ACKNOWLEDGEMENT

I take this opportunity with pride and immense pleasure in expressing my deep sense of gratitude to my beloved teacher and guide, Dr .V. Sankar, M Pharm., Ph.D whose able guidance, encouragement, innovative ideas and constructive suggestions has made this research work a grand success. My sincere gratitude to our beloved Principal Dr.M.Ramanathan., M.Pharm., Ph.D, for providing the necessary facilities for carrying out this work. I extend my sincere gratitude to Dr. C. Vijaya Raghavan, M.Pharm., Ph.D., Vice Principal cum ead of the Pharmaceutics Department for his

support and encouragement throughout the work. I would like to express my sincere thanks to Dr. C. R Srivivas. MD !"kin and VD#, Professor, and Dr M K mar!san, MD !DV$#, %ssistant Professor, Dept. &f Dermatology, P"' ospitals for guiding me

effectively for completing the clinical trails successfully. (ords can)t express my sincere gratitude and obligation to all the v"# nt!!rs who were kind enough to participate in the clinical trials conducted. My work would not be a success without their kind co* operation. I would like to thank Dr. M. Ar $hamy, D+,,M- , Professor, Dept. of Plastic "urgery, P"' ospitals for providing uman -adaver "kin for skin

permeability tests , Mr. saj!!sh. % A an& Mr 'arikrishna ("##a, Deputy Manager !..%#,Dr /eddy)s $aboratories Pvt $td, giving gift sample of finasteride. My sincere gratitude to P"'IM"/ Principal Dr S Rama#ingam M.D for providing the necessary facilities for carrying out this work. ydrabad for

am

elated

to

place

on

record

my

profound

sense

of gratitude to Dr. S. D rgaramani, M.Pharm.Ph.D, Dr.(.Din!sh k mar, M.Pharm.ph.D, Mr. S.M. 'a)i) r Rahman, M.Pharm., Mr.S )hramanyam, M.Pharm., and Mr. K. (a#ak mar M.%harm., 0aculties of Department of Pharmaceutics, P"' -ollege of Pharmacy, -oimbatore, for all their help and suggestions during this dissertation work My most sincere gratitude to my very dear friends, Ms. Mariam A#!*an&!r, Ms. (. Sr!! T!jas+i, Mr. %armar Ni#ayk mar N., Mr %. Karthi$k, Mr. Ramakrishna (a#anag , Mr.Nisar S.%., Mr. N.

Tami#s!#van, Mr. A. Karthik!yan an& Mr. S. Raj!sh for their timely help, moral support and encouragement without which this work would not be a reality. I would like to thank Mrs.R.Chitra, G.Kaya#vi,hi - Ms.Sh!!#a, and all other T!a$hing and +on 1eaching "taff for their kind co*operation during this work. I remain obligated for ever to Ms. Sn!ha nd Ms. M"ni$a G., for helping me in the framing of the pro2ect work in such a beautiful manner. (ords can)t express my thanks to my dear .ath!r, m"th!r, sist!r, An !tt!n, Ram!sh mama and all other family members whose

unconditional love and support has made this work a reality. 1hey continue to remain my main fortitude in all the walks of my life. My sincere thanks to all those who have directly or indirectly helped me to complete this pro2ect work. %bove all, I humbly submit my dissertation work, into the hands of A#mighty, who is the source of all wisdom and knowledge for the successful completion of my thesis.