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Chapter
Exercise Metabolism
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Chapter 4
Objectives
1. Discuss the relationship between exercise intensity/duration and the bioenergetic pathways that are most responsible for the production of ATP during various types of exercise. 2. Define the term oxygen deficit. 3. Define the term lactate threshold. 4. Discuss several possible mechanisms for the sudden rise in blood-lactate concentration during incremental exercise.
Chapter 4
Objectives
5. List the factors that regulate fuel selection during different types of exercise. 6. Explain why fat metabolism is dependent on carbohydrate metabolism. 7. Define the term oxygen debt. 8. Give the physiological explanation for the observation that the O2 debt is greater following intense exercise when compared to the O2 debt following light exercise.
Chapter 4
Outline
Energy Requirements at Rest Rest-to-Exercise Transitions Recovery from Exercise: Metabolic Responses Metabolic Responses to Exercise: Influence of Duration and Intensity
Short-Term, Intense Exercise Prolonged Exercise Incremental Exercise
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Rest-to-Exercise Transitions
Rest-to-Exercise Transitions
ATP production increases immediately Oxygen uptake increases rapidly Reaches steady state within 14 minutes After steady state is reached, ATP requirement is met through aerobic ATP production Initial ATP production through anaerobic pathways ATP-PC system Glycolysis Oxygen deficit Lag in oxygen uptake at the beginning of exercise
Copyright 2009 The McGraw-Hill Companies, Inc. All Rights Reserved.
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Rest-to-Exercise Transitions
Figure 4.1
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Rest-to-Exercise Transitions
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Rest-to-Exercise Transitions
Figure 4.2
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Rest-to-Exercise Transitions
In Summary
In the transition from rest to light or moderate exercise, oxygen uptake increases rapidly, generally reaching a steady state within one to four minutes. The term oxygen deficit applies to the lag in oxygen uptake in the beginning of exercise. The failure of oxygen uptake to increase instantly at the beginning of exercise suggests that anaerobic pathways contribute to the overall production on ATP early in exercise. After a steady state is reached, the bodys ATP requirement is met via aerobic metabolism.
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Excess post-exercise oxygen consumption (EPOC) Terminology reflects that only ~20% elevated O2 consumption used to repay O2 deficit Many scientists use these terms interchangeably
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Oxygen Debt
Rapid portion of O2 debt Resynthesis of stored PC Replenishing muscle and blood O2 stores Slow portion of O2 debt Elevated heart rate and breathing = energy need Elevated body temperature = metabolic rate Elevated epinephrine and norepinephrine = metabolic rate Conversion of lactic acid to glucose (gluconeogenesis)
Copyright 2009 The McGraw-Hill Companies, Inc. All Rights Reserved.
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20% converted to glucose 10% converted to amino acids Lactic acid is removed more rapidly with light exercise in recovery Optimal intensity is ~3040% VO2 max
Copyright 2009 The McGraw-Hill Companies, Inc. All Rights Reserved.
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Figure 4.4
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In Summary
During high-intensity, short-term exercise (i.e., two to twenty seconds), the muscles ATP production is dominated by the ATP-PC system. Intense exercise lasting more than twenty seconds relies more on anaerobic glycolysis to produce much of the needed ATP. Finally, high-intensity events lasting longer than forty-five seconds use a combination of the ATP-PC system, glycolysis, and the aerobic system to produce the needed ATP for muscular contraction.
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Figure 4.6
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Figure 4.7
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Lactate Threshold
The point at which blood lactic acid rises systematically during incremental exercise Appears at ~5060% VO2 max in untrained subjects At higher work rates (6580% VO2 max) in trained subjects Also called: Anaerobic threshold Onset of blood lactate accumulation (OBLA)
Blood lactate levels reach 4 mmol/L
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Figure 4.8
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Figure 4.9
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In Summary
Oxygen uptake increases in a linear fashion during incremental exercise until VO2 max is reached. The point at which blood lactic acid rises systematically during graded exercise is termed the lactate threshold or anaerobic threshold. Controversy exists over the mechanism to explain the sudden rise in blood lactic acid concentrations during incremental exercise. It is possible that any one or a combination of the following factors might provide an explanation for the lactate threshold: (1) low muscle oxygen, (2) accelerated glycolysis, (3) recruitment of fast fibers, and (4) a reduced rate of lactate removal. The lactate threshold has practical uses such as in performance prediction and as a marker of training intensity.
Copyright 2009 The McGraw-Hill Companies, Inc. All Rights Reserved.
Chapter 4
16 CO2 23 O2
= 0.70
6 CO2 6 O2
= 1.00
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In Summary
The respiratory exchange ratio (R) is the ratio of carbon dioxide produced to the oxygen consumed (VCO2/VO2). In order for R to be used as an estimate of substrate utilization during exercise, the subject must have reached steady state. This is important because only during steady-state exercise are the VCO2 and VO2 reflective of metabolic exchange of gases in tissues.
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Figure 4.11
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At higher exercise intensities (~50% VO2 max) Lower percentage of energy (~40%) from fat Total energy expended is higher
Total fat oxidation is also higher
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Figure 4.14
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FFA converted to acetyl-CoA and enters Krebs cycle Primary source of fat during low-intensity exercise Becomes more important as muscle triglyceride levels decline in long-duration exercise
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Figure 4.15
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Figure 4.16
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Figure 4.17
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In Summary
The regulation of fuel selection during exercise is under complex control and is dependent upon several factors, including diet and the intensity and duration of exercise. In general, carbohydrates are used as the major fuel source during high-intensity exercise. During prolonged exercise, there is a gradual shift from carbohydrate metabolism toward fat metabolism. Proteins contribute less than 2% of the fuel used during exercise of less than one hours duration. During prolonged exercise (i.e., three to five hours duration), the total contribution of protein to the fuel supply may reach 5% to 10% during the final minutes of prolonged work.
Copyright 2009 The McGraw-Hill Companies, Inc. All Rights Reserved.
Chapter 4
Study Questions
1. Identify the predominant energy systems used to produce ATP during the following types of exercise:
a. Short-term, intense exercise (i.e., less than ten seconds duration) b. 400-meter dash c. 20-kilometer race (12.4 miles)
2.
Graph the change in oxygen uptake during the transition from rest to steady-state, submaximal exercise. Label the oxygen deficit. Where does the ATP come from during the transition period from rest to steady state? Graph the change in oxygen uptake and blood lactate concentration during incremental exercise. Label the point on the graph that might be considered the lactate threshold or lactate inflection point. Discuss several possible reasons why blood lactate begins to rise rapidly during incremental exercise.
Copyright 2009 The McGraw-Hill Companies, Inc. All Rights Reserved.
3.
4.
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Study Questions
5. Briefly, explain how the respiratory exchange ratio is used to estimate which substrate is being utilized during exercise. What is meant by the term nonprotein R? List two factors that play a role in the regulation of carbohydrate metabolism during exercise. List those variables that regulate fat metabolism during exercise. Define the following terms: (a) triglyceride, (b) lipolysis, and (c) lipases. Graph the change in oxygen uptake during recovery from exercise. Label the oxygen debt.
6. 7. 8. 9.
Chapter 4
Study Questions
10. How does the modern theory of EPOC differ from the classical oxygen debt theory proposed by A.V. Hill? 11. Discuss the influence of exercise intensity on muscle fuel selection. 12. How does the duration of exercise influence muscle fuel selection?