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NEW TEST SERIES - II

Duration: 2.00 hours 100 Max Marks:

1. 2. 3. 4. 5. 6. 7.

This question paper contains 50 objective type questions. Q. 1 to 40 carry 2 marks each. Q. 41and 50 are common data based question, each carry two marks. In case of wrong answer 0.5 marks will be deducted. Using HP pencil, darken the appropriate double under each digit of your registration number and the letters corresponding to your paper code. Calculator is allowed in the examination hall. charts, graph sheets or tables are NOT allowed in the examination hall Rough work can be done on the question paper itself. Additionally blank pages are given at the end of the question paper for work.

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NEW TEST SERIES-II


1. Which of the following statement is correct about -interferons (a) It produced by T lymphocyte and natural (b) It induced by mitogens or lecithins killer cell (c) It encoded on chromosomes 12 (d) All a Which antiviral drug is generally used for CMV (a) Ganciclovir and foscarnet a (b) Idoxurudine and foscarnet (c) Idoxurudine and methisazone (d) Idoxurudine and ribavarin In which capsule filling equipment the powder must be free flowing (a) Zanasi (b) Macofar (c) MG-2 (d) Parke davis a the capacity of capsule size 1 is (a) 0.68 ml (b) 250 gm (c) 0.37 ml (d) 320 gm a In the higher energy state of a molecule, if the spins of the electron are paired then it is called as (a) Excited triplet state (b) Excited singlet state a (c) Excited doublet state (d) Excited grounded state Cidofovir is antiviral drug which is (a) Guanine nucleoside analogue (b) Pyrimidine analogue (c) Acyclonucleotide analogue a (d) Purine analogue Erweka KEA equipment is used for the purpose of (a) High speed capsule weighing (b) Dedusting and polishing a (c) Cleaning and polishing (d) Filled capsule sorting machine Pan polishing of capsule is done in (a) Driacoater tablet coating pan (b) Glatt coater tablet coating pan (c) Accela cota tablet coating pan (d) None a The drug which is used in urinary tract infection in patients with renal impairment is (a) Methanamine mendelate (b) Nalidixic acid (c) Nitrofurantoin (d) Norfloxacin a Sealing temperature of the gelatin film in usually in the range of (a) 30-32 oC (b) 32-35 oC o (c) 35-37 C (d) 37-40 oC a The purpose of vitamin A palmitate encapsulation is (a) Taste masking (b) Sustained release (c) Reduce gastric irritation (d) Stabilization to oxidation a Which of the coating material of microencapsulation is water soluble resin (a) Ethyl cellulose (b) Polyamide (c) Cellulose acetate thalate (d) Gelatin a Which of the microencapsulation process is not used when the core material is liquid (a) Multiorifice centrifugal (b) Air suspension a (c) Spray drying and congealing (d) Coaservation phase separation Which drug is used in the treatment of filariasis (a) Albendazole (b) DEC a (c) Thibendazole (d) Nicolosamide The energy required for various transition in UV- Visible spectroscopy obeys the following order (a) * > n * > *> n * a (b) * > *> n * > n * (c) * > n * > n *> * (d) * > n *> n * > * The absorption maximum for methyl chloride is . than methyl iodide (a) Less a (b) More (c) Equal (d) None 2

2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16.

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19 20.

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30.

31.
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A antihelmintic drug which inhibit specific fumerate reductase enzyme and also arrest nematode cell division in metaphase. The drug is (a) Ecgonine + methyl alcohol + cinnamic acid (b) Ecgonine + methyl alcohol + benzoic acid a (c) Ecgonine + methyl alcohol + truxillic acid (d) Ecgonine + methyl alcohol + citric acid Which of the following statement is correct about IR spectroscopy (a) Inter molecular hydrogen bonds are sharp and well defined (b) Intramolecular hydrogen bonds give rise to broad bands (c) Inter molecular hydrogen bonds are concentration dependent (d) All a Lower the base adsorption of solid and higher the density of the mixture then the capsule will be (a) Smaller a (b) Larger (c) Intermediate (d) Not predicted Which of the capsule is considered to be dry (a) Capsule with 20-30% RH at 25 to 30 oC (b) Capsule with 20-30% RH at 21 to 24 oC a (c) Capsule with 10-20% RH at 25 to 30 oC (d) Capsule with 10-20% RH at 21 to 24 oC A antihelmintic drug which inhibit specific fumerate reductase enzyme and also arrest nematode cell division in metaphase. The drug is a) Albendazole (b) DEC (c) Piperazine (d) Thibendazole a Which alkaloidal drug are used for only extraintestinal amoebiasis (a) Emetine (b) Chloroquine a (c) Quinine (d) Diloxanide furoate Capsule is not used for KBr, KCl and NH4Cl etc. because (a) These are extremely soluble (b) They release in stomach (c) They irritate in stomach (d) All a max = 0.87 X 1020.P.a. In this equation P is transition probability with values from (a) -1 to +1 (b) 0 to +1 a (c) +1 to 10 (d) All The mechanism of action of emetin is (a) Arrest intraribosomal translocation of t- (b) DNA helix destabilization and strand RNA- amino acid comples a breakage (c) Inhibit ornithin decarboxylase (d) Inhibit fungal cytochrome P-450 R band originate due to (a) * (b) n * a * (c) (d) n * Thickness of hard gelatin capsule wall depends on (a) Viscosity of gelatin sol (b). Speed of dipping (c) Time of dipping (d) All a Gynocomastia, loss of libido and oligozoospermia is side effect of (a) Cotrimazole (b) Ketokonazole a (c) Miconazole (d). Fluconazole Which antihelminthesis drug causes flaccid paralysis in worms and used in the treatment of ascariasis (a) DEC (b) Pyrantel palmatate (c) Piperazine A (d) Thibendazole In UV visible spectroscopy it has been found that increase in the polarity of the solvent genrally shift n * and n * bands to (a) Longer wavelength (b) Shorter wavelength a (c) Both (d) Not shift at all Which of the following antifungal is first line drug for dermatophyte infection including 3

32. 33. 34.

35 36. 37. 38. 39. 40.

oncomycosis (a) Terbinafine a (b) Griseofulvin (c) Ketokonazole (d) Amphotericin B The absorption maximum in the UV spectrum of 2,4 hexadiene is (a) 217 nm (b) 227 nm a (c) 222 nm (d) 232 nm Hamycin was isolated from (a) S. nodosus (b) S. pimprina a (c) S. noursis (d) S. fusarum The antiviral drug amantadine act on which phase of virus cycle (a) Phase 1- attachment and penetration (b) Phase III-synthesis of viral component (c) Phase IV- assembly of viral protein a (d) Phase V- release of the virus Which antiviral drug is not used simultaneously with zidovudine a) Aspirin (b) Cetrazine (c) Paracetamol a (d) Streptomycin In a linear molecule of carbon dioxide, the number of vibrational degrees of freedom is (a) 2 (b) 3 (b) 4 a (d) 9 In IR technique, the solvent may be used are (a) Chloroform (b) Carbon disulphide (c) Carbo tetra chloride (d) All a Most important dose dependent toxicity of dapsone is (a) Methamoglobinamia (b) Hepatitis (c) Haemolysis a (d) Dermatisis The absorption maximum for O-H stretching depends upon (a) Concentration (b) Nature of the solvent (c) Temperature (d) All a The tetracycline with highest antileptotic activity is (a) Minocyclin a (b) Doxycyclin (c) Oxytetracyclin (d) Demeclocyclin The following figure represent a drug acting on viral M2 proteins (a) Amantadine (b) Rimantadine (c) Trifluridine (d) Vidarabine The drug acts during -------- stage (a) On early steps in viral replication (b) During the late step of viral assembly (c) Both (d) None

41. 52.

Tri

LINKED QUESTION
. 53 the drug that is fungicidal and acts by non competitive inhibitor of squalene epoxidase ,and first line drug for dermatophyte infection The drug is (a) (c) 55. Hypotensive Antineoplastic (b ) (d ) Antidiabetic All a

54

LINKED QUESTIONS
The virus directed reverse transcriptase enzyme is inhibited by (a) acylovire (b) Amantadine (c) Vidarabine (d) Zidovudine a 4

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56.

The above drugs is analogue of (a) deoxycytidine (b) thymidine.

a(c)

purine

(d) deoxyguanosine

LINKED QUESTION
57. The drug that can be used orally for intestinal amoebiasis intravaginally for trichomonas vaginitis and topically for dermatophytosis. (a) Ornidazole (b) Quinodoclore a (c) Hamycine (d) Furazolidone The following antiamoebic drug should not be used in children because (a) Anaemia (b) Risk of causing blindness a (c) Gastric irritation (d) Reduse g.f.r

58.

LINKED QUESTION
59. 60. The following anthemintic has been found to be safe during pregnancy (a) Pyrantal pamoate (b) Piperazine a (c) Albendazole (d) Thiabendazole The mode of action of these drug are (a) Alteration of microfiliariasis membrane (b) Blocking glucose uptake a (c) Block the response of ascariasis muscle to (d) Inhibit oxidative phasphorylase acetyle choline a

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