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PY TEST SERIES-VIII Duration: 2.

00 hours Max Marks: 100

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This question paper contains 50 objective type questions. Q. 1 to 40 carry 2 marks each. Q. 41and 50 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

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Sunil mokati

-TEST SERIES-VIII1. Nucleoside are the combination of (a) Nitrogenous base + pentose + (b) Non-nitrogenous base + pentose phosphate (c) Nitrogenous base + phosphate (d) Nitrogenous base + pentose Haloperidol is competitive inhibitor of (a) Xanthine oxidase (b) Succinate dehydrogenase (c) THF reductase (d) All Following are abnormal constituents of urine except (a) Sugar (b) Albumin (c) Uric acid (d) Acetone The coding unit of the DNA is called as (a) Intron (b) Exon (c) Cistron (d) Prion A high hematocrit value is inductive of (a) Dehydration (b) Overdehydration (c) Anemia (d) All Hematological testing of a patient with AIDS is most likely to show which of the following abnormality (a) Basophilia (b) Eosinophilia (c) Lymphopenia (d) Lymphocytosis Ribovalvin is a constituents of (a) Co-carboxylase (b) Co-decarboxylase (c) NAD (d) FAD All the compound listed below act as antivitamine except (a) Avidin (b) Menadion (c) INH (d) Methotrexate The effect of food on drug bioavailability is/are (a) Reduced (b) Increased (c) Not affected by food (d) All Drug intraction may be classified as (a) Pharmacokinetic intraction (b) Pharmacodynamic intraction (c) Pharmaceutics intraction (d) All All of the hormone drug posses a steroidal nucleus except (a) Ethinyl estradiol (b) Norethindrone (c) Leothyronine (d) fluoxymesterone The following str. Is a hormone .it would be classified best as (a) An estrogen (b) Progestin (c) An androgen (d) A gonadotropin Which of the following glucoticoids produces the local sodium retention . (a) Cortisone (b) Hydrocortisone (c) Prednisolone (d) Dexamethasone
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Which of the following classes of compounds stimulant the release of insulin free pancreatic -cells (A) progestins (b) thiourylenses (c) sulfonylureas (d) biguanides Chemodems are regarded as group of plant of species which have (a) Identical morphological character and chemical nature (b) Identical morphological character but differ in chemical nature (c) Differ in morphological character and indentical in chemical nature (d) Differ in morphological character and chemical nature Methimazole is derived from (a) Thioimidazole (b) Imidazole (c) Thiadiazole (d) A & C Which one of the drug that inihibit peripheral conversion of T4 to T3: (a) Methimazole (b) Carbimazole (c) Propylthiouracil (d) All Carbimazole is the dug that (a) Bind to thyroid peroxidase (b) Inhibit iodination of thyrosin residus in thyroglobulin (c) inhibit coupling of tyrosin residus to from T3 & T4 (d) All Nitrates are fobic inhibitor which produce toxicity (a) Nephrotoxicity (b) Outotoxicity (c) Bone marrow (d) Methemoglobinamia I131 emits (a) -partical (b) -partical (c) x-ray (d) -partical and x-ray The drug cause depolarisetion by redusing conductance of ATP sensitive K+ chachannel this increases Ca ++ influx (a) Meglitol (b) Glimepridin (c) Metformin (d) All . Most serious side effect of metformin is (a) Bone marrow depression (b) Decrease the frequency of anginal attacks (c) Lactic acidosis (d) Hypokalemia Glucagone is used in (a) Hypoglycemia (b) Cardiogenic shock (c) Diagnosis of pheochromocytoma (d) All Short acting corticosteroid are
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(a) Cortisone (b) Predinisolon (c) Paramithasone (d) A&B The drug used in asthma (a) Beelomethasone (b) Budesonide (c) Fludrocortison (d) A&B Chemically beetamethasone is (a) Fludro + 1 2 + CH3 at 16 (b) Cortisone + 1 2 CH3 at 16 2 (c) Hydrocortisone + F at 9 + 1 2 + (d) A&C CH323 at 16 In corticosteroid which one of the drug have substitution at18 position (a) orednisolon (b) Aldosteron (c) cortison (d) Fludrocortison Metyrapone inihibit (a) 11- -hydroxilase (b). 17-- -hydroxilase (c) 11-desoxycortisol (d) A & C 5- -reductase inihibitor is (a) Stanozolol (b) Nandrolon (c) Finesteride (d). Danazole Impeded androgens are (a) Danazole (b) Finisteride (c) Steneozolol (d) A & B Fludrocortison is potent mineralo corticoid its potency is due to (a) F at9 position (b) F at 6 position (c) OH - at 11 position (d) OH at 17 position Crypt antigen is (a) Antigen specific for each (b) individual (c) Antigen not free for circulation (d) Low molecular weight substance Antigenic determinants unavailable for antigan-antibody reaction

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PolymyxinB I.P. is assayed by (a) Microccus luteus (b) Pasteurella pestis (c) Bordetella bronchiseotica (d) Staphylococcus aureus The following enzyme are obtained from A.niger EXCEPT (a) Cellulase (b) Lipase (c) Pectinase (d) Protease Rhizopus oryzae is a source for which of the following acid (a) Lactic acid (b) Citric acid (c) Itraconic acid (d) Fumaric acid Wasserman test (complement fixation test )is used for diagnosis of (a) Syphilis (b) Diphtheria (c) Typhus fever (d) Brucellosis Immunoglobulin found in saliva is
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(a) IgM (b). IgG (c) IgE (d) IgA Travellar diarrhea is caused due to (a) Staph. Albus (b) Ricketsiae (C) Clostridium cuelchii (d). Enterotoxigenin The precursor for the biosynthesis of tropane group of alkaloids is (a) Leucine (b) Lysine (c) Ornithine (d) Tyrosine Phenyl alanine, ornithine and methionine are involved in he biogenesis of (a) Lysergic acid (b) Reserpine (c) l- hyoscyamine (d) Papaverine DATA FOR 41-42 Aids is a viral disease caused by HIV and is dredful disease : ELISA test when compared with western blot technique is. (a) More sensitive,less specific (b) Less sensitive ,more specific (c) Less sensitive,specific (d) More sensitive, more specific Diagnostic tests for AIDS include all EXCEPT (a) Western blot test (b) Karpus test (c) Particle agglutination test (d) Australian antigen test DATA FOR 43-44 All natural and syntheric coticoids, except one corticoid, are effective by oral route. The above except one corticoid is (a) Triamcinolone (b) Desoxycorticosterone acetate (c) Betamethasone (d) Fludrocortisone For the above drug the route of administration is (a) Parentral (b) Subcutaneous (c) Sublingual (d) Intra spinal DATA FOR 45-46 In glucose metabolism, name the enzyme catalyzing the following steps Conversion of glucose to glucose 6 phosphate (a) Hexokinase (b) Glucose-6-phosphate dehydrogenase (c) Glycogen phosphorylase (d) Glycogen synthase Conversion of 2- phosphoglycerate to phosphoenol pyruvate (a) Pyruvate kinase (b) Phosphoglycerate mutase (c) Phosphoglycerate kinase (d) Enolase LINKED QUESTION 47-48 Antidiabetic drug are tend to reverse insuline resitance by stimulating G L U T 4 expression ans translocation .hepatic gluconeogenesis suppressed lower serum triglyceride level and raises H D L level The antidiabetic drug are (a) ropaglinide (b) Phenformine (c) Glipizide (d) Pioglitazone
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48.

MOA of above drug are (a) Cause depolarization by reducing (b) conductance of ATP sensitive K + channel (c) Interfere agonist mitochondrial (d) respiratory chain

Closure of ATP dependent K + channel

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Sedative agonist for nuclear peroxisome prolifactor activated receptor {PPARY} LINKED QUESTION 49-50 Which type of intraction is caused by smoking (a) Enzyme induction (b) Enzyme inhibition (c) Mixed (d) None The effect of above intraction of smoking is (a) Increases theophylline clearance (b) Decreases theophylline clearance (c) Increases anticoagulant effect (d) Decreases anticoagulant effect

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