Course EPIB-660

PRACTICAL ASPECTS OF PROTOCOL DEVELOPMENT Session 3 SETTING RESEARCH IN CONTEXT

2011

Friday, May 13: 12h30 - 14h30 D. M.R. Becklake Dr Beth. Foster

Assignment 1 (to be completed for, and presented in session 3, on Friday, May 13) This assignment illustrates different approaches to the following research question: Does exposure to grain dust at work adversely affect respiratory health?

1. Each students will spend 10-15 min. presenting the paper they were assigned. Each presentation will be followed by a 10-15 min. discussion of their paper in relation to the previous presentation(s).

Course EPIB-660
PRACTICAL ASPECTS OF PROTOCOL DEVELOPMENT Session 3 continued Assignment 1 Readings 1-16 (all enclosed)

2011

Friday, May 13: 12h30 - 14h30

General Background 1. Warren CPW. Grain dust and health: the problem and the role of the Canadian Lung Association,
and the Canadian Lung Association Task Force Report on the health of grain workers. CLA Bulletin, March 1979, 3-7.

Research studies 1974-1993 2. Warren P et al. Hypersensitivity reactions to grain dust. J Allergy Clin Immunol 1974; 53:139-49. 3. DoPico GA et al. Respiratory abnormalities among grainhandlers: a clinical, physiologic and immunologic study. Am Rev Respir Dis 1977; 115:915. 4. Dosman J et al. Chronic bronchitis and decreased forced expiratory flow rates in lifetime nonsmoking grain workers. Am Rev Respir Dis 1980; 121:11-16. 5. Yach D, et al.A respiratory epidemiologic survey of grain mill workers in Cape Town, South Africa. Am Rev Respir Dis 1985; 131:505-510. 6. Chan-Yeung M, et al. Epidemiological survey of grain elevators in BC. Arch Environ Health
1981; 36:75-81. 7. Tabona et al. Host factors affecting longitudinal decline in lung spirometry among grain elevator workers. Chest 1984; 85:781-6. 8. Enarson D, et al. Rapid decline in FEV in grain handlers. Am Rev Respir Dis 1985,132: 814-79. 9. Zejda J, et al. Decline of spirometric variables in grain workers commencing employment. Br J Ind Med 1992; 49:576-580.

Review papers 10. Chan-Yeung M et al. The impact of grain dust on respiratory health. Am Rev Respir Dis 1992;
145:476-87.

11. Fonn S, et al. Documentation of ill-health effects of occupational exposure to grain dust thr-ough
sequential, coherent, epidemiologic investigation. Scand J Work Environ Health 1994; 20:12-21. 12. Canadian Thoracic Society Standards Committee. Recommendations for reducing the effect of grain dust on the lungs. CMAJ 1996; 155: 1399-1403