ADVOCACY
by Barbara Loe Fisher
Barbara Loe Fisher is co-founder
and president of the National Vaccine
Information Center (www.NVIC.
org), a non-profit founded in 1982
by parents of vaccine-injured children
to prevent vaccine injuries and deaths
through public education and defend
the informed consent ethic.
She has served on the National Vaccine
Advisory Committee, Institute of
Medicine Vaccine Safety Forum, FDA
Vaccines & Related Biological Products
Advisory Committee, Vaccine Policy
Analysis Collaborative, and Consumers
United for Evidence Based Healthcare
– U.S. Cochrane Collaboration. She is
the mother of three children.
34 THE AUTISM FILE | www.autismfile.com REPRINTED WITH PERMISSION OF THE AUTISM FILE
T
he Great Denial of vaccine risks for
the past three decades by vaccine
makers, pediatricians, and government
officials operating the mass vaccination
system is the reason why more and more
parents today question and do not trust
doctors who tell them to give their children
69 doses of 16 vaccines from the day of
birth through age 18, triple the numbers
of vaccinations that children were given in
the 1970s. When Harris Coulter and I co-
authored DPT: A Shot in the Dark1 in 1985
exposing flaws in the mass vaccination
system that allowed the highly reactive DPT
vaccine to stay on the market unimproved
for more than 40 years, we never imagined
that those tragic flaws in the system would
remain largely intact in 2009.
I knew then that the alliance between
industry, organized medicine, and the
government was powerful. But it is only
after a quarter century of witnessing the
Great Denial of vaccine risks, and the
refusal to do the credible science that
will fully evaluate those risks, that the
magnitude of that unchecked power has
been fully revealed. Even as America
celebrated the inauguration of a new
president promising an unprecedented
transparency and engagement by
government with the people, there are
new indications that the powerful and
wealthy Vaccine Lobby is gearing up
to use the government to minimize the
significance of new reports of Gardasil
vaccine risks;2 block efforts to conduct
research into vaccine-related autism;3
ruin the reputations of researchers
investigating vaccine-related injuries;4
and deny vaccine-injured children federal
compensation5 while protecting vaccine
manufacturers from liability for vaccine
injuries and deaths.6
New attacks on freedom to investigate,
freedom to speak, and freedom to
publish in science are compromising
truth in science. And one only has to
look at the inappropriate influence of the
pharmaceutical industry on the kinds of
vaccine studies that get published in the
medical literature7 to understand why good
vaccine science is not being published and
bad vaccine science is being used to cover
up what will one day be acknowledged
as an unprecedented iatrogenic epidemic
of inflammation and chronic disease.
What gives this tragic epidemic its special
poignancy is that it is likely that many
more vaccine deaths and injuries will have
to occur before steps will be taken by
those in power to end it.
No matter what is done now by
government, industry, and medical
organizations fighting to protect the
status quo and deny the reality of vaccine
casualties, they cannot unring the bell that
has been ringing in the U.S. since 1982.
That bell, which tolls for children robbed
of health by poorly regulated vaccines
and one-size-fits-all vaccine policies that
do not acknowledge biodiversity, will
continue to ring louder and louder with
each vaccine casualty despite attempts to
silence it.
ISSUE 31 2009
 The question on the minds of many
parents today is: Why are so many
highly vaccinated children so sick and
disabled? During the past quarter
century, once prevalent childhood
infectious diseases in America
like whooping cough, measles,
mumps, and chicken pox have been
suppressed with the use of multiple
vaccines, but now 1 in every 6
children8 becomes developmentally
delayed while 1 in 150 or more
children develops autism.9
 Is there scientific evidence to suggest
there could be an association
between increased use of vaccines by
America’s children and increases in
chronic disease and disability among
children? In a new book, Vaccines,
Autism & Chronic Inflammation: The
New Epidemic10 (which is an altered
version of a chapter I wrote for
Envisioning a Bright Future edited
by Patricia Lemer) the evidence from
the medical literature is presented
to support a “Yes” answer to that
question.
Although the U.S. Court of Claims
recently declined to award federal
vaccine injury compensation to three
children, who regressed into autism
after vaccination, the several biological
mechanisms being argued were confined
to ones involving thimerosal (mercury)
and MMR vaccine.11 Whether one
agrees or disagrees about the quantity
and quality of the scientific evidence
demonstrating causation or lack of
causation with regard to the specific
biological mechanisms that were argued
in these three cases, the fact remains that
a causal relationship between vaccination
and chronic brain and immune system
dysfunction has been very well
established in the medical literature for
more than a century.
Complications of Infections and
Vaccination Similar
A review of more than a century of
medical literature reveals ample evidence
that neurological and immune system
dysfunction caused by infectious diseases
are often identical to neurological and
ISSUE 31 2009 REPRINTED WITH PERMISSION OF THE AUTISM FILE www.autismfile.com | THE AUTISM FILE
immune system dysfunction caused
by vaccines created using those same
lab-altered viruses and bacteria. A host/
disease or host/vaccine interaction
causes inflammation, which is acute at
first and becomes chronic rather than
resolving and leaving the host with good
health. In both cases, the end result
is unresolved inflammation leading to
immune-mediated brain dysfunction
of varying degrees of severity, which is
the same profile many have observed
in children with autism spectrum
disorders.12,13
Researchers have found evidence of
chronic inflammation in the brains of
patients with autism, particularly in the
cerebellum. Autistic brains have been
observed to be in “a chronic state of
specific cytokine activity.” The suggested
biological mechanisms responsible
for the observed brain inflammation
included chronic disease or an external
environmental source.14
Beginning with smallpox vaccine,
which was the first attempt to prevent
an infectious disease by injecting a
portion of a microorganism associated
with the disease into human beings,
the most feared complication of both
smallpox and smallpox vaccination was
brain inflammation.15 In the early 1930s,
virologist Thomas Rivers studied the brain
damaging effects of rabies vaccine and
provided the first evidence that immune
cells can attack the brain.16
Acute brain inflammation, whether
it follows infectious disease17,18,19 or
vaccination, can become chronic and
result in various kinds of mild to severe
neurological dysfunction manifested by
learning disabilities, ADD/ADHD, seizure
disorders, autism, mental retardation, and
other developmental delays.
The association between vaccination
and the development of autistic
behaviors in previously healthy children
was first reported in 1985 in DPT: A Shot
in the Dark in which Harris Coulter and
I documented never-before-reported
case histories of DPT vaccine-related
brain inflammation and permanent brain
damage in previously healthy children.
These cases were considered by an
Institute of Medicine (IOM) Committee
preparing a landmark report Adverse
Effects of Pertussis and Rubella Vaccines
in 1991.20
Vaccines Can Cause Acute and
Chronic Brain and Immune
Dysfunction
The 1991 IOM Committee examining
the evidence for and against a causal
relationship between DPT vaccine and
neurological dysfunction concluded that
“the evidence is consistent with a causal
relation” between DPT vaccine and
acute encephalopathy, encephalitis, or
encephalomyelitis. (In that same report,
35
 the IOM concluded that the “evidence
is consistent with a causal relation”
between rubella vaccine and acute and
chronic arthritis, an autoimmune disorder
involving inflammation of the joints.)
In 1994, another IOM Committee went
further after re-analyzing the landmark
1981 prospective, case-controlled British
National Childhood Encephalopathy
Study (NCES)21 and concluded in a
report entitled DPT Vaccine and Chronic
Neurological Dysfunction that:
The NCES data are consistent with
the possibility that some children
without underlying brain or metabolic
abnormalities might experience serious
acute neurologic illness within 7 days
after receiving DPT and that acute
illness could have chronic nervous
system sequelae. The NCES data are
also consistent with the possibility that
some children with underlying brain or
metabolic abnormalities (which foster
a “triggering” by DPT of an acute
neurologic illness) might go on to develop
chronic nervous system dysfunction
due to a DPT-triggered acute illness.
Therefore, the Committee concludes that
the balance of evidence is consistent
with a causal relation between DPT and
the forms of chronic nervous system
dysfunction described in the NCES in
those children who experience a serious
acute neurologic illness within 7 days
after receiving DPT vaccine….the
estimated excess risk ranged from 0 to
10.5 per million immunizations.22
Although the word “autism” did
not appear in the NCES, the types of
DPT-induced chronic neurological
dysfunction that were listed in that study
of neurological dysfunction in children
were described as “neurologic, motor,
sensory, educational, behavioral and self-
care dysfunctions” such as severe febrile
and non-febrile convulsions, tremor,
gross and fine motor incoordination,
A healthy, mature immune system requires an equal
balance of cellular and humoral immune system responses.
A disruption in this balance can lead to development
of allergy and autoimmune disorders, including
neuroimmune disorders.
36 THE AUTISM FILE | www.autismfile.com REPRINTED WITH PERMISSION OF THE AUTISM FILE
muscle weakness, abnormal tendon
reflexes, hyperactive behavior, unsociable
behavior, vision and hearing losses. It
is worth noting that the original 1981
NCES found that “the risk of a serious
neurological disorder within 14 days after
measles vaccine in previously normal
children irrespective of eventual clinical
outcome is 1 in 87,000 immunizations”
while the NCES authors found that “the
attributable risk of a serious neurological
disorder within seven days after DTP
vaccine in previously normal children
irrespective of eventual clinical outcome
is 1 in 110,000 immunizations.”
A 1994 IOM Committee examining the
medical literature concluded in the report
Adverse Events Associated with Childhood
Vaccines that “the evidence establishes a
causal relation between measles vaccine
and death from measles vaccine-strain
viral infection.”23 In 1998, CDC officials
published a study of cases of brain
inflammation within 15 days of MMR or
measles vaccination that ended in death
or permanent brain injury, including
“mental regression and retardation,
chronic seizures, motor and sensory
deficits, and movement disorders.” The
authors noted a clustering of cases
with signs and symptoms of brain
inflammation (such as seizures) occurring
on days 8 and 9 after MMR or measles
vaccination and concluded that “a causal
relationship between measles vaccine and
encephalopathy may exist.”24 In 1999, a
study was published in Clinical Infectious
Diseases in which the authors state, “we
believe that the present report is the
first to clearly demonstrate that severe
neurological disease can be caused by the
vaccine strain of measles virus.”25
Multiple Vaccines, Genetic
Vulnerability and Brain and
Immune Dysfunction
The possibility that genetically vulnerable
children may develop neurological
dysfunction after repeated atypical
manipulations of the immune system
with multiple vaccines in early childhood
is an hypothesis I first presented to the
Institute of Medicine Immunization
Safety Review Committee in January
2001. I stated:
There is a compelling argument to
be made that the dramatic increase in
chronic brain and immune dysfunction in
children, especially the rising number of
reports of regression in previously healthy
children, is due to an early exposure
that is being experienced by all children
but which is harming an expanding
minority of them…. Many biological
responses are at least partially under
genetic control. If, for example, adverse
responses to vaccination are tied to the
genes responsible for predisposition to
autoimmunity and immune-mediated
neurological dysfunction, then it is
possible that the addition of more doses
of vaccines to the routine schedule in
the past two decades has affected more
and more children with that genetic
predisposition…26
Therefore, when all children were
exposed only to DPT and polio vaccine
in the early 1960s, a tiny fraction of
the genetically susceptible responded
adversely. But with the addition of
measles, mumps, and rubella to the
routine schedule in 1979, and then
HIB, hepatitis B, and chicken pox in the
late 1980s and 1990s, far more of the
genetically susceptible have been brought
into the adverse-responder group.
This hypothesis could not be examined
by the IOM in their 2002 report on
Multiple Immunizations and Immune
Dysfunction. After reviewing evidence
in the medical literature, the IOM
Immunization Safety Review Committee
stated that:
The committee was unable to address
the concern that repeated exposure of a
[genetically] susceptible child to multiple
immunizations over the developmental
period may also produce atypical or
non-specific immune or nervous system
injury that could lead to severe disability
or death (Fisher, 2001). There are no
epidemiological studies to address
this. Thus, the committee recognizes
ISSUE 31 2009
with some discomfort that this report
addresses only part of the overall set
of concerns of some of those most
wary about the safety of childhood
immunization.27
The Hygiene Hypothesis
The hygiene hypothesis, first proposed
in 1989 by researcher D.E. Strachen,
suggests that the reduction of early
childhood infections in technologically
advanced countries due to improved
living conditions and sanitation,
widespread vaccination, and antibiotic
use in the 20th century has caused
an increase in chronic allergic and
autoimmune diseases in children.28
Strachen theorized that preventing
children from being naturally challenged
by exposure to certain viral and bacterial
infections during childhood, when the
immune system is maturing and learning
how to successfully respond to viruses
and bacteria in the environment, could
weaken the immune system and make it
more susceptible to immune dysfunction.
In 2005, researchers at the University
of Illinois at Chicago conducted a study
relating asthma, hay fever, and eczema
and vaccination status. Working with
the National Vaccine Information Center
membership, researchers anonymously
identified 515 never vaccinated, 423
partially vaccinated and 239 completely
vaccinated children. They concluded that
parents of unvaccinated children were
11 times less likely to report asthma for
children with no family history of the
disease and no exposure to antibiotics
in infancy. Parents of unvaccinated
children were 10 times less likely to
report hay fever among children with
no family history of hay fever. Eczema
was also reported significantly less in
unvaccinated children.29
Unvaccinated children also appear
to have a lower incidence of autism,
according to a 2005 investigation by
UPI reporter Dan Olmsted, who looked
at an unvaccinated Amish population
in Lancaster, Pennsylvania. If the CDC’s
2005 calculation that one in 166 children
was autistic is correct, Olmsted calculated
that at least 100 children in Lancaster
should have autism. He found only three:
a girl adopted from China, an Amish child
Vaccine developers of preventive and therapeutic vaccines
continue to have trouble developing safe and effective
vaccines which mimic the complex interplay between innate
and adaptive immunities involved in the stimulation of the
immune system during the natural disease process.
who had been vaccinated and developed Because vaccine developers do
autism shortly afterwards, and another not fully understand the biological
child whose vaccination status was mechanisms involved in the immune
unclear.30 response to natural infection or
vaccination, the achievement of vaccine-
Good Health: A Balancing Act induced mucosal (cellular) immunity has
Humans and infectious microbes have been elusive.35,36 Vaccine developers
coexisted for as long as humans have of preventive and therapeutic vaccines
walked the earth, and the human continue to have trouble developing
immune system has developed an safe and effective vaccines which mimic
efficient way of dealing with viral and the complex interplay between innate
bacterial infections. When infected with and adaptive immunities involved in
a micro-organism, the body’s first line the stimulation of the immune system
of defense is for the cellular or “innate” during the natural disease
part of the immune system to mount an process.37
inflammatory response. This response Newborn infants do
then signals the humoral or “learned” not mount a rapid
part of the immune system to produce or strong antibody
anti-inflammatory chemicals and response to
antibodies that resolve inflammation, so vaccination, which
that healing can take place and establish is an atypical
future resistance to re-infection. A manipulation
healthy, mature immune system requires of the immune
an equal balance of cellular and humoral system with
immune system responses. A disruption lab-altered
in this balance can lead to development
of allergy and autoimmune disorders,
including neuroimmune disorders.31,32,33
Vaccination attempts to fool the
body into believing it has come in
contact with the real microorganism
that causes infection. But vaccination
does not exactly mimic the natural
infection progress and often bypasses
cellular immunity in favor of humoral
immunity.34 Most live-virus and killed-
bacterial vaccines are injected into
the body, whereas in the natural
disease process, microorganisms
enter the body primarily through
the mucous membranes of the
respiratory and gastrointestinal
tracts, where the inflammatory
immune response to the
challenging microorganism
begins.
 viruses and bacteria.38 “Babies are born
with a very immature cellular immune
system,” says Lawrence Palevsky, MD,
a New York pediatrician and co-founder
of the Holistic Pediatric Association.
“Childhood viral infectious diseases
like measles, mumps, and chicken-pox
initially stimulate the cellular part of
the immune system, which leads to the
production of the signs of inflammation
- fever, redness, swelling, and mucus.
This cellular immune response stimulates
the humoral part of the immune system
to produce anti-inflammatory chemicals
and antibodies that assist in recovery
from these illnesses. The natural process
helps the cellular and humoral immune
systems to mature.”39
In other words, this natural “exercise”
of the immune system can make it
stronger and better able to maintain
good health. When the immune system
does not function normally, as in many
children with autism spectrum disorders,
it may become “stuck” on inflammation
and lead to chronic illness.
The elimination of most natural
experience with infectious disease in
early childhood, through mass use
of multiple vaccines, may disrupt
the balance of cellular and humoral
immunity, thus causing children to
be susceptible to developing chronic
inflammation and chronic illnesses,
including autism. Those children
genetically predisposed to inflammatory
conditions, such as autoimmune
disorders or allergies, may be at special
risk when they are additionally subjected
to atypical manipulation of the immune
system with multiple vaccines in early
childhood.
Chronic Inflammation: At the Root
of Most Chronic Disease
Many scientists are now concluding that
persistent inflammation is at the root of
most chronic brain and immune system
disorders40,41 and that genetic variations
in the population make some individuals
genetically vulnerable to inflammatory
disease.42,43
The dramatic increase in autism,
learning disabilities, and other
developmental delays in American
children during the past three decades
38 THE AUTISM FILE | www.autismfile.com REPRINTED WITH PERMISSION OF THE AUTISM FILE
Since the early 1980s, there has been a doubling or tripling
of the numbers of children suffering from autism and other
forms of brain and immune system dysfunction at the same
time that the numbers of doses of vaccines have tripled, and
vaccination rates are at an all time high.
has been accompanied by similar
increases in autoimmune disorders.
Many American children today,
including those with autism, have food
and environmental allergies, gluten,
and/or casein intolerance, inflammatory
bowel disorders, asthma, and other
signs of immune dysfunction.
Unresolved inflammation may play
an important role in the development
and persistence of autism in children,
and genetic factors that predispose
children to autoimmunity may be very
important in the development of autism
in some children. Researchers have
found that mothers of autistic children
and family members often have a
history of autoimmune disorders, such
as thyroid disease, rheumatoid arthritis,
and other illnesses marked by chronic
inflammation.44
Conclusion
Since the early 1980s, there has been
a doubling or tripling of the numbers
of children suffering from autism and
other forms of brain and immune
system dysfunction at the same time
that the numbers of doses of vaccines
have tripled, and vaccination rates are
at an all time high. It is possible that,
when children are prevented from
having any experience with viral and
bacterial infections in childhood and
are repeatedly subjected to atypical
manipulation of the immune system
from vaccination, they may become
more vulnerable to chronic inflammation
leading to chronic illness and disability,
including regressive autism.
Children, who are genetically
vulnerable to immune mediated chronic
inflammation, may be at special risk
for vaccine-induced neuroimmune
dysfunction. The biological mechanisms
involved in the type of injury they will
suffer are likely dependent upon the
individual vaccines or combination
of vaccines given and on the child’s
individual genetic profile. Additives
such as mercury, aluminum, and other
toxins in vaccines can cause harm
on their own and may contribute to
chronic inflammation that leads to
neuroimmune dysfunction.
There is an urgent need for
methodologically sound, basic science
research into the biological mechanisms
for vaccine-induced brain and immune
dysfunction at the cellular and
molecular level. Pathological profiles
must be developed to separate out what
is and is not vaccine-induced to identify
which children are more vulnerable
than others for suffering harm from
vaccination so they can be identified
and their lives spared and to find ways
to address neuroimmune dysfunction so
affected children can begin to heal.
Most importantly, there needs to be
a re-examination of what constitutes
good health and a recognition that
some experience with infections in
early childhood may be necessary for
normal immune and brain development.
Individual and public health is not
measured simply by an absence of
infectious disease as chronic disease can
be more devastating and costly over the
long run.
Attempting to prevent all infections
with the use of multiple vaccines
in childhood and throughout life
may play a significant role in the
mysterious rise in chronic disease
and disability, including autism, that
has developed over the past quarter
century. With several hundred vaccines
in development in more than 2,000
clinical trials worldwide45 and calls in the
U.S. for more vaccine mandates and no
exemptions,46 a re-examination of what
“good health” really means is a matter
of great urgency.
ISSUE 31 2009
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