2013

Dialysis of Drugs

George R. Bailie, PharmD, PhD Albany College of Pharmacy and Health Sciences Nancy A. Mason, PharmD University of Michigan College of Pharmacy Renal Pharmacy Consultants, LLC Saline, Michigan USA

2013 Dialysis of Drugs

DISCLAIMERThese Dialysis of Drugs guidelines are offered as a general summary of information for pharmacists and other medical professionals. Inappropriate administration of drugs may involve serious medical risks to the patient that can only be identied by medical professionals. Depending on the circumstances, the risks can be serious and can include severe injury, including death. These guidelines cannot identify medical risks specic to an individual patient or recommend patient treatment. These guidelines are not to be used as a substitute for professional training. The absence of typographical errors is not guaranteed. Use of these guidelines indicates acknowledgment that neither Renal Pharmacy Consultants, LLC, nor its sponsors will be responsible for any loss or injury, including death, sustained in connection with or as a result of the use of these guidelines. Readers should consult the approved Product Information for each agent indicated before prescribing medications. Guides such as this one can only draw from information available as of the date of publication. Neither Renal Pharmacy Consultants, LLC. nor its sponsors is under any obligation to update information contained herein. Future medical advances or product information may affect or change the information provided. Pharmacists and other medical professionals using these guidelines are responsible for monitoring ongoing medical advances relating to dialysis. Copyright 2013 Renal Pharmacy Consultants, LLC. All rights reserved. This material may not be published, rewritten or redistributed.

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I USE OF THIS GUIDE

Use Of This Guide

These guidelines are designed to provide extensive, easy-to-read information regarding the dialyzability of drugs. Numerous literature sources have been used in preparing the guidelines. For many drugs, including newlyapproved medications, investigational agents and medications available in other countries, there have been no dialysis pharmacokinetic studies. In some cases, the available data may conict. Conditions of dialysis used in published studies may not reect current dialysis practice and technology. Variations in the duration of dialysis, blood and dialysate ow rates, dialysis membranes, and whether peritoneal dialysis is continuous or intermittent, will all affect drug removal. These guidelines distinguish between conventional hemodialysis and high permeability (high-ux) hemodialysis where such data are available. No information is provided on drug dialyzability with continuous renal replacement therapy (CRRT) or with plasmapheresis. For additional information on specic drugs, the reader should consult the primary literature. Users of the following tables are referred to www.renalpharmacyconsultants.com for background and explanatory material to assist in the interpretation of the tabular data. The website provides specic information about factors that inuence drug dialyzability and special considerations, such as CRRT, plasmapheresis and drugs of abuse. Users must be familiar with this information prior to using
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2013 Dialysis of Drugs

the following tables. The website also includes a table presenting sieving coefcient data from in vitro and in vivo evaluations, which can be used to predict dosing requirements in CRRT, and a table regarding removal of drugs of abuse.

Key
Yes Indicates that dialysis enhances plasma clearance by 30% or more. Supplemental dosing may be required or dosing after dialysis should be considered. No Indicates that dialysis does not have a clinically important effect on plasma clearance. Supplemental dosing is usually not required. U Indicates that no published data exist but physicochemical characteristics of the drug suggest that signicant drug removal is unlikely during dialysis. L Indicates that no published data exist but physicochemical characteristics of the drug suggest that signicant drug removal is likely during dialysis. ND Indicates no data exist on drug dialyzability with this type of dialysis. NS Indicates the type of membrane was not specied. Note: In these tables, conventional hemodialysis is dened as the use of a dialysis membrane whose in vitro coefcient of ultraltration (KUf) 8 mL/hour/mm Hg. Data also are placed in the conventional column if the literature does not specify the type of dialysis membrane employed. High permeability hemodialysis is dened as the use of a dialysis membrane whose KUf >8 mL/hour/mm Hg. In the tables, the KUf of the membrane(s) used is included in parentheses.
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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Abacavir Abatacept Abciximab Abiraterone Acamprosate Acarbose Acebutolol (diacetolol) Acenocoumarol Acetaminophen (paracetamol) Acetazolamide Acetohexamide Acetophenazine Acetylcysteine Aciclovir (acyclovir) Acid colloidal hydrocolloid Acitretin Aclidinium bromide Acrivastine Acyclovir (aciclovir) Adalimumab Adefovir Adenosine Adrenaline (epinephrine) Aibercept Adipiodone Agalsidase alfa Agalsidase beta

U U U No (NS) ND ND Yes (NS) U Yes (NS) U U U Yes (7.5) Yes (NS) U No (NS) U ND Yes (NS) U Yes (NS) U ND ND ND No (7.5) U

No (40) U ND No (NS) ND ND L U L ND ND ND ND L U U U ND L U ND ND ND ND ND No (10) U

ND U U U ND ND ND U No No U U ND No U U U ND No U ND U ND ND ND U U

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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Agomelatine Albendazole Albinterferon alfa-2b Albumin Albuterol (salbutamol) Alcaftadine Aldesleukin Alefacept Alemtuzumab Alendronate Alfacalcidol (1-alphahydroxy vitamin D3) Alfentanil Alfuzosin Alginic acid Alglucerase Alimemazine (trimeprazine) Aliskiren Alitretanoin Allopurinol Almotriptan Alosetron Alpha tocopherol Alprazolam Alprostadil Alteplase Altretamine Aluminum Alvimopan
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ND No (NS) No (NS) U No (NS) ND ND ND U No (NS) ND U U U U ND ND ND Yes (NS) ND ND ND No (NS) U U ND ND ND

ND ND U ND ND ND ND ND U ND ND ND U U U ND ND ND L ND ND ND ND No (11.1) ND ND ND ND

ND U U U U ND ND ND U ND ND U U U U ND ND ND ND ND ND ND U ND U ND No ND

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Amantadine Ambenonium Ambrisentan Amdinocillin Amifostine Amikacin Amiloride Aminocaproic acid Aminoglutethimide Aminoguanidine (pimagedine) Aminophylline Aminosalicylic acid Amiodarone Amisulpride Amitriptyline Amlexanox Amlodipine Ammonium chloride Amoxapine Amoxicillin Amphetamine Amphotericin B Amphotericin B lipid complex Ampicillin Amprenavir Amrinone Amsacrine (m-AMSA) Anagrelide

No (NS) ND U No (NS) ND Yes (NS) ND Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) No (NS) U No (NS) ND No (NS) ND U Yes (NS) ND No (NS) No (NS) Yes (NS) U U U ND

ND ND U ND ND L ND ND L ND L L U U ND ND U ND U L ND No (10.1, 36) ND L ND ND U ND

No ND U No ND Yes ND Yes ND ND No ND No U No ND No ND U No ND No U No U No U ND
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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Anakinra Anastrozole Ancestim Ancrod Anidulafungin Anisindione Anisoylated plasminogen streptokinase activator complex (Anistreplase) Anistreplase (anisoylated plasminogen streptokinase activator complex) Antihemophilic factor, (Factor VIII) Antithymocyte globulin Apixaban Apomorphine Apraclonidine Aprepitant Aprotinin Arbutamine Argatroban Aripiprazole Armodanil Arsenic trioxide Artemether Artemether/ lumefantrine
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No (NS) ND ND ND No (NS) U

ND ND ND ND U U

No ND ND ND U U

ND

ND

ND U ND U ND No (NS) U ND U U ND No (NS) U ND

ND ND ND U ND U ND ND No (10.7-36) U ND ND U ND

ND U ND U ND U U ND ND U ND U U ND

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Articaine Ascorbic acid (sodium ascorbate, vitamin C) Asenapine Asparaginase Aspirin Atazanavir Atenolol Atomoxetine Atorvastatin Atovaquone Atracurium Atropine Auranon Avanal Axitinib Azacitidine Azathioprine Azelastine Azilsartan medoxomil Azithromycin Azlocillin Aztreonam Bacampicillin Baclofen Balsalazide Basiliximab Belimumab Benazepril (benazeprilat)

ND Yes (5.5) U U Yes (NS) U Yes (NS) U No (NS) U U No (NS) No (NS) ND ND ND Yes (NS) U No (NS) Y (NS) Yes (NS) Yes (NS) Yes (NS) ND U U ND No (NS)

ND Yes (8.8) U ND L U L U U ND ND ND ND ND ND ND L U No (NS) L L L L Yes (60) U ND ND ND

ND Yes U U Yes U No U U U U ND ND ND ND ND ND U ND No No No No ND U U ND ND

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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Benazeprilat (benazepril) Bendamustine Bendroumethiazide Benserazide Benzhexol (trihexyphenidyl) Benzphetamine Benzquinamide Benztropine Bepotastine besylate Bepridil Beractant Besioxacin Betahistine Betaine Betamethasone Betaxolol Bethanechol Bevacizumab Bexarotene Bezabrate Biapenem Bicalutamide Bimatoprost Biperiden Bisoprolol Bivalirudin Bleomycin Boceprevir
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No (NS) U No (NS) U ND ND U ND ND No (NS) U ND ND ND ND No (NS) ND U U No (NS) Yes (NS) U ND ND No (NS) Yes (NS) No (NS) No (NS)

ND U ND U ND ND ND ND ND ND U ND ND ND ND ND ND No (NS) U U Yes (NS) ND ND ND ND ND ND No (NS)

ND U U U ND ND ND ND ND U U ND ND ND ND No ND U U No ND U ND ND ND ND No U

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Bortezomib Bosentan Brentuximab vedotin Bretylium Brinzolamide Bromazepam Bromfenac Bromocriptine Brompheniramine Budesonide Buomedil Bumetanide Buphenine (nylidrin) Bupivacaine Buprenorphine Bupropion Buserelin Buspirone Busulfan Butalbital Butoconazole Butorphanol C1 esterase inhibitor Cabazitaxel Cabergoline Caffeine Calcitonin Calcitriol Calcium carbonate Calcium folinate

No (NS) U U Yes (NS) ND ND No (NS) U ND U No (NS) U ND U U No (NS) ND No (NS) Yes (NS) ND U U ND U ND ND U No (4.2-5.3) Y No (NS)

ND No (11.1) U L ND ND U ND ND U No (20) U ND U U No (10) ND ND Yes (8.1) ND U ND ND U ND ND U No (31) Y ND

ND U U ND ND ND U U ND U U U ND U U No ND ND ND ND U U ND U ND ND U U Y ND
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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Calcium folinate (leucovorin) Calcium polystyrene sulfonate Calcium sodium alginate Calfactant Canakinumab Candesartan Capecitabine Capreomycin Captopril Carbamazepine Carbenicillin Carbidopa/levodopa Carbimazole Carbinoxamine Carboplatin Carboprost Carlzomib Carglumic acid Carisoprodol Carmustine Carprofen Carteolol Carumonam Carvedilol Caspofungin CCNU (lomustine) Cefaclor

ND U U ND U No (NS) ND Yes (NS) Yes (NS) No (NS, 5.5) Yes (NS) ND/U No (NS) ND Yes (NS) ND No (NS) ND Yes (NS) No (NS) U ND Yes (NS) No (NS) No (NS) No (NS) Yes (NS)

ND U U ND U No (8.1) ND L L Yes (22, 55) L ND/U ND ND Yes (NS) ND No (NS) ND L ND U ND L U U ND L

ND U U ND U ND ND ND No No No ND/U No ND No ND U ND Yes ND U ND ND U U U Yes

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Cefadroxil Cefalotin Cefamandole Cefazolin Cefdinir Cefditoren Cefepime Cexime Cefmenoxime Cefmetazole Cefodizime Cefonicid Cefoperazone Ceforanide Cefotaxime Cefoxitin Cefpirome Cefpodoxime Cefprozil Cefradine Cefroxadine Cefsulodin Ceftaroline fosamil Ceftazidime Ceftibuten Ceftizoxime Ceftobiprole Ceftriaxone Cefuroxime Celecoxib

Yes (NS) Yes (NS) Yes (NS) Yes (6, 8) ND No (NS) Yes (NS) No (NS) Yes (NS) Yes (NS) No (NS) No (NS) No (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) ND Yes (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) ND No (NS) Yes (NS) U

L L L Yes (8.1-60) Yes (NS) ND Yes (40, 60) ND L L ND ND ND L L L Yes (40) L L L ND L Yes (NS) L L L ND ND L U

No No No No ND ND Yes No ND No No No No No No No No No ND Yes ND Yes L Yes ND No ND No No U

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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Cephalexin Cephalothin Cephapirin Cephazolin Cephradine Certolizumab Cetirizine Cetrorelix Cetuximab Cevimeline Chloral hydrate Chlorambucil Chloramphenicol Chlordiazepoxide Chlormethine (mechlorethamine, mustine) Chloroprocaine Chloroquine Chlorothiazide Chlorphenamine (chlorpheniramine) Chlorpheniramine (chlorphenamine) Chlorpromazine Chlorpropamide Chlorprothixene Chlorthalidone Chlorzoxazone Cholecalciferol (vitamin D3)
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Yes (NS) Yes (NS) Yes (NS) Yes (6, 8) Yes (NS) U U ND No (NS) ND Yes (5.5) No (NS) Yes (NS) No (NS) U ND No (NS) No (NS) Yes (NS) Yes (NS) No (NS) No (NS) U No (NS) ND U

L L L Yes (8.1-60) L U No (18.7-66.7) ND U ND L ND L U U ND ND ND L L U ND ND ND ND U

No No No No Yes U U ND U ND ND No No U U ND No U No No No No U U ND U

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Cholestyramine Choriogonadotropin alfa (chorionic gonadotrophin) Chorionic gonadotrophin (choriogonadotropin alfa) Ciclesonide Cidofovir Cilastatin Cilazapril Cilostazol Cimetidine Cinacalcet Cinoxacin Ciprooxacin Cisapride Cisatracurium Cisplatin Citalopram Citric acid Cladribine Clarithromycin Clavulanic acid Clemastine Clevidipine Clinaoxacin Clindamycin Clobazam Clodronate

U U

U U

U U

U U ND Yes (NS) Yes (NS) U No (NS) No (NS) No (NS) No (NS) No (NS) U No (NS) No (8) L ND ND Yes (NS) U U No (6.4) No (NS) No (4.2) ND

U U Yes (60) L L U ND U ND ND U ND Yes (64) No (40) L ND ND L U U No (8.1, 8.8) ND ND Yes (8.1)

U U No ND ND U No No U No U U No U L ND ND Yes U U ND No ND No
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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Clofarabine ND Clofazimine No (NS) Clobrate No (NS) Clomiphene ND Clomipramine U Clonazepam No (NS) Clonidine No (NS) Clopidogrel U Clorazepate No (NS) Clotrimazole U Cloxacillin No (NS) Clozapine No (NS) Cocaine No (NS) Codeine/metabolites (morphine-3 and morphine-6 No/Yes (NS) glucuronides, codeine-6 glucuronide) Colaspase U Colchicine No (NS) Colesevalam U Colestipol U Colistimethate No (NS) Colistin (polymyxin B) No (NS) Collagenase clostridium U histolyticum Conivaptan U Corifollitropin ND Cortisone No (NS)
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ND ND U ND U ND ND ND ND U ND U ND

ND No No ND U U No U U U No U U

ND

ND ND U U ND ND U U ND ND

U No U U No No U U ND No

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Cotrimoxazole (sulfamethoxazole/ trimethoprim) Crizotinib Cromolyn sodium Cyanocobalamin (vitamin B12) Cyclacillin Cyclobenzaprine Cyclophosphamide Cycloserine Cyclosporine Cyproheptadine Cyproterone Cystadane Cysteamine Cytarabine (cytosine arabinoside)/Ara-U Cytosine arabinoside (cytarabine)/Ara-U Dabigatran Dacarbazine Daclizumab Dactinomycin Dalbavancin Dalfampridine (fampridine) Dalteparin Danaparoid Danazol Dantrolene

Yes (NS)/Yes (NS) U U No (NS) Yes (NS) U Yes (6.4) ND No (NS) ND ND ND Yes (NS) ND/ND ND/ND Yes (NS) ND U ND No (NS) ND U ND ND ND

L/L U U No (40, 65) L U L Yes (30, 52) U ND ND ND ND

No/No U U ND No U ND ND No ND ND ND No

Yes (NS)/Yes (ND) No/ND Yes (NS)/Yes (ND) No/ND L ND ND ND ND L ND ND ND ND ND ND U ND U ND No ND ND ND

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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Dapsone Daptomycin Darbepoetin alfa Darifenacin Darunavir Dasatinib Daunorubicin Decitabine Deferasirox Deferiprone Deferoxamine (desferrioxamine) Deazacort Degarelix De-glymidodrine (midodrine) Delavirdine Demeclocycline Denileukin Denosumab Desferrioxamine (deferoxamine) Desipramine Desloratadine Desmopressin Desogestrel Desvenlafaxine Dexamethasone Dexamphetamine Dexchlorpheniramine

Yes (NS) No (11) U U Yes (NS) U ND ND U ND Yes (NS) No (NS) U ND U ND U U Yes (NS) No (NS) No (NS) ND U No (NS) No (NS) ND Yes (NS)

L Yes (59, 62) No (11.1-55) U L U ND ND U ND L ND U Yes (8.1) ND ND U U L ND ND ND U U ND ND L

ND No No U U U ND ND U ND ND U U ND U ND U U ND No No ND U U No ND No

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Dexfenuramine Dexlansoprazole Dexmedetomidine Dexmethylphenidate Dexpanthenol Dexrazoxane Dextran Dextroamphetamine Dextropropoxyphene Dezocine Diacetolol (acebutolol) Diatrizoate Diazepam Diazoxide Dibekacin Diclofenac Dicloxacillin Dicyclomine Dicycloverine Didanosine Dideoxycytidine (zalcitabine) Dienogest Diethylpropion Diethylstilbesterol (fosfestrol) Diunisal Digitoxin Digoxin Digoxin immune Fab

ND U U ND ND ND U ND No (NS) ND Yes (NS) L No (NS) Yes (NS) Yes (NS) U No (NS) ND ND No (7.9) ND ND ND No (NS) No (NS) No (NS) No (NS) No (NS)

ND U U ND ND ND U ND ND ND L Yes (NS) ND L L ND ND ND ND No (40) ND ND ND ND ND ND ND U

ND U U ND ND ND U ND No ND ND ND U Yes ND U No ND ND No ND ND ND ND U No No No
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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Dihydrocodeine ND Dihydroergotamine ND Diltiazem No (NS) Dimenhydrinate ND Dimyristoyl lecithin ND Dinoprostone ND (prostaglandin E2) Diphenhydramine U Diphenoxylate/atropine ND Dipyridamole U Dirithromycin No (NS) Disopyramide No (NS) Disulram U Divalproex No (NS) Dobutamine No (NS) Docetaxel No (NS) Dofetilide ND Dolasetron ND Domperidone U Donepezil U Dopamine No (NS) Doripenem Yes (NS) Dornase alfa U Dosulepin (dothiepin) U Dothiepin (dosulepin) U Doxacurium No (NS) Doxapram ND Doxazosin No (NS) Doxepin No (NS) Doxercalciferol No (NS)
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ND ND ND ND ND ND ND ND ND ND U U ND ND U ND ND U ND ND Yes U U U ND ND ND ND U

ND ND No ND ND ND U ND ND No U U No No No ND ND U U U ND U U U U ND No No U

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Doxorubicin Doxorubicin, pegylated liposomal Doxycycline Doxylamine Dronabinol Dronedarone Droperidol Drospirenone Drotrecogin alfa Duloxetine Dutasteride Dydrogesterone Ecallantide Eculizumab Edetate calcium (EDTA) Edrophonium EDTA (edetate calcium) Efalizumab Efavirenz Eformoterol (formoterol) Eletriptan Eltrombopag Emtricitabine Enalapril (enalaprilat) Enalaprilat (enalapril) Encainide

No (NS) ND No (NS) ND U U U U U U U ND ND U Yes (NS) ND Yes (NS) U No (NS) ND ND U Yes (NS) Yes (NS) Yes (NS) No (NS)

ND ND ND ND ND U ND U U U U ND ND U L ND L U ND ND ND U ND L L ND

ND ND No ND U U U U U U U ND ND U Yes ND Yes U No ND ND U ND Yes Yes ND

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Enfuvirtide Enoxacin Enoxaparin Entacapone Entecavir Ephedrine Epinephrine (adrenaline) Epirubicin Eplerenone Epoetin alfa Epoetin beta Epoprostenol (prostacyclin) Eprosartan Eptacog alfa Eptibatide Ergocalciferol Ergometrine (oxytocin) Ergotamine Eribulin mesylate Erlotinib Ertapenem Erythromycin Escitalopram Eslicarbazine Esmolol Esomeprazole Estazolam Estradiol
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No (NS) No (NS) No (NS) U No (NS) ND ND ND No (7) No (NS) U ND U U ND ND ND ND ND U Yes (NS) No (NS) ND Yes (NS) Yes (NS) U U No (NS)

U ND Yes (11.5-55) U ND ND ND ND ND No (11.1-55) U ND No (60) U ND ND ND ND ND No (NS) L ND ND L L U U U

U No No U No ND ND ND ND No U ND U U ND ND ND ND ND U No No ND ND Yes U U U

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Estramustine Estrogens, conjugated Estrone Estropipate (piperazine estrone) Eszopiclone Etanercept Ethacrynic acid Ethambutol Ethanol Ethanolamine oleate Ethchlorvynol Ethinyl estradiol Ethinyloestradiol Ethionamide Ethopropazine (prophenamine) Ethosuximide Ethotoin Ethynodiol diacetate Etidronate Etodolac Etonogestrel Etoposide Etoricoxib Etravirine Everolimus Exametazime Exemestane Exenatide

ND ND No (NS) U ND No (NS) No (NS) No (NS) Yes (NS) ND No (NS) U U U ND Yes (NS) ND ND ND No (NS) ND No (NS) No (NS) No (NS) ND ND U ND

ND ND ND U ND U U No (80) L ND ND U U No (30, 52) ND L ND ND ND U ND No (NS) U U ND ND U ND

ND ND ND U ND U U U ND ND No No No U ND ND ND ND ND U ND No U U ND ND U ND
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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Ezetimibe Ezogabine Factor VIII (antihemophilic factor) Famciclovir (penciclovir) Famotidine Fampridine (dalfampridine) Febuxostat Felbamate Felodipine Fenuramine Fenobrate Fenoldopam Fenoprofen Fenoterol Fentanyl Ferric carboxymaltose Ferric gluconate Ferrous (iron) salts Ferumoxytol Fesoterodine Fexofenadine Fibrinogen Fidaxomicin Filgrastim Finasteride Fingolimod Flavoxate

U ND ND Yes (NS) No (NS) ND U ND No (NS) ND No (NS) U No (NS) ND U U No (NS) U No (NS) ND No (NS) ND U No (NS) U ND ND

U ND ND L ND L U ND U ND U ND U ND No (10.1) U ND ND ND ND ND ND U ND ND ND ND

U ND ND ND No ND U ND U ND U No U ND ND U U U ND ND U ND U U U ND ND

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Flecainide Fleroxacin Floctafenine Florbetapir F-18 Floxuridine Flucloxacillin (oxacillin) Fluconazole Flucytosine Fludarabine Fludrocortisone Flumazenil Flunitrazepam Fluorouracil/FBAL Fluoxetine Fluoxymesterone Flupenthixol Fluphenazine Flurazepam Flurbiprofen Flutamide Fluticasone Fluvastatin Fluvoxamine Folic acid Follitropin alfa Follitropin beta Fomepizole Fondaparinux

No (NS) U ND ND ND No (NS)

ND No (8.1, 22) ND ND ND ND

U No ND ND ND ND Yes Yes ND ND ND ND ND No ND ND U U No U U U U ND ND ND ND U

Yes (NS) L Yes (NS) L ND ND ND ND ND ND ND ND No (NS)/ND Yes (71)/Yes (40) No (NS) U ND ND ND ND U ND No (NS) ND U U No (NS) ND U U No (NS) U U No (NS) Yes (NS) L ND ND ND ND Yes (NS) L No (NS) ND

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Formoterol (eformoterol) Fosamprenavir Fosaprepitant Foscarnet Fosfestrol (diethylstilbesterol) Fosfomycin Fosinopril (fosinoprilat) Fosinoprilat (fosinopril) Fosphenytoin Fotemustine Frovatriptan Frusemide Fulvestrant Furosemide Fusidic acid Gabapentin Gadobenate Gadobutrol Gadodiamide Gadofosveset Gadolinium Gadopentetate Gadoteric acid Gadoteridol Gadoversetamide Gadoxetate Galantamine Gallamine
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ND U No (NS) Yes (4.1) No (NS) Yes (NS) No (NS) No (NS) U ND ND No (NS) U No (NS) No (NS) Yes (NS) ND Yes (5.5) Yes (NS) ND Yes (NS) Yes (NS) No (NS) ND ND Yes (NS) ND ND

ND U U Yes (18-60) ND L ND ND U ND ND U U U ND L ND L L ND ND L U ND Yes (NS) L ND ND

ND U U ND ND ND No No U ND ND U U U No ND ND ND No ND ND ND U ND ND ND ND ND

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Gallium Gallopamil Galsulfase Ganciclovir Ganirelix Garenoxacin Gatioxacin Geftinib Gemcitabine Gembrozil Gemioxacin Gemtuzumab Gentamicin Gestodene Gestrinone Glatiramer Glibenclamide (glyburide) Gliclazide Glimepiride Glipizide Glucagon Glucarpidase Glutethimide Glyburide (glibenclamide) Glyceryl trinitrate Glycopyrrolate Gold sodium thiomalate

ND U U Yes (NS) ND No (NS) ND U Yes (7) No (NS) No (NS) U Yes (NS) U ND ND No (NS) U U U U ND No (NS) No (NS) No (NS) ND No (NS)

ND U U L ND ND ND No (20) Yes (53, 58) U ND U Yes (13.2-60) U ND ND U U U U ND ND ND U ND ND ND

ND U U ND ND No ND U ND No ND U Yes U ND ND U U U U U ND No U No ND U

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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Golimumab Goserelin Granisetron Grepaoxacin Griseofulvin Guaifenesin Guanabenz Guanadrel Guanethidine Guanfacine Guanidine H1N1 Vaccine Halofantrine Haloperidol Heparin Heroin Hexamine (metenamine is mandelic acid salt) Hexobarbital (hexobarbitone) Hexobarbitone (hexobarbital) Hirudin Human growth hormone Hydralazine Hydrochlorothiazide Hydrocodone Hydrocortisone

U ND ND ND ND ND U ND ND No (NS) ND ND ND No (NS) No (NS) U ND No (NS) No (NS) No (4.3-6.5) U No (NS) No (NS) ND U

U ND ND ND ND ND U ND ND ND ND ND ND U ND ND ND ND ND Yes (20-90) U ND ND ND ND

U ND ND ND ND ND U ND ND No ND ND ND No No U ND U U ND U No U ND U

28

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Hydromorphone/ hydromorphone-3No/Yes (7.5) glucuronide Hydroxocobalamin U Hydroxycarbamide No (NS) (hydroxyurea) Hydroxychloroquine ND Hydroxyurea No (NS) (hydroxycarbamide) Hydroxyzine No (NS) Ibandronate ND Ibritumomab U Ibuprofen No (NS) Ibutilide ND Icatibant ND Icosapent ethyl U Idarubicin U Idebenone U Idursulfase U Ifosfamide Yes (1.6) Iloperidone U Iloprost ND Imatinib No (NS) Imidapril (imidaprilat) No (NS) Imidaprilat (imidapril) No (NS) Imiglucerase U Imipenem Yes (NS) Imipramine No (NS) Immune globulin U (immunoglobulin, IVIg)

ND/L No (40, 65) ND ND ND U Yes (8.1) U U ND ND U U U U L U ND U U U U L U U

U ND U ND U No ND U U ND ND U U U U ND U ND U U U U Yes No U

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

29

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Immunoglobulin U (immune globulin, IVIg) IVIg (immune globulin U (immunoglobulin) Indacaterol U Indapamide No (NS) Indinavir U Indomethacin No (NS) Iniximab U Ingenol mebutate ND Insulin No (NS) Insulin aspart U Insulin detemir No (NS) Insulin glargine U Insulin glulisine U Insulin lispro U Interferons No (NS) Iobenguane No (NS) Iodipamide ND Iodixanol Yes (3.1, 4.2) Ioupane I-123 ND Iohexol Yes (NS) Iomeprol Yes (6.8) Iopamidol Yes (4.8) Iopromide Yes (5.5-6.8) Iotrolan Yes (NS) Ioversol Yes (6.3) Ioxaglic acid L Ioxilan Yes (NS) Ioxitalamic acid ND
30

U U U ND No (40) U U ND ND ND U ND ND ND Yes (20-33) ND ND L ND Yes (15.5) L L Yes (8.1-62) L L Yes (15.5) L ND

U U U U ND U U ND No U ND U ND U No ND ND ND ND ND Yes Yes ND ND ND ND ND ND

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Ipilimumab Irbesartan Irinotecan/SN-38 Iron dextran Iron polymaltose complex Iron saccharate (sucrose) Iron sorbitol-citric acid complex Iron sucrose (saccharate) Isocarboxazid Isoniazid Isoprenaline (Isoproterenol) Isoproterenol (Isoprenaline) Isosorbide dinitrate Isosorbide mononitrate Isotretinoin Isradipine Itraconazole Ivabradine Ivacafator Ivermectin Ixabepilone Kanamycin Ketamine Ketoconazole Ketoprofen

U No (NS) U/U U U U ND U ND No (NS) ND ND No (NS) Yes (NS) U No (NS) No (NS) ND ND ND ND Yes (NS) No (NS) No (NS) U

U ND No (8.5)/No (8.5) No (8.1-10.1) U No (11.1-55) ND No (11.1-55) ND No (80) ND ND ND L U U No (65) ND ND ND ND L ND ND U

U ND U/U U U U ND U ND No ND ND No No U No U ND ND ND ND Yes U No U
31

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Ketorolac U Ketotifen ND L-deprenyl (selegiline) ND L-tryptophan U Labetolol No (NS) Lacosamide L Lactulose U Lamivudine No (NS) Lamotrigine No (NS) Lanreotide ND Lansoprazole No (NS) Lanthanum carbonate No (NS) Lapatinib U Laronidase U Lead/CaNa2EDTA ND Leunomide No (NS) Lenalidomide Yes (NS) Lenograstim No (NS) Lepirudin No (4.3-6.2) Lercanidipine ND Letrozole ND Leucovorin (folinic ND acid) Leuprolide ND Leuprorelin ND Levamisole ND Levetiracetam Yes (NS) Levobupivacaine U Levocarnitine Yes (NS) Levocetirizine No (NS)
32

U ND ND No (8.1-40) ND Yes (NS) U No (11.4) ND ND U U U U Yes (85) No (8.1) ND ND Yes (20-90) ND ND ND ND ND ND L ND L U

U ND ND ND No U U No U ND U U U U ND No ND U ND ND ND ND ND ND ND ND U ND U

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Levodopa Levooxacin Levoleucovorin Levomethadyl Levonorgestrel Levorphanol Levosimendan Levothyroxine Lidocaine Lignocaine Linagliptin Lincomycin Linezolid Liothyronine Liraglutide Lisdexamfetamine Lisinopril Lithium Lomeoxacin Lomustine (CCNU) Loperamide Lopinavir Loracarbef Loratadine Lorazepam Lorcaserin Losartan Loteprednol etabonate Lovastatin Loxapine

U U ND U U ND No (6.4) U No (NS) No (NS) ND No (NS) Yes (NS) ND U ND Yes (NS) Yes (NS) No (NS) No (NS) ND U Yes (NS) No (NS) No (NS) No (NS) No (NS) U U ND

U No (>69) ND U ND ND U ND ND ND ND ND Yes (9.3-65) ND U ND L Yes (40, 70) ND ND ND No (NS) L U ND No (NS) No (10.1-52) U U ND

U No ND U U ND U U U U ND No ND ND U ND ND Yes No U ND U ND No U U No U U ND
33

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Lubiprostone Lucinactant Lumefantrine Lumiracoxib Lurasidone Lysergide (LSD) Macrogol 3350 Magnesium oxide Mangafodipir Mannitol Maprotiline Maraviroc Marijuana (THC) Mazindol MDMA (Ecstasy) Mebendazole Mebeverine Mecamylamine Mecasermin Mechlorethamine (chlormethine, mustine) Meclofenamate Medroxyprogesterone Mefenamic acid Meoquine Megestrol acetate Melatonin/6sulfatoxymelatonin Meloxicam

U U U ND U U U L ND Yes (NS) No (NS) ND U ND ND No (NS) ND ND ND U U U No (NS) U ND Yes (NS) No (NS)

U U U ND U ND U L ND L U ND ND ND ND U ND ND ND U ND U U ND ND L U

U U U ND U U U L ND Yes U ND U ND ND U ND ND ND U U U U U ND ND U

34

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Melphalan No (NS) ND Memantine ND ND Menadiol ND ND Meningococcal ND ND vaccine Menotropins ND ND Mepenzolate ND ND Meperidine/ normeperidine No (NS)/ND No (8.1)/Yes (8.1) (pethidine) Meprobamate Yes (NS) L Mercaptopurine Yes (NS) L Meropenem Yes (NS) L Mesalamine (5-ASA, Yes (5.5) ND mesalazine) Mesalazine (5-ASA, Yes (5.5) ND mesalamine) Mescaline (peyote) U ND Mesna ND ND Mesoridazine U ND Mesterolone ND ND Mestranol U U Mesuximide ND ND Metaproterenol ND ND (orciprenaline) Metaxalone ND ND Metformin Yes (NS) L Methadone No (NS) U Methaqualone No (NS) ND Methenamine ND ND Methicillin No (NS) U
SEE DISCLAIMER REGARDING USE OF THIS GUIDE

ND ND ND ND ND ND U/ND Yes ND ND U U U ND U ND U ND ND ND ND No No ND No
35

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Methimazole Methocarbamol Methohexital Methotrexate Methotrimeprazine Methoxsalen Methylphenobarbital Methoxy polyethylene glycol-epoetin beta Methscopolamine Methsuximide Methyl aminolevulinate HCl Methyldopa Methylergonovine Methylnaltrexone Methylphenidate Methylprednisolone Methysergide Metoclopramide Metolazone Metoprolol Metronidazole Mexiletine Mezlocillin Mianserin Micafungin Miconazole Midazolam

No (NS) ND U Yes (NS) ND ND Yes (NS) U ND ND U Yes (NS) ND ND U Yes (NS) ND No (NS) No (NS) Yes (NS) Yes (NS) Yes (NS) Yes (NS) No (NS) U No (NS) No (NS)

ND ND U Yes (20, 60) ND ND Yes (60) U ND ND U L ND ND ND L ND U U L Yes (56) L L ND U U U

No ND U Yes ND ND Yes U ND ND U Yes ND ND U ND ND No U ND No No No ND U No U

36

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Midodrine (deglymidodrine) Mifepristone Miglitol Miglustat Milnacipran Milrinone Minocycline Minoxidil Mirabegron Mirtazapine Misoprostol Mithramycin (plicamycin) Mitomycin Mitotane Mitoxantrone Mivacurium Moclobemide Modanil Moexipril Molindone Mometasone Montelukast Moricizine Moroctocog alfa Morphine Moxioxacin Moxonidine Muromonab-CD3

ND U ND ND U ND No (NS) Yes (NS) U No (7.5) U ND ND ND No (NS) ND ND ND ND U ND U U U ND ND ND U

Yes (8.1) U ND ND U ND ND L U ND ND ND ND ND U ND ND ND ND ND ND ND ND U Yes (8.1, 10.1) ND ND ND

ND U ND ND U ND No Yes U U U ND ND ND No ND ND ND ND U ND U U U No No ND U
37

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Mustine (chlormethine, U mechlorethamine) Mycophenolate No (NS) Nabilone ND Nabumetone No (NS) Nadolol Yes (NS) Nadroparin ND Nafarelin ND Nafcillin No (NS) Nalbuphine ND Nalidixic acid U Nalmefene No (4.1-5.9) Naloxone ND Naltrexone No (NS) Nandrolone ND Naproxen No (NS) Naratriptan ND Natalizumab U Nateglinide/M1 U/Yes (NS) metabolite Nebivolol U Nedocromil ND Nefazodone U Nefopam No (NS) Nelarabine U Nelnavir U Neomycin Yes (NS) Nesiritide U Netilmicin Yes (NS) Nevirapine ND
38

U U ND U L ND ND ND ND U U ND U ND U ND U U/Yes (NS) U ND U ND U No (71) L U L Yes (40)

U No ND U ND ND ND No ND U U ND U ND U ND U U/ND U ND U ND U No Yes U Yes Yes

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Niacin (vitamin B3, nicotinic acid) Niacinamide (nicotinamide) Nicardipine Nicorandil Nicotinamide (niacinamide) Nicotine Nicotinic acid (niacin, vitamin B3) Nifedipine Nilotinib Nilutamide Nimodipine Nisoldipine Nitazoxanide Nitisinone Nitrazepam Nitrendipine Nitrofurantoin Nitroglycerin Nitroprusside Nizatidine Nomegestrol/ oestradiol Nomifensine Nonacog alfa Noradrenaline (norepinephrine) Norelgestromin

ND ND No (NS) ND ND ND ND No (NS) No (NS) ND No (NS) No (NS) U ND ND No (NS) Yes (NS) No (NS) Yes (NS) No (NS) ND ND U ND ND

ND ND U ND ND ND ND U U ND U U U ND ND U L ND L ND ND ND U ND ND

ND ND U ND ND No ND No U ND No No U ND ND U ND No Yes No NS ND U ND ND
39

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Norepinephrine (noradrenaline) Norethindrone Norethisterone Noroxacin Norgestimate Norgestrel Nortriptyline Nylidrin (buphenine) Nystatin Octocog alfa Octreotide Oestradiol Oestriol Oestrogens, conjugated Ofatumumab Ooxacin Olanzapine Olmesartan Olsalazine Omalizumab Omapatrilat Omega-3-acid ethyl esters Omeprazole Ondansetron Oprelvekin Orboban Orlistat
40

ND ND ND No (NS) U ND No (NS) ND U U Yes (NS) No (NS) ND ND U Yes (6.0) No (NS) No (NS) U U No (NS) ND U U U Yes (NS) U

ND ND ND ND U ND U ND U U L ND ND ND U Yes (8.5) U No (NS) ND U ND ND ND ND U L U

ND No No U U ND No ND U U ND ND ND ND U No No U U U ND ND U U U ND U

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Ornidazole Yes (NS) Ornipressin U Orciprenaline ND (metaproterenol) Oritavancin No (NS) Orphenadrine ND Oseltamivir Yes (2.8-4.0) Oxacillin No (NS) Oxaliplatin ND Oxandrolone U Oxaprozin No (NS) Oxazepam No (NS) Oxcarbazepine ND Oxpentifylline U (pentoxifylline) Oxprenolol U Oxtriphylline Yes (NS) Oxybutynin ND Oxycodone ND Oxymetholone ND Oxymorphone U Oxytocin (ergometrine) ND Paclitaxel No (NS) Palifermin U Paliperidone ND Palivizumab U Palonosetron ND Pamidronate Yes (6.4) Pancreatic extract U Pancuronium ND

L U ND No (NS) ND L U Yes (71, NS) U ND ND ND ND U L ND Yes (48) ND U ND U ND ND U ND L U ND

No U ND ND ND Yes No ND U U U ND ND U No ND ND ND U ND No ND ND U ND ND U ND
41

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Panitumumab Pantoprazole Papaverine Para-aminosalicylate Paracetamol (acetaminophen) Parecoxib Paricalcitol Paromomycin Paroxetine Pazopanib Peoxacin Pegademase Pegaspargase Peglgrastim Peginesatide acetate Peginterferon alfa-2a Peginterferon alfa-2b Pegloticase Pegvisomant Pemetrexed Pemoline Penbutolol Penciclovir (famciclovir) Penicillamine Penicillin Pentamidine Pentastarch

U No (5.1) U U Yes (NS) No (NS) No (5.5) ND No (NS) U No (NS) U U No (NS) U U U U U ND Yes (NS) No (NS) Yes (NS) Yes (NS) Yes (NS) No (NS) U

U U U No (30, 60) L U ND ND U U ND U ND U U No (8.7-33) No (8.7)/Yes (20-33) U U ND L ND L L L ND U

U U U U No U ND ND U U No U U U U U U U U ND No No ND ND No No U

42

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Pentazocine Yes (NS) L Pentobarbital No (NS) ND Pentosan polysulfate ND ND Pentostatin ND ND Pentoxifylline U U (oxpentifylline) Perexane ND ND Perutren ND ND Pergolide U U Perhexiline U U Pericyazine ND ND Perindopril Yes (NS) L (perindoprilat) Perindoprilat Yes (NS) L (perindopril) Perphenazine U U Pertuzumab ND ND Pethidine/norpethidine No (NS)/ND No (8.1)/Yes (8.1) (meperidine) Phenacetin ND ND Phenazopyridine ND ND Phencyclidine (PCP) U ND Phendimetrazine ND ND Phenelzine ND ND Phenindione ND ND Pheniramine ND ND Phenobarbital Yes (NS) Yes (60) Phenobarbitone Yes (NS) Yes (60) Phenoxybenzamine ND ND Phentermine ND ND

ND U ND ND U ND ND U U ND ND ND U ND U/ND ND ND U ND ND ND ND Yes Yes ND ND

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

43

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Phentolamine ND Phenylbutazone No (NS) Phenyltoloxamine ND Phenytoin No (NS) Phytomenadione (phytonadione, ND vitamin K) Phytonadione (phytomenadione, ND vitamin K) Pilocarpine ND Pimagedine Yes (NS) (aminoguanidine) Pimozide ND Pinaverium U Pindolol ND Pioglitazone No (NS) Piperacillin Yes (NS) Piperazine oestrone ND (estropitate) Pipotiazine ND Piroxicam U Pitavastatin U Pivmecillinam No (NS) Pizotifen (pizotyline) U Pizotyline (pizotifen) U Plerixafor ND Plicamycin ND (mithramycin) Pneumococcal vaccine ND Polidocanol ND
44

ND U ND Yes (36) ND

ND U ND No ND

ND ND ND ND U ND U L ND ND U U ND U U L ND ND ND

ND ND ND ND U ND U No ND ND U U U U U ND ND ND ND

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Polyethylene glycol Polymyxin B (colistin) Polythiazide Poractant alfa Pormer Posaconazole Pralatrexate Pralidoxime Pramipexole Pramlintide Prasugrel Pravastatin Prazepam Praziquantel Prazosin Prednisolone Prednisone Pregabalin Primaquine Primidone Probenecid Probucol Procainamide/N-acetyl procainamide (NAPA) Procarbazine Prochlorperazine Procyclidine Profenamine Progesterone Proguanil

U No (NS) No (NS) ND No (NS) No (NS) ND ND No (NS) ND U No (5.3) No (NS) No (NS) No (NS) U No (NS) Yes (NS) No (NS) Yes (NS) U No (NS) Yes (NS)/ Yes (NS) ND U ND ND U No (NS)

U ND ND ND U U ND ND U ND U ND ND ND U No (NS) ND L U L U ND L/L ND U ND ND U U

U No No ND U U ND ND U ND U ND U ND No U No ND U ND U No No/No ND U ND ND U U
45

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Promazine Promethazine Propafenone Propantheline Prophenamine (ethopropazine) Propofol Propoxyphene Propranolol Propylthiouracil Prostacyclin (epoprostenol) Prostaglandin E2(dinoprostone) Protriptyline Prucalopride Pseudoephedrine Psilocybin Pyrantel Pyrazinamide Pyridostigmine Pyridoxine Pyrilamine Pyrimethamine Quazepam Quetiapine Quinagolide Quinapril (quinaprilat) Quinaprilat (quinapril) Quinidine

U No (NS) No (NS) ND ND U No (NS) No (NS) No (NS) ND ND No (NS) U No (NS) ND ND Yes (NS) ND ND ND ND U ND U No (NS) No (NS) No (NS)

ND U U ND ND U ND U ND ND ND U U U ND ND Yes (80) ND Yes (36) ND ND U ND U U U U

U U No ND ND U No No ND ND ND No U U ND ND No ND ND ND ND U ND U No No No

46

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HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Quinine No (NS) Quinupristin/ ND dalfopristin Rabeprazole U Raloxifene U Raltegravir Yes (NS) Raltitrexed ND Ramelteon ND Ramipril (ramiprilat) No (NS) Ramiprilat (ramipril) No (NS) Ranibizumab U Ranitidine No (NS) Ranolazine ND Rapacuronium ND Rasagiline ND Rasburicase U Reboxetine U Recainam No (NS) Remifentanil U Repaglinide U Reserpine No (NS) Reteplase ND Reviparin No (NS) Rho(D) immune U globulin Ribavirin No (NS) Rifabutin U Rifaldazine (rifampicin, No (NS) rifampin)

U ND U U L ND ND ND ND U Yes (NS) ND ND ND U U ND U No (60) U ND ND U U No (40) No (80)

No No/No U U ND ND ND ND ND U No ND ND ND U U U U U No ND U U U U No

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

47

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Rifampicin (rifaldazine, No (NS) rifampin) Rifampin (rifampicin, No (NS) rifaldazine) Rifapentine U Rifaximin U Rilmenidine No (NS) Rilonacept U Rilpivirine U Riluzole U Rimantadine No (NS) Risedronate ND Risperidone ND Ritodrine Yes (NS) Ritonavir Yes (NS) Rituximab No (NS) Rivaroxaban ND Rivastigmine ND Rizatriptan ND Rocuronium ND Roumilast U Romidepsin U Romiplostim ND Ropinirole U Ropivacaine U Rosiglitazone No (NS) Rosuvastatin No (NS) Rotigotine U Roxithromycin ND Ruboxistaurin U
48

No (80) No (80) U U ND U U U U ND ND L No (40) U ND ND ND ND U U ND U U U ND U ND U

No No U U U U U U U ND ND Yes No U ND ND ND ND U U ND U U No U U No U

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Runamide No (NS) Ruoxacin ND Ruxolitinib No Sacrosidase ND Salbutamol (albuterol) No (NS) Salcatonin U Salmeterol ND Salsalate Yes (NS) Sapropterin ND Saquinavir U Sargramostim ND Saxagliptin Yes (NS) Secobarbital No (NS) Secretin ND Selegiline (l-deprenyl) ND Sermorelin (GRF 1-29) ND Sertindole No (NS) Sertraline No (NS) Sevelamer U Sevourane ND Sibutramine U Sildenal U Silodosin U Silver sulfadiazine No (NS) Simethicone U Simvastatin U Sirolimus No (NS) Sisomicin Yes (NS) Sitagliptin No (NS) Sitaxsentan U
SEE DISCLAIMER REGARDING USE OF THIS GUIDE

ND ND No ND ND U ND L ND No (40) ND Yes (NS) ND ND ND ND U U U ND U No (65) U ND U U U L ND U

U ND U ND U U ND No ND U ND ND No ND ND ND U U U ND U U U U U U U ND ND U
49

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Sodium ascorbate (ascorbic acid, vitamin C) Sodium aurothiomalate Sodium calcium edetate Sodium chondroitin sulfate Sodium clodronate Sodium cromoglycate Sodium diatrizoate Sodium fusidate Sodium nitroprusside Sodium oxybate Sodium picosulfate Sodium polystyrene sulfonate Sodium thiosulfate Sodium valproate Solifenacin Somatropin Sorafenib Sotalol Sparoxacin Spectinomycin Spinosad Spiramycin Spirapril (spiraprilat) Spiraprilat (spirapril) Spironolactone
50

Yes (5.5) U Yes (NS) ND ND U L No (NS) Yes (NS) ND ND U ND No (NS) U No (NS) No (NS) Yes (NS) ND Yes (NS) U ND U U U

Yes (8.8) U L ND Yes (8.1) U Yes (NS) ND L ND ND U Yes (NS) Yes (62) U U Yes (NS) L ND L U ND ND ND ND

Yes U Yes ND No U ND No Yes ND ND U ND No U U U ND ND Yes U ND U U U

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Stanozolol Stavudine Streptokinase Streptomycin Streptozocin Sucralfate Sufentanil Sulbactam Sulfadiazine Sulfadoxine Sulfamethoxazole Sulfapyridine Sulfasalazine Sulnpyrazone Sulsoxazole Sulindac Sulthiame Sumatriptan Sunitinib Tacrine Tacrolimus Tadalal Tauprost Taliglucerase alfa Talinolol Tamoxifen Tamsulosin Tapentadol Tazobactam Tebazumab

ND Yes (NS) U Yes (NS) ND No (NS) U Yes (NS) ND ND Yes (NS) ND U No (NS) Yes (NS) No (NS) ND ND U ND No (NS) No (NS) ND ND No (NS) ND U U Yes (NS) No (NS)

ND Yes (NS) U L ND ND U L ND ND L ND U U L ND ND ND No (NS) ND U U ND ND ND ND U U L ND

ND ND U Yes ND No U No ND ND No ND U U Yes U ND ND U ND U U ND ND ND ND U U No U
51

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Tegafur Tegaserod Teicoplanin Telaprevir Telavancin Telbivudine Telithromycin Telmisartan Temazepam Temocillin Temozolomide Temsirolimus Tenecteplase Teniposide Tenofovir Terazosin Terbinane Terbutaline Teriparatide Terlipressin Tesamorelin acetate Testolactone Testosterone Tetrabenazine Tetracycline Thalidomide Thallous chloride Theophylline Thiabendazole Thiamazole
52

Yes (NS) No (NS) No (NS) ND ND No (NS) ND No (NS) No (NS) Yes (NS) ND No (NS) U U ND No (NS) U ND ND ND U ND No (NS) ND No (NS) U ND Yes (NS) ND No (NS)

L U ND ND L ND ND ND U L ND U U ND Yes (50) U U ND ND ND U ND U ND ND No (65) ND L ND ND

ND U No ND U ND ND U U No ND U U U ND No U ND ND ND U ND U ND No U ND No ND No

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Thiamine (vitamin B1) Thiethylperazine Thioguanine Thioproperazine Thioridazine Thiotepa Thiothixene Thrombin alfa Thyrotropin alfa Thyroxine Tiagabine Tiaprofenic acid Tibolone Ticagrelor Ticarcillin Ticlopidine Tigecycline Tilidine Tiludronate Timolol Tinidazole Tinzaparin Tiotropium Tipranavir Tiroban Tizanidine Tobramycin Tocainide Tocilizumab Tocopherol (vitamin E)

No (NS) ND ND ND U ND U U U U No (NS) U ND U Yes (NS) U No (NS) No (NS) U No (NS) Yes (NS) U ND U Yes (NS) ND Yes (NS) Yes (NS) ND ND

ND ND ND ND U ND ND U U ND U U ND U L U ND ND ND ND L ND ND U L ND L L ND ND

U ND ND ND U ND U U U U U U ND U No U U U U No ND ND ND U ND ND Yes ND ND ND
53

SEE DISCLAIMER REGARDING USE OF THIS GUIDE

2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Tolazamide Tolbutamide Tolcapone Tolmetin Tolterodine Tolvaptan Topiramate Topotecan Toremifene Torsemide Tositumomab Tosuoxacin Trabectedin Tramadol Tramazoline Trandolapril (trandolaprilat) Trandolaprilat (trandolapril) Tranexamic acid Tranylcypromine Trapidil Trastuzumab Trazodone Treprostinil Tretinoin Triamterene Triazolam Trientine Triuoperazine
54

U No (NS) U U U U Yes (NS) Yes (8.0) U No (NS) U No (NS) No (NS) No (NS) ND Yes (NS) Yes (NS) ND ND ND U U U ND ND No (NS) ND No (NS)

ND ND U U U U L L U U U ND ND Yes (50) ND L L ND ND ND U ND U ND ND ND ND U

U U U U U U ND ND U U U ND ND ND ND ND ND ND ND ND U U U ND ND U ND No

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I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Triupromazine Trihexyphenidyl (benzhexol) Trimebutine Trimeprazine (alimemazine) Trimethobenzamide Trimethoprim Trimetrexate Trimipramine Triprolidine Triptorelin Trisodium citrate Tropisetron Trospium Trovaoxacin Tryptophan Ulipristal Urofollitropin Ursodeoxycholic acid (ursodiol) Ursodiol (ursodeoxycholic acid) Ustekinumab Valacyclovir Valdecoxib Valganciclovir Valproic acid Valrubicin Valsartan

U ND ND ND ND Yes (NS) U U ND ND ND U ND No (NS) U ND ND U U ND Yes (NS) U Yes (NS) No (NS) ND No (NS)

ND ND ND ND ND L U U ND ND ND U ND ND No (8.1-40) ND ND U U ND L U ND Yes (62) ND ND

U ND ND ND ND No U U ND ND ND U ND ND ND ND ND U U ND No U ND No ND U

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2013 Dialysis of Drugs

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Vancomycin Vandetanib Vardenal Varenicline Vecuronium Velaglucerase Velosulin Vemurafenib Venlafaxine Verapamil Verteporn Vigabatrin Vilazodone Vildagliptin Vinblastine Vincristine Vinunine Vinorelbine Vismodegib Vitamin B1 (thiamine) Vitamin B12 (cyanocobalamine) Vitamin C (ascorbic acid, sodium ascorbate) Vitamin D3 (cholecalciferol) Vitamin E (tocopherol) Vitamin K (phytonadione, phytomenadione)
56

No (NS) ND ND Yes (NS) U U U U No (NS) No (NS) ND Yes (NS) U ND ND ND ND ND ND No (NS) No (NS) Yes (5.5) U ND ND

Yes (10.1-60) ND ND ND ND U U U U ND ND L U ND ND ND ND ND ND ND No (40, 65) Yes (8.8) U ND ND

Yes ND ND ND U U U U U No ND ND U ND ND ND ND ND ND U ND Yes U ND ND

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I CHART

HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Voriconazole Vorinostat Warfarin Zarlukast Zalcitabine (dideoxycytidine) Zaleplon Zanamivir Zidovudine/GZDV (azothymidine, AZT, ZDV) Zileuton Zinc Ziprasidone Zoledronic acid Zolmitriptan Zolpidem Zonisamide Zopiclone Zuclopenthixol

No (NS) ND No (NS) U ND ND ND No (NS)/Yes (NS) U ND No (NS) ND U No (NS) Yes (NS) No (NS) ND

No (NS) ND ND U ND ND ND ND/L No (8.3, 10.1) ND U ND U U ND ND ND

No ND No U ND ND ND No/Yes U ND U ND U U ND U ND

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2013 Dialysis of Drugs

Drugs of Abuse
HEMODIALYSIS Drug Conventional High Permeability Peritoneal Dialysis

Amphetamine Cocaine Ethanol Heroin Lysergide (LSD) Marijuana (THC) MDMA (Ecstasy) Mescaline (peyote) Nicotine Phencyclidine (PCP) Psilocybin

ND No (NS) Yes (NS) U U U ND U ND U ND

ND ND L ND ND ND ND ND ND ND ND

ND U ND U U U ND U No U ND

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