To provide optimal angle of interrogation angles for accurate Doppler signal acquisition. Remember that interrogation angles closest to 0 degrees provide highest frequency shifts.
Recommendation
veins in the neck and extremities are somewhat straight. Using Doppler/color invert makes it fairly simple to maintain a red or blue display regardless of the angle of Doppler interrogation. This is not the case in abdominal or cardiac Doppler. In these studies, red conventionally indicates positive flow, and blue indicates negative flow.
REGION OF INTEREST SIZE Function
Spectral Doppler requires angles less than 60 degrees in vascular work and 0 degrees in cardiac for accurate conversion of frequency shifts to velocities. The closer your angles are to 0 degrees, the better the quality of the signal will be, and velocity conversion will be even more accurate. Color Doppler does not display velocity data; therefore, angle is not as critical. Most color mappers provide steering angles of 20 degrees left or right of center. This provides directional color (red/ blue). Vessels that lie closest to 0 degrees will display the highest shifts and can cause aliasing. Remember, if you need directional color, steer left or right. Maximum color sensitivity to extremely slow flow, however, is obtained at the 0-degree angle.
DOPPLER/COLOR INVERT Function
The color region of interest (ROI) is adjustable in the axial and lateral dimensions to facilitate sampling large and small organs, various lengths of vessels, and small areas such as stenotic heart valves.
Recommendation
A Doppler invert control simply reverses the direction of the Doppler display. This helps maintain an antegrade or retrograde display for exam continuity regardless of flow direction.
Recommendation
The color ROI should be kept as small as possible to maintain optimal system performance. Opening the ROI in the axial dimension adds hundreds and sometimes thousands of sample volumes for color processing. If these sample volumes are in tissue and not the vasculature being sampled, the system is made inefficient by having to service sample sites of no interest. Increasing the ROI in the lateral dimension has a direct result on system frame rate and therefore temporal resolution. The wider the ROI is opened, the slower the frame rate becomes. Conversely, the smaller the ROI, the faster the frame rate. For optimal system performance, keep the ROI as small as possible while sampling the necessary area of interest.
Clinical Situations
Tortuous vasculature will have flow that moves in one direction in the vessel but in many directions to the interrogating Doppler beam. Use the Doppler/ color invert control to maintain a unidirectional color or spectral display.
Clinical Situations
Vascular labs have adopted the practice of displaying arteries as red and veins as blue. This can be easily accomplished as the major arteries and
It can be advantageous to display long segments of vessels, entire organs such as the kidneys, or complete cardiac chambers. This makes for easy interpretations, but frame rate and temporal resolution can be severely compromised. When it is necessary to increase ROI width, try reducing the color quality setting. By reducing the number of times each color vector is sampled, frame rate will increase. When color quality is set at its lowest set-
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ting and the ROI is at its smallest size, the system will be at its most efficient performance level.
COLOR QUALITY Function
Controls the dwell time or sampling time for color Doppler. Color quality is also known as packet size or length and ensemble length. It simply means how many times and for how long does the system sample each color vector for our three basic components of flow, direction, speed and variance, or turbulence.
Recommendation
These vessels contain moving blood that Doppler is detecting, but since they are not seen as black, the system does not write color in them. B-scan/ color priority overcomes this liability by reducing the priority of gray scale in the decision process of writing color data. By reducing the gray-scale priority, color will be written in areas that are detected by Doppler but not displayed in B-mode imaging.
Clinical Situations
Color quality is directly related to how good the color display is. The longer the dwell time, the prettier and more homogeneous the color display. A shorter dwell time results in a more pixilated color display with a more accurate display of hemodynamic changes. The sonographer must decide what the quality of the color display will be.
Clinical Situations
Incorrect B-scan/color priority settings will eliminate flow from tiny vessels that are not visualized. When performing color Doppler studies of the thyroid, testicles, fingers, tumors, etc., which typically have microvasculature, be certain that the priority is given to colornot B-scan.
COLOR MAPS Function
To provide different color schemes for the display of various hemodynamic conditions.
Recommendation
Color quality affects frame rates. The longer the dwell time, the prettier the color, but the slower the frame rate becomes. Reduced dwell times provide color images that may not be as aesthetically pleasing but will have faster frame rates and therefore better temporal resolution.
B-SCAN/COLOR PRIORITY Function
Everyone perceives color differently. Select the color map that presents the most frequency data (color) to your eyes. Icon or preset maps are usually best suited for their particular applications.
Clinical Situations
Allows color Doppler information to be displayed when vasculature is too small to be visualized in B-scan.
Recommendation
Red/blue maps provide directional indication. A rainbow map displays more colors than red and blue to match the various frequency shifts present. A rainbow map shows all flow present. The variance map should be used to indicate turbulent flow associated with luminal stenosis or valvular stenosis.
IMAGE/DOPPLER FREQUENCY CONFIGURE Function
A color mapper is designed to write color where it sees no gray-scale tissue data. This makes it easy for the system to write color on black vessels and not on tissue. There are many blood vessels in the body, however, that are smaller than the image resolution capabilities of ultrasound technology.
Provides multiple frequencies for 2D, spectral, and color Doppler imaging. These frequencies may all be different from the center frequency of the probe.
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Recommendations
Frequency configure is an extremely important control as it lets the sonographer optimize the proper frequency to the clinical situation. When it becomes advantageous to use higher transmit or receive frequencies for increased backscatter, greater sensitivity, improved spatial resolution, or lower frequencies to increase penetration and reduce aliasing, frequency configure should be used.
Clinical Situations
= =
1 sq. decameter
1 sq. hectometer 1 sq. kilometer
= = =
When using a 2.25-MHz transducer to image the heart, shifting image and Doppler frequencies can increase/decrease image resolution and Doppler sensitivity, increase/decrease Doppler backscatter, and improve color resolution. Backscatter can be increased for signal strength, small signals can be received at higher frequency shifts for easier detection, and resolution can be increased in both imaging and Doppler.
1 yard
1 mile
25.4 millimeters 2.54 centimeters 30.48 centimeters 3.048 decimeters 0.3048 meter 0.9144 meter 3.2808 feet 1.0936 1609.3 meters 1.6093 kilometers
1 centimeter 1 decimeter
39.37 inches
1 meter
1 kilometer
Prefix giga mega kilo hecto deca deci centi milli micro nano
Symbol G M k h da d c m n
Meaning billion million thousand hundred ten tenth hundredth thousandth millionth billionth
= = = = = =
COMPLIMENTARY METRIC UNITS Numbers billions and billionths millions and millionths thousands and thousandths hundreds and hundredths tens and tenths Metric Equivalents giga & nano mega & micro kilo & milli hecto & centi deca & deci G&n M& k&m h&c da & d
= = =
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JDMS 21:3637
January/February 2005