OralDosageFormsThatShouldNotBeCrushed

JohnF.Mitchell,PharmD,FASHP1

Lastupdated:August2013 DrugProduct AcipHex Actiq ActiveIngredient(s)2 RABEprazole fentaNYL DosageForm(s) Tablet Lozenge Reasons/Comments3 Extendedrelease Slowrelease Note:thislollipopdeliverysystemrequiresthe patienttoslowlydissolveinmouth Irritant Note:chewed,crushed,orsuckedtabletsmay causeoropharyngealirritation Extendedrelease Extendedrelease(a) Slowrelease(h) Extendedrelease Mucousmembraneirritant Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Note:formerlyfampridineSR Extendedrelease

Actonel

risedronate

Tablet

AdalatCC AdderallXR AeroHistPlus AfeditabCR Afinitor Aggrenox AlavertAllergy(Sinus12Hour) AllegraD ALPRAZolamER Altoprev AmbienCR AmibidDM Ampyra Amrix

NIFEdipine amphetaminesalts combination NIFEdipine everolimus combination combination combination ALPRAZolam lovastatin zolpidem combination dalfampridine cyclobenzaprine

Tablet Capsule Tablet Tablet Tablet Capsule Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule

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DrugProduct Aplenzin Apriso Aptivus AquatabC AquatabD Aricept23mg

ActiveIngredient(s)2 buPROPion mesalamine tipranavir combination combination donepezil

DosageForm(s) Tablet Capsule Capsule Tablet Tablet Tablet

Arthrotec Asacol Aspirinentericcoated Atelvia AzulfidineEN AugmentinXR AVINza Avodart

diclofenac mesalamine aspirin risedronate sulfaSALAzine combination morphine dutasteride

Tablet Tablet Tablet,Caplet Tablet Tablet Tablet Capsule Capsule

Reasons/Comments3 Extendedrelease Extendedrelease(a) Note:maintainpHatlessthanorequalto6.0 Note:oilemulsionwithinspheres;taste Slowrelease(h) Slowrelease(b) Note:crushingthe25mgtabletmaysignificantly increasetherateofabsorption;the5and10mg tabletarenotaffected Delayedrelease;Entericcoated Slowrelease Delayedrelease;Entericcoated Extendedrelease;Note:tabletcoatingisan importantpartofthedelayedrelease Delayedrelease Extendedrelease(b,h) Entericcoated(a;notpudding) Note:drugmaycausefetalabnormalities;women whoare,ormaybecome,pregnant,shouldnot handlecapsules;allwomenshouldusecautionin handlingcapsules,especiallyleakingcapsules Entericcoated Extendedrelease Extendedrelease Extendedrelease Taste(h) Extendedrelease(h) Entericcoated(c) Entericcoated(c)

BayerRegular BiaxinXL BidexA BidhistD Biltricide BiohistLA BisaLax BisacEvac

aspirin clarithromycin combination combination praziquantel combination combination bisacodyl

Caplet Tablet Tablet Tablet Tablet Tablet Tablet Tablet

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DrugProduct Bisacodyl Boniva BromfedPD BudeprionSR CalanSR Carbatrol CardeneSR Cardizem

ActiveIngredient(s)2 combination ibandronate combination combination verapamil carBAMazepine niCARdipine diltiazem

DosageForm(s) Tablet Tablet Capsule Tablet Tablet Capsule Capsule Tablet

CardizemCD CardizemLA CarduraXL CartiaXT CefaclorER Ceftin Cefuroxime CellCept CharcoalPlus ChlorTrimeton CiproXR ClaritinD ClaritinD24Hour Colace Colestid Concerta

diltiazem diltiazem doxazosin diltiazem combination cefuroxime combination mycophenolate charcoal,activated combination ciprofloxacin combination combination docusate colestipol methylphenidate

Capsule Tablet Tablet Capsule Tablet Tablet Tablet Capsule,Tablet Tablet Tablet Tablet Tablet Tablet Capsule Tablet Tablet

Reasons/Comments3 Entericcoated(c) Note:chewed,crushed,orsuckedtabletsmay causeoropharyngealirritation Extendedrelease(b) Extendedrelease Extendedrelease(h) Extendedrelease(a) Extendedrelease Note:althoughnotinthePI,thedrughasa coatingthatisintendedtoreleasethedrugover approximately3hours Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Taste(b) Note:usesuspensionforchildren Taste(b) Note:usesuspensionforchildren Teratogenicpotential(i) Entericcoated Extendedrelease(b) Extendedrelease(b) Extendedrelease(b) Extendedrelease Taste(e) Slowrelease Extendedrelease

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DrugProduct Commit CoregCR

ActiveIngredient(s)2 Nicotine carvedilol

DosageForm(s) Lozenge Capsule

CotazymS Creon Crixivan

pancrelipase pancrelipase indinavir

Capsule Capsule Capsule

Cymbalta

DULoxetine

Capsule

Cytoxan Cytovene Depakene Depakote DepakoteER DepakoteSprinkles DetrolLA Dexilant Diclegis DilacorXR DilatrateSR DiltCD DiltiaXT DitropanXL DivalproexER Doxidan

cyclophosphamide ganciclovir divalproex divalproex divalproex divalproex tolterodine dexlansoprazole doxylamine/pyridoxine diltiazem isosorbide diltiazem diltiazem oxybutynin combination bisacodyl

Tablet Capsule Capsule Tablet Tablet Capsule Capsule Capsule Tablet Capsule Capsule Capsule Capsule Tablet Tablet Tablet

Reasons/Comments3 Note:integritycompromisedbychewingor crushing Extendedrelease(a) Note:mayaddcontentsofcapsuletochilled,not warm,applesauceandconsumeimmediately Entericcoated(a) Extendedrelease(a) Taste Note:capsulemaybeopenedandmixedwithfruit puree(e.g.,banana) Extendedrelease(a) Note:mayaddcontentsofcapsuletoapplejuice orapplesaucebutNOTchocolate Note:drugmaybecrushedbutcompany recommendsusinginjection Skinirritant Slowrelease;mucousmembraneirritant(b) Delayedrelease Extendedrelease Extendedrelease(a) Extendedrelease Delayedrelease(a) Delayedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Entericcoated(c)

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DrugProduct Drisdol Droxia

ActiveIngredient(s)2 ergocalciferol hydroxyurea

DosageForm(s) Capsule Capsule

Dulcolax DynaCircCR ECNaprosyn Ecotrin(all) E.E.S.400 EfferK EffervescentPotassium EffexorXR Embeda EMycin Enablex EntocortEC Equetro Ergomar Erivedge

bisacodyl isradipine combination aspirin erythromycin potassiumbicarbonate venlafaxine morphinesulfate erythromycin darifenacin budesonide carBAMazepine ergotamine vismodegib

Tablet;Capsule Tablet Tablet Tablet Tablet Tablet Tablet Capsule Capsule Tablet Tablet Capsule Capsule Tablet Capsule

EryTab ErythromycinStearate ErythromycinBase ErythromycinDelayedRelease Evista Exalgo

erythromycin raloxifene HYDROmorphone

Tablet Tablet Tablet Capsule Tablet Tablet

Reasons/Comments3 Liquidfilled(d) Note:exposuretothepowdermaycauseserious skintoxicities;healthcareworkersshouldwear glovestoadminister Entericcoated(c);Liquidfilled Extendedrelease Delayedrelease;entericcoated Entericcoated Entericcoated(b) Effervescenttablet(f) Effervescenttablet(f) Extendedrelease Extendedrelease(a);donotgiveviaN/Gtube Entericcoated Slowrelease Extendedrelease;Entericcoated(a) Extendedrelease(a) Sublingualform(g) Note:PIindicatespotentialteratogenic;MSDS warnsagainstskincontact;healthcareworkers shouldtakeappropriatecautions Delayedrelease;Entericcoated Entericcoated Entericcoated EntericcoatedPellets(a) Taste;teratogenicpotential(i) Extendedrelease Note:breaking,chewing,crushing,dissolving beforeswallowingorinjectingcouldresultin overdose

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DrugProduct Exjade Extendryl(all) Feenamint Feldene FentaNYL

ActiveIngredient(s)2 deferasirox combination bisacodyl piroxicam

DosageForm(s) Tablet Capsule Tablet Capsule Lozenge

Reasons/Comments3 Note:donotgiveastablet;tabletsaremeantto begivenasaliquid;seecompanyinsert. Extendedrelease(b) Entericcoated(c) Mucousmembraneirritant Slowrelease Note:thislollipopdeliverysystemrequiresthe patienttoslowlydissolveinmouth Note:buccaltablet;swallowingthetabletwhole orcrushingmayreduceeffectiveness Entericcoated(b) Entericcoated(b) Entericcoated Slowrelease Slowrelease Extendedrelease. Entericcoated(c) Slowrelease Extendedrelease(a) Extendedrelease Mucousmembraneirritant Taste(h) Note:maybedissolvedinwaterorapplejuice Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease Extendedrelease

Fentora Feosol Feratab Fergon FeroGrad500mg FerroSequels FlagylER FleetLaxative Flomax FocalinXR Fortamet Fosamax Gleevec GlucophageXR GlucotrolXL Glumetza Gralise Guaifed GuaifedPD GuaiFENesin/Pseudoephedrine

fentaNYL ferroussulfate ferroussulfate ferrousgluconate combination combination metroNIDAZOLE bisacodyl tamsulosin dexmethylphenidate metFORMIN alendronate imatinib metFORMIN glipiZIDE metFORMIN gabapentin combination combination

Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule Capsule Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule Capsule Tablet

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DrugProduct GuaifenexDM GuaifenexGP GuaifenexPSE GuaimaxD Halfprin81 Horizant HistaVentDA Hydrea

ActiveIngredient(s)2 combination combination combination combination aspirin gabapentin combination hydroxyurea

DosageForm(s) Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule

Imdur InderalLA IndomethacinSR InnoPranXL Intelence

isosorbide propranolol indomethacin propranolol etravirine

Tablet Capsule Capsule Capsule Tablet

Reasons/Comments3 Extendedrelease(h) Extendedrelease Extendedrelease(h) Extendedrelease Entericcoated Extendedrelease Extendedrelease(h) Note:exposuretothepowdermaycauseserious skintoxicities;healthcareworkersshouldwear glovestoadminister Extendedrelease(h) Extendedrelease Extendedrelease(a,b) Extendedrelease Note:tabletshouldbeswallowedwholeandnot crushed;tabletmaybedispersedinwater (g) Extendedrelease Extendedrelease Extendedrelease(h) (g) (g) Extendedrelease Mucousmembraneirritant Note:seePIformakingasuspension Note:womenwhoare,ormaybecome, pregnant,shouldnothandlecrushedor brokentablets(I) Extendedrelease

Intermezzo Intuniv Invega IsoptinSR IsordilSublingual IsosorbideDinitrateSublingual IsosorbideSR ISOtretinoin Jakafi Jalyn

zolpidem guanFACINE paliperidone verapamil isosorbide isosorbide isosorbide ISOtretinoin ruxolitinib dutasteride/tamsulosin

Tablet(sublingual) Tablet Tablet Tablet Tablet(sublingual) Tablet(sublingual) Tablet Capsule Tablet Capsule

JanumetXR

sitaGLIPtin/metFORMIN

Tablet

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DrugProduct Kadian

ActiveIngredient(s)2 morphine

DosageForm(s) Capsule

Kaletra

lopinavir/ritoavir

Tablet

Kapidex Kapvay Kazano KeppraXR Ketek KlorCon KlorConM

dexlansoprazole cloNIDine alogliptin/metFORMIN levETIRAcetam telithromycin potassium potassium

Capsule Tablet Tablet Tablet Tablet Tablet Tablet

KombiglyzeXR KDur

combination potassium

Tablet Tablet

KLyte KLyteCL KLyteDS KTab LaMICtalXR LescolXL Letairis Levbid

potassium potassium potassium potassium lamoTRIgine fluvastatin ambrisentan hyoscyamine

Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet

Reasons/Comments3 Extendedrelease(a) Note:mayaddcontentsofcapsuletoapplesauce withoutcrushing) Filmcoated(b) Note:activeingredientsaresurroundedbyawax matrixtopreventhealthcareexposure;women whoare,ormaybecome,pregnant,shouldnot handlecrushedorbrokentablets Delayedrelease(a) Extendedrelease Note:notscored;nostudiesavailablefrom company Extendedrelease(b) Slowrelease(b) Extendedrelease(b) Extendedrelease(b,h) Note:tomakealiquid,placetabletin120mLof water;dispersefor2minutes;stir Extendedrelease Note:tabletmatrixmayremaininstool Extendedrelease Note:tomakealiquid,breaktabletinhalfand dispersein120mLofwaterfor2minutes;stir Effervescenttablet(f) Effervescenttablet(f) Effervescenttablet(f) Extendedrelease(b) Extendedrelease Extendedrelease Slowrelease Extendedrelease(h)

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DrugProduct Levsinex Lialda Liquibid Lithobid Lodrane24 Lodrane24D LoHist12Hour Lovaza LuvoxCR MaxifedDM MaxifedDMX MaxiphenDM MestinonER MetadateER MetadateCD MethylinER MetoprololER MicroKExtencaps MirapexER Moxatag Morphinesulfateextendedrelease Motrin MSContin Mucinex MucinexDM Myfortic Myrbetriq NamendaXR Naprelan

ActiveIngredient(s)2 hyoscyamine mesalamine combination lithium brompheniramine combination brompheniramine combination fluvoxaMINE combination combination combination pyridostigmine methylphenidate methylphenidate methylphenidate potassiumchloride pramipexole amoxicillin ibuprofen morphine guiaFENesin combination mycophenolate mirabegron memantine naproxen

DosageForm(s) Capsule Tablet Tablet Tablet Capsule Capsule Tablet Capsule Capsule Tablet Tablet Tablet Tablet Tablet Capsule Tablet Tablet Capsule Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule Tablet

Reasons/Comments3 Extendedrelease Delayedrelease Extendedrelease(h) Extendedrelease Extendedrelease Extendedrelease Extendedrelease Note:contentsofcapsulemayerodewallsof styrofoamorplasticmaterials Extendedrelease Slowrelease(h) Slowrelease(h) Slowrelease(h) Extendedrelease(b) Extendedrelease Extendedrelease(a) Extendedrelease Extendedrelease Extendedrelease(a,b) Extendedrelease Extendedrelease Extendedrelease Taste(e) Extendedrelease(b) Slowrelease Slowrelease Delayedrelease Extendedrelease Extendedrelease(a) Extendedrelease

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DrugProduct NexIUM Niaspan NicotinicAcid NifediacCC NifedicalXL Nitrostat NorflexER NorpaceCR Norvir NucyntaER

ActiveIngredient(s)2 esomeprazole nicotinicacid NIFEDipine NIFEDipine nitroglycerin orphenadrine disopyramide ritonavir tapentadone

DosageForm(s) Capsule Tablet Capsule;Tablet Tablet Tablet Tablet Tablet Capsule Tablet Tablet

Oleptro Oracea OramorphSR OrphenadrinecitrateER OxyCONTIN

traZODone doxycycline morphine oxyCODONE

Tablet Capsule Tablet Tablet Tablet

OxymorphoneER PancreaseDelayedRelease PancreaseMT Pancrecarb Pancrelipase PaxilCR Pentasa Pradaxa PreHistD

pancrealipase pancrealipase pancrealipase PARoxetine mesalamine dabigatran combination

Tablet Capsule Capsule Capsule Capsule Tablet Capsule Capsule Tablet

Reasons/Comments3 Delayedrelease(a) Extendedrelease Slowrelease(h) Extendedrelease Extendedrelease Sublingualroute(g) Extendedrelease Extendedreleaseformwithinaspecialcapsule Note:crushingtabletshasresultedindecreased bioavailabilityofdrug(b) Extendedrelease Note:toxicdosemayoccuriftabletissplitor crushed Extendedrelease Delayedrelease Extendedrelease(b) Extendedrelease Extendedrelease Note:tabletdisruptionmaycauseapotentially fataloverdoseofoxyCODONE Extendedrelease Extendedrelease Entericcoated(a) Entericcoated(a) Entericcoated(a) Extendedrelease Slowrelease Note:bioavailabilityincreasesby75%whenthe pelletsaretakenwithoutthecapsuleshell Extendedrelease(h)

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DrugProduct Plendil Prevacid PrevacidSoluTab

ActiveIngredient(s)2 felodipide lansoprazole lansoprazole

DosageForm(s) Tablet Capsule Tablet

Reasons/Comments3 Extendedrelease Delayedrelease Note:orallydisintegratingdonotswallow; dissolveinwateronlyanddispense viadosingsyringeorNGtube Slowrelease Note:containsentericcoatedgranules;mixwith wateronly;notforNGuse Delayedrelease(a) Delayedrelease Extendedrelease Extendedrelease Note:womenwhoare,ormaybecome,pregnant, shouldnothandlecrushedorbrokentablets Extendedrelease Note:womenwhoare,ormaybecome,pregnant, shouldnothandlecrushedorbrokentablets Slowrelease Entericcoated Extendedrelease Extendedrelease Slowrelease Note:pharmacokineticNanoCrystaltechnology maybeaffected(b) Delayedrelease Note:releaseisdependentuponintactcoating Extendedrelease Note:tabletsexpandinliquidifbrokenorcrushed

PrevacidSuspension

lansoprazole

Suspension

PriLOSEC PriLOSECOTC Pristiq ProcardiaXL Propecia

omeprazole omeprazole desvenlafaxine NIFEDipine finasteride

Capsule Tablet Tablet Tablet Tablet

ProquinXR Proscar

ciprofloxicin finasteride

Tablet Tablet

Protonix PROzacWeekly Qdall QdallAR Ranexa Rapamune Rayos RazadyneER Renagel

pantoprazole FLUoxetine combination combination ranolazine sirolimus predniSONE galantamine sevelamer

Tablet Tablet Capsule Capsule Tablet Tablet Tablet Capsule Tablet

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DrugProduct Renvela RequipXL Rescon ResconJR ResconMX Respahist RespaireSR Revlimid

ActiveIngredient(s)2 sevelamercarbonate rOPINIRole combination combination combination combination combination lenalidomide

DosageForm(s) Tablet Tablet Tablet Tablet Tablet Capsule Capsule Capsule

RitalinLa RitalinSR RTanna RythmolSR Ryzolt Sensipar SEROquelXR SinemetCR SinuventPE SloNiacin Solodyn Somnote Sprycel

methylphenidate methylphenidate combination propafenone traMADol cinacalcet QUEtiapine levo/carbidopa combination nicotinicacid minocycline chloralhydrate dasatinib

Capsule Tablet Tablet Capsule Tablet Tablet Tablet Tablet Tablet Tablet Tablet Capsule Tablet

Reasons/Comments3 Note:tabletsexpandinliquidifbrokenor crushed(b) Extendedrelease Slowrelease(h) Slowrelease(h) Slowrelease(h) Extendedrelease(a) Extendedrelease Note:teratogenicpotential;healthcareworkers shouldavoidcontactwithcapsulecontents/body fluids Extendedrelease(a) Extendedrelease Slowrelease Extendedrelease Extendedrelease Note:crushingmaycauseoverdose Note:tabletsarenotscoredandcutting maycausevariabledosageaccuracy Extendedrelease Extendedrelease(h) Extendedrelease(h) Slowrelease(h) Extendedrelease Liquidfilled Filmcoated Note:activeingredientsaresurroundedbyawax matrixtopreventhealthcareexposure;women whoare,ormaybecome,pregnant,shouldnot handlecrushedorbrokentablets

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DrugProduct Strattera Sudafed12hour Sudafed24hour Sular SymaxDuotab SymaxSR Tasigna TaztiaXT Tecfidera TEGretolXR Temodar

ActiveIngredient(s)2 atomoxetine combination combination nisoldipine hyoscyamine hyoscyamine nilotinib diltiazem dimethylfumarate carBAMazepine temozolomide

DosageForm(s) Capsule Capsule Capsule Tablet Tablet Tablet Capsule Capsule Capsule Tablet Capsule

Reasons/Comments3 Note:capsulecontentscancauseocularirritation Extendedrelease(b) Extendedrelease(b) Extendedrelease Controlledrelease Extendedrelease Note:disruptionofcapsulemayyieldhighblood levelscausingenhancedtoxicity Extendedrelease(a) Delayedrelease Extendedrelease(b) Note:accidentallyopenedordamagedcapsules requirerigorousprecautionstoavoidinhalationor contactwiththeskinormucousmembranes(i) Note:swallowwhole;localanesthesiaoftheoral mucosa;chokingcouldoccur Extendedrelease Note:containsbeadsthatdissolvethroughoutthe GItract Extendedrelease Extendedrelease(a) Taste;Taste(a) Extendedrelease(h) Extendedrelease(h) Extendedrelease(h) Extendedrelease Note:womenwhoare,ormaybecome,pregnant, shouldnothandlecrushedorbrokentablets

TessalonPerles Theo24

benzonatate theophylline

Capsule Capsule

Theochron Tiazac Topamax ToprolXL TouroCCLD TouroLALD Toviaz Tracleer

theophylline diltiazem topiramate metoprolol combination combination fesoterodine bosentan

Tablet Capsule Tablet;Capsule Tablet Tablet Tablet Tablet Tablet

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DrugProduct TRENtal Treximet Trilpix TylenolArthritis Uceris UltramER

ActiveIngredient(s)2 pentoxifylline combination fenofibric acetaminophen budesonide traMADol

DosageForm(s) Tablet Tablet Capsule Tablet Tablet Tablet

Ultrase Uniphyl UrocitK Uroxatral Valcyte VerapamilSR Verelan VerelanPM VidexEC Vimovo ViramuneXR VoltarenXR VoSpireER Votrient

pancrealipase theophylline potassiumcitrate alfuzosin valGANCiclovir verapamil verapamil didanosine naproxen/esomeprazole nevirapine diclofenac albuterol pazopanib

Capsule Tablet Tablet Tablet Tablet Tablet Capsule Capsule Capsule Tablet` Tablet Tablet Tablet Tablet

Reasons/Comments3 Extendedrelease Note:uniquedrugmatrixenhancesrapiddrug absorption Extendedrelease Controlledrelease Note:coatingontabletisdesignedtobreakdown atpHof7.0orabove Extendedrelease Note:tabletdisruptionmaycauseapotentially fataloverdoseofdrug Entericcoated Slowrelease Waxcoated;preventsupperGIrelease Extendedrelease Teratogenicandirritantpotential(i,b) Extendedrelease(h) Sustainedrelease(a) Extendedrelease(a) Delayedrelease Delayedrelease Extendedrelease(b) Extendedrelease Extendedrelease Note:crushingsignificantlyincreasestheAUCand Tmax;crushedorbrokentabletsmaycause dangerousskinproblems Extendedrelease Extendedrelease Delayedrelease(b)

WellbutrinSR,XL XanaxXR ZegeridOTC

buPROPion ALPRAZolam omeprazole/NaHCO3

Tablet Tablet Capsule

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DrugProduct Zenpep Zolinza

ActiveIngredient(s)2 pancrealipase vorinostat

DosageForm(s) Capsule Capsule

Zortress Zyban ZyfloCR

everolimus buPROPion zileuton

Tablet Tablet Tablet

Reasons/Comments3 Delayedrelease(a) Note:irritant;avoidcontactwithskinormucous membranes;avoidcontactwithcrushedorbroken tablets Note:crushedpowdermaycause dangerouseffectstomucusmembranes Slowrelease Extendedrelease

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(a)
Capsulemaybeopenedandthecontentstakenwithoutcrushingorchewing;softfoodsuchasapplesauceorpuddingmayfacilitateadministration;contentsmay generallybeadministeredvianasogastrictubeusinganappropriatefluidprovidedentirecontentsarewasheddownthetube.

(b) (c) (d) (e) (f) (g) (h) (i)

Liquiddosageformsoftheproductareavailable;however,dose,frequencyofadministrationandmanufacturersmaydifferfromthatofthesoliddosageform. Antacidsand/ormilkmayprematurelydissolvethecoatingofthetablet. Capsulemaybeopenedandtheliquidcontentsremovedforadministration. Thetasteofthisproductformwouldlikelybeunacceptabletothepatient;administrationvianasogastrictubeshouldbeacceptable. Effervescenttabletsmustbedissolvedintheamountofdiluentrecommendedbythemanufacturer. Tabletsaremadetodisintegrateunderthetongue. Tabletisscoredandmaybebrokeninhalfwithoutaffectingreleasecharacteristics. Skincontactmayenhancetumorproduction;avoiddirectcontact.

Disclaimer:Thislistingisnotmeanttorepresentallproducts,eitherbygenericortradename.Theauthorencouragesmanufacturers,pharmacists,nurses,andotherhealth professionalstonotifyhimofanychangesorupdates. 1.Correspondenceregardingthislistmaybeaddressedto: JohnF.Mitchell,PharmD,FASHP Email:rxmitchell@att.net 2.Thegenericnameisprovidedmerelyasareferencepointandisonlylistedforsingleingredientmedications;itshouldnotbeassumedthatdrugswiththesamegenericare equivalenttothespecificbrandnamelistedrelativetocrushingorchewing.Ifquestionsarise,pleasecheckwithyourpharmacist. 3.TwoofficialUSPtermsareusedtodesignatespecialreleasemedicationforms:"extendedrelease"and"delayedrelease".Otherssuchas"sustainedrelease",controlled release",etc.arecommonlyusedonpackagelabeling.Theterm"Slowrelease"isbeingusedheretosignifyallsuchdrugswithaspecialreleasemechanism. Copyright2011,2012,2013.Nopartofthislistmaybereproducedinanyformatwithouttheexpressedpermissionoftheauthor.

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