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Culture Documents
Status) Aldesleukin 22 million units (1.3 mg) (Novartis) (F)(PFL) no preservative1 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
1.2 mL SWI1,2 direct diluent against side of vial during reconstitution1 do not shake1
48 h F1
50 mL D5W1 30 70 mcg/mL1 Less than 30 mcg/mL: dilute in D5W containing human albumin 0.1%2
48 h F1
- do not use in-line filter1,2 - avoid bacteriostatic water for injection or NS due to increased aggregation1
N/A
SC syringe5
- do not shake6
100 mL NS or D5W4
100 mL NS or D5W7
8 h F or RT6 **(PFL)6
9.7 mL NS only8
50 mg/mL8
24 h F, 5 h RT8
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Amsacrine 75 mg/1.5 mL (Erfa Canada) (RT) no preservative10 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
glass syringes preferred during reconstitution; max. time in plastic syringe10: 15 min 13.5 mL supplied diluent (L-lactic acid)1 transfer 1.5mL from ampoule into the diluent vial10
5 mg/mL10
24 h RT10 PFL10
7 d F, 48 h RT10-12
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Asparaginase13 (asparaginase E. coli) 10,000 units (Orphan Pharmaceutical International) (F) no preservative14 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
do not shake; roll to reconstitute9,15 4 mL SWI16 Intradermal test : Reconstitute with 5 mL SWI to give 2000 units/mL Transfer 0.1 mL to 10 mL vial (or 12 mL syringe) Add 9.9 mL SWI roll to dissolve to give 20 units/mL 2 unit test dose = 0.1 mL (Note: the rest of the reconstituted vial has a concentration of 2000 units/mL)9
9
2500 units/mL13
48 h F, RT13
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Erwinia asparaginase (asparaginase Erwinia chrysanthemi) 10,000 units (Orphan Pharmaceuticals International) (F) no preservative19 PEG-asparaginase (pegasparagase) (pegylated asparaginase E. coli) 750 units/mL (Enzon) (F) no preservative20 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
10000-5000 units/mL
N/A
750 units/mL20
IM: maximum volume 2 mL; if greater than 2 mL use multiple sites20 IV: 100 mL NS or D5W20
syringe: 4 h20,21
bag: 4 h20,21
- discard cloudy solution20 - do not shake20 - do not use if stored out of refrigerator for greater than 48 h20 - do not use if previously frozen20
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Azacitidine 100 mg (Celgene) (RT) no preservative22 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
25 mg/mL22
8 h F, 45 min RT22
SC syringe22
8 h F, 45 min RT23 Refrigerated syringes23: allow up to 30 min prior to administration to reach a temperature of approximately 20 25C discard syringe if time elapsed at RT is greater than 30 min
- discard if contains large particles22 - re-suspend syringe contents before injection by vigorously rolling syringe between palms22
2 h F, RT24
50 mL NS24
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) BCG (Tice substrain) 50 mg = 1 to 8 x 108 CFU (Hospira/Organon) (F)(PFL) no preservative26 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
1 mL preservative free NS for injection26 use reconstitution device provided allow to stand for a few minutes, then gently swirl to suspend26
1 to 8108 CFU/vial26
2 h F (PFL)26
transfer from vial to 60 mL syringe, rinse vial with another 1 mL NS. Add rinse to same 60 mL syringe. qs to 50 mL with NS26
2 h F26
- auxiliary label: biohazard25 - overfill unknown - protect from light26 - do not filter26
25 mg vial: add 5 mL SWI27 100 mg vial: add 20 mL SWI27 shake well; dissolves completely in 5 minutes27
5 mg/mL27
30 minutes27
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Bevacizumab 100 mg/4 mL 400 mg/16 mL (Roche) (F)(PFL) do not shake no preservative28 Bleomycin 15 units (NB: dose in units only) (Bristol) (F) no preservative30 Bleomycin 15 units (NB: dose in units only) (Hospira) (F)(PFL) no preservative32 Bleomycin 15 units (NB: dose in units only) (PPC) (F)(PFL) no preservative35 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
25 mg/mL28
48 h F, RT18,28,29
- do not shake28
6 mL* NS30
2.5 units/mL
48 h F30
50 mL* NS30
24 h RT30
- no overfill31
6 mL* NS or SWI32
2.5 units/mL32
48 h F, 24 h RT32
24 h RT33
- no overfill34
6 mL NS35
2.5 units/mL35
48 h F35
50 mL NS35
24 h RT35
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Bortezomib 3.5 mg (Ortho Biotech, formerly Millennium) (RT)(PFL) no preservative36 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
3.5 mL NS36
1 mg/mL36
2d RT11,37
syringe36
8 h RT38
- auxiliary label: WARNING: SUBCUTANEOUS or INTRAVENOUS use only. Fatal if given by other routes25 - solution should be clear to slightly opalescent, colorless, and free of visible particulates39
10.5 mL SWI39 Direct diluent against side of vial during reconstitution39 Do NOT shake39
5 mg/mL39
24 h F39
N/A
use 5-micron nylon filter provided with ampoule to withdraw drug40 6 mg/mL40
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cabazitaxel 60 mg/1.5 mL (sanofi-aventis) (RT) no preservative41 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
Supplied diluent : Withdraw entire contents of the diluent vial and inject into the concentrate vial.41 Slowly direct diluent against inside of concentrate vial during reconstitution to limit foaming.41 Mix by repeated inversions for 45 sec.41 Do NOT shake.41 Let sit for 5 minutes.41
10 mg/mL41
1 h RT41
- concentrate and diluent vials contain overfill41 - use non-PVC (nonDEHP) bag and tubing41 - use 0.22 micron inline filter41 - diluent contains 13% (w/w) ethanol in water41 - discard if crystallization occurs41
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) CARBOplatin 50 mg/5 mL 150 mg/15 mL 450 mg/45 mL 600 mg/60 mL (Hospira) (RT)(PFL) no preservative42 CARBOplatin 50 mg/5 mL 150 mg/15 mL 450 mg/45 mL (Teva/Novopharm) (RT)(PFL) no preservative45 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
10 mg/mL42
24 h RT,44 48 h F42
N/A
10 mg/mL45
8 h RT45
3 mL diluent (supplied)48 diluent to reach RT, then dissolve drug with 3 mL diluent; add 27 mL SWI48 record time of reconstitution
24 h F, 8 h RT48
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cetuximab 100 mg/50 mL 200 mg/100 mL (ImClone/BMS) (F) do not dilute do not shake no preservative49 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
2 mg/mL49
syringe49 sterile evacuated container or bag e.g. polyolefin, polyethylene, ethylene vinyl acetate, DEHP plasticized PVC, PVC bag, or glass49
12 h F, 8 h RT49 12 h F, 8 h RT49
- administer with a 0.2 or 0.22 micron low protein binding in-line filter49 - normal saline may be used to flush the line49 - solution may contain white particulates which do not affect product quality49 - do NOT use aluminum-containing needle, syringe or tubing50
N/A
1 mg/mL50
48 h RT51
Less than or equal to 60 mg: 100 mL* NS Greater than 60 mg: 250 mL* NS 500 or 1000 mL* NS, D5-NS, D5-1/2S, D5NS with mannitol, D51/2S with mannitol50,52; D5W1/3S with mannitol50
48 h RT51
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) CISplatin 10 mg/10 mL 50 mg/50 mL 100 mg/100mL (Sandoz) (RT)(PFL) no preservative53 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
1 mg/mL53
48 h RT53,54
Less than or equal to 60 mg: 100 mL NS* Greater than 60 mg: 250 mL NS* NS; 0.45 % Sodium Chloride with or without mannitol55 2 L of D5 on one-half or one-third NS containing 37.5 g of mannitol53
24 h RT53
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cladribine 10 mg/10 mL (Janssen-Ortho) (F)(PFL) no preservative56 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
1 mg/mL56
SC syringe57
500 mL NS only56 Do NOT use D5W56 Cassette: qs to 100 mL with bacteriostatic NS only via SIMS DELTEC INC. MEDICATION CASSETTES56 filter drug and diluent through 0.22 micron filter as each solution is being introduced into the cassette
at least 7 days56
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cladribine 10 mg/10 mL (PPC) (F)(PFL) no preservative60 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
1 mg/mL60
SC syringe57
500 mL NS only Do NOT use D5W Cassette: qs to 100 mL with bacteriostatic NS only via SIMS DELTEC INC. MEDICATION CASSETTES60 filter drug and diluent through 0.22 micron filter as each solution is being introduced into the cassette Clodronate 300 mg/10 mL (Oryx) (RT) no preservative61 N/A 30 mg/mL61 discard unused portion61 500 mL NS or D5W61
at least 7 days60
12 h RT61
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cyclophosphamide 200 mg 500 mg 1000 mg 2000 mg (Baxter) (RT)(PFL) no preservative62 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
NS63 200 mg: 10 mL 500 mg: 25 mL 1000 mg: 50 mL 2000 mg: 100 mL62
20 mg/mL62
48 h F,54,62,64 24 h RT62
Less than or equal to 1 g: 100 mL NS* Greater than 1 g: 250 mL NS* high dose in BMT: may need 500 NS* NS, D5W, D5NS62
72 h F,62,64 24 h RT62
N/A
50 mg/mL65
- polyoxyethylated castor oil/ethanol vehicle65 - do NOT refrigerate or freeze65 - use non-PVC bag and tubing66 - do not use for IT injection
Cytarabine 100 mg/1 mL 1000 mg/10mL 2000 mg/20mL (Hospira) (RT)(PFL) no preservative67
100 mg/mL67
24 h RT67
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cytarabine 100 mg (Pfizer) (RT)(PFL) no preservative68 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
20 mg/mL68
reconstituted with NS, D5W or SWI: discard at end of day54,68 reconstituted with BWI: 48 h RT68
NS, D5W68
- for high dose use, do not use diluent containing benzyl alcohol68
Cytarabine IT injection 100 mg/1 mL 1000 mg/10mL 2000 mg/20mL (Hospira) (RT)(PFL) no preservative67
100 mg/mL67
24 h RT67
diluents containing preservatives should NOT be used for intrathecal administration67 qs to 6 mL with preservative free NS69
- auxiliary label70: IT - label to include route in full (i.e., INTRATHECAL injection) attached to both syringe and outer ziplock bag70
20 mg/mL68
diluents containing preservatives should NOT be used for intrathecal administration68 qs to 6 mL with preservative free NS69
- auxiliary label70: IT - label to include route in full (i.e., INTRATHECAL injection) attached to both syringe and outer ziplock bag70
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Cytarabine SC injection: 100 mg (Pfizer) (RT)(PFL) no preservative71 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
20 mg/mL71
48 h RT71,72
syringe
14 d F, 48 h RT72
- for high dose use, do not use diluent containing benzyl alcohol73 - do not use for IT injection
10 mg/mL74
72 h F, 8 h RT74
- protect container from light during storage and administration75 - overfill unknown
10 mg/mL76
48 h F, 8 h RT76 (PFL)77
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Dactinomycin 0.5 mg (Lundbeck) (RT)(PFL) no preservative78 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
1.1 mL SWI (preservative-free)78 Do NOT use SWI with preservative (may form precipitate)78
syringe78
- drug loss reported with some cellulose ester membrane inline filters78
1.1 mL SWI (preservative-free)80 Do NOT use SWI with preservative (may form precipitate)80 4 mL SWI83
24 h F, RT81
syringe80,82
24 h F, RT54
- do not filter80,82
5 mg/mL83,86
48 h F, 24 h RT85
24 h RT, 48 h F83
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) DAUNOrubicin 20 mg (Teva/Novopharm) (RT)(PFL) no preservative87 Degarelix 80 mg 120 mg (Ferring) (RT) do not shake no preservative88 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
4 mL SWI87
5 mg/mL87
100-250 mL NS or D5W9
48 h F, 24 h RT87 **(PFL)87
80 mg: 4.2 mL SWI (supplied diluent)88 120 mg: 3 mL SWI (supplied diluent)88 do NOT use bacteriostatic water for injection88 swirl gently; keep vial vertical at all times88 reconstitution may take up to 15 min88
20 mg/mL88
2 h RT88
SC syringe88
2 h RT89
40 mg/mL88
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Denosumab (XGEVA) 120 mg/1.7 mL (Amgen) (F)(PFL) do not shake no preservative90 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
71 mg/mL90
SC syringe90
- not interchangeable with PROLIA90 - do not use if solution is cloudy; trace amounts of translucent to white proteinaceous particles are acceptable90 - avoid vigorous shaking90 - bring to room temperature 15-30 minutes prior to administration90
10 mg/mL91
6 h F91
6 h RT92
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Dexrazoxane (same formulation, no diluent provided) 250 mg 500 mg (Pfizer) (RT) no preservative93 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
10 mg/mL93
MUST BE FURTHER DILUTED With Lactated Ringers Injection to 1.3 3.0 mg/mL93
1 h RT, 4 h F93
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) DOCEtaxel 20 mg/2 mL 80 mg/8 mL 160 mg/16 mL (Hospira) (F, RT)(PFL) preservative94 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
10 mg/mL94
- use non-PVC (nonDEHP) bag and IV administration set94 - do not use chemo dispensing pins96
80 mg/8 mL or 160 mg/16 mL vial (maximum number of punctures: up to 3 doses can be removed when a venting needle is also inserted, i.e., 6 punctures total)97 14 d F25,94 **(PFL)25,94
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) DOCEtaxel 20 mg/0.5 mL 80 mg/2 mL (sanofi-aventis) (F, RT)(PFL) no preservative98 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
supplied diluent : - if vials were refrigerated, allow to warm for 5 min at RT. Withdraw entire contents of the diluent and inject the entire contents of the syringe into the corresponding concentrate vial. Mix by repeated inversions for 45 sec98 DO NOT SHAKE98 Let sit for 5 minutes98
10 mg/mL98
48 h F, RT25,98,99
NS, SWI, D5W100 (NS reconstitution takes longer) 10 mg: 5 mL 50 mg: 25 mL 150 mg: 75 mL
2 mg/mL100
48 h F, 24 h RT11,100
syringe100
48 h F, 24 h RT11,101
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) DOXOrubicin 10 mg/5 mL 20 mg/10 mL 50 mg/25 mL 200 mg/100 mL (Teva/Novopharm) (F)(PFL) no preservative102 DOXOrubicin 10 mg/5 mL 50 mg/25 mL 200 mg/100 mL (Pfizer) (F) no preservative103 DOXOrubicin Pegylated Liposomal 20 mg/10 mL (Janssen) (F) no preservative104 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
2 mg/mL102
8 h102
N/A
2 mg/mL103
48 h F, 24 h RT103
N/A
2 mg/mL104
Less than 90 mg: 250 mL D5W only104 Greater than or equal to 90 mg: 500mL D5W only104
24 h F104
- do not filter104
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) DOXOrubicin Pegylated Liposomal 20 mg/10 mL 50 mg/25 mL (Schering) (F) no preservative105 Epirubicin 10 mg/5 mL 20 mg/10 mL 50 mg/25 mL 150 mg/75 mL 200 mg/100 mL (Novopharm) (F)(PFL) no preservative106 Epirubicin 10 mg/5 mL 50 mg/25 mL 200 mg/100 mL (PPC) (F)(PFL) no preservative107 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
2 mg/mL105
Less than 90 mg: 250 mL D5W only105 Greater than or equal to 90 mg: 500mL D5W only
24 h F105
- do not filter105
N/A
2 mg/mL106
8 h F, RT106
syringe106
2 mg/mL107
8 h107
syringe107
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Epirubicin 10 mg/5 mL 50 mg/25 mL 200 mg/100 mL (Pfizer) (F)(PFL) no preservative108 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
2 mg/mL108
8 h108
syringe108
N/A
0.5 mg/mL109
24 h F, 6 h RT109 48 h F, 24 h RT109
- do not administer through dextrose containing lines109 - vials contain dehydrated alcohol USP (5% v/v)109 - use non-PVC bag and tubing only
Etoposide 100 mg/5 mL 500 mg/25 mL 1000 mg/50 mL (BMS) (RT) preservative110
N/A
20 mg/mL110
14 d RT9,11,111-113
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Etoposide 100 mg/5 mL 200 mg/10 mL 500 mg/25 mL 1000 mg/50 mL (Teva/Novopharm) (RT)(PFL) no preservative114 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
20 mg/mL114
0.2-0.3 mg/mL: 7 d F,115 2 d RT115,116 0.4-0.5 mg/mL: 1 d F,115 1d RT115 0.6-9.0mg/mL: generally unstable 9.5 mg/mL: 2 d F,115 1d RT115 10-12 mg/mL: 7 d F,115 2 d RT115,116
D5W114 Fludarabine 50 mg (Berlex) (F) no preservative118 2 mL SWI118 25 mg/mL118 48 h F or RT11,51 dilute to maximum of 1 mg/mL118,119 50-100 mL* NS or D5W118
4 h RT114,117 48 h F, RT11,51
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Fludarabine 50 mg (Teva/Novopharm) (F) no preservative120 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
25 mg/mL120
48 h F, 24 h RT120
N/A
50 mg/mL121
8 h RT121,122
syringe11
48 h RT11,18,122
24 h RT121,122
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Fluorouracil 500 mg/10 mL 5000 mg/100 mL (Sandoz) (RT)(PFL) no preservative124 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
50 mg/mL124
4 h RT25
syringe
4 h RT25
D5W124
24 h RT124
38 mg/mL125
24 h RT125
48 h RT112,126
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Gemcitabine 200 mg 1000 mg (Eli-Lilly) (RT) no preservative127 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
38 mg/mL127
48 h RT127,128
syringe127
48 h RT11,127,128
0.110 mg/mL NS127,128 Gemcitabine 200 mg 1000 mg 2000 mg (Hospira) (F) no preservative129 Gemcitabine 200 mg 1000 mg 2000 mg (Hospira) (RT)130 no preservative131 N/A 38 mg/mL129 discard unused portion at the end of the day129 0.1 38 mg/mL NS, D5W129
48 h F, RT11,127,128
24 h RT129
38 mg/mL130
48 RT54,130,132
syringe130
24 h RT130,132
48 h RT54,132
BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00 Activation Date: 2 March 2006 Revised Date: 14 January 2014
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Gemcitabine 200 mg 1000 mg (Teva/Novopharm) (RT) no preservative133 Gemcitabine 200 mg 1000 mg (Sandoz Standard) (RT) no preservative134 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
38 mg/mL133
24 h RT133
24 RT133
38 mg/mL134
48 h RT134,135
syringe134
48 h RT134-136
0.1 - 38 mg/mL NS or D5W134,137 IDArubicin 5 mg 10mg (Pfizer) (RT)(PFL) no preservative139 5 mg: 5 mL SWI139 10 mg: 10 mL SWI139 vial contents under negative pressure139 do NOT use BWI to reconstitute139 1 mg/mL139 48 h F, 24 h RT139 **(PFL)139 syringe139
48 h RT11,138
48 h F, 24 h RT139
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) IDArubicin PFS 5 mg/5 mL 10 mg/10 mL 20 mg/20 mL (Pfizer) (F)(PFL) no preservative139 IDArubicin 5 mg/5 mL 10 mg/10 mL 20 mg/20 mL (PPC) (F)(PFL) no preservative140 Ifosfamide 1000 mg 3000 mg (Baxter) (RT)9 no preservative141 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
1 mg/mL139
24 h RT, 48 h F **(PFL)139
syringe139
N/A
1 mg/mL140
syringe140
50 mg/mL141
48 h F11,141
0.620 mg/mL141 5001000 mL* NS, D5W, D5-NS, D5-1/2NS, Lactated Ringers9,141
72 h F141 24 h F, RT when mixed with mesna9 D5W or Lactated Ringers when mixed
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Ifosfamide 1000 mg 3000 mg (PPC) (RT) no preservative142 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
50 mg/mL142
72 h F, 24 h RT142
72 h F 24 h RT142 24 h F, RT when mixed with mesna9 D5W or Lactated Ringers when mixed 24 h RT143 - *may also use empty IV bag and qs to final volume of 250 mL with NS, D5W143
N/A
10 mg/mL143
250 mL NS, D5W dilute to 250 mL final volume by withdrawing volume from bag equal to volume of drug to be added*143
Interferon Alfa -2b 18 million units/3 mL (Schering) (F)(or up to 7 days at RT before use)144 preservative145
N/A
6 million units/mL144
48 h F11,144
2 d F11,146 24 h F, RT146
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Interferon Alfa -2b 10 million units/1 mL 25 million units/2.5 mL (Schering) (F)(or up to 7 days at RT before use)144 preservative145 Interferon Alfa -2b 10 million units (Schering) (F)144 no preservative (unless reconstituted with BWI)145 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
10 million units/mL144
48 h F11,144
2 d F11,146 24 h F, RT146
10 million units/mL144
24 h F144
syringe144
24 h F, RT146
48 h RT9,11
48 h F, RT11,144
14 d F, 48 h RT11,147 48 h RT9,11
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Interferon Alfa -2b 18 million units (Schering) (F)144 no preservative (unless reconstituted with BWI)145 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
18 million units/mL144
24 h F144
syringe144
24 h F, RT146
48 h RT9,11
48 h F, RT11
14 d F11,147 48 h RT9,11
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Ipilimumab 50 mg/10 mL 200 mg/40 mL (BMS Canada) (F)(PFL) no preservative149 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
5 mg/mL149
24 h F,RT149
1 4 mg/mL in NS, D5W 100 mL149 OR undiluted in empty viaflex bag or glass bottle (allow vials to stand at RT for ~5 min prior to withdrawal of contents)149
24 h F,RT149
- do NOT shake149 - administer with 0.2 or 0.22 low protein binding in-line filter149 - vials may contain translucent-to-white amorphous particles149 - discard if cloudy or has pronounced colour change (should be clear to pale yellow)149 - flush line with NS or D5W after infusion149 - do NOT refrigerate if in NS153
N/A
20 mg/mL150
2 days RT11,151,152
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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART DRUG & STRENGTH (Storage Prior to Use, Manufacturer, Preservative Status) Irinotecan 40 mg/2 mL 100 mg/5 mL (Pfizer) (RT)(PFL) no preservative153 Irinotecan 40 mg/2 mL 100 mg/5 mL 500 mg/25 mL (Sandoz) (RT)(PFL) no preservative154 Ixabepilone 15 mg (contains 16 mg) 45 mg (contains 47 mg) (BMS) (F)(PFL) no preservative155 Reconstitute With: To Give: Vial Stability Product Product Stability Special Precautions/Notes
N/A
20 mg/mL153
N/A
20 mg/mL154
2 mg/mL155
1 h RT155
0.2 0.6 mg/mL in Lactated Ringers Injection USP (use non-PVC infusion container)155
6 h RT155
- use 0.2-1.2 micron in-line filter155 - use non-PVC (i.e., DEHP-free) administration set155
* Suggested volume based on usual dose range and any concentration range of stability data ** Protect from light means minimizing exposure to direct sunlight over a storage period. More specific information on protection from light (eg, protecting container and tubing during administration) will be indicated in the Under the Special Precautions/Notes column.
Centres are not to change the content locally but should forward suggestions to the Cancer Drug Manual staff.
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Explanatory Notes
Stability data assumes products prepared using standard aseptic technique in biological safety cabinet at low risk for contamination according to the classification 18,156 outlined in USP 797 Vial stability: Stability of solution after first puncture or reconstituted solution Storage temperature: If information states same stability with refrigerator and room temperature storage, then fridge stability is bolded as preferred (ie, to minimize growth of micro-organisms). Discard unused portion: Unused portion from single use vials should be discarded at the end of the day. overfill known is stated if the manufacturer states overfill that is present is within acceptable limits.
Abbreviations
PFL = protect from light RT = room temperature F = refrigerate SWI = sterile water for injection NS = normal saline D5W = dextrose 5% in water BWI = bacteriostatic water for injection
References
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