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theguardianweekly
Egypt 5 July 1994
Human genetics
Life sciences
Setting rules that govern the limits of science is one of the more dicult and absorbing problems of the modern age. Last week, the British government accepted the recommendation from the Human Fertilisation and Embryology Authority to approve a radically new technique that enables women with dysfunctional mitochondria to have their own children free of the inherited abnormality that often leads to severely life-limiting disorders. The technique involves replacing damaged mitochondrial DNA often described as the battery for human cells in an embryo with healthy mitochondrial DNA from another embryo. Now parliament has to decide whether to change a rule that has banned making changes to DNA that can be passed from one generation to the next. The human dimension is easy enough to grasp. It means women who inherited a particular mitochondrial abnormality from their own mothers can be the rst generation in history to pass healthy DNA to their children. But it is also easy to see it as eugenics, a dangerous leap into the fantasy world of supermen. On the one hand, theres the powerful human instinct to alleviate individual suffering; on the other the ethical base of wider society. Would legitimising the procedure mean that helping people now was more important than exposing future generations to the unknown risks of genetic modication? It means accepting that identity is more than the sum of your genes, and that family as many children, either with adoptive parents or growing up in merged families, already know is more than your biological parents. Its at moments like this that processes become more important than outcomes. For most of us, there is no absolute certainty about the right answer. Some recoil at what feels like tinkering with the building blocks of humanity. But it can also be seen as an incremental development in a eld British scientists have made their own, openly researched and for which public consent is being sought. It is the right thing to do.