SAFC®

3050 Spruce Street, St, Louis, MO 63103 USA

Tel: (800) 244 1173 (314) 534 4900 Fax: (314) 652 0000
www.safcglobal.com

FORWARD INQUIRIES TO:

Bruce Lehr
Director of Marketing
SAFC Biosciences
Phone: +1.913.227.6790
E-mail: bruce.lehr@sial.com

MEDIA INQUIRIES:
Mark Button
Impress Public Relations
Phone: +1.503.616.3817
E-mail: mark@impress-pr.com

SARTORIUS STEDIM BIOTECH PARTNERS WITH CELL CULTURE MEDIA SPECIALIST

SAFC BIOSCIENCES® TO PROVIDE WORLD-CLASS FLUID MANAGEMENT AND LIQUID/POWDER
SYSTEM SOLUTIONS

Global agreement strengthens customized manufacturing solutions for upstream and downstream
processing and moves the “disposable factory” closer to reality

Goettingen, Germany | St. Louis, MO, USA – July 14, 2009 – Sartorius Stedim Biotech (Euronext:
DIM), and SAFC Biosciences, a business segment of SAFC and member of the Sigma-Aldrich group
(Nasdaq: SIAL), both leading suppliers to the biopharmaceutical industry, announced the signing of a
global partnership agreement that combines Sartorius Stedim Biotech’s (SSB) expertise in filtration and
liquid handling systems with SAFC Biosciences’ proficiency in development and manufacturing of cell
culture media and downstream purification products. The alliance is expected to provide more robust and
comprehensive solutions to biopharmaceutical manufacturers.

The companies will combine their expertise in generating application data on filter and mixing
performance with critical purification buffers and cell culture media. Similarly, extractable and leachable
data will be generated with buffers and media, and filters and biobag combinations. In addition, SAFC
expects to utilize SSB technology for storage and mixing of cell culture media to optimize its fluid/powder
handling systems. According to the agreement, each company will offer its products with the assistance
and support of its partner, working together to better serve customers in solution creation, validation
support, process improvement, technical support and problem solving. Additionally, the strength of the
partnership’s combined technical resources should create a larger range of integrated manufacturing
solutions and a wider array of options for biopharmaceutical manufacturing customers.

Reinhard Vogt, Executive Vice President and board member of Sartorius Stedim Biotech, acknowledges
the agreement as an essential milestone in expanding the full potential of single-use technologies for the
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 SAFC®
3050 Spruce Street, St, Louis, MO 63103 USA
Tel: (800) 244 1173 (314) 534 4900 Fax: (314) 652 0000
www.safcglobal.com

Page 2

benefit of the biopharmaceutical industry. “This additional capability is instrumental for offering fully
integrated cell culture media storage and mixing solutions. For customers, this partnership will yield a
powerful combination of fluid management and liquid/powder systems and help them to enhance the
efficiency of their cell culture processes. With this agreement, we are moving one step closer to the
reality of a “totally disposable factory” with integrated technologies and control systems.”

Archie Cullen, SAFC Vice President Global Sales, explained the benefits for SAFC, stating: “Sartorius
Stedim Biotech offers SAFC Biosciences the opportunity to partner with a market leader in process and
single-use technologies development, and enables us to provide integrated, single-use systems to the
global biopharmaceutical cell culture community. This agreement enhances our position as the cell
culture partner with the widest range of highly customized products and services. It further demonstrates
that our customer intimacy approach helps us lead as the biopharmaceutical industry’s “responsive
expert”.

About Sartorius Stedim Biotech: Sartorius Stedim Biotech is a leading provider of cutting-edge
equipment and services for the development, quality assurance and production processes of the
biopharmaceutical industry. Its integrated solutions covering fermentation, filtration, purification, fluid
management and lab technologies are supporting the biopharmaceutical industry around the world to
develop and produce drugs safely, timely and economically. For next-generation processes, Sartorius
Stedim Biotech focuses on single-use technologies and value-added services to meet the rapidly
changing technology requirements of the industry it serves. Strongly rooted in the scientific community
and closely allied with customers and technology partners, the company is dedicated to its philosophy of
“turning science into solutions” on a daily basis.

Headquartered in Aubagne, France, Sartorius Stedim Biotech is listed on the Eurolist of Euronext Paris.
With its own manufacturing and R&D sites in Europe, North America and Asia and a global network of
sales companies, Sartorius Stedim Biotech enjoys a worldwide presence. Its key manufacturing and R&D
site is in Germany. The company employs over 2,300 people, and in 2008 generated sales revenue of
368.0 million euros. For more information about SSB, visit www.sartorius-stedim.com

About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and
development services for upstream and downstream processes in the biopharmaceutical industry.
Providing an integrated services package in mammalian cell culture media development, along with
analytical and regulatory support, SAFC Biosciences employs a wealth of industry experience and
scientific know-how to deliver reliable, consistent solutions that accelerate customer success - from
development through to commercialization. The unit has a 35-year history as a manufacturing partner
providing leading biopharmaceutical companies with the broadest range of highly customized products
and services possible.
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 SAFC®
3050 Spruce Street, St, Louis, MO 63103 USA
Tel: (800) 244 1173 (314) 534 4900 Fax: (314) 652 0000
www.safcglobal.com

Page 3

About SAFC: SAFC® is the custom manufacturing and services business unit within Sigma-Aldrich that
focuses on high-purity inorganics for high technology applications, cell culture products and services for
biopharmaceutical manufacturing, biochemical production and the manufacturing of complex, multi-step
organic synthesis of APIs and key intermediates. SAFC has manufacturing facilities around the world
dedicated to providing manufacturing services for companies requiring a reliable partner to produce their
custom manufactured materials. SAFC has four business segments – SAFC Pharma®, SAFC Supply
Solutions®, SAFC Biosciences®, and SAFC Hitech® – and had annual sales of over $620 million in 2008.
SAFC is considered a top 10 fine chemical company. For more information about SAFC, visit
www.safcglobal.com.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its
chemical and biochemical products and kits are used in scientific research, including genomic and
proteomic research, biotechnology, pharmaceutical development and as key components in
pharmaceutical, diagnostic and other high technology manufacturing. The Company has customers in
life science companies, university and government institutions, hospitals, and in industry. Over one
million scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has
7,800 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating
Customer Success through Innovation and Leadership in Life Science, High Technology and Service. For
more information about Sigma-Aldrich, please visit its award-winning Web site at http://www.sigma-
aldrich.com.

Cautionary Statement: This release contains forward-looking statements relating to future performance,
goals, strategic actions and initiatives and similar intentions and beliefs and other statements regarding
the Company’s expectations, goals, beliefs, intentions and the like, which involve assumptions regarding
the Companies’ operations and conditions in the markets the Companies serve. The Companies do not
undertake any obligation to update these forward-looking statements.

SAFC®, SAFC Biosciences®, SAFC Supply Solutions®, SAFC Pharma®, SAFC Hitech® and Sigma-
Aldrich® are registered trademarks of Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.

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