Level 1 Diet Recommends
From Nature's Way
Cayenne
Extract
450mg,
40,000
Heat
Units, 180
Caps (Up
to 60-Day
High in Capsaicin
Supply) - 25% special blending,
guarantees potency.
$7.73
40,000 H.U.
What Does Nature's Way Cayenne
Contain?
Nature's Way Cayenne is a specal blend of
powdered natural red pepper from the
Cayenne Pepper plant, pictured above.
High potency, is guaranteed with at least
0.25% Capsaicin per capsule, or a 25% of
pure natural capsaicin. Cayenne Pepper
(Capsicum annuum) fruit is a blood-red
warming herb that invigorates multiple
body systems. Special blending guarantees
0.25% capsaicin with a consistent potency
of 40,000 H.U. (Heat Units).
Natures Way Cayenne is carefully grown,
tested and produced to certified quality
standards.
DIRECTIONS: Start with taking 1 capsule
three times daily, preferably with food.
WARNINGS: If you suffer from heartburn
hiatal hernia, gastritis, or peptic ulcer
disease, please consult your healthcare
professional before using this product.
Excessive doses may cause GI irritation in
sensitive individuals.
Freshness & safety sealed with printed
outer shrinkwrap and printed inner seal. Do
not use if either seal is broken or missing.
Keep out of reach of children.
DISCLAIMER: These statements have not
been evaluated by the FDA. These
products are not intended to diagnose, treat,
Red Pepper (Capsaicin)
Benefits
Cayenne Red Chili Pepper
This page summarizes dozens of scientific studies
from medical journals
describing the health benefits of capsaicin from red
peppers. Read why it is the
one of the most important herbal supplements you
can add to your daily diet.
Extracts of capsaicin from red chili peppers are used
as a fresh ingredient in foods, as medicinal herbs to
treat pain and inflammation and in concentrated
sprays as non-lethal weapons.
New understanding of the way capsaicin functions
inside the body to reduce inflammatory responses and
improve nerve cell signalling is rapidly expanding the
use of this herb to treat a wide variety of medical
conditions. For example, recent research in Toronto,
Canada*, has proven that injections of pure capsaicin
into the pancreas of diabetic mice has immedately
restored their ability to produce insulin, effectively
curing type-1 diabetes. The injected capsaicin
restored nerve-cell signalling around the inactive
beta-cells, which quickly restored production of
insulin to approximately normal levels. The effect
lasted months after the injection.
While underlying systemic insulin resistance and
metabolic syndrome was not alleviated, the
restoration of insulin production by capsaicin is
considered a revolution in the treatment of diabetes.
The astonishing breakthrough was announced in
December, 2006. Scientists had previously thought
that type-1 diabetes was uncurable. Research is now
beginning on possible applications of this discovery for humans. Red pepper ointments,
lotions and cremes have proven useful for many years in the treatment of pain due to
arthritis, swollen or stiff joints, sprains, backaches, and shingles, as well as in the
symptomatic treatment of pain from diabetic peripheral neuropathy. Research continues
on this excitng herb.
* Dr. Michael Salter, Dr. Hans Michael Dosch, et al, Hospital for Sick Children, Toronto, Canada; "Diabetes Breakthrough: Toronto Scientists
Cure Disease in Mice", The National Post at www.canada.com, December 15, 2006. Research aided by the University of Calgary, Alberta,
Canada, and the Jackson Laboratory, Bar Harbor, Maine, U.S.A. Download the full report in PDF form or read the online page from the peer
reviewed scientific journal, Cell, published online - 12/15/2006.

The chemical compound capsaicin (8-methyl-N-vanillyl-6-nonenamide) is the active

component of chili peppers, which are plants belonging to the genus Capsicum. It is an
irritant for mammals, including humans, and produces a sensation of burning in any
tissue it comes in contact with. Capsaicin and several related compounds are called
capsaicinoids and are produced as a secondary metabolite by chili peppers, probably as
deterrents against herbivores. Pure capsaicin is a hydrophobic, colorless, odorless,
crystalline to waxy compound.

About Capsaicinoids
Capsaicin is the main capsaicinoid in chili peppers, followed by dihydrocapsaicin. These
two compounds are also about twice as potent to the taste and nerves as the minor
capsaicinoids nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin. Dilute
solutions of pure capsaicinoids produced different types of pungency; however, these
differences were not noted using more concentrated solutions.

Uses and Benefts of Capsaicin Red

Pepper Extracts
Food Benefts of Capsaicin Red Pepper
Because of the burning sensation caused by capsaicin when it comes in contact with
human flesh, it is commonly used in food products to give them added spice or "heat"
(piquancy). The degree of heat found within a food is measured on the Scoville scale.
Typically the capsaicin is obtained from chili peppers. Hot sauce is an example of a
product customarily containing large amounts of capsaicin and may contain chili peppers
or pure capsaicin.

Capsaicin is a nonpolar molecule, and is therefore hydrophobic. Consequently, drinking

water to reduce the burning caused by the molecule is ineffective, as the nonpolar
capsaicin is unable to dissolve in the polar water molecules, and is instead spread across
the surface of the mouth. This works by the same principle that causes oil and water to
separate.
Instead, consuming foods high in fats and oils, such as milk or bread and butter, will help
alleviate the burning. The lipophilic capsaicin is able to mix freely with the fats in the
food and is removed from the surface of the mouth. Alcohol and alcoholic beverages also
dissolve capsaicin due to the solvent characteristics of ethanol. Of course, over time the
capsaicin will dissipate on its own.

Medical Benefts of Capsaicin Red Pepper

Capsaicin is currently used in topical ointments to relieve the pain of peripheral
neuropathy such as post-herpetic neuralgia caused by shingles. It may be used in
concentrations of between 0.025% and 0.075%.

It may also be used as a cream for the temporary relief of minor aches and pains of
muscles and joints associated with arthritis, simple backache, strains and sprains. The
treatment typically involves the application of a topical anesthetic until the area is numb.
Then the capsaicin is applied by a therapist wearing rubber gloves and a face mask. The
capsaicin remains on the skin until the patient starts to feel the "heat", at which point it is
promptly removed. Capsaicin is also available in large adhesive bandages that can be
applied to the back.

The result appears to be that the nerves are overwhelmed from the burning sensation and
are unable to report pain for an extended period of time. With chronic exposure to
capsaicin, neurons are depleted of neurotransmitters and it leads to reduction in sensation
of pain and blockade of neurogenic inflammation. If capsaicin is removed, the neurons
recover.

Capsaicin is being explored as a cure for diabetes by researchers in Toronto, Canada.

Early work curing diabetic mice looks promising. Capsaicin was injected into pancreatic
sensory nerves of mice with Type 1 diabetes because of a suspected link between the
nerves and diabetes.

Capsaicin & Red Pepper Link to Diabetes

 Capsaicin (in Red Pepper)

Suspecting a link between the

nerves and diabetes, scientists
at a Toronto hospital used an
old experimental trick --
injecting capsaicin, the active
ingredient in hot chili peppers,
to kill the pancreatic sensory
nerves in mice that had an (E)-N- (4-hydroxy- 3-
equivalent of Type 1 Systematic
methoxybenzyl) - 8-methylnon-
diabetes.Almost immediately, Name
6-enamide
the islets began producing
insulin.It turns out the nerves Melecular
C(18)-H(27)-NO(3)
secrete neuropeptides that are Formula
instrumental in the proper
CC(C)/C=C/CCCCC(NCC1=CC
functioning of the islets.So SMILES
(OC)=C(O)C=C1)=O
next they injected the
neuropeptide "substance P" in CAS
the pancreases of diabetic [404-86-4]
Number
mice. The results were
dramatic.The islet Molecular
305.41 g/mol
inflammation cleared up and Mass
the diabetes was gone. Some
Melting
have remained in that state for 62 - 65 �C
Point
as long as four months, with
just one injection.

Capsaicin & Red

Pepper Use in Non-lethal Force
Capsaicin is also the active ingredient in the chemical riot control agent pepper spray.
When the spray comes in contact with skin, especially eyes or mucous membranes, it is
very painful. Refer to the Scoville scale for a comparison of pepper spray to other sources
of capsaicin.

In large quantities, capsaicin can cause death. Symptoms of overdose include difficulty
breathing, blue skin, and convulsions. The large amount needed to kill an adult human
and the low concentration of capsaicin in chilis make accidental poisoning by chili
consumption exceedingly unlikely.

Capsaicin & Red Pepper as a Possible drug Abuse

Deterrent
Clifford Woolf, the Richard J. Kitz Professor of Anesthesia Research at Harvard Medical
School, has suggested using capsaicin to deter abuse of certain extended-release drugs
such as OxyContin and Ritalin. When taken as prescribed, morphine-based prescription
drugs such as OxyContin release their opioids over time, but when crushed and snorted,
taken as a suppository, chewed, or injected intravenously, the drugs produce an intense
high that is highly addictive. Woolf has argued that adding capsaicin into the capsules
would be a safe way to deter abuse. A person taking the capsule in the prescribed way
(i.e., swallowing it whole) would suffer no ill effects from the additive. However, a
person crushing it would expose the irritant. Anyone then swallowing it, snorting it, or
injecting it would be exposed to the full power of the chemical. "Imagine snorting an
extract of 50 jalape�o peppers and you get the idea," Woolf said in an interview with the
Harvard University Gazette. As of 2006, Woolf's proposal is still in the preliminary
stages of development and the additive has not yet entered the production stage.
However, the two substances can be separated using cold water extraction.

Pest Deterrent Uses for Capsaicin & Red Pepper

Capsaicin is also used to deter pests. A common example is the use of ground-up or
crushed dried chili pods in birdseed to deter squirrels, since birds are unaffected by
capsaicin. Insects are also affected by capsaicin.

Mechanism of Action of Capsaicin & Red Pepper

The burning and painful sensations associated with capsaicin result from its chemical
interaction with sensory neurons. Capsaicin, as a member of the vanilloid family, binds to
a receptor called the vanilloid receptor subtype 1 (VR1). First cloned in 1997, VR1 is an
ion channel-type receptor. VR1, which can also be stimulated with heat and physical
abrasion, permits cations to pass through the cell membrane and into the cell when
activated. The resulting "depolarization" of the neuron stimulates it to signal the brain. By
binding to the VR1 receptor, the capsaicin molecule produces the same effect that
excessive heat or abrasive damage would cause, explaining why the spiciness of
capsaicin is described as a burning sensation.

With chronic exposure to capsaicin, neurons are depleted of neurotransmitters. This leads
to reduction in sensation of pain and blockade of neurogenic inflammation. If capsaicin is
removed, the neurons recover.

The VR1 ion channel has subsequently been shown to be a member of the superfamily of
TRP ion channels, and as such is now referred to as TRPV1. There are a number of
different TRP ion channels that have been shown to be sensitive to different ranges of
temperature and probably are responsible for our range of temperature sensation. Thus,
capsaicin does not actually cause a chemical burn; it causes only the sensation of one.

The Capsaicin "High"

The "capsaicin high" is a euphoric sensation caused by the consumption of large
quantities of capsaicin from capsaicin-laden foods. It is theorized that the pain induced by
capsaicin causes the human body to release endorphins. Eventually, enough are released
to create a sensation that is frequently compared to "runner's high".

Next read: How I Lost Over 85 Pounds, Reversed Metabolic Syndrome and Beat Type-2
Diabetes with the Anti-Inflammation Level 1 Diet

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Much of the content on this page was obtained from the Wikipedia, which is licensed
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the National Institutes of Health Pubmed.org online database.

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