Session Name:

Title: Fibroblasts as a Bio-cellular Model for Studying Amino Acids Transport in Schizophrenia, Bipolar and elated !NS "isorders
Dr. Nikolaos Venizelos*, Chang-Ren Chen, and Nguyen Vu Lan Director rebro University Sweden

Abstract
Tyrosine and tryptophan are precursors to dopamine and serotonin and are involved in partial regulation of dopamine and serotonin synthesis. Changes in tyrosine and or tryptophan availability may influence dopamine-serotonin function that may cause widespread changes both in neurotransmission and psychopathology in patients with schizophrenia bipolar-! and related C"S disorders. Competitive transport with other amino acids or aberrant transport of these precursors across the cell membranes#blood brain barrier $%%%& can cause a limited availability of tyrosine and#or tryptophan to the brain. Transport of neutral amino acids including tyrosine tryptophan and alanine mainly occurs through ' and ( system. (berrant tyrosine transport in schizophrenia bipolar-! disorders and autism results from different investigations functionality and the relationship between tyrosine tryptophan and alanine transport in fibroblasts will be presented and discussed.

%iography

Dr. "i)olaos *enizelos +edicine Doctor $,h.D.-medicine& now is an (ssociate professor of %iomedicine head of the "europsychiatric -esearch 'aboratory and %io-ban) of the Department Chairman for -esearch %oard of %iomedicine ,rogram director of %iomedicine education program +ember of the Sweden.s "ational %io-ban)s Council. /e got his % Sc in biomedicine + Sc in cell biology Specialist in clinical chemistry +edicine Doctor.s degree $,h.D.& at 0arolins)a !nstitute Docent. (nd Dr. "i)olaos *enizelos got the "orage-,harmacia (ward in 1223 and a -esearch (ward from 4!ntern. "europsychiatry Congress $!"(-56S%,&7 (thens 8993. Currently Dr. "i)olaos *enizelos: researches focus on the %iocellular membrane and amino acid transporters in "europsychiatric disorders. Studies on the mechanisms of cellular membrane transport of dopamine and serotonin precursors in schizophrenia +edicine Doctor $,h.D.-medicine& now is an (ssociate professor of %iomedicine head of the "europsychiatric -esearch 'aboratory and %io-ban) of the Department Chairman for -esearch %oard of %iomedicine ,rogram director of %iomedicine education program +ember of the Sweden.s "ational %io-ban)s Council. /e got his % Sc in biomedicine + Sc in cell biology Specialist in clinical chemistry +edicine Doctor.s degree $,h.D.& at 0arolins)a !nstitute Docent. (nd Dr. "i)olaos *enizelos got the "orage,harmacia (ward in 1223 and a -esearch (ward from 4!ntern. "europsychiatry Congress $!"(-56S%,&7 (thens 8993. Currently Dr. "i)olaos *enizelos: researches focusate professor of %iomedicine head of the "europsychiatric -esearch 'aboratory and %io-ban) of the Department Chairman for -esearch %oard of %iomedicine ,rogram director of %iomedicine education program +ember of the Sweden.s "ational %io-ban)s Council. /e got his % Sc.

6ull "ame; Title; Director Department; Stanford Tumor <lycome 'aboratory =rganization; Stanford University School of +edicine Country; US(