Drug amiodarone

Indication VF/VT and atrial arrhythmia

Do/utre0

12F! cardiogenic shock! decrease )P ! decrease 1O!

Dopamine

7pinephrine

9e#ophed

,ilirinone

$& '%mcg/kg/min. as high as .$mcg/kg/min +ith stress testing Decrease )P! Dopaminergic5 Dopaminergic5 shock and renal $&* renal failure. #asodilation. )eta mcg/kg/min. '5 3 inotrope! )eta '5 *.%&'$ increase 26 mcg/kg/min Alpha5 6ange5 $.%&*$ #asoconstriction! mcg/kg/min increase )P Decrease )P "timulate /oth $.$&* alpha and /eta mcgkg/min receptors 8#asoconstriction! increase 26! increase )P4 increase contractility Decrease )P Potent alpha $.$&$.% stimulation +ith mcg/kg/min /eta one stimulation "hort term Increase 9oading dose of mgmt of se#ere contractility! %$mcg/kg 12F and enhances e0tent o#er'$. diastolic of diastolic $.*%&$.:% dysfunction! rela0ation! mcg/kg/min symptom decrease arterial ,a05 '.'( mgmt and #enous tone mg/kg

Action Antiarrhythmic that has all the properties. Jack of all trades. Prolongs repolari ation! decreases "A node automaticity! prolongs AV node! negati#e inotrope 3 inotrope! /eta ' selecti#e.

Dose $.%&'mg/min for a drip. '%$&($$ mg IVP) dilute in *$&($ ml d%+. ,A- *.*g/*.h.

Onset #aria/le

Onset '&'$. duration 4'$.

Onset 4%. duration 4'$

Immediate. Duration 4'$

Immediate. Duration 4% Onset; %&'% Duration (&% hours

propofol

"edate for cardio#ersions! hypothermia! mechnical #entilation. 1ontrol "VT! #entricular rates +ith AF/flutter! 2T>! refractory 1P! refractory VT 2T>! urgency emergency! aortic dissection

,etoprolol IVP

"edati#e/hypnotic for general anesthetic and for sedation in critical care en#ironments. ,ore /eta ' selecti#e! /eta * inhi/ition seen at higher doses.

9a/etalol IV

Inhi/its alpha nd /eta ' and * 8e<ually=.

$.%$mcg/kg/min 1ardio#ersion gi#e IVP per ,D 8usually *$&.$mg IVP <'$ secs= %mg IVP ?i#e up to a total of *%mg in onset of dosing. 6ounds of IVP can /e gi#en < (&@ hours prn. IVP5*$ mg o#er * then .$&A$ IV gtt5 $.$*&*.% mg/min. ma0 daily dose *.$$mg. .$ units IVP in arrest -' .$&$.' units/min

Onset %&'% Duration (&%h

,a0 /lockade *$ after /olus. Duration %&A hours.

Vasopressin

2ypotension in sespsis

Potent peripheral #asoconstrictor. antidiuretic

Bithin % +utg na0unak effect %&'%. may take up to *. hour +ith gtt. Duration *&. h up to *. h at times. Onset5 '&( for )P effect Duration ($& @$.

Drug amiodarone

>otes

Do/utre0

Dopamine

2emodynamic effects Arrhythmias! Decrease 26! decrease )P decrease "V6I! +ith cooling pts decrease )P! use #ery decrease 1O cautiously. Arrythmias. Increase 1O! >ot used as increase 26 much as increase )P! milrinone due decrease "V6I! to effect on 26 decrease P1BP 8increase 26=. and 1VP ?i#e centrally Increase 26! #ery necrotic to increase "V6I! peripheral increase 1VP tissues and P1BP at higher doses! increase 1O!

7pinephrine

9e#ophed

,ilirinone

propofol

,etoprolol IVP

9a/etalol IV

Vasopressin

decrease )P in dopaminergic range! increase )P Arrythmias! Increase 26! ischemia. Cse increase )P! e0treme caution increase "V6I! in se#ere 9V increase 1VP dysfunction and P1BP! increase 1O Decrease )P Increase )P4 +ith /olus! increase "V6I! arrythmias. increase 1VP and P1BP 1ardiac Decrease "V6I! depressant decrease 1VP 8decrease )P and P1BP! and decrease increase 1O! 26=. change may decrease tu/ing <*.h! )P. green urine! pain +ith inDection! P6I" Cse cautiously Decrease 1O! in heart failure. decreas "V6I! Cse cautious if decrease )P pt asthmatic or decrease 26! 1OPD. decrease 1VP and P1BP Cse cautiously Decrease 26! in 2F. Cse Decrease )P cautiously if pt asthmatic or 1OPD. As metoprolol. Decrease 26! Also decrease decrease )P! insulin decrease "V6I a#aila/ility Cse e0treme Increase "V6I! caution in se#er increase 1VP 9V dysfunction and P1BP