With effect from the academic year 2008-2009 BM 251 UE BIOMEDICAL INSTRUMENTATION Instruction Duration of University Examination University

Examination Sessionals Credits 4 Periods per week 3 Hours 75 Marks 25 Marks 4

UNIT-I Concepts of Biomedical Instrumentation Evolution of medical instrumentation. Components of a medical instrumentation system. Static & Dynamic characteristics of medical instruments. Bio-signals: Bio-signals, their origin, characteristics. Problems encountered with measurements from human beings. Generalized medical instrument specifications. Medical instrument development stages & process. UNIT-II Medical display Devices and recorders Display Devices: Basic requirements for the display and recording of Bio-signals, Types of medical display devices. Medical recorders: Classification of recorders, PMMC writng systems. General features of ink-jet, thermosensitive and optical recorders. Oscilloscopes: Basic description, Cathode Ray Oscilloscope(CRO), Dual beam oscilloscope, Analog storage oscilloscope, Digital storage oscilloscope, Medical, Multibeam & Non-fade display systems. Liquuid crystal displays: Introduction, Passive-matrix and active matrix addressed LCDs. UNIT III Medical Analytical Instrumentation Methods of chemical analysis. Absorption Photometry, emission photometry, Flurometry, chromatography for blood gas analusis. Colorimetry, spectrophotometry. Electrophoresis. Automation in chemical Analysis. UNIT IV Cardiac Instrumentation Electrocardiography: Block diagram.Circuits, electrodes and their placement. Lead configuration and general ECG waveforms ECG monitors: Single channel& multi-channel ECG systems. Holter monitors, Stress test systems. Blood Pressure measurement: Introduction to blood pressure. Direct and indirect methods of Blood Pressure measurements. Blood Flow measurement: Introduction to hemodynamics. Electromagnetic and Ultrasonic technique of Blood flow measurement. Heart sounds: Origin of Heart Sounds, types of microphones for heart sound measurement. Contact and non-contact type of measurement. Phonocardiography. UNIT -V Neuro-muscular Instrumentation Electroencephalography: EEG-Block diagram and circuits, electrodes and their placement. Lead configuration and general EEG graphs. Evoked potentials and their measurement. Filters for EEG rhythm analysis. ELctromyography: Introduction to EMG signals. EMG-Block diagram and circuits. Electrodes and their placement. Nerve conduction velocity determination using EMG. Stimulators for EMG recording.

Suggested Readings: 1. Webster J.G., Medical Instrumentation Application and Design. Houghton Mifflin,1994. 2. Bronzino Joseph D, Hand Book of Biomedical Engineering, CRC Press, 1995 3. Khandpur R.S. Hand Book of Biomedical Instrumentation, Tata McGrawHill,1994 4. John Enderle, Susan M. Blanchard, and Joseph Bronzino, Introduction to Biomedical Engineering, Second Edition,2005 5. Myer Kutz, Standard Handbook of Biomedical Engineering & Design, McGraw-Hill Professional. 1Edition, 2002 6. Laurence J. Street, Introduction to Biomedical Engineering Technology, CRC Press 2007 7. Michael M. Domach, Introduction to Biomedical Engineering, Prentice Hall,2003

With effect from the academic year 2008-2009 BM 252 UE TRANSDUCER AND BIOSENSORS ENGINEERING Instruction Duration of University Examination University Examination Sessionals Credits 4 Periods per week 3 Hours 75 Marks 25 Marks 4

UNIT-I Bio-potential Electrodes Origin and characteristics of biopotentials-ECG, EEG, EGG, EMG, ENG, EOG, ERG Electrode-Electrolyte Interface, Half cell potential, Offset Voltage. Electrodes- Types of external. Internal and Microelectrodes. Mathematical Treatment of Electrodes: Equivalent circuits and applications. UNIT II Chemical transducers Electrochemical transducers-Electrode potential and reference electrodes. Potentiometric sensors. Amperiometric sensors. Electro-chemical gas sensors. Optically based Chemical Transducers Spectrophotometric chemical analysers, Fiber optic chemical transducer. Chemical Transducers of Acoustic and Thermal Properties. Biosensors Enzymes-based bio-sensors, Immuno Sensors, microbial sensors. UNIT III Transducers Basic requiremens of transducers. Passive and Active transducers. Classification based on application and operating principle. Principle of operation, associated circuits and applications of temperature and displacement transducers. UNIT IV Principle of operation, associated circuits and applications of Pressure(Blood, Air), flow(blood flow and respiratory gas flow)and humidity transducers. UNIT V Bio-MEMS Biophysical and chemical principles. Micro and nano scale devices. Solid state transducers, optical transducers, electrochemical transducers, biomedical microelectronics. Clinical applications.
Suggested Reading: 1. John G. Webster, Medical Instrumentation-Application & Design. John Wiley and Sons Inc., 3rd Edition, 2003. 2. Bronzino Joseph D, Hand Book of Biomedical Engineering, CRC Press, 1995 3. Tatsuo Togawa, Toshiyo Tamura & P. Ake Oberg, Biomedical Transducers and Instruments, CRC Press, Boca Raton, 1997. 4. Richard S.C. Cobbold, Transducers for Biomedical Measurements: Principles and Applications. John Wiley and Sons Inc., 1974 5. Anthony P.F.Turner, Isao Karube, George S. Wilson Book, Biosensors: Fundamentals and Applications, Oxford University Press,1987. 6. Gabor Harsanyi, Sensors in Biomedical Applications: Fundamentals, Technology & Applications, CRC Press, 2000 7. Paul R. Mathewson, John W. Finley, Biosensor Design and Application, Oxford University Press, 1992. 8. Donald G. Buerk, Biosensors: Theory and applications, CRC press, 1Edition, 1995. 9. Jon Cooper (Editor), Tony Cass (Editor), Biosensors (The practical Approach Series), Oxford University press, USA, 2Edition, 2004.

With effect from the academic year 2008-2009 CE 151 UE ENVIRONMENTAL STUDIES Instruction Duration of University Examination University Examination Sessionals Credits 4 Periods per week 3 Hours 75 Marks 25 Marks 4

UNIT I Environmental Studies: Definition, scope and importance, need for public awareness. Natural resources: Water resources; use and over utilization of surface and ground water, floods, drought, conflicts over water, dams-benefits and problems. Effects of modern Agriculture, fertilizer-pesticide problems, water logginh and salinity. UNIT II Ecosystems: Concept of an ecosystem, structure and function of an ecosystem, producers, consumers and decomposers, energy flow in ecosystem, food chains, ecological pyramids, aquatic ecosystem(ponds, streams, lakes, rivers, oceans, estuaries). Energy resources: Growing energy needs renewable and non-renewable energy sources. Land Resources, land as a resource, land degradation, soil erosion and desertification. UNIT III Biodiversity: Genetic species and ecosystem diversity, bio-geographical classification of India. Value of biodiversity, threats to biodiversity, endangered and endemic species of India, conservation of biodiversity. UNIT IV Environmental Pollution: Causes, effects and control measures of air pollution, water Pollution, soil pollution, noise pollution, noise pollution, thermal pollution and solid waste management. Environment protection act: Air, water, forest and wild life Acts, enforcement of Environmental legislation. UNIT V Social Issues and the Environment: Water conservation, watershed management, and environmental ethics. Climate change, global warming, acid rain, ozone layer depletion. Disaster management: Types of disasters, impact of disasters on environment, infrastructure and development. Basic principles of disaster mitigation, disaster management, and methodology, disaster management cycle, and disaster management in India. Suggested readings: 1. De A. K., Environmental Chemistry, Wiley Eastern Ltd. 2. Odum E.p., Fundamentals of Ecology, W.B.Sunders Co., USA. 3. Rao M.N and Datta A.K., Waste water Treatment, Oxford and IBK Publications. 4. Benny Joseph, Environmental Studies, Tata McGraw Hill, 2005 5. Sharma V.K., Disaster Management, National Center for Disaster management, IIPE, Delhi,1999.

With effect from the academic year 2008-2009 EC 254 UE SIGNAL ANALYSIS AND TRANSFORM TECHNIQUES (Common to BME and CSE) Instruction Duration of University Examination University Examination Sessionals Credits 4 Periods per week 3 Hours 75 Marks 25 Marks 4

UNIT I Definitions and classification of Signals and systems:- The environmental signal, analogy between vector and signal, Signal representation by discrete set of orthogonal; functions, Orthonormality and completeness, Exponential and trigonometric Fourier series, convergence, Dirichelets conditions, the discrete Spectrum, Application of Fourier series to electrical networks. UNIT II Signal representation by continuous exponentials:- The direct and inverse Fourier transform, continuous spectrum, Existence and properties of Fourier transform, singularity functions, Parsevals theorem. UNIT III Convolution integral:- Convolution integral, convolution as summation, graphical method of convolution, network functions, poles and zeros, time domain behavior from pole zero plot and stability. UNIT IV Discret Signals:- Sampling of continuous time sampling, sampling theorem and problems, discrete time signals and systems-Linear shift invariant, linear, stable, causal and memory less. Linear ConstantCoefficient Difference equations, frequency domain representation of systems, Realization of discrete time system-direct, cascade and parallel Forms. UNIT V Z Transform and Properties:- Z transform, Properties of the region of convergence for the Z-Transform, Inverse Z Transform, Z transform properties, Inverse Z-Transform using Contour Integration, partial fraction expansion, Long division methods, Parsevals relation and analysis of discrete time systems using Z-Transform Suggested Reading: 1. Lathi B.P.Signals, Systems.and communication, BSP-2001 2. Alan V. Oppenheim and Ronald W. Schafer, Discrete Time Signal processing, PHI-1992. 3. Ashok Ambardar, Analog and Digital Signal Processing, Thomson Asia, Pte Ltd, 2004.

With effect from the academic year 2008-2009 EC 271 UE ELECTRONIC ENGINEERING-II (Common to BME and EEE) Instruction Duration of University Examination University Examination Sessionals Credits 4 Periods per week 3 Hours 75 Marks 25 Marks 4

UNIT-I Feedback Amplifiers: Concept of Feedback, feedback amplifier configurations, circuits, Advantages of negative feedback, analysis of simple feedback amplifiers using BJT and FET. UNIT -II Oscillators: Barkhausen Criterion, RC Oscillators: Weinbridge, Phase shift, LC oscillator, Hartly and Colpitts oscillator, Crystal controlled oscillators (analysis of oscillators using BJTs only) stability of oscillator, Non-sinusoidal oscillators (using OP amps). UNIT -III Butterworth Filters: Active Low Pass Filter, High Pass Filter, band Pass Filter, Notch Filter, design of second, forth and sixth order Filters using OP-Amps. UNIT -IV Carrier Amplifier: Chopper amplifier, Principles and Applications, Phase sensitive detector, Classification of power amplifiers, analysis of class A and Class B power amplifier: distortion in amplifier, push-pull amplifier, complementary symmetry, IC power amplifiers. UNIT -V Wave Shaping Circuits: RC Low Pass and High Pass circuits, response to step, pulse Ramp and Square wave input, Differentiator and Integrator, Clipping circuits for single level and two level, Clamping circuit and applications, Multivibrator circuit: Astable, Monostable and Bistable circuit using Op-Amp and 555 timer, Schmitt Trigger circuit.

Suggested Reading: 1. Millman Jacob, Herbert Taub and MS, Prakash Rao, Pulse, digital and Switching Waveforms, Tata McGraw-Hill, New Delhi, 2007. 2. Millman J., Halkias CC and Satyabrata Jit, Electronic Devices and Circuits, Tata McGraw-Hill, New Delhi, 2008. 3. Millman J., Halkias CC and Satyabrata Jit, Integrated Electronics, Tata McGraw-Hill, New Delhi, 2008.

With effect from the academic year 2008-2009 MT 201 UE MATHEMATICS-III (Common to all Branches) Instruction Duration of University Examination University Examination Sessionals Credits 4 Periods per week 3 Hours 75 Marks 25 Marks 4

UNIT-I Partial differential equations: Formation of first and second order partial differential equations, Laranges solution, Standard types, Charpits method of solution, Quasi-linear second order differential equations: Monges method. UNIT-II Fourier series: Expansion of a function in Fourier series for a given range- half range sine and cosine expansions, Fourier series of odd and even functions, change of interval. UNIT-III Applications of Fourier series: Classification of linear second order partial differential equations, separation of variables method, solution of Heat equation, Wave equation, and Laplace equation. UNIT-IV Laplace Transforms and Fourier Transforms: Laplace transform, inverse Laplace transform, properties of Laplace transforms, Laplace transforms of Unit step function, Dirac-Delta function with constant coefficients using Laplace transform Fourier transforms-inverse Fourier Transforms-sine and cosine transforms-inverse and cosine transforms. UNIT-V Numerical methods; Solution of Algebraic and Transcendental equations Bisection method, Regula falsi method, Newton-Raphson method, Solution of linear system of equation gauss elimination method, Gauss Seidel iterative method, interpolation, Newtons Forward and Backward difference interpolation, Newtons divided difference interpolation, numerical Differentiation and Integration, Solution of ordinary differential equations. Taylors Method, Eulers Method, Modified Eulers method. Suggested Reading: 1. Kreyszig E, Advanced Engineering Mathematics, 8th Edition, john Wiley & Sons Ltd, 2006. References: 2. Jain R.K. & Lyengar S.R.K. Advanced Engineering Mathematics, Third Edition, Narosa Publications, 2007. 3. Dass H.K, Advanced Engineering Mathematics, 19th edition, S.Chand & Co. Etd, 2008. 4. Shanker Rao G, Engineering Mathematics-II, I.K. International Publications House Pvt. Ltd., New Delhi, 2008.

With effect from the academic year 2008-2009 BM 281 UE MEDICAL INSTRUMENTATION LAB

Instruction Duration of University Examination University Examination Sessionals Credits I. Study of the following Transducers: 1. Thermistor, Thermocouple, RTD 2. Potentiometric transducer 3. Strain Gauge 4. LVDT 5. Capacitive transducer 6. Piezoelectric transducer 7. Photoelectric transducer 8. Hall Effect transducer II. Usage, study and analysis of the following equipment: 1. Colorimeter 2. Spectrophotometer 3. Electrophoresis Apparatus 4. Chromatograph 5. ECG 6. EEG 7. EMG

3 Periods per week 3 Hours 50 Marks 25 Marks 2

With effect from the academic year 2008-2009 EC 291 UE ELECTRONICS ENGINEERING LAB Instruction Duration of University Examination University Examination Sessionals Credits 3 Periods per week 3 Hours 50 Marks 25 Marks 2

I. Characteristics of: 1. Semi-conductor Diodes (Si, Ge and Ze) 2. Bi-junction Transistors (only CB and CE) (only Static Characteristics) II. Rectifiers: 1. Half-wave Rectifier 2. Full-wave Rectifier without Filters 3. Half-wave Rectifier with Filters III. Regulators: 1. Series and Shunt Regulators 2. Regulators ICs 3. SMPS Circuits for power supply regulation IV. RC Amplifiers: 1. RC Coupled Amplifier 2. Frequency response of BJT version 3. Frequency response of FET version V. Feedback Amplifiers: 1. Voltage series configuration 2. Current Shunt configuration VI. Oscillators: 1. Wein Bridge 2. RC Phase Shift Oscillation 3. LC Oscillator 4. Hartley Oscillator 5. Colpitts Oscillator VII. Butterworth Filter: 1. Active Low Pass Filters 2. Active High Pass Filters 3. Band Pass Filters 4. Notch Filters VIII. Power Amplifier: 1. Class A Amplifier 2. Class B Amplifier IX. Wave Shaping Circuits: 1. Differentiator Circuits 2. Integrator Circuits 3. Clipping Circuits 4. Clapping Circuits X. Multivibrator Circuits: 1. Astable Multivibrator using 555 timer 2. Monostable Multivibrator using 555 timer 3. Bistable Multivibrator using 555 timer