Turmeric and Cancer - Prevention and Treatment

Research findings have demonstrated at least a dozen separate ways in which Curcumin interferes with cellular pathways that may lead to cancer. Laboratory data indicate that Curcumin can inhibit tumor initiation, promotion, invasion, angiogenesis and metastasis, while animal studies have shown that Curcumin may inhibit the growth of cells and promote cell death in three different melanoma lines. Anti-Cancer and Anti-Angiogenic Effects of Curcumin !orld "ournal of #astroenterology Epidemiological evidence indicates lower incidence of certain cancers in people who consume Curcumin than in those who do not. Recent findings show that, besides chemo preventive activity, Curcumin may also be effective in the treatment of cancer. $ultiple $olecular %argets in Cancer Chemoprevention by Curcumin %he American Association of &harmaceutical 'cientists "ournal (umerous mechanisms have been described for the cellular activity of Curcumin, including inhibition of proliferation of tumor cells, induction of apoptosis )a mode of cell death*, inhibition of transformation of cells from normal to tumor, inhibition of invasion and metastasis and suppression of inflammation. Curcumin triggers a process called +apoptosis+ through which the body destroys abnormal cells that may develop to be cancerous. Curcumin does not induce apoptosis in healthy cells. ,nduction of Apoptosis by Curcumin and its ,mplications for Cancer %herapy Current Cancer -rug %argets .//0

!hen it comes to cancer treatment it is always recommended to discuss any supplements with your doctor and to chec1 compatability of curcumin with other cancer treatments. Curcumin and 'tomach Cancer Research has shown that curcumin can prevent the bacteria that causes stomach ulcer, 2elicobacter pylori, from causing cancer. %he bacteria increase the levels of cyto1ine that activates (3-14. Curcumin bloc1s the process. 3or further reference please go to5 'pecific inhibition of C67-. e8pression by dietary curcumin in human colon cancer cells - -epartment of $edicine, 9C 'an -iego Curcumin and Colon Cancer Curcumin has been observed to be effective in preventing colon cancer in research performed with rodents. !hen researchers set up a study to analyze how curcumin operates, they found that it inhibits free radical damage of fats )such as those found in cell membranes and cholesterol*, and prevents the formation of the

inflammatory chemical cycloo8ygenase-. )C67-.*. %he potential use of curcumin as chemo preventive agent against colorectal neoplasia is supported by animal studies and human observational data. Curcumin with :uercetin were found to reduce both the size and number of precancerous lesions in the human intestinal tract and inhibit the development of colon cancer in such patients. Curcumin replaces nonsteroidal anti-inflammatory drugs )('A,-s such as aspirin, ibuprofen* that have been used to treat patients with this condition, but these drugs often produce side effects li1e gastrointestinal ulcerations and bleeding, whereas curcumin is a strong anti-inflammatory with no side effects. %he regular use of Curcumall; can play a protective role against the development of colorectal cancer. 3or further reference please go to5 Combination %reatment !ith Curcumin of Adenomas - Clinical #astroenterology and 2epatology .//< Curcumin and &rostate Cancer &rostate cancer=the second leading cause of cancer death in American men with 0//,/// new cases appearing each year=is a rare occurrence among men in ,ndia, whose low ris1 is attributed to a diet rich in brassica family vegetables and the curry spice, turmeric. 'cientists tested turmeric, a source of the phytonutrient curcumin, along with phenethyl isothiocyanates, a phytochemical abundant in cruciferous vegetables including cauliflower, cabbage, broccoli, 4russels sprouts, 1ale, 1ohlrabi and turnips. !hen tested separately, both phenethyl isothiocyanate and curcumin greatly retarded the growth of human prostate cancer cells implanted in mice. ,n mice with well-established prostate cancer tumors, the researchers found that the combination of curcumin with phenethyl isothiocyanate had a protective effect that significantly reduced both tumor growth and the ability of the prostate cancer cells to spread )metastasize*. %he researchers believe the combination of cruciferous vegetables and curcumin could be an effective therapy not only to prevent prostate cancer, but to inhibit the spread of established prostate cancers. 3or further reference please go to5 %herapeutic &otential of Curcumin in 2uman &rostate Cancer ?@ ,ssue ? Curcumin and $elanoma Researchers have demonstrated that curcumin inhibited the growth and promoted cell death in three different melanoma cell lines. Curcumin suppressed the production of the proteins in the cancer cells that normally protect the cells from cell death. All doses tested decreased cancer cell growth and triggered cell death. 2igher doses were more effective, and the higher the dose used, the more cancer cells died. 3or further reference please go to5 Curcumin-induced Antiproliferative and &roapoptotic Effects in $elanoma Cells Cancer >ol. A/? ,ssue ? %he &rostate >ol.

Curcumin and ':uamous-cell Carcinoma Curcumin triggered the death of head and nec1 s:uamous cell carcinoma. %he studies have been performed in vitro on three cell lines as well as in vivo with s:uamous cell tumors in mice. Curcumin was found to augment the effect of radiation by inhibiting the C67-. e8pression and E#3R phosphorylation. ,n a recent study curcumin was found to enhance the effect of Cisplatin in the suppression of head and nec1 s:uamous cell carcinoma. 3or further reference please go to5 Curcumin5 a potential radio-enhancer in head and nec1 cancer Laryngoscope .//B %he

Curcumin Enhances 'uppression of 2ead and (ec1 ':uamous Cell Carcinoma $olecular Cancer %herapeutics Curcumin and $ultiple $yeloma Researchers at the 9niversity of %e8as demonstrated that curcumin can stop the spread of multiple myeloma, a cancer of the bone marrow. Curcumin stopped the activation of processes 1nown to lead to the spread of myeloma cells and triggered cell apoptosis, a process where cancer cells program themselves to die. 3or further reference please go to5 Curcumin leads to suppression of proliferation and induction of apoptosis in human multiple myeloma cells "ournal of the American 'ociety of 2ematology Curcumin circumvents chemoresistance in human multiple myeloma Cancer %herapeutics Curcumin and &ancreatic Cancer Curcumin has been shown to stop the growth of human pancreatic cancer cells by inhibiting the production of interlu1in-C, a protein produced by white blood cells that contributes to tumor growth. Researchees have shown that oral curcumin is well tolerated and has shown biological activity in patients with pancreatic cancer. 3or further reference please go to5 Curcumin -own-Regulation is Associated with the ,nhibition of Cell #rowth and the ,nduction of Apoptosis in &ancreatic Cancer Cells American Cancer 'ociety .//< &hase ,, %rial of Curcumin in &atients with Advanced &ancreatic Cancer American Association for Cancer Research 2ead and (ec1 Cancer Curcumin has been found to suppress a cell signaling pathway that drives the growth of head and nec1 cancer. Curcumin has also shown to reduce the level of cancer enhancing cyto1ines in research perfomed with head and nec1 cancer. 3or further reference please go to5 $olecular

,nhibition and Reduction of Cancer #rowth Center 9CLA

"onsson Comprehensive Cancer