BIF306 Version No.

Course Prerequisites Objectives: Expected Outcome:

Unit No. 1

IMMUNOLOGY and LTPC: 3 0 0 3 IMMUNOINFORMATICS 1.0.0 System Biology To introduce the concept of immune response in a mammalian host thereby emphasize their significance in innovation in developing therapeutic modalities for immunological disorders of humans using bioinformatics approach. The course outlines the basis of immune responses using bioinformatics methods. Also it describes use of bioinformatics tools and softwares to study the functions and importance of immune system in maintaining a healthy system. Number of hours: 9 Introduction to the Immune System

An overview of the immunology Cells and tissues of the immune system-. Haematopoiesis: Origin and differentiation of Lymphocytes and phagocytic cells- receptors and signals that control lymphocyte lineage commitment. Immunogens and antigens Unit No. 2 Number of hours: 9 Immune response Classification of the immune response : Innate : Role of inflammatory cells, complement-biology and pathways of activation; acquired immunity and its components Humoral and Cellular Immunity- the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules- Classes of MHC MHC/HLA genetic loci. Unit No. 3 Number of hours: 9 Immunological databases and Tools IMGT Databases Igs TCR MHC Antigens: binding to MHC, eliciting Ab response, allergens, epitopes, haptens KIR peptides with antimicrobial activity or antibiotic peptides Immuno-deficiency Innate immunity genes and tools for their analysis. Unit No. 4 Number of hours: 9 Structural Immunoinformatics Structural features of MHC peptides MHC peptide interaction parameters interface area between peptide and MHC intermolecular H-bonds complementarity between surfaces structural prediction techniques docking algorithms peptide docking procedure In-silico QSAR based predictions of class I and class II MHC molecules. Unit No. 5 Number of hours: 9 Applied Immunoinformatics Deimmunization sources of biological therapeutic immunogenicity epitope directed deimmunization components of immune response to biologicals types of Abs to biological therapeutics factors contributing to development of Abs T-dependent and T-independent immune response epitope mapping and modifying epitopes. Text Books 1. Goldsby. R.A, Kindt.T.J, Kuby J and Osborne BA Immunology, 5th Eds. W.H. Freeman Pubn. 2002. 2. Novartis foundation symposium: Immunoinformatics: Bioinformatic strategies for better understanding of immune function. 2003. References 1. Roitt I.M., Brostoff. J, Male. D.K. Immunology, 5th B. k & Cdr eds, Garland Pub Ltd. 2001. 2. Ranganathan S, Brusic V, Schonbach C. Immunoinformatics. Springer, 2008. Mode of Evaluation Announced / Unannounced Quiz / tests, Assignments and Written Examination Recommended by the Board of Studies on 11th November 2009 Date of Approval by the Academic Council