Second Supplement of the Revised Guidelines on the Credit Linked Capital Subsidy Scheme (CLCSS) for Technology Upgradation

of Micro and Small Enterprises approved by the Technical Sub-Committee on the CLCSS (TSC) in its 7th meeting held on the 13th day of July, 2009 under the chairmanship of the Additional Secretary & Development Commissioner (MSME)

Office of the Development Commissioner (MSME), Ministry of Micro, Small and Medium, Enterprises Government of India, Nirman Bhawan, New Delhi

INDEX Sr. No. Technology Need

Technologies

Page No.
1-19

ii): Common Effluent Treatment Plant: Deleted.

iv: Drugs & Pharmaceuticals : (iv)(a) List of Machineries/ Equipments Recommended for Drug And Pharmaceutical Products, Sub-Sector-Wise (Including the Existing Technologies In The CLCSS) Required for Schedule M Compliance and Indian/International Standards for Inclusion At S. No. IV in the Credit Linked Capital Subsidy Scheme For Technology Upgradation.

S. No. 1.

Activity

Technology Need

Approx. Cost (Rs. lakh) 3-4.0

Advantages

External Preparations Mixing and Storage Reactor

2 3. 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27

Reaction Reactor Mixing Vessel Planetary Mixing Mixture Colloidal Milling Emulsifier Milling Ointment Mill Liquid filling Filling Machine Filling Jar Filling Equipment In Oral Liquid Preparation Stirring Agitator Colloidal Milling Colloidal Mill Filtration Filter Pill proof capping Capping machine Clarity testing Inspection unit Mixing Reactor Reaction Reactor Bottle Filling 4 head filling machine Distillation Distillation unit Tablets
Dispensing Reverse laminar flow equipment

2-2.5 3-3.5 3-3.5 0.6-0.9 1-1.5 2-2.5 1.5-2.0 0.3-0.5 0.3-0.5 0.3-0.5 1-1.2 0.2-0.3 4-8 2-3 2-3 4-5
1.5 - 2.0

WHO-GMP Compliance Better Quality --do---do---do---do---do---do---do---do---do---do---do---do---do---do---do---do-Safety of personnel

Storing De-Dusting of Tablet Dissolution test Sifter Powder Mixing Mass Mixing Granulation Weighing Thermostatically controlled hot air

Storage Cabinet On-line de-duster Lab testing apparatus 24 Dia Sifter Blender R MG Roller Compactor Balance TD 2

0.5-0.8 0.4-0.6 1-1.2 0.8-1.0 2-2.5 3-5 1.5-3 0.8-1 2-3

Storage GMP Quality testing WHO-GMP Compliance --do--do--do--do-

28

Tablet compression

16 station rotary tablet machine 27 station rotary tablet machine Inspection Table Lab instruments AHU Strip/blister packing machine Vacuum leak tester Counter Dehumidifier Reactor Coating Pan Dust Extractor Dehumidifier Balance Multi mill Blender 24Dia Sifter SS vessels & scoops Filling machine Balance Blender Capsules filling machine Capsules Counter Balance Disintegration Tester Polishing equipment

2.0 3.0

Increased productivity

3.25 4.0 1-1.2 2-2.5 15-17 6-9 1-1.2 0.3-0.5 8-10 2-3 1.5-3 0.3-0.5 8-10 0.8-1 1-1.5 2-2.5 0.8-1.0 0.2-0.9 4-6 0.8-1 2-2.5 8-15 1-1.2 0.8-1 0.4-0.6 2-3 2-2.5 1-2 1-2 2-3 2-3 10-15 1-2 1-2 10-18 4-5 2-3 4-8 1-1.2 3 --do--doGMP Production Analysis Packing GMP WHO-GMP Compliance --do---do-GMP GMP Production --do--do--do--do--doProduction --do--do--do--do--do--doQ --do--do--do--do--do--doWHO-GMP Compliance --do--do--do-

29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65

Tablet Inspection In process testing AHU Strip/blister packing Leak testing Table Counter AHU Reaction Coating Exhaust System AHU Weighing Disintegration Powder Mixing Sifter Vessels Filling Weighing Capsules Mixing Filling Counter Weighing Disintegration Capsules polishing Surgical Dressing Rolling Trimming Cutting Folding & pressing

Roller machine Trimming machine Cutting equipment Folding & pressing machine Mixing Medicating processing tanks Heating Dry steam sterilizer Air heating Oven Working place Tables Steam Sterilization DHS Ophthalmic Preparations Heating Temp controlled Oven Reaction Mixing Colloidal milling Reactor Reactor Ointment mill

66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101

Tube filling Cleaning

Crimping Equipment Tube cleaning

1-4 0.8-1

102 103

Automatic washing Tube washing machine 1-3 Drying Oven 2-4 Automatic vial Vial washing machine 1-3 washing Washing Rubber bungs washing 2-3 Filter Cartridge candle filter 1.5-3 Liquid filling Liquid filling machine 2-5 Sterilization Ventilator autoclave 2-6 AHU Dehumidifier 8-10 Laminar flow Laminar air flow unit 1-1.5 Peccaries and Suppositories Mixing Reactor 1-1.5 Moulding Moulding equipment 1-1.2 Weighing Balance 1-1.5 Inhalers & Vitrallae Mixing Reactor 1-2 Measuring Graduated measuring 1-2 equipment Sealing Sealing machine 1-1.2 Repacking of Drugs & Pharmaceutical Chemicals Powder Powder disintegrator 1-1.2 disintegration Sieving Sifter 1.5-2 Scoops Scoop 0.2-0.3 Weighing Balance 1-1.5 Filling Filling machine 2-2.5 Pill proof capping Capping machine 1-1.2 Sealing Sealing machine 0.3-0.5 Water lines SS pipes 3-5 Parental Preparation De-ionization Ion exchange unit 12-15 Distillation Triple effect evaporators 4-5 Water storage Thermal controlled reactor 3-5 Pumping Pump 2-3 Piping SS Lines for Water 4-6 Container & closer preparation Automated Rotary Ampoule washing machine 5-7 Washing Closure washing Machine 2-3 Storage Storage cabinet 2-3 Storage benches SS benches 2-3 Automatic vial Vial washing machine 4-5 washing Rubber bung Rubber bung washing 1-3 washing machine Solution preparation Stirring Agitator 0.3-0.5 Filtration Filter 2-3 4

--doWHO-GMP Compliance --do---do---do---do---do---do---do-GMP Sterility --do---do---do---do---do---do---do---do---do---do---do---do---do---do---do-Sterility --do---do---do---do---do---do---do---do---do--

--do---do--

104 105 106

107 108 109 110 111 112 113 114 115 116 117 118 119 120 121

Pumping Pump Benches SS benches Preparation Reactor tank Filling capping Ampoule Ampoule/vial filling filling machine Gas lining SS pipes Benches SS Benches Pressure leak Pressure leak Test testing equipment Steam Autoclave Sterilizer Dry heat DHS sterilizer Quarantine Room storage area Platforms SS Platforms Visual Belt Type inspection table inspection Benches SS benches Parental Preparations in Plastic Containers DM water Ion exchange unit Distillation Triple effect evaporators Water storage Thermal controlled reactor Pumping Pump Water SS lines for water transportation Solution preparation area Pumping Pump Water storage Thermal controlled reactor filteration Membrance filter Sterile filling Sterile filling machine Filling Batch coding Labeling Batch coding Labeling unit Automatic vial washing Vial drying Autoclave Laminar flow AHU Plastic filling machine Batch coding Machine Labeling machine Batch coding Machine Labeling machine Vial washing machine Oven Autoclave Laminar air flow unit HVAC

2-3 1-2 2-4

--do---do---do--

3-5 2-4 1-2 1-1.2 10-12 14-18 4-7 2-4 1-3 1-1.5 12-15 4-5 3-5 2-3 4-6

--do---do---do---do---do---do---do---do---do---do-WHO-GMP Compliance Sterility --do---do---do--

122 123 124 125 126 127 128 129 130 131 132 133 134 135

2-3 3-5 1-2 2-3 2-3 1-1.2 2-3 1-1.2 2-3 4-5 2-4 4-5 1-1.5 10-15

--do---do---do-WHO-GMP compliance Process --do---do---do---do---do---do---do Sterility --do--

Bulk Drugs Sl. Activity No. 1 Weighing

Technology Need Automatic electronic balance 300 kg.; 150 kg and 1 kg.

Cost (Rs. in lakh)

Advantages Accurate weighing of raw materials; Increased productivity. Suitable for process

4 5

6 7 8 9 10 11 12 13 14 15

0.5 to 2.0 depending on the model Reaction MS, SS, MS/GL Lead/ 25 RL linned Reaction Vessel Filtration Centrifuge, Nutch 15 filter, Vacumm filter, filter press, Pressure filter SS, MS/GL Distillation Unit SS Distillation Unit 15 Dryer TD, VTD, Nauta dryer, 15 Rotatory Vacuum, SS Dryer with modern facilities, spray / flash Storage tanks MS, SS, MS/RL 10 Storage tanks Pumps Centrifugal, Rotopump 5 Multistage Powder Multimill, vibrator, 10 Processing blender, Coating Scrubber Glass/MS/RL 5 Laboratory HPLC, FTIR, UV, Kf 35 Equipments testing, HTTLC Mixing Blenders 5 Micronisation Jet mill, pulverizer 25 Compacting Roll compacter 15 Distillation SS Condensers 10

Suitable for process

Solvent quality Reusable Quality upgradation

Avoid mixing Process Handling Quality Requirements Environmental Improvement Quality Requirements For uniformity of the product For better dissolution rate For increasing bulk density of the product For improving recovery of solvents and uniform reaction 1. Saving of time. 2. Saving of labour. 3. No loss of material. 4.Increase in the profitability. 1. To get the best possible precise results. 2. Less time consuming & immediate results display. 1.Quality of products improves due to finest

16

17

Raw material Electronic Weighing 0.15 and finished Machine. product weighing. Quality control. Laboratory Equipment 10 of latest technology, spectrophotometer, Gas Chromatograph & others. ITR, Pulverisation. Latest technology 4 pulverisers Impact 6

Type.

18 19 20 21 22 23

Heating Power Chilling

Boilers DG Set

10 10 15 25 50 5 25 30 45

24 26

Chilling units, cooling towers. WAS systems Instrumentation Online PH meters, temperature meters AHU Air conditioning & Rh control Chilling Cooling water, Chilled Water Chilled brine, air, water, VAS system Accurate Digital balances, Weighing Non-reactive Storage Storage Tanks Number & size to depend on operation Containers

particles. 2.Physical loss of material is very less For heating For unintrupted power during process To maintain process parameters To maintain process parameters Quality up gradation To maintain process conditions Parameters For accuracy For handling of pharmaceuticals in- process

1 1 8 lacs

27

Storage Containers 15 Number & size to depend on operation 28 Process Measuring 2 5 lacs Instruments temperature, pressure 29 Pumps Centifugure, vaccum 5 Quality Control Department 30 31 Dispensing Weighing Reverse laminar flow equipment Automatic electronic balance 300 kg.; 150 kg. and 1 kg. 1.5 2

Material Handling

Process control Atomization Safety of personnel Accurate weighing of raw materials; Increased productivity. Accurate drug analysis

32

0.5 to 2.0 depending on the model Drug assay and HPLC, HPTLC, FTIR, 20 40 testing automatic titratator, pH meter, melting point, karl fisher instrument Gas Chromatograph, small rato evaporator system with vacuum pump Tablet hardness tester, Dissolution test apparatus, Disintegration test apparatus, UV Spectroscope, 7

Laminar Flow benches, TLC/FID detector 33 Microbiological 1) B.O.D. Incubators. 10 Lab in Quality 2) Incubators. Control 3) Laminar Air Flow. Department. 4) AHU 5) Oven 6) Ozone reader 7) Auto Clave 8) Microscopes 34 Stability Two stability 7 lacs chambers chambers at 40 & 25 with alarm bell and printer Environment Control Devices. 35 Weighing Automatic electronic balance 300 kg.; 150 kg. and 1 kg. 0.5 to 2.0 depending on the model 10.0 30.0

These machines are required to improve the quality of the finished products by way of testing.

Accurate weighing of raw materials; Increased productivity. Improve product stability, enhance personal comfort

36

37

38

39

40 41

Air conditioning Air conditioning and humidity control of all Humidity control types of areas equipment (Dehumidifier) Air handling for Air handling unit with parenteral HEPA filters, Ducting (Sterile) area with insulation; Chilled water piping; electrical cabling and panels; Chilled water pump; Chilled water control Air handling Air handling unit with 5 other for micron filters, parenteral area Miscellaneous Ducting with fittings insulation; chilled water piping; electrical cabling and panels; chilled water pump; chilled water control Energy DG Generation Pollution control Effluent Treatment Pollution Control machinery

15.0 40.0 Improves product quality, enhanced personal safety

10.0 15.0 Improves product quality, enhanced personal safety 5.0 6.0 Improves product quality, enhanced personal safety

2.0 12.0 l For continuous Production 10.0 15.0 Biochemical treatment of effluent removes 90 to 95% of soluble organic matter in the waste

42 43 44

Recovery

Reverse osmosis plant, Scrubbers Pollution control Incinerators Cleaning Vacuum cleaner and scrubbers

10 20 2

To improve discharge or waste water For solid waste disposal For maintaining cleanness as required Schedule M

(vii) Plastic Moulded/Extruded Products and Parts/ Components including reinforced plastic/composite material (vii)(e) Printed lamination/multilayer Plastic films

Sl Activity Technology need Cost No Rs in lakh 1. Rotogravure Rotogravure Printing Upto 50.00 Printing Machine having upto 8 colour printing machine with web guiding system, in-feed, out-feed, digital five drive system. 2. 3. 4. 5. -doLamination -doMulti film Diesel operated hot air 2.0 heaters with web Adhesive base Upto 15.00 lamination machine

Advantages Enhance printing quality, speed, less rejection, and high productivity

-doBetter quality & high efficiency. -doBetter quality & high efficiency and improved productivity

Diesel operated hot air 2.00 heaters layer Fully automatic micro Upto 75.00 process controlled plastic extrusion machine to manufacture film from two layers to five layers, air compressor, water pump, chilling plant, static remover

10

(vii) Plastic Moulded/Extruded Products and Parts/ Components including reinforced plastic/composite material (f) Intra ocular lens Sl. No. 1. Activity Intra ocular lens: Manufacture of sterile device intended for the external or internal use in human eyes(sight saving device) Technology Need 1. Mill/Lathe combination system for making cataract lenses . 2. Accessories to enable Lathe and Milling Machine workable at 15 degree Celsius. Cost (Rs. in Advantages lakh) 90.5 Leads (Including automation import duty Energy saving charges) More accuracy High efficiency in production Improvement in Quality 12.25 Low Rejection (Including Low pollution import duty Easy operation charges) and less labour cost.

11

ix Food Processing(Including Ice Cream Manufacturing) ix(a) Food Processing: Sl. Activity No. 5.1 Rice Milling (Post Colour Sorting Segregator in Rice Mills) Technology Need Cost (Rs. in lakh) 20 Advantage.

Reverse Colour ScannerOptical

It will reduce wastage and provide better productivity.

ix Food Processing(Including Ice Cream Manufacturing) ix(d) Rice Flakes/Chiwra(Poha) and Murmura(Puffed Rice) Sl. Activity No. 1.1 Technology Need Cost Advantage.

Rice Flakes/ Thermic Fluid Chiwra(Poha) Rotor Roaster and Murmura(Puffed Rice) Roaster

Heated

(Rs. in lakh) 6 It will provide uniform temperature to the roaster, better quality product, improved productivity, energy efficient and less air pollution.

12

xiv Electronic equipment viz. test, measuring and assembly/manufacturing, industrial process control; Analytical, Medical, Electronic Consumer & Communication equipment etc.

Sl. Activity No.

Technology Need

Cost (Rs. in lakh) 33

Advantage.

2.

Assembling/Manufacturing 1.Computerized Automatic Pick and Place Machine 2. Full Convection reflow oven 3. Solder paste printer 4. On-line UPS 5. Air-compressor 6. Airconditioner

Automated assembly of SMT component on both side of PCB in small space at faster rate

13

xxi- Auto parts and components including re-refining of lubricating oil

Sl. No.

Activity

Technology Need

Cost (Rs. in lakh) 10

Advantage.

3(a) Splined Worm Gear(Auto Component)

Broaching Machine with automatic retrieves system with self releasing broach holder

i). Fast and Efficient Machine ii). Self releasing broach holder for quick of the broaching tool from the holder, it save time iii) Automatic retriever system of tool otherwise it has to manually lifted and fitted to the machine, which results in workers fatigue. The new system eliminates physical work of lifting and loading of tool. For making many components, this saves lot of time and increases productivity

14

xxi- Auto parts and components including re-refining of lubricating oil

Sl. Activity No. 6 Re-refining of Lubricating Oil

Technology Need

Cost (Rs. in lakh) As per prevalent market rates do do

Advantage.

(c)Thin Film Evaporation Process (d) Vacuum Distillation with Clay Treatment (e) Vacuum distillation with hydro treating

Eco-friendly technology

do do

15

xxvi General Engineering Works Sl. No. Activity Technology Need Cost (Rs. in lakh) 23-30 Advantage.

1(a) CNC Cylindrical Grinding Machine

CNC Cylindrical Grinding Machine for manufacturing precision machined parts under General Engineering for multiple uses including Gears/Motors for lift

i. ii. iii.

iv.

v.

Upgraded improved technology. Automatic CNC Machine Suitable for precision cylindrical grinding jobs. Can be used for vide variety of parts where precision and accuracy is needed in cylindrical grinding . Plunge & transverse operation can be done in same set up of the machine.

16

xxvii: Gold Plating and Jewellery: (c) Jewellery Making Technology Need Cost (Rs. in lakh) 4-4.2 Advantage.

Sl. Activity No. 1. Jewellery Making

a) Vibrating Machine

Fast Technology, Less operating cost and less wastage Do Do

b) Big Ball Machine c) Ice Lathe Refrigeration unit &

16-16.25 1-2

d) High-Speed Venetion chain making machine e) CNC Diamond Cutting Machine f) 7 Heads Forming Machine

10-10.5

Do

18-19

Do

13-13.5

Do

17

xxxv: Wooden Furniture: Sl. Activity No. 1. Wood Seasoning Vacuum & high frequency seasoning Plants Solar Power based wood seasoning plant 23-30 10-25 For Part seasoning of Wood Fast & Low cost Seasoning Technology Need Cost (Rs. in lakh) Advantage.

18

(xxxxvii) Printing Industry:

Sl. No. 8.7

Activity Printing Section

Technology Need 5 colour offset machine 19x26 and size 28x40 Flexo printing press 1/2/4 colour offset m/c L-10-8 colour

Cost (Rs. in lakh) 400

Advantages Five colour in one operation and speed Speed Quality & less wastage

8.8

300

19