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Contents
The Forum 5
North-East Indians Made Us Proud 6
News
a) Science News 7
b) Forum Members in News 9
Instrument of the Issue
Scanning Electron Microscopy (SEM) 10
Dr. Arindam Adhikari
Some Award Winning SEM Images 13
Molecule and Material of the Issue
Sagopilone: A Modified Epothilone Analogue as Promising Anti Cancer Agent 14
Dr. Joshodeep Boruwa
Article Section
I. Invited Article
Zeta Potential Characteristics of an Iron Rich Kaolinite Clay 15
Mr. Pinaki Sengupta
II. Green Clean: A Hope 25
Ms. Nabanita Bhattacharyya
III. Positron Emission Tomography 27
Dr. Diganta Sarma
IV. Thermo Responsive Magnetic Nanoparticles and their Applications 29
Dr. Smriti R. Deka
V. RNA interference(RNAi) 32
Mr. Khirud Gogoi
VI. Nanoscience and Nanotechnology for Improvement of Human Lives 36
Mr. Pankaj Bharali
Ph. D. Thesis Abstract
Abstract 1: Adsorption of Organic Anions on the Metal Oxide Surfaces 40
Dr. Manash R. Das
Abstract 2: De Novo Designed Molecules Based on Non-covalent
Interactions: Design, Synthesis and Structural Studies 47
Dr. Pranjal K. Baruah
Information About Forum Members 51
Higher Study Abroad 52
Through the Lenses of Forum Members 57
Science News
The State Government of Assam has India aims for ‘quantum jump’ in science:
prepared a concept paper for establishing a In the month of January, 2008, our Prime
science and technology university in the Minister Dr. Manmohan Singh has
State. The Science and Technology announced unprecedented funding for
Department of Assam is holding discussions science education and research, saying it is a
with Education Department with this aim in top priority for the government. He has
view. The Assam Government is planning to announced a range of schemes to attract
set up a science city in Guwahati. It has also students and replenish government agencies'
proposed a biotechnology park in the city shrinking pool of scientific personnel.
during the current year. (March 28, 2008,
The Assam Tribune). It is planned to fund 30 new Central
Universities, five new Indian Institutes of
Science Education and Research, eight new
The Northeast is likely to have another Indian Institutes of Technology, and 20 new
National Institute of Technology, with the Indian Institutes of Information Technology.
Central Government considering In the next five years, Dr. Singh added, India
establishment of an institute in Manipur. will also be launching 1,600 polytechnics,
Addressing the ongoing Social Editor’s 10,000 vocational schools and 50,000 skill-
Conference, HRD Ministry officials said a development centres. One million
Central team after visiting the State has schoolchildren will receive science
submitted its report last November. The innovation scholarships of 5,000 rupees
report is under process currently, said the (US$130) each over the next five years, and
official. (January 29, 2008, The Assam 10,000 scholarships of 100,000 rupees per
Tribune). year will go to those enrolling on science
degree courses.
Yengkhom Daevson from Imphal, Manipur, Discipline-specific education programmes
has invented a unique weaving machine that will be launched in strategic sectors such as
makes garments without any stitches. This nuclear and space sciences “to capture talent
news came into focus in a press conference at the school leaving stage itself”. (Courtesy:
on 19th December 2007 in National Institute NatureNews)
of Fashion Technology (NIFT), Delhi,
Ministry of Textile, Government of India. A Editorial comment: We hope the
Special event organised for Y. Daevson an announcement by our honourable prime
alumni of NIFT, who has invented “BEMM” minister will encourage, not only the present
a seamless woven garment making machine science students, but also will motivate the
that makes woven seamless garments.It is a new generation to do something in science.
unique combination of fashion and Everybody should welcome this effort and
innovation with technological development. help the government to fulfil the motive, and
With this new machine, one can combine the of course, forgetting oppositional political
textile and the garment industry. There is views. Hope India will diminish the brain-
advantage; it does not involve any stitching. drain by the 'quantum jump' in science.
Smallest Black hole: Astrophysicist claimed, Nation invests USD 208 million in N.E.
they've found the smallest black hole so far, education infrastructure: The central
which is less than four times the mass of our sun government has launched an ambitious Rs.
and about the size of a large city. Nikolai 8.17-billion ($208 million) scheme to
Shaposhnikov of NASA's Goddard Space Flight develop educational infrastructure in India's
Center says “This black hole is really pushing
eight north-eastern states, according to an
the limits. For many years astronomers have
wanted to know the smallest possible size of a official report. “Of the Rs. 8.166 billion, Rs.
black hole, and this little guy is a big step toward 6.558 billion have been released so far for
answering that question”. The scientists found various educational projects in Arunachal
the black hole in a system in the southern Pradesh, Assam, Manipur, Meghalaya,
constellation Ara, in our own Milky Way galaxy. Mizoram, Nagaland, Sikkim and Tripura,”
This black hole probably be stronger than bigger said an official report of the central human
black holes found at the centres of galaxies. It resource development (HRD) ministry. The
was formed by a star that ran out of fuel and shut development plans in the northeast are
down, collapsing due to its own gravity. The centrally financed on the basis of 90 percent
new black hole has a mass 3.8 times that of our
grant and 10 percent loan, the report said.
sun and would be about 24 kilometres across,
“In addition to that allocation, Rs. 520
they estimate. (Courtesy: ABC Science)
million was released to five universities
located in the states of Meghalaya,
Scientists find host of antibiotic-eating Nagaland, Mizoram, Assam, Manipur,
germs: Several strains of bacteria in the soil Arunachal Pradesh and Tripura for setting
can make a meal of the world's most potent up of engineering and management
antibiotics, researchers said, in a startling faculties.”
finding that illustrates the extent to which The central government converted the
these germ-fighting drugs are losing the war Arunachal Pradesh and Tripura universities
against superbugs. A study of soil microbes into central universities in August 2007 and
taken from 11 sites uncovered bacteria that established a new central university in
could withstand antibiotics 50 times stronger Sikkim. According to the report, Tripura
than the standard for bacterial resistance. Engineering College in Agartala has also
George Church, a geneticist at Harvard been upgraded into a National Institute of
Medical School in Boston, whose research Technology (NIT) and the HRD ministry
appears in the journal Science, said “It will soon convert Manipur Institute of
certainly was very surprising to us. Many Technology into a NIT.
bacteria in many different soil isolates can The HRD ministry, with the help of the
not only tolerate antibiotics, they can Indian Space Research Organisation (ISRO)
actually live on them as their sole source of and the north-eastern states has launched
nutrition.” The bacteria were not known to satellite-based educational facilities in the
attack humans, but some were close region aimed at increasing the knowledge
relatives, such as members of the base of students.
Burkholderia cepacia complex, a group of On Aug 14, 2007, the satellite-based facility
bacteria that infect people with cystic was started in Tripura with the help of the
fibrosis, and Serratia marcescens, which can Edusat, a dedicated satellite of the ISRO to
cause blood infections in people with beam educational and training programmes
compromised immune systems. (Courtesy: in the country. (Courtesy: National Network
NewsDaily). of Education, India)
SEM also has much higher resolution, so typically has an energy ranging from a few
closely spaced specimens can be magnified hundred eV to 100 keV, is focused by one or
at much higher levels. Due to the manner in two condenser lenses into a beam with a
which this image is created, SEM images very fine focal spot sized 0.4 nm to 5 nm.
have great depth of field yielding a The beam passes through pairs of scanning
characteristic three-dimensional appearance coils or pairs of deflector plates in the
useful for understanding the surface electron optical column, typically in the
structure of a sample. As characteristic x- objective lens, which deflect the beam
rays are emitted when the electron beam horizontally and vertically so that it scans in
causes the ejection of inner shell electrons a raster fashion over a rectangular area of the
from the sample and thus can also be used to sample surface. When the primary electron
tell the elemental composition of the sample beam interacts with the sample, the electrons
(EDS or EDX, energy-dispersive X-ray lose energy by repeated scattering and
spectroscopy). Because the SEM uses absorption within a teardrop-shaped volume
electromagnets rather than lenses, the of the specimen known as the interaction
researcher has much more control in the volume, which extends from less than 100
degree of magnification. All of these nm to around 5 µm into the surface. The size
advantages, as well as the actual strikingly of the interaction volume depends on the
clear images, make the scanning electron electrons' landing energy, the atomic number
microscope one of the most useful of the specimen and the specimen's density.
instruments in research today. The energy exchange between the electron
beam and the sample results in the emission
of electrons and electromagnetic radiation,
which can be detected to produce an image.
The image consists of thousands of spots of
varying intensity on the face of a cathode ray
tube that correspond to the topography of the
sample.
Molecule and Material of the Issue crisscrosses the inside of the cell, the part of
the cytoskeleton that both stabilizes the cell
and makes it flexible.
Sagopilone: A Modified Epothilone
The taxanes, already in successful
Analogue as Promising Anti Cancer
use for many years now, prove that the
Agent
cytoskeleton provides a suitable target for
Dr. Joshodeep Boruwa cancer medication. Originally harvested
jboruwa@googlemail.com from the bark of Pacific yew trees, they are
now synthesized from substances found in
Cancer cells sometimes defend the needles of the European yew. Like the
themselves against medication by epothilones, the taxanes inhibit the
transporting active ingredients back out of breakdown of the cytoskeleton. But why all
the cell through built-in pumps. Even the effort to develop the epothilones as an
taxanes, some of the most effective cancer alternative to the taxanes when they both
drugs, are occasionally expelled in this target the same site? As potent as the taxanes
manner and therefore remain virtually are, they have drawbacks: tumor cells are
ineffective. Researchers at Bayer Health often able to expel the taxanes via pumps
Care are now performing clinical tests on a before they can attack the cancer cells. Due
new substance that is not recognized by the to this tendency to develop resistance, other
pumps. Intensive structural modifications agents are very welcome. In addition, unlike
were performed on epothilones to overcome the epothilones, the taxanes are not water-
the limitations associated with this novel soluble and must therefore be administered
class of anticancer substances. During this in an oily solution that can induce allergies.
optimization process, more than 350 However the synthesis process to this
biologically active epothilones were molecule was very complex, But starting
synthesized, from which sagopilone was with three purchasable initial materials and
selected for clinical development because of more than 100 additional ingredients, the
its outstanding preclinical properties. research group required a total of 39
Sagopilone exhibits a high level of in individual steps to produce three initial sub-
vitro and in vivo activity against a broad units which they then used to construct the
range of different human tumour models, finished molecule.
including those that are particularly sensitive Report from Bayer Health:
to taxanes but also those that are resistant to Clinical experts must now prove that
taxanes or other commonly used sagopilone is really as promising as previous
chemotherapeutic agents and therefore no studies indicate. If the results of the
longer respond to these compounds. following clinical studies are good, cancer
It is well known that anticancer researcher Ulrich Klar predicts that
agents inhibit cell division and researchers sagopilone, either alone or together with
have long focused on cell division, as the other medications, will play an important
majority of tumors become dangerous only role in getting a vice-like grip on cancer of
as a result of their unchecked growth. The various origins and in all of its stages.
first drug products introduced were the
cytostatics, which typically damage cells by
About The Author:
interfering with metabolic activity during
cell division. Epothilones target a very Dr. J. Boruwa is currently a postdoctoral
different area. They attach themselves like a research fellow at Fechbereich Chemie,
vice to the network of protein threads that Universitst Konstanz, Germany.
Invited Article
Zeta Potential Characteristics of an contains silica in the form quartz. The nature
Iron Rich Kaolinite Clay and proportions of these impurities depend
on the mode of origin of the deposit and
differs from place to place. For most modern
industrial and other uses, kaolin must be
extensively refined and processed to enhance
certain important characteristics. Removal of
iron- and titanium-bearing materials from
clay and other minerals, in addition to
impurities like silica, is of great interest even
today.
The kaolin used in this investigation
was collected from Deopani deposit (latitude
Mr. Pinaki Sengupta 26o 14/ 27// to 26o 14/ 39// N; longitude 93o
pinakiajitsengupta@yahoo.com
45/ 54// to 93o 46/ 05// E) of Karbi Anglong
district of Assam (India). The clay, which is
Introduction
rich in iron contaminants, is yet to be
economically utilized because of lack of
The knowledge of Zeta potential is
detailed characterization and beneficiation
very much essential in respect of mineral
process. Before we proceed further in
processing and utilization. North Eastern
discussing the zeta potential characteristics
region is endowed with various minerals like
of the iron rich Deopani kaolin, it is essential
clay, limestone, graphite, coal etc.
to recapitulate the structure of clay minerals.
Beneficiation and utility studies are pre-
requisites for meaningful utilization of these
Structure of the clay minerals
mineral resources.
Kaolin is one of the most versatile
Clay minerals belong to the
materials used in various industries. The
‘phyllosilicates’ (meaning layered silicates),
term Kaolin is used for near-white clay
having two dimensional arrays of silicon-
deposits, which are dominantly composed of
oxygen tetrahedra and two dimensional
kaolinite mineral. The oldest known use of
arrays of aluminium-oxygen-hydroxyl
the kaolin clay is as a ceramic raw material.
octahedra as the principal building elements.
Presently, the clay also finds application as a
The analogous symmetry and the almost
coating and filler pigment for paper, as a
identical dimensions in the tetrahedral and
filler for paint, rubber, insecticide,
the octahedral sheets allow the sharing of
formulation of medicine, cosmetics, etc.
oxygen atoms between these sheets. This
About 80 % of the total kaolin produced
sharing of atoms may occur between one
worldwide is used in paper industry and the
silica and one alumina sheet, as is the case in
rest 20 % in ceramics, plastics, rubber,
the 1:1 layer minerals. In the 2:1 layer
paints, insecticides, etc. Apart from these
minerals, one alumina or magnesia sheet
kaolinite minerals also find application in
shares oxygen atoms with two silica sheets,
organic reactions as catalysts. Almost all the
one on each side. The combination of an
economic deposits of kaolin are
octahedral sheet and one or two tetrahedral
contaminated by various ferrouginous and
sheet is called a layer. Several such layers
titanium-bearing minerals. Mined kaolin also
are then stacked together face-to-face, with The charge on the first part of the double
interlayer cations, to build up the unit cells layer, i.e., the negative charge on the surface
of clay. Kaolinite is the commonest example of the clay particle remains always fixed.
of 1:1 clay minerals, whereas, smectite or The charge on the other side of the double
montmorillonite represents 1:2 clay layer, i.e., the solution side containing the
minerals. A diagrammatic sketch of the counter ions (cations in the case of clay
structures of both the kaolinite and smectite suspension) can be divided into two parts – a
layer is shown in Figure 1. fixed part of the counter ions at a distance
A schematic representation of the from the clay surface and another diffuse (or
atom arrangements in a ‘unit cell’ of the clay mobile) portion of counter ions with
minerals of the ‘kaolinite’ group having 1:1 concentration gradually falling off or rising
layer structure is shown in Figure 2. The to that prevailing in the bulk of the aqueous
‘unit cell’ of the clay minerals of the phase. This concept of composite layers is
‘smectite’ or ‘montmorillonite’ and the known as Stern’s double layer concept.
‘illite’ groups are derived from the Because of the charge distribution in the
prototypes of the structures of the 2:1 layer electrical double layer, a sharp drop of
(Figure 3) by introducing more or less potential exists from the negatively charged
random atom substitutions in the octahedral clay surface to the positively charged fixed
and/or tetrahedral sheet in the crystal part of the double layer on the aqueous
structure. phase side. It is then followed by a gradual
change in potential across the diffuse part up
Zeta potential of clay to the bulk of the solution. The total
potential drop from the solid clay surface to
If two phases of different chemical the bulk of the solution is called the double
composition are in contact, an electric layer potential (ψ). The difference in
potential difference develops between them. potential between the fixed part of the
This potential difference is accompanied by counter ions and the diffuse portion of the
a charge separation, one side of the interface double layer is termed as zeta potential (ζ).
being positively charged and the other being When clay particles are suspended in
negatively charged. When clay particles are water, the system may be considered as a
suspended in water, the exchangeable spherical condenser, with two concentric
cations of the clay would be solvated and charged plates (Figure 5). If ‘e’ is the
ionized. The OH- ions from the water would amount of the effective electrical charge on
also get adsorbed at the broken bonds of the the particle, ‘d’ is the effective distance
clay lattice. These would make the clay between the fixed positive and negative
surface negatively charged. The negatively layers, and ‘D’ is the dielectric constant of
charged surface would attract some cations the surrounding liquid (water), then the zeta
in its vicinity (Figure 4). At equilibrium, potential (ζ) of the system is given by –
therefore, an electrical double layer would
exist at the particle-liquid interface. One part
of the double layer consists of a negatively 4πed
charged layer on the surface of the clay ζ= ......................(1)
particle and the second part of the double D
layer in the aqueous phase comprises ions
with overall positive charge predominance.
Figure 1: Diagrammatic sketch of the structure of kaolinite (A) and smectite (B)
Figure 2: Atom arrangement in the unit cell of a 1:1 layer mineral (schematic)
Figure 3: Atom arrangement in the unit cell of a 2:1 layer mineral (schematic)
major iron and titanium bearing minerals. Figures 6 shows the variation of zeta
The SEM-EDXA investigation showed that potential with pH in oxalic acid leached
apart from being present as discrete (Fe2O3: Oxalic acid mol ratio = 1.0:1.0) fine
particles, the iron and titanium bearing (- 4 μm) and medium (- 10 μm + 4 μm)
minerals are also present as coatings of the fractions of the clay. The samples used for
clay particles. It is very much possible that this experiment were prepared under similar
these naturally occurring iron and titanium conditions and were washed completely free
bearing minerals have structural defects and of all soluble matters. The trend line of the
structural & adsorbed anionic impurities. zeta potential was drawn by using a
Due to this, the isoelectric points (iep) of polynomial equation of 3rd degree chosen
these minerals are possibly shifted to low pH automatically by the software used
values. The ζ potential value of the magnetic (Microsoft Excel 2002 version
portion, containing high amount of iron and 10.2614.2625). The correlation factors (R2)
titanium, is found to be highly negative (- shown on the graph indicate that the trend of
36.7 mV) at the pH of measurement. The ζ potential is well fitted with the
lower iron and titanium content of the experimental points.
nonmagnetic portion than the as such – 53 Clay particles when suspended in
μm fraction clay indicate that the water develop two types of charges, negative
nonmagnetic portion obtained after removal charges on its surfaces and positive charges
of the magnetic portion is partially free from on its edges. Various factors like isomorphic
the iron and titanium bearing minerals. The ζ substitution in clay crystal lattice, hydration
potential value of the nonmagnetic portion, and dissociation of the exchangeable cations,
therefore, decreases from that of the – 53 μm splitting of clay crystals / particles,
fraction clay due to removal of the iron and heterogeneous splitting of the – Si – O – Al
titanium bearing minerals having high – O - bonds etc. are responsible for this.
negative ζ potential value. However, the effective charges on clay
Although the iron content of the fine particles are always negative because the
fraction separated from the untreated – 53 amount of negative charges developed due
μm fraction clay decreases, the titanium to isomorphic substitution in octahedral sites
content increases, possibly due to the of clay crystal lattice is always higher than
accumulation of titanium bearing minerals in the amount of positive charges developed
the finer fraction. The ζ potential value of due to other reasons. Consequently, the clay
the untreated fine fraction is found to be particles always show negative ζ potential
higher than that of the – 53 μm fraction clay. value. For a particular system of clay
On leaching with oxalic acid, the iron suspension, the D of the suspension medium
and titanium content of the fine fraction (in this case water) is constant and the ζ
decreases with increase in acid potential value depends on e and d (cf.
concentration. The removal of the iron and equation 1).
titanium bearing minerals, therefore, results At acidic pH range (pH < 7.0), the
in the decrease of the ζ potential value of the clay particles will adsorb H+ ions at the
fine fraction with increasing oxalic acid negatively charged sites resulting in decrease
concentration. in the e. The exchangeable cations will also
The iron content of the three oxalic be replaced by the H+ ions. The size of the
acid leached fractions increases in the order: H+ ions and its hydration sphere is small.
fine < medium < coarse. Consequently, the ζ The e/r ratio (e = charge on the hydrated
potential value of these fractions increases in ionic sphere and r = radius of the hydrated
the order: fine < medium < coarse. ion) of the H+ ions is high. As a result the
attraction between the negatively and adsorptions of OH- ions are taking place and
positively charged layers of the electrical all adsorption sites are saturated.
double layer of the clay particle in
suspension increases. The thickness of the
electrical double layer (d) of H+ exchanged 10
clay particle, therefore, reduces resulting in pH
Table 1. Zeta potential values (ξ ) of the oxalic acid leached fraction of Deopani clay
Coarse: – 53 μm + 10 μm, Medium: – 10 μm + 4 μm, Fine: – 4 μm.; Shearing rate: high ~ 14000 rpm;
Shearing time: 12 hours; Leaching temperature: room temperature (28 ± 4 oC).
potential value of the medium and fine 2. Veglio, F., Pagliarini, A. and Toro, L.,
fractions increases with increase in pH of the 1993. Factorial experiments for the
suspension due to adsorption of OH- ions development of a kaolin bleaching
and attains a constant value (– 58.5 and - process. Int. J. of Miner. Process., 39, pp
53.9 mV respectively) at a pH of about 9.08, 87-99.
indicating that no further adsorptions of OH- 3. Bhatt, J. V., 1998. Opportunities for
ions takes place and all adsorption sites are value added china clay projects in
saturated beyond this pH. The iso electric Gujarat. Report of Industrial Extension
point (iep) of the clay fractions possibly lies Bureau, Govt. of Gujarat, Ahmedabad,
below pH 2.0 and could not be determined. India. pp 27-32.
References and further readings 4. Theng, B. K. G., 1974. Chemistry of clay
organic reactions. John Wiley & Sons,
1. Searle, A. B. and Grimshaw, R. W., New York. pp 1-3, 198-206, 261-291.
1960. The Chemistry and Physics of 5. Tsimus, S. G., Komiotou, M. A.,
Clays and Other Ceramic Materials. 3rd Moutsatson, A. K. and Parrisakis, G. K.,
ed., Ernest Benn Limited, London, pp 1995. Reducing the iron content of
100-104, 126-143, 273, 280, 292-293, kaolin from Milos, Greece, by a
436. hydrometullurgical process. Trans. Inst.
Article section
makes PET imaging safer than X-ray organic framework; work-up and
examination in terms of radiation exposure. chromatographic purification of the tracer;
This is in marked contrast to commonly used and, administration of the tracer to humans.
long lived radionuclides, including 3H Thus, the time allowed for tracer synthesis
(tritium) and 14C, with half-lives of 12.3 and should be only about 5–10 min, necessitating
5730 years, respectively, which cannot be a rapid chemical reaction. Another difficulty
used in humans. However, the short-life of encountered in PET-tracer synthesis is the
positron emitting radionuclides places a availability of tiny amounts of precursor,
temporal restriction on the preparation of requiring the use of an extremely dilute
PET tracers. In general, the total time solution (of the order of pM–µM) of the
allowed for PET-tracer synthesis, including reaction mixture, much lower than those
purification should be within two-to-three used in normal organic reactions mM–M. In
half-lives of the corresponding radionuclide addition, the efficient purification of a small
(e.g., the synthesis of a 11C-labeled tracer amount of synthesized tracer from large
should be accomplished within 40–60 min). amounts of remaining precursors must also
This should include: derivatization of the be considered. These severe demands on
radionuclide produced by the synchrotron as PET-tracer synthesis have limited 11CH3
an appropriate precursor, such as 11CH3I, incorporation to N- and O-methylations.
11
CO, or 11CO2; incorporation of 11C into an
Applications
RNA interference in the nematode worm C. carrying only short, non-coding regions of
elegans, which they published in 1998. viral RNA sequences would show similar
levels of protection. Researchers believed
History and discovery that viral RNA produced by transgenes
could also inhibit viral replication. The
The discovery of RNAi was preceded reverse experiment, in which short
first by observations of transcriptional sequences of plant genes were introduced
inhibition by antisense RNA expressed in into viruses, showed that the targeted gene
transgenic plants, and more directly by was suppressed in an infected plant. This
reports of unexpected outcomes in phenomenon was labeled "virus-induced
experiments performed by plant scientists in gene silencing" (VIGS), and the set of such
the U.S. and the Netherlands in the early phenomena were collectively called post
1990s. In an attempt to alter flower colors in transcriptional gene silencing.
petunias, researchers introduced additional After these initial observations in
copies of a gene encoding chalcone plants, many laboratories around the world
synthase, a key enzyme for flower searched for the occurrence of this
pigmentation into petunia plants of normally phenomenon in other organisms. Craig C.
pink or violet flower color. The Mello and Andrew Fire's 1998 Nature paper
overexpressed gene was expected to result in reported a potent gene silencing effect after
darker flowers, but instead produced less injecting double stranded RNA into C.
pigmented, fully or partially white flowers, elegans. In investigating the regulation of
indicating that the activity of chalcone muscle protein production, they observed
synthase had been substantially decreased; in that neither mRNA nor antisense RNA
fact, both the endogenous genes and the injections had an effect on protein
transgenes were downregulated in the white production, but double-stranded RNA
flowers (Fig.1). successfully silenced the targeted gene (Fig.
2). As a result of this work, they coined the
term RNAi. Fire and Mello's discovery was
particularly notable because it represented the effects of this decrease can show the
the first identification of the causative agent physiological role of the gene product. Since
for the phenomenon. Fire and Mello were
awarded the Nobel Prize in Physiology or
Medicine in 2006 for their work.
Cellular mechanism
The RNA interference pathway is RNAi may not totally abolish expression of
often exploited in experimental biology to the gene, this technique is sometimes
study the function of genes in cell culture referred as a "knockdown", to distinguish it
and in vivo in model organisms. Double- from "knockout" procedures in which
stranded RNA is synthesized with a expression of a gene is entirely eliminated.
sequence complementary to a gene of Most functional genomics applications of
interest and introduced into a cell or RNAi in animals have used C. elegans (Fig.
organism, where it is recognized as 2) and Drosophila (Fig. 4), as these are the
exogenous genetic material and activates the common model organisms in which RNAi is
RNAi pathway. Using this mechanism, most effective. C. elegans is particularly
researchers can cause a drastic decrease in useful for RNAi research for two reasons:
the expression of a targeted gene. Studying firstly, the effects of the gene silencing are
Biotechnology
RNA interference has been used for
applications in biotechnology, particularly in
the engineering of food plants that produce
lower levels of natural plant toxins. Such
techniques take advantage of the stable and
heritable RNAi phenotype in plant stocks.
For example, cotton seeds are rich in dietary
Figure 4. A normal adult Drosophila fly, a protein but naturally contain the toxic
common model organism used in RNAi terpenoid product gossypol, making them
experiments
unsuitable for human consumption. RNAi
Medicine has been used to produce cotton stocks
It may be possible to exploit RNA whose seeds contain reduced levels of delta-
interference in therapy. Although it is cadinene synthase, a key enzyme in gossypol
difficult to introduce long dsRNA strands production, without affecting the enzyme's
into mammalian cells due to the interferon production in other parts of the plant, where
response, the use of short interfering RNA gossypol is important in preventing damage
mimics has been more successful. Among from plant pests. Similar efforts have been
the first applications to reach clinical trials directed toward the reduction of the
were in the treatment of macular cyanogenic natural product linamarin in
degeneration and respiratory syncytial virus, cassava plants.
RNAi has also been shown to be effective in
the reversal of induced liver failure in mouse Conclusions:
models. The discovery that cells have a
Other proposed clinical uses center special mechanism for suppressing the
on antiviral therapies, including the expression of homologous genes by
inhibition of viral gene expression in recognizing and processing double-stranded
cancerous cells, knockdown of host RNA was totally unexpected and has
receptors and coreceptors for HIV, the dramatically expanded the knowledge of
silencing of hepatitis A and hepatitis B gene control. Remarkably, the RNAi
genes, silencing of influenza gene machinery can handle double-stranded RNA
expression, and inhibition of measles viral entering the cell as well as double-stranded
replication. Otential treatments for RNA generated within the cell. The
neurodegenerative diseases have also been development of an organism and proper
proposed, with particular attention being function of its cells and tissues are
paid to the polyglutamine diseases such as dependent on an intact RNAi machinery.
Huntington's disease. RNA interference is Infection by RNA viruses can be blocked by
also often seen as a promising way to treat RNAi, especially in plants and lower
cancer by silencing genes differentially animals, and foreign elements in the genome
upregulated in tumor cells or genes involved (viruses and transposons) can be kept silent.
in cell division. A key area of research in the Finally, the discovery of RNAi has not only
use of RNAi for clinical applications is the provided a powerful new experimental tool
to study the function of genes but also raises current photolithography; that is, the science
expectations about future applications of of objects with smallest dimensions ranging
RNAi in medicine. from a few nanometers to less than 100
nanometers. In chemistry, this range of sizes
References has historically been associated with
1.Fire A., Xu S., Montgomery M., Kostas S., colloids, micelles, polymer molecules,
Driver S. and Mello C. (1998) Nature ,391 phase-separated regions in block
(6669): 806-11. copolymers, and similar structures typically,
2. Daneholt, B. Advanced Information: RNA very large molecules, or aggregates of many
interference. The Nobel Prize in Physiology molecules. More recently, structures such as
or Medicine 2006. buckytubes, silicon nanorods, and compound
3. Elbashir S .M., Harborth, J., Lendeckel, semiconductor quantum dots have emerged
W., Yalcin, A., Weber, K. and Tuschl, T . as particularly interesting classes of
(2001) Nature, 411, 494-498. nanostructures. In physics and electrical
engineering, nanoscience is most often
About The author associated with quantum behavior, and the
Khirud Gogoi has recently completed Ph. behavior of electrons and photons in
D. from National Chemical Laboratory, nanoscale structures. Biology and
biochemistry also have a deep interest in
Pune, India in the area of Nucleic Acids
nanostructures as components of the cell;
Chemistry. His areas of research include many of the most interesting structures in
design and synthesis of novel biology from DNA and viruses to
oligonucleotides for therapeutics purpose, subcellular organelles and gap junctions can
ribozymes and cellular delivery of siRNA. be considered as nanostructures. The
combination of the promise of new
---------------------000--------------------- phenomena new science with an extension
of an extremely important technology is the
Nanoscience and Nanotechnology for force that drives nanoscience. Nanoscience
Improvement of Human Lives has now been with us for a decade.
Technologies growing from it are still few,
and the rate at which they have emerged has
seemed slower than that in areas such as
biotechnology. There will certainly be in
fact, there already is an evolutionary
nanotechnology, based on products that
already exist, and that have micro- and
nanometer-scale features. Commercial
nanotechnology exists, and is in the robust
health of early childhood. The more
Mr. Pankaj Bharali interesting question is whether there will be
pankaj_rrlj@yahoo.co.in revolutionary nanotechnologies, based on
fundamentally new science, with products
Nanoscience is the emerging science that we cannot presently imagine. The
of objects that are intermediate in size nanotechnology that is already with us is that
between the largest molecules and the of microelectronics where engineers have
smallest structures that can be fabricated by already shown how to extend existing
methods for making microelectronic devices
to new systems with sub-70-nm wires and Nanotechnology will also help with water
components, materials science where many resources, allowing low energy purification
of the properties of polymers, metals, and and desalination, and reducing water waste
ceramics are determined by 1–100 nm in manufacturing and farming. Nanoscale-
structures, and chemistry where nanometer- related improvements in energy technology
scale drugs are routinely used to control will reduce the dependence on fossil fuels,
proteins and signaling complexes, and where make photovoltaic energy production
macromolecules have dimensions of many competitive with other sources, allow
nanometers. These technologies are entrance into a potential hydrogen economy,
evolutionary nano. The nanotechnology and improve renewable energy systems like
whose form and importance is yet undefined biomass. In order to preserve the
is revolutionary nano; that is, technologies environment, we would use nanotechnology
emerging from new nanostructured materials to remediate waste and pollution, produce
(e.g., buckytubes), or from the electronic systems and materials that use resources
properties of quantum dots, or from most efficiently, recycle pollution into raw
fundamentally new types of architectures materials, and ensure safety and
based on nanodevices for use in computation sustainability of new materials.
and information storage and transmission. Developments in cognitive sciences and
Nanosystems that use or mimic biology are humanities resulting from scientific and
also intensely interesting. There is no technological developments will increase
question that revolutionary nanoscience their contribution to the quality of life.
exists in the laboratories now, and that new Potential risks and unexpected consequences
forms of nanotechnology will be important; need to be monitored and included in any
it is just not clear at the moment how much assessment of overall changes of quality of
of this exciting, revolutionary science will life.
migrate into new technology, and how
rapidly this migration will occur. The history Medicine and nanotechnology
of technology suggests, however, that where
there is smoke, there will eventually be fire; Understanding the cell, that is,
that is, where there is enough new science, understanding life is one of the great
important new technologies will eventually unanswered questions in science. The cell is
emerge. the quantum of biology the smallest and
In the next paragraphs some aspects of most fundamental unit the one from which
nanoscience and nanotechnology for the the rest is built. The cell is a system of
improvement of human lives are described. molecules and remarkable nanoscale
machines functional molecular aggregates of
Life, environment, energy and great complexity. Understanding these
nanotechnology molecular nanostructures in their full,
Research should indentify the qualities mechanistic, molecular complexity is vital to
a reductionist understanding of the cell.
of work, life and the environment to which
citizens give highest priority and identify Doing so will require new methods of
examining these systems: in isolation, in the
branches of nanotechnology most relevant to
cell, and in the organism. The methods that
them. Nanotechnology will help ensure that
emerge from this research will help us to
we can produce enough food by improving
move closer to understanding human life and
inventory storage and the ability to grow at
health, and thus toward nanomedicine.
high yield and a diversity of crops locally.
Nanostructures may also be useful in
Table 1: Some of problematic social trends and ways nanotechnology could contribute to
solutions
Collapse of birth rate in most advanced nations, Convergence of nanotechnology with biotechnology
below level required for population stability to overcome infertility
Poverty and inequality, most urgently in under Economic progress, fueled by technological
developed nations developments requiring systematic control of
nanoscale processes and materials
Environmental degradation, including global Reduced pollution from more efficient use of
warming materials; specific new pollution remediation
nanotechnologies; improved environmental
Medical: diminishing returns from research; Fresh approaches to disease diagnosis and treatment
rising cost of health care from nanotechnology; prevention of disease from
better nutrition and from quick detection and
treatment of conditions
predisposing to disease
for the adsorption of benzoate and salicylate anions on the metal oxide surfaces (Biber
on γ-Al2O3. Whereas, Parfitt (1977) found and Stumm, 1994; Nordin et al., 1997, Klug
that the state of equilibrium for adsorption of and Forsling, 1999; Phambu, 2002;
benzoate on goethite (α-FeOOH) surfaces Rosenqvist et al., 2003). In the case of
was attained after one week. In the case of adsorbate containing carboxylic group the
oleate-natural hematite system in aqueous difference between the νas(COO−) and
medium, the state of equilibrium found to be νs(COO−) bands, their relative shifting and
36 min (Ofor and Anusiem, 1999). In most boarding of the asymmetric carboxylic band
of the reported studies, adsorption isotherms have been considered for the plausible
are carried out at arbitrary chosen surface complexation structure on metal
equilibration time (Yost et al., 1990; oxide and oxy(hydroxide) surfaces. Based
Tejedor-Tejedor et al., 1992; Filius et al., on the shifting of νas(COO−) and νs(COO−)
1997; Szekeres et al., 1998; Hur and bands of benzoate after adsorption on
Schlautman, 2003; Tombácz et al., 2004). bayerite (α-Al(OH)3), Phambu (2002)
Therefore, adsorption kinetics is an concluded that the benzoate forms bidentate
important parameter for subsequent bridging complex on bayerite surface. Biber
adsorption isotherms of adsorption of and Stumm (1994) reported the different
surface-active agent at the metal oxide-water types of surface complexation of salicylate
interface. on the metal oxide and oxy(hydroxide)
surfaces depending on the shifting of the
νas(COO−) and νs(COO−) bands. Phthalate
COOH COOH also form different types of surface
OH complexes either outer sphere (Nilsson et al.,
1996; Rosenqvist et al, 2003) or both outer-
and inner-sphere (Nordin et al., 1997;
Persson et al., 1998; Klug and Forsling,
Benzoic acid Salicylic acid 1999) complexes with aluminium oxide,
aluminium (oxy)hydroxide and goethite
COOH
depending on the pH and ionic strength of
COOH the medium. Surface complexation of small
aromatic organic anions with different
COOH polydispersity and polyfunctionality at
OH different pH and ionic strength are markedly
different (Nordin et al., 1997; Persson et al.,
P-hydroxy benzoic acid Phthalic acid 1998; Rosenqvist et al., 2003). Therefore,
surface complexation of the model anions
Figure 2 Structure of small well-defined onto different adsorbents using FTIR
aromatic acids, which are the constituting spectroscopy would be worth to this field of
models of functional groups occurring in research.
humic acid
Chapter II: Experimental
Fourier transform infrared (FTIR)
spectroscopy studies provide the information
In this chapter, the experimental
regarding nature of surface complexation of
techniques for the measurement of zeta
small aromatic organic anion on metal oxide
potential, kinetics of adsorption at three
surfaces. Literatures have focused on the
different temperatures, adsorption isotherms
complexation of small aromatic organic
and FTIR spectra have been described. The salicylate on α-alumina was studied over a
adsorbents and adsorbates used in the entire wide range of concentrations of salicylate in
study with purity are also included here. aqueous medium over the pH range 4−9.
The adsorption isotherms were found to be
Chapter III: Kinetics and Adsorption Langmuir in nature. The maximum
Behaviour of Salicylate on α-Alumina in adsorption density was found to be 6.348
Aqueous Medium μmol m−2 at pH 4, which decreases with pH
up to 7 and then it become almost constant.
Zeta potential of α-alumina and its At IEP (pH 7.2) the adsorption density is
influence on the adsorption behaviour of found to be ~0.5 μmol m−2 as against the
salicylate on α-alumina surfaces, kinetics of expected value of zero. This is expected due
adsorption, adsorption isotherms at different to the fact that at IEP of α-alumina, the
pH values and the influence of the ionic neutral surface site are available and
strength on the adsorption have been salicylate is interacting with the >AlOH
discussed in this chapter. Thermodynamic (surf). The adsorption density of salicylate
parameters are estimated from the rate on α-alumina surface decreases with the
constant for adsorption. Finally, surface increase the ionic strength of the medium.
complexation of salicylate on α-alumina For example, at pH 4 adsorption density
surface at pH 5 and 7 in aqueous medium is decreases by ~39% as the ionic strength
also proposed. increases from 0.5 to 10 mmol dm−3. The
The zeta potential of α-alumina at activation energy for adsorption is estimated
different ionic strengths was measured as a using Arhenius equation. The positive ΔH
function of pH of the medium at 25 oC. The (19.10 kJ mol−1) suggests that the adsorption
isoelectric point (IEP) of α-alumina was process is endothermic in nature.
found to be in between pH 7.15 to 7.3. The FTIR spectra of salicylate after
Kinetics of adsorption of salicylate on α- adsorption on α-alumina surfaces at pH 5
alumina surface was studied at pH 5 and at and 7 were recorded for obtaining the
25, 30 and 40 oC. The state of equilibrium bonding properties of salicylate. The
was obtained after 2.5 h within the frequency due to phenolic group is shifted
temperature range of the study. Different by 13 cm−1 (1253 to 1266 cm−1) after
kinetics models e.g. a first order kinetics adsorption, which is due to the
equation proposed by Bajpai (1994), pseudo intramolecular hydrogen bonding between
first order Lagergren equation (Lagergren, the phenolic hydrogen and carboxylic
1898), pseudo second order kinetics oxygen. Therefore, phenolic group is not
equation (Tien and Huang, 1991; Ho and deprotonated. The shifting of characteristic
McKay, 1999; Ho et al., 2001), intra-particle peak frequency of −COO− and appearance of
diffusion (Ho and McKay, 1998) and liquid
a new band at ~1700 cm−1 due to >C=O
film diffusion models (Boyd et al., 1947)
indicate that the salicylate is coordinate
were applied to evaluate the rate constant.
monodentally with respect to the carboxyl
The temperature was found to influence the
group.
adsorption density of salicylate on α- Chapter IV: Kinetics and Adsorption
alumina at equilibration. The adsorption Behaviour of Benzoate and Phthalate at
density of salicylate on α-alumina surface at the α-Alumina−Water Interface:
300 min is around 1.6 and 3.0 times more at Influence of Functionality
30 and 40 oC, respectively than that at 20 oC.
The variation of adsorption density of
This chapter presents the comparative on α-alumina surface decreases with the
study of adsorption kinetics at a fixed pH, increase in ionic strength from 0.05 to 10
adsorption isotherms at different pH values, mmol dm−3 depending on the pH of the
influence of ionic strength on the adsorption medium. The positive ΔH values suggest
behaviour and the nature of surface that the adsorption process for the both the
complexation of benzoate and phthalate onto systems are endothermic in nature. The more
α-alumina surfaces. The influence of negative Gibbs free energy of phthalate−α-
functionality on the adsorption of benzoate alumina than that of benzoate−α-alumina
and phthalate on α-alumina surfaces has implies that the adsorption of phthalate on
been discussed in this chapter. α-alumina is highly favorable than benzoate
The IEP of α-alumina was found to be on the same adsorbent. The solubility of α-
6.7, which is 2.5 unit lower than the reported alumina in presence of benzoate and
value. The reason for the lower IEP of α- phthalate was found to be depended on the
alumina is the presence of less number of pH of the medium and the concentration of
surface hydroxyl groups. Kinetics of sodium chloride. The surface complexation
adsorption study showed that the state of of benzoate and phthalate on α-alumina
adsorption equilibrium of benzoate at α- surfaces was investigated using the FTIR
alumina-water interface is attained at 30 h spectroscopy. Benzoate forms outer-sphere
within the temperature range of the study complexes with α-alumina surfaces at pH 5
(25−40 oC). In the case of phthalate-α- and 6 depending on the shifting of the
alumina system, adsorption density of asymmetric and symmetric −COO− bands.
phthalate on α-alumina surfaces increases Whereas phthalate forms both outer- and
upto ~25 h at 30 and 40 oC after that it inner-sphere surface complexes with α-
decreases with the increase in adsorption alumina surfaces.
time. But at 25 oC state of equilibrium is
attained at 10 h and beyond 37 h adsorption Chapter V: Kinetics and Adsorption of
density decreases. The rate constant for Benzoate and Salicylate at the Natural
adsorption of benzoate− and phthalate−α- Hematite−Water Interface
alumina systems was estimated using
kinetics models like a first order kinetics The zeta potential of natural hematite,
equation proposed by Bajpai (1994), pseudo kinetics of adsorption, adsorption isotherms
first order Lagergren equation and pseudo at different pH values and at a fixed ionic
second order kinetics equation. The variation strength, I = 5×10−4 mol dm−3 and the
of adsorption density of benzoate and thermodynamic parameters have been
phthalate on α-alumina surfaces was carried discussed in this chapter.
out over a wide range of concentrations of The zeta potential of natural hematite as
an adsorbate at a fixed ionic strength, I = 5 × a function of pH at different ionic strengths
10−4 mol dm−3 and pH 5−10. The adsorption was measured at 25 oC. The IEP of natural
isotherms for both the systems were found to hematite was found to be 5.80. Kinetics of
be Langmuir in nature. The maximum adsorption of benzoate and salicylate onto
adsorption density of phthalate is 1.1−5.1 natural hematite surfaces have been carried
times more than that of benzoate on the out at pH 5 and at a fixed ionic strength, I =
same adsorbent under similar condition. This 5×10−4 mol dm−3. The state of equilibrium
difference is attributed to the presence of an was attained at 144 and 70 h for benzoate
adjacent −COOH group in phthalate. The and salicylate, respectively. The rate
adsorption density of benzoate and phthalate constant for benzoate−natural hematite and
complex with hematite surfaces at pH 5, 6 Beckett, R., Surface and Colloid Chemistry
and 9. in Natural Waters and Water Treatment,
Plenum Press, New York, 1990.
Chapter VII: Kinetics, Adsorption Biber, M.V.; and Stumm, W., Environ. Sci.
Isotherms and Thermodynamic Technol., 1994, 28, 763.
Parameters for Adsorption of Salicylate at Boyd, G.E.; Adamson, A.W.; and Myers
the Silica−Water Interface L.S., J. Am. Chem. Soc., 1947, 69, 2836
This chapter includes kinetics of Evanko, C.R.; and Dzombak, D.A., Environ.
adsorption, adsorption isotherms at different Sci. Technol.,1998, 32, 2846.
pH, effect of ionic strength on the adsorption Evanko, C.R.; and Dzombak, D.A., J.
and the thermodynamic parameters for Colloid Interface Sci., 1999, 214, 189.
adsorption of salicylate at the silica-water Filius, J.D.; Hiemstra, T.; and Van
interface. Riemsdijk, W.H., J. Colloid Interface Sci.,
Kinetics of adsorption of salicylate onto 1997, 195, 368.
silica surfaces were carried out at pH 5 and Ho, Y.S.; and Mckay, G., Trans. IChemE. B,
at a fixed ionic strength, I = 5×10−4 mol 1999, 77, 165.
Ho, Y.S.; and Mckay, G., Trans. IChemE. B,
dm−3. The state of equilibrium was attained
1998, 76, 183.
at 320 h and found to be independent on the
Ho, Y.S.; Ng, J.C.Y.; and Mckay, G., Separ.
temperature. Bajpai kinetics model (1994)
Sci. Technol., 2001, 36, 241.
comparatively yields better rate constant,
Hur, J.; and Schlautman, M.A., J. Colloid
which increases with the increase in
Interface Sci., 2003, 264, 313.
temperature. The variation of adsorption
Klug, O.; and Forsling, W., Langmuir, 1999,
density of salicylate on the silica surfaces
15, 6961.
with wide range of concentrations of
Kummert, R.; and Stumm, W.J., J. Colloid
salicylate was studied in aqueous medium
Interface Sci., 1980, 75, 373.
over pH range 5−9 and at a fixed ionic
Lagergren, S., Ksver. Vetenskapsakap.
strength, I = 5×10−4 mol dm−3 NaCl. The Handingar, Band, 1898, 24, 1.
Langmuir adsorption isotherm equation was Mahiuddin, S.; Bondyopadhyay, S.; and
used to fit the experimental data. The Γmax Baruah, J.N., Int. J. Miner. Process, 1989,
value decreases (0.1456 to 0.0318 μmol m−2) 26, 285.
with the increase in pH of the medium upto Mahiuddin, S.; Suryanarayan, I.; Dutta,
pH 8 and at pH 9 it becomes zero. The N.N.; and Borthakur, P.C.; Colloids Surf.,
activation energy for this system is found to 1992, 64, 177.
be 18.30 kJmol−1. The negative ΔH (−18.04 Mesuere, K; and Fish, W., Environ. Sci
kJmol−1) implies that the adsorption of Technol., 1992a, 26, 2357.
salicylate on silica surfaces is exothermic in Mesuere, K; and Fish, W., Environ. Sci
nature. Technol., 1992b, 26, 2365
Nilsson, N.; Persson. P.; Lövgren, L.; and
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Ali, M.A.; and Dzombak, D.A., Environ. Nordin, J.; Persson. P.; Laiti, E.; and
Sci. Technol., 1996a, 30, 1061. SjÖberg, S., Langmuir, 1997, 13, 4085
Ali, M.A.; and Dzombak, D.A., Geochim. Ofor, O.; and Anusiem, A.C.I., J. Colloid
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List of publications:
3. Enforcing Periodic Secondary Structures
1. Self-assembly with degenerate prototropy: in Hybrid Peptides: A Novel Hybrid
Baruah, P. K.; Gonnade, R.; Phalgune, U. Foldamer Containing Periodic γ-Turn
D.; Sanjayan, G. J. J. Org. Chem. 2005, 70, Motifs: Baruah, P. K.; Sreedevi, N. K.;
6461-6467. Gonnade, R.; Ravindranathan, S.;
Damodaran, K.; Hofmann, H.-J.; Sanjayan,
2. The solid-state behaviour of 4,6-dioxo- G. J. J. Org. Chem. 2007, 72, 636-639.
5,5-diethylenepyrimidine-2-isobutylurea:
Spencer, E. C.; Howard, J. A. K.; Baruah, 4. BINOL-Based Foldamers - Access to
P. K.; Sanjayan, G. J. CrystEngComm 2006, Oligomers with Diverse Structural
8, 468–472. Architectures; Baruah, P. K.; Gonnade, R.;
The Central Dogma of molecular biology states that "DNA makes RNA makes protein".
(Collected from web: Editor)
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(1) Job Title: Postdoctoral position in the Department of Chemistry at Nagoya Univ., Japan in
Synthetic Organic Chemistry, Profs. Noyori and Saito; SAI01/08
Job Number: 4003115 (Ref.#. SAI01/08)
Date Posted: 03/31/2008
Application Deadline: Open Until Filled
Job Details:
A position as postdoctoral fellow in the area of synthetic organic chemistry is open in the group of Profs.
Ryoji Noyori and Susumu Saito in the Department of Chemistry at Nagoya University. For one year
starting any time, with possibility of extension for another year. Two or three vacant slots would be open
from October 1st, 2008. Please feel free to get in touch.
Research Area: Our emphasis is on the exploration of new synthetic methods, strategies, and concepts to
solve challenging synthetic problems to realize ideal chemical synthesis and molecular catalysis, thereby
putting forward the revolution of environmentally benign chemical technology for 21th century.
Representative interests:
(i) Activation of alcohols and utilizing them as electrophiles using molecular catalysis (ii) Degradation of
biomass such as cellose, amylose, or lignin, etc. to make them as important carbon resources for 21th
century (iii) Activation of CO2 and using it as a important C1 resource for the 21th century’s chemical
synthesis (iv) Chemical Synthesis of sugar and deoxy-sugar derivatives of pharmaceutical importance (v)
Chemical synthesis without waste: changeover of molecular catalysis from strongly acidic or basic to
neutral (vi) Hydrogenation using novel molecular catalysts (vii) Molecular manipulation of hydrogen
bonds and dative bonds for generating molecular catalysis (viii) Molecular catalysis based on hydrogen
atom transfer (ix) Chemical process involving H2O: embedding water into, or liberating water from, a
carbon chain Please check out the web site at: http://noy.chem.nagoya-u.ac.jp/index(eng).htm
Preference will be given to candidates with strong background directly related to relevant research fields.
Candidates who did not previously publish several papers in international, peer-reviewed journals and
cannot make a statement why exactly they want to join this research group and should be considered for
this position will not receive a reply.
(2) Job Title: PhD positions available at the Department of Chemistry, Nagoya University,
Japan
Job Number: 4003035
Date Posted: 03/13/2008
Application Deadline: Open Until Filled
Several PhD positions are available immediately at the Department of Chemistry, Nagoya University,
Japan within the framework of a newly established Global-COE (Global Center of Excellence) devoted to
the “Elucidation and Design of Materials and Molecular Functions”.
17 Research groups are involved in this new Global-COE from a wide range of topics like (1) “Highly
Efficient Chemical Synthesis” through selective molecular catalysis; (2) “Use of Polymer Science for
Development of Molecules with Novel Properties and Functions” including higher-order structure control
for polymers and supramolecules; (3) “Development of Molecules with New Functions Through
Nanochemistry” for nanocarbons, thin films, and supramolecular materials; and (4) “Chemical Aspects of
Life Science” for understanding the complexity of biological phenomena from a chemical viewpoint.
This Global-COE will develop young global research leaders responsible for the future of materials
science through comprehensive and world-class education and research for creating new trends in
development of molecular functions in materials science. The Department of Chemistry at Nagoya
University is proud to be the home of Nobel Laureate Prof. Ryoji Noyori.
Job description: Candidates are sought for 1 fully funded PhD studentship to work on the theoretical
design of a working all-optical diode, based on Photonic Crystals with a quasiperiodic arrangement of the
layers. The final aim of this PhD project is to develop new analytical and numerical techniques to study
Photonic Crystals based on conceptually new designs. This will require the study of the linear and non-
linear optical properties of Photonic Crystals. Knowledge of Classical Electromagnetism is essential.
Please visit webpage at http://www.optik.uni-erlangen.de/mpf/php/abteilung3/jrg/index.html.
This post is available from 1 September 2008, but the position will remain open until a suitable candidate
is found. A letter of application containing at least 1 reference letter and a full CV containing a detailed
description of the candidate's knowledge and expertise, should be emailed directly to Dr. Fabio
Biancalana: fabio.biancalana@gmail.com
Job description: A postdoctoral position is available in the field of self-assembly of block copolypeptides.
Outstanding candidates with a strong background in polymer physics/polymer chemistry are encouraged
to apply. The candidate should have polymer synthesis skills and be familiar with Small Angle x-ray
Scattering (SAXS). Additional knowledge in Transmission Electron Microscopy (TEM), Atomic Force
Microscopy (AFM) and the other physico-chemical techniques is an advantage. Working language is
English. Competitive salaries are offered. This project is line collaboration with EPFL. Starting date: end
2008-January 2009. Interested candidate can send CV, motivation letter and at least two references to:
Prof. Dr. Raffaele Mezzenga Department of Physics and Frimat Center for Nanomaterials University of
Fribourg Chemin du Musée 3 CH - 1700 Fribourg Switzerland raffaele.mezzenga@unifr.ch
An opportunity is available for a Postdoctoral Research Fellow in the laboratory of Dr. John Koomen at
Moffitt Cancer Center. This is a post-graduate position in which the individual is responsible for assisting
with research activities as well as conducting independent research projects when appropriate under
limited supervision. The focus of the proposed research is to develop biomarkers to measure response to
therapy and prognosis in cancer patients. The work will start with sequence and post-translational
modification analysis of selected targets to examine molecular changes upon drug treatment. These
experiments will be conducted using LC-MS/MS, typically with a Dionex nanoLC and an Orbitrap mass
spectrometer. After determining peptides and post-translational modifications of biological and clinical
interest, quantitative assays will be generated using multiple reaction monitoring on triple quadrupole
platforms.
The candidate must have experience in mass spectrometry, particularly LC-MS/MS and/or LC- RM, and a
completed PhD in MS or a related field. Excellent communication skills and previous experience with the
equipment described above will also be required. Excellent verbal and written communication skills are
required to work in a multidisciplinary team of research nurses and data managers.
The Moffitt Cancer Center is a modern facility on the University of South Florida Campus that conducts
research on various aspects of Cancer Biology with emphasis on translational research. It is the third
largest Cancer Center in the US based on patient volume. The research environment includes state of the
art modern core facilities and pathogen-free modern animal facilities, access to clinical material, etc.
Please visit www.moffitt.org/careers to apply online to REQ ID 3003, and send CV, cover letter and three
references to Dr. John Koomen at john.koomen@moffitt.org.
Contact:
H. Lee Moffitt Cancer Center & Research Institute
12902 Magnolia Drive
Tampa, FL 33612
Web Site: http://www.moffitt.org Online Application: Apply for this position from Employer's website.
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http://tech.groups.yahoo.com/group/northeast_india_research/
www.neindiaresearch.org