Advanced Methods for Bioprocess Modeling and Optimisation UPV, Valencia, Spain, 21 September 2006

INPL-ENSAIA, Nancy, France F. Fournier (frantz.fournier@ensaia.inpl-nancy.fr)

Advanced Methods for Bioprocess

Modeling and Optimisation
International Seminar in Life Science

21 September 2006
Here is a (non exhaustive) list of references for those who would like to get further with some
topics presented during this brief introduction to bioprocess modeling and optimisation.

1 Modeling

1.1 How to use models

Schuegerl K, Bellgardt K, 2000, Bioreaction Engineering, Modeling and Control. Berlin: Springer-Verlag

Ramkrishna, D, 2003, On modeling of bioreactors for control. J. of Process Control, 13: 581-589

1.2 Bioprocess Models

1.2.1 Black box models

Search on database using the following keywords : Regression, Least Squares (LS), Principal
Component Analysis,…

See also Artificial Neural Network

Baughman, D. R.; Liu, Y. A., 1995, Neural Networks in Bioprocessing and Chemical Engineering;
Academic Press: San Diego, CA.

Bulsari, A. B. Neural Networks for Chemical Engineers; Elsevier: Amsterdam, 1995.

1.2.2 Knowledge models

Coulson J.M and J.F. Richardson, 1994, Chemical & biochemical reactors & process control. Ed. by
J.F. Richardson and D.G. Peacock, London: Pergamon

Nielsen, J., Villadsen, J. and G. Lidén, 2002, Bioreaction Engineering Principles, 2nd Ed, Springer.

2 Bioprocess Optimisation

2.1 Methodology

Experimental Design
Box G.E.P., Hunter, W.G., and J.S. Hunter, 1971, Statistics for Experimenters, John Wiley and
Sons, New York.

Victoria C.P. Chen, Kwok-Leung Tsui, Russell R. Barton and Janet K. Allen, 2003, A review of
design and modeling in computer experiments. In: R. Khattree and C.R. Rao, Editor(s), Handbook of
Statistics, Elsevier, Volume 22, Statistics in Industry, Pages 231-261.

Identification
E. Walter and L. Pronzato, Identification of Parametric Models, Springer, London, 1997

INPL-ENSAIA, Nancy, France F. Fournier (frantz.fournier@ensaia.inpl-nancy.fr)

Advanced Methods for Bioprocess Modeling and Optimisation UPV, Valencia, Spain, 21 September 2006

Optimisation
Fletcher R., 1980, Practical Methods for Optimization, Vol 1, Unconstrained optimization, John Wiley
& Sons Ltd.

Ray W.H. and J. Szekely, 1973, Process optimisation, John Wiley & Sons Ltd.

Bryson, A.E., 1999, Dynamic optimization. Menlo Park, CA: Editorial Addison Wesley
Longman Inc.

2.2 Evolutionary Algorithm

Goldberg B., 1989, Genetic Algorithm, and Machine Learning. Addison-Wesley Publishing
Company, Inc., Reading, MA.

Baeck T., Hoffmeister F and H.P. Schwefel, 1991, A survey on evolution strategy. In International
Conference on Genetic Algorithms, pp2-10, 13-16 July 1991.

2.3 Multicriteria Optimisation

Updated list of references on Evolutionary Multiobjective Optimization from C. A. Coello Coello:

http://www.lania.mx/~ccoello/EMOO/EMOObib.html

3 Advanced Modeling and Optimisation

3.1 How to improve the methodology

Related research topics at ENSAIA, in French

Viennet R., 1997, Nouvelle méthodologie de planification expérimentale pour l’optimisation multicritère de
procédés, PhD Thesis, INPL Nancy, France.

Muniglia L., 2001, Elaboration d'

une stratégie expérimentale multicritère appliqué à la conception optimale
d'
un procédé continu de production d'arômes laitiers, PhD Thesis, INPL Nancy, France

Makhlouf. A., 2006, Méthodologie pour l’optimisation dynamique multicritère d’un procédé discontinu
alimenté : application à la production bactérienne d’arômes laitiers, PhD Thesis, INPL Nancy, France

Recently published on Multicriteria Dynamic Optimisation:

D. Sarkar, J. M. Modak, 2005, Pareto-optimal solutions for multi-objective optimization of fed-batch
bioreactors using nondominated sorting genetic algorithm, Chemical Engineering Science 60, pp481 –
492