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Culture Documents
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of
NORTH EAST INDIA RESEARCH FORUM
http://tech.groups.yahoo.com/group/northeast_india_research/
www.neindiaresearch.org
CONTENTS
1. THE FORUM 05
3. NEWS
a. Research and Developments 07
b. Forum Members in News (awards, fellowships, visit etc) 10
5. ARTICLES:
a. Nanomedicine: Nanoparticles in Drug Delivery
Dr. Jadab Sharma [ jadab.s@gmail.com ] 14
b. Disposable Plastics
Mr. Binoy Kumar Saikia [ binoyrrl@yahoo.com ] 17
should be used to blame a child for being scientists have found that a protein called
involved in bullying. "The information Ecadherin is essential to keeping cells
should help schools and parents find new stuck together and when its levels fall,
ways to deal with bullying." (Courtesy: other proteins move to the surface of the
Times of India) cells and they manage to break away and
spread, the Daily Mail reported on
■ South Korean scientists have cloned Thursday. "Understanding how cancer
cats that glow red under ultraviolet light, cells spread is tremendously important for
as part of research aimed at developing cancer research. It is the ability of tumours
treatments for human genetic diseases, say to invade other tissues and spread around
officials. the body that makes them so dangerous.
The cancer just overwhelms the body,"
lead researcher Chris Ward was quoted as
saying. "Potentially, our findings can be
applied to the most common form of
cancer, carcinoma, found in the breast,
lung and gut for example, which makes up
80 to 90 per cent of all cancers," Ward
added. The researchers, who used
embryonic stem cells to unlock the secret
A team of scientists led by Professor Kong behind how cancer spreads around the
Il-keun, a cloning expert at Gyeongsang body, now plan to create drugs that
National University in Jinju, produced interfere with this process. "These findings
three glowing Turkish Angoras cats, say may enhance our ability to come up with
the country's Ministry of Science and more effective drugs". Norman Barrett of
Technology. According to the Korea the Association for International Cancer
Times, the scientists added red Research, which funded the study, said,
fluorescence protein (RFP) genes to the "Dr Ward and his team are pursuing
skin cells of the mother cat. They then research which could change the lives of
inserted the skin cells into ova to produce tens of thousands of people in the United
cloned cats genetically modified to contain Kingdom and many more across the
the RFP gene. "It marked the first time in world". (Courtesy: Nature)
the world that cats with RFP genes have
been cloned," says the ministry of science
■ The Department of Science and
and technology. "The ability to produce
Technology (DST) is looking at ensuring
cloned cats with the manipulated genes is
enrolment of at least 250 PhD students in
significant as it could be used for
nanosciences over the next five years.
developing treatments for genetic diseases
They will be registered in leading central
and for reproducing model [cloned]
and state universities and specialized
animals suffering from the same diseases
research institutes. While it is not clear
as humans." The technology will also help
how many will graduate in a year, 50 pass-
to develop stem cell treatments - noting
outs a year are needed to ensure India has
that cats have some 250 kinds of genetic
at least 250 nano scholars by 2012.
diseases that also affect humans. The
However, fresh scholars cannot register as
technology will also help clone
it would take them a minimum of three
endangered animals like tigers, leopards
years, if not four, to complete their PhD.
and wildcats, Kong says. (Courtesy: The
But as nanoscience is an inter-disciplinary
Ministry of Science and Technology/AFP)
subject, students already enrolled in
courses relating to or contributing to
■ British scientists claim to have nanosciences could be considered nano
discovered the mechanism cancer cells use research scholars. What exactly the
to spread around the body - a research will focus on will have to be
breakthrough which could stop the disease decided by the institution concerned after
right in its tracks. In their research, the consulting senior academics and policy-
diffraction maximum or reflection has be 0.1 mm to 0.5 mm, not cracked and not
associated with it a structure factor F(hkl) twinned.
measured relative to the scattering by a 2. Stable crystals of typical organic,
single electron. The structure factor may organometallic or coordination complexes
be represented as a complex vector: F(hkl) can usually be grown by slow
= A(hkl) + iB(hkl) where A(hkl) and recrystallization from common solvents.
B(hkl) are the real and imaginary Other types of compounds may require the
components of F(hkl). use of sublimation, zone refinement,
solvent diffusion, low temperature and
Instrumentation: inert-atmosphere techniques.
for the use in cancer treatment and are IMAGING BIO COMPATIBILITY
(FLOURESCEIN PROBE)
intravascularly injectable. Their
CELL PERMEABILITY
envisioned use is for the in vivo, non- DRUG MOLECULES
HN CH2 CH2 SH
14
O
Degradable plastics:
-Enzymes Electrodes
Biosensor and its applications -Cells, Microorganisms
Tissues and organelles
Transistors
Thermistors
Sample Optical detectors Amplifier
-Antibodies and
Receptors Piezoelectric
Mr. Manashjit Gogoi -Nucleic Acids crystal
0.12345
Bioreceptors Physical
Introduction: Transducer
where Pi is the added component property morphologies and device geometries, etc
and n is an experimental parameter ( 1 ≤ [6]. Polymer based magnetic
n ≤ 1). Nanocomposites differ from their nanocomposites with high initial
bulk components in terms of the strong permeability and high dielectric constant
interactions of grains around the grain are interesting because of their flexibility,
boundaries. There are six properties of compatibility and easy fabrication nature.
interest in nanocomposites. These are: Polymer/metal/ferrite composites consist
mechanical, magnetic, electrical, optical, of a polymer, a magnetic metal and a
quantum dots and catalytic properties. ferrite material either on the coronal
Nanocomposites exhibit unique behavior surface or in the interior core of the
due to three effects (i) the smaller size polymer microdomains as filler. This is a
effect, (ii) the large grain boundary effect, totally innovative composite material,
and (iii) the quantum confinement effect. where properties of both the matrix
Moreover, they exhibit high reactiveness polymer and the nanocomposite
during synthesis and in processing components are synergized. In such
situations. Thus, these conditions leads to polymer/metal/ferrite composites, high
increase in strength and hardness of initial permeability can be obtained by
ceramic matrix nanocomposites, lowering dispersing ferrite particles with large
in melting point and increase in electrical initial permeability in the polymer matrix
resistivity of metallic matrix as filler, and in addition, dielectric
nanocomposites, increase in absorption of constant can be enhanced over their
UV wavelength in polymer matrix polymer matrix. Thus, merging these two
nanocomposites, increase in shielding the different properties in polymer based
electrostatic field for semiconducting composites, it will be easier to overcome
matrix nanocomposites, etc. the disadvantages of purely ceramic based
Nanocomposites find their applications in composites. Finally we can expect some
various areas, such as electromagnetic more enhanced applications from the
wave absorber, biocompatible magnetic nanocomposites.
nanofibre, conducting polymer
nanocomposites, cheaper optoelectronic, References:
photonic and electronic devices, integrated
circuit (IC) products, etc [4]. 1. J. B. Schutz, Cryogenics 38 (1998) 3.
2. D. Xie, I.-D. Chung, G. Wang and J.
Out of the application oriented Mays, J. Biomater. Appl. 20 (2006)
nanocomposites, magnetic 221.
nanocomposites in which magnetic species 3. P. M. Ajayan, L. S. Schadler and P. V.
are dispersed within nonmagnetic or Braun, Nanocomposite Science and
magnetic matrices are practically very Technology, (Wiley-VCH GmbH &
useful. Magnetic recording, GMR, Co. KGaA, Weinheim, 2003).
magnetic refrigeration, etc., are some 4. H.-L. Tasi, J. L. Schindler, C. R.
important areas in which magnetic Kannewurf and M. G. Kanatzidis,
nanocomposites have importance [3,5]. Chem. Mater. 9 (1997) 875.
One newly studied nanocomposite 5. H. Zeng, J. Li, J. P. Liu, Z. L. Wang
material is the polymer/metal/ferrite and S. Sun, Nature 420 (2002) 395.
composite. The importance of such a 6. D. Y. Godovsky, Adv. Poly. Sci. 153
system is that after little modification, (2000) 163.
these can be used as capacitors and
inductors. Moreover, they have advantages About the author:
over the current ferromagnetic-
ferroelectric ceramic composites in Sasanka Deka hails from Kamrup, Assam.
various terms. The main advantages of He has completed his B.Sc. degree from B.
magneto-polymer composites are the Barooah College, Guwahati in 1998 and
ability to tailor materials for special Master degree from the department of
purposes, low cost of production, Chemistry, Gauhati University in 2000.
availability to develop totally new material After clearing CSIR-UGC-NET he joined
Scheme 3.2
(c.f. protein structure) and obtain insights brief account of this experiment has been
into the realm of sulfidoamide chemistry. included in this chapter.
VO2F(dmpz)2, H2O2, H+ QA
+ Traditional synthesis
– –
3Br Br3 QABr3 O
0.01 : 3.2 : 1.2 CHO CHO
Reduction
+
QA = Tetrabutylammonium or Benzyl triethyl ammonium NO2
Condensation N
NH2
Scheme 5.2a
Scheme 6.1
bromide and sulfides using H2O2 as the (2008) degrees in Chemistry, under the
oxidant. The use of cost-effective, supervision of Prof. M. K. Chaudhury,
innocuous, recyclable catalysts and from the Indian Institute of Technology,
environmentally benign oxidant and eco- Guwahati, India. Presently, he is working
friendly solvents are some of the important as a post doctoral fellow in Nanophotonics
and Nanomedical Research Group,
attributes in the protocols. The work
Pohang University of Science and
embodied in the thesis satisfies the tenets
Technology, Pohang, Republic of Korea.
of “Green Chemistry” and it is anticipated
that the results reported herein will
provide scope for further studies. Effect of Solvent Media in Altering The
Rates of Diel-Alder Reactions an Other C-C
Reference Bond Forming Reactions:
1. A. Sheldon, I. Arends and U.
Hanefeld, Green Chemistry and
Catalysis Wiley-VCH, Weinheim, 1st
Ed., 2007.
2. R. Noyori, Proceedings of Indian
National Science Academy 2006, 72,
267.
3. R. Noyori, M. Aoki and K. Sato,
Chem. Commun. 2003, 1977. Dr. Diganta Sarma
4. M. L. Kantam, V. Neeraja, B. Kavita,
B. Neelima, M. K. Chaudhuri and S. Conventionally most of the organic
Hussain, Adv. Synth. Catal. 2005, 347, reactions are carried out in solution phase.
763. The solution phase, that contains pure or
5. (a) M. K. Chaudhuri, S. Hussain, M. mixed solvents, plays a pivotal role in
L. Kantam and B. Neelima, determining the course of reactions and
Tetrahedron Lett. 2005, 46, 8329; (b) the amount of product formed. There are
M. K. Chaudhuri and S. Hussain, J. other parameters like temperature,
Mol.Catal. A: Chemical 2007, 269, pressure, concentration of reactants and
214. stability of product that are also essential
6. S. Hussain, S. K. Bharadwaj, M. K. in governing the course of reactions.
Chaudhuri and H. Kalita, Eur. J. Org.
Chem. 2007 361.
7. S. Hussain, G. Das and Mihir K.
Chaudhuri, J. Mol. Structure 2007,
837, 190-196
8. M. K. Chaudhuri, S. K. Dehury, S.
Hussain, A. Duarah, N. Gogoi and M.
L. Kantam, Adv. Synth. Catal. 2005,
347, 1349. Scheme I
9. M. K. Chaudhuri, S. K. Dehury, Sahid
Hussain, A. Duarah and N. Gogoi,
Org. Prep. Proc. Int. 2006, 38, 331. However, the change of a solvent in
10. M. K. Chaudhuri and S. Hussain, J. an organic reaction can bring about great
Chem Sci. 2006, 118, 199. changes in its kinetic profiles. There are
several interesting properties of solvents,
About the author: which may be considered significant in
altering the reaction kinetics of organic
Sahid Hussain obtained his B.S. (1999) reactions. The solvent media may promote
from Science College, Jorhat; the Master the reaction rates by stabilizing the
(2001) from Cotton College, Gauhati transition state. The polarity, dielectric
University, Assam. He qualified CSIR-JRF constant, ionizing power, surface tension,
examination and then completed his Ph.D.
viscosity, etc. of solvents can play crucial environmental pollution caused by the use
role in directing the kinetics of organic of these volatile organic solvents, there is
reactions in a specific manner. a greater need to replace them by
environmentally benign solvents. In this
The Diels-Alder reaction is one of the regard ionic liquids have emerged as
most important C-C bond forming important substitutes for several organic
reactions in organic chemistry to form solvents. Many ionic liquids have been
cyclic structures. It is a class of developed for specific synthetic problems.
cycloaddition reaction between a For this reason, ionic liquids have been
conjugated diene and an alkene, termed “designer solvent”. Ionic liquids
commonly termed the dienophile, to form are considered green solvents in
a cyclohexene system. The remarkable substituting many volatile organic solvents
importance of Diels-Alder reaction lies in as they possess some special properties
the synthesis of natural products and like: (1) They are nonvolatile, (2) They are
physiologically active molecules. For a nonflammable, (3) They have
long time solvent polarity was believed to physicochemical properties that can be
have no effect on the course of a Diels- altered / controlled by judicious selection
Alder reaction due to involvement of of the cation and/or anion and (4) Most
isopolar activated complex. Berson, importantly they can be recycled for a
however, showed a clear relationship number of times without loss of activity.
between the endo/exo product ratio and
solvent polarity in the Diels-Alder reaction Several parameters have been
of cyclopentadiene and acrylates. Diels- discussed to explain dramatic variation in
Alder reactions in aqueous media were reaction rates as well as stereoselectivities
first carried out back in the 1930s, but no in the above mentioned solvent media.
particular attention was paid to this fact The possible origin of forces includes
until 1980, when Breslow and coworkers hydrophobic packing, solvent pressure,
made the startling observation that the hydrogen bonding, hydrophobic hydration,
reaction of cyclopentadiene with butenone and salting-out (S-O) and salting-in (S-I)
in water was more than 700 times faster effects, etc. However, no single parameter
than the same reaction in 2,2,6- can explain the rate profiles of all
trimethylpentane; whereas the reaction reactions studied.
rate in methanol is comparable to that in a
hydrocarbon solvent. Such an unusual The present thesis deals with
acceleration of the Diels-Alder reaction by delineation and understanding of origins
water was attributed to the “hydrophobic of possible forces responsible for rate
effect”, in which the hydrophobic acceleration and stereoselectivities in
interactions brought together the two water, aqueous salt solutions and ionic
nonpolar groups in the transition state. liquids. These have been discussed in
detail in seven separate chapters:
Another important C-C bond
formation reaction is Michael addition. Chapter I describes a critical literature
The reaction is the addition of an enolate survey of the physical organic, green
of a ketone or aldehyde (Michael donors) chemistry and asymmetric aspects of
to an α,β-unsaturated carbonyl compound carbon-carbon bond forming reactions, in
(Michael acceptors) at the β-carbon and particular Diels-Alder and Michael
involves conjugate addition. The reaction reactions. The frontier orbital description
donors are active methylenes such as of cycloaddition as well as mechanistic
malonates and nitroalkanes, and the aspects of Diels-Alder reaction has been
acceptors are activated olefins such as α,β- discussed. The role of secondary orbital
unsaturated carbonyl compounds. interaction in understanding the
stereochemistry of Diels-Alder reactions
The conventional organic solvents has been introduced. Efforts have been
used in organic reactions are known to be made to explain the special role of water
environment pollutants. In view of the highlighting the possible factors like
O
the investigations carried out based on the +
literature survey. It also describes the O O
organization of the thesis.
O O
Chapter III is concerned with the
competing role of secondary orbital +
interaction and hydrophobic effect in O O
hydrophobic effect. .
N
MeO O
O O H
N OMe
R = H, CH3
(CH2)n N
N N X
+ 1. Hydrolysis
2. Methanolysis
Scheme III
Figure I. Ionic liquids studied
MeO N O
O
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Scheme IV.
Miss Babita Baruwati (12th September, Mr. Bolin Chetia from Sivasagar, Assam,
1980) is originally from Jamugurihat, received Bachelor degree in Chemistry
Sonitpur, Asom. She did her B Sc in from Govt. Science College, Jorhat
Physics from Cotton College, Guwahati (Dibrugarh University) in 1999. After
(Gauhati University) securing first class receiving Master degree in Chemistry
10th position with distinction in the year (First class first position, in 2002) from
2000. She finished her M Sc Physics Dibrugarh University, Assam (Organic
(High Energy, Nuclear Physics) in the Chemistry specialization), he joined as a
year 2002 from Gauhati University Lecturer in the department of Chemistry,
securing first class 7th position. She Dibrugarh University in January 2003 and
cleared her CSIR-JRF exam in June 2002 serve there till April 2004. Then he moved
and joined the Nanomaterials Group, to Regional Research Laboratory (RRL),
Indian Institute of Chemical Technology, Jorhat, as a research fellow where he
Hyderabad for her PhD under Dr. S. V. worked for almost four months. He
Manorama in March 2003. Her PhD thesis qualified CSIR-UGC JRF and GATE held
entitles “Studies on the Synthesis, in 2003. Currently he is doing his doctoral
Characterization, Surface Modification research in Indian Institute of Technology
and Application of Nanocrystalline Guwahati, since December 2004. His area
Nickel Ferrite”. She has published her of research is to develop better techniques
works in eight international journals for getting nanomaterials, synthesize new
including Applied Physics Letters and hybrid materials with tunable properties
Organic Letters. She has attended many and testing their catalytic, electronic
national and international symposia held at properties as well as look for newer
several places. She will be joining Dr. R. applications for chemical & biological
S. Varma at National Risk Management sensors, light emitting devices,
Laboratory, Cinncinati, Ohio, USA as a solar/photovoltaic cells (PVC) etc. During
postdoctoral fellow in February, 2008. this period, he visited Kyushu Institute of
Technology, Kitakyushu, Japan from 28th
---------------------0---------------------- Aug. to 10th Sept. 2005 to deliver an
invited talk entitled “Energy efficient
organic-inorganic hybrid materials”.
I am the queen
Twilight at Bharalu
First light
Looking ahead
Message:
Hope this picture will always serve as a reminder to us that how fortunate we are
and that we must never ever take things for granted.
---------------------0----------------------
---------------------0----------------------
Postdoctoral Positions:
Description: This new project is under the direction of A. M. Orville, and is also
associated with the PXRR group (www.px.nsls.bnl.gov) at Brookhaven National
Laboratory (BNL). The PXRR group conducts research, technology development,
operations, and training at six beamlines (X8, X12b, X12c, X25, X26c, X29) at the
National Synchrotron Light Source (NSLS). A long-term goal for the PXRR group
is to create a resource for macromolecular crystallography at NSLS-II, the new
synchrotron light source that is being created at BNL during the next five to
seven years. Microcrystals only a few microns along an edge are often easy to
obtain; but, are typically of no use for traditional diffraction studies. In contrast,
the brightness and focused beam anticipated at NSLS-II provides an ideal
opportunity to use microcrystals for diffraction studies. A major barrier that
remains to be overcome is how to manipulate microcrystals for structure
determination. Part of the research strategy will be to use a large number of
randomly oriented microcrystals, from each of which only a small fraction of the
whole dataset is collected, in order to build-up the complete dataset. Full
expression of these methods may approach the physical limits of crystal
diffraction and will clearly help motivate the optimum performance of NSLS-II.
Consequently, we will develop novel microcrystallography methods at the NSLS
and look forward to utilizing the outstanding characteristics of NSLS-II facility.
The position requires a Ph.D. in biochemistry, structural biology, chemistry, or
physics. Experience in macromolecular crystallography and/or synchrotron x-ray
sources is desired. The prospective candidate must be able to interact with a
diverse group of scientists and engineers, as well as work independently. Send
CV and contact information for four mentors or referees to felicia@bnl.gov
referring to Position No. FH4835.
(5) In Nanomagnetism
Universität Konstanz
Fachbereich Physik
Dr. Mathias Kläui
E-mail: M.Klaeui@uni-konstanz.de
Moderators:
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