ANTI-ADRENERGICS (BLOCKER or ANTAGONIST)

Phenoxybenzamine *High doses inhibit

catecholamine reuptake AND irrev. block muscarinic, serotonergic, histaminic receptors

A1/A2 Effects last 7 days blocker

Action -Arterial and venous dilation HR (reflex) -Response of Catech. Impaired -Blockade A1 mediated contract nonvascular SM (trigone& int. sphi)

USE Irreversible A1 & A2 Blockade Pheochromocytoma Hypertension Carcinoid Syndrome Raynauds Phenomenon USE Reversible A1 & A2 Blockade Short term Pheochromocytoma HTN USE Treatment of Hypertension Treatment of BPH

Or

Phentolamine

A1/A2 Blocker

Or Re Im

Prazosin

A1 Blocker

Tamsulosin
(Flomax)

A1 Blocker

Propanolol

B1 &B2 Blocker

Sotolol

Beta
B1/B2 Blocker

Labetolol

A1- antagonist B1/B2- partial agonist B1/B2

Timolol

Action -Mainly blockade A1 -inhibit phosphodiesterase (high dose) -slight contractility - No change in HR Action -Mainly blockade A1 -inhibit phosphodiesterase (high dose) -slight contractility - No change in HR Action -HR, conduction, contractility -CO; myocardial perfusion -TPR then normalizes -BP -Bronchoconstriction is minimal but life-threatening in asthma - Aqueous humor production - rennin secretion - VLDL & HDL Action ** pronounced K+ channel blockade Action Marked TPR Minimal HR & CO Action ** profoundly lowers intraocular pressure ** Local anesthetic action

1s Sy Se Le Dr

USE Treatment of BPH Prevents Urine Retention

USE Myocardial Infarction Migraine Hypertension Tachycardia Exertional Angina Thyrotoxicosis (Hyperthyroidism)

Br He Fa Im

USE

Pindolol

Beta Blocker with partial B agonist activity

USE Hypertension Atrial Fibrillation USE Treatment of Open Angle Glaucoma o AH secretion USE
Beta Antagonist & Sympathomimetic activity

Hy Fa

Sim

Sim

Treatment of Hypertension in Patients with Bradycardia

Acebuolol A

B1

Betaxolol B

B1

Esmolol E

Selective B1 blocker

Atenolol A

Selective B1 blocker

Metopolol M

Selective B1 blocker

Metyrosine -Inhibits tyrosine kinase, the rate limiting step in syn. of catecholamines

USE Treatment of Hypertension Exertional Angina Arrhythmias USE Treatment of Hypertension Exertional Angina Arrhythmias USE Treatment of Short Action given IV in surgical situations USE Treatment of Hypertension Exertional Angina Arrhythmias USE Treatment of Hypertension Exertional Angina Arrhythmias USE -Pheochromocytoma pre-op and management of inoperable/metastatic case with A antagonists USE Treatment of Hypertension (RARELY) USE Hypertension (RARELY)

Similar to Propa Bronchiconstric

Similar to Propa Bronchiconstric

Similar to Propa Bronchiconstric

Similar to Propa Bronchiconstric

Similar to Propa Bronchiconstric

-orth

-Extrapyra

Guanethidine false neurotransmitter Reserpine false neurotransmitter

Enters peripheral nerves via NOR reuptake mechanism & blocks release of NOR Blocks the Nerve terminal ability to store NOR by inhibiting NOR Transport from the cytoplasm into Storage Vesicles

Orthostatic Hyp Sexual Dysfunct

Mental Seda Depression Bradycardia