ACKNOWLEDGEMENT

At this moment of outmost satisfaction and pride I would like to gratefully acknowledge those persons whose encouragement and support tremendously helped me to complete this seminar report successfully. First and foremost, I acknowledge the abiding presence of abounding grace of God Almighty for his unseen hand yet tangible guidance all through the formation of this seminar report. I thank all our faculties of Electrical Department for their guidance and help. Also I extend my gratitude to all our laboratory staff of Electrical laboratory. I express my deep sense of respect and gratitude to this seminar. I am also grateful to our seminar coordinators rs.%reekala De$i !. and rs.Dinu r.!urian "argheese, #ead of the

Department, Electrical and Electronics Engineering for the encouragement he ga$e us throughout

&homas, Associate 'rofessors, Electrical and Electronics Department for their guidance, inspiration, ad$ice and timely suggestions which helped in the completion of my work on this seminar at the right time. I remember their patience and sincerity for the success of my seminar work. At last but not the least I would like to thank my friends for their support, co( operation, encouragement throughout the seminar preparation and the entire presentation. I on this occasion remember the $aluable prayers of my family members which were ine$itable for its success full completion.

ABSTRACT

'arkinson)s disease *'D+ is a central ner$ous system disorder with $ast symptoms. &he disease is caused by degeneration or malfunctioning of basal ganglia *,G+. &his portion is composed of different parts and its main function is mo$ement control. 'arkinson)s disease, chronic, progressi$e and neurological, is characteri-ed by a loss of dopamine, leading to symptoms such as bradykinesia, akinesia, rigidity and tremor. Deep brain stimulation *D,%+ is now well established as an effecti$e method of treating the symptoms of medically refracti$e 'arkinson)s disease. &his method is a no$el treatment for 'D, obtained on the basis of pre$ious experiences on impro$ement of the patients by destruction of some parts of the brain.D,% is applied usually for the treatment of 'arkinson)s Disease, which is typically a high fre.uency charge balanced pulse train applied most often to the subthalamic nucleus *%&/+ $ia surgically implanted electrodes. &his paper entitled 0Can Control Theory Throw Light on Parkinson s Disease an! Treat"ent With Dee# Brain Sti"$lation% makes use of ideas from control theory i.e., the root locus method, 1yapuno$)s theorem of first approximation, the describing function, /y.uist stability theory and the concept of the e.ui$alent nonlinearity associated with dither in2ection in a nonlinear feedback loop, the phenomenon of .uenching of pathological neural oscillations by D,% is explored. &hese .uenching pathological neuronal oscillations that arise as a result of dopamine depletion. &he exact mode of action of D,%, howe$er, remains open to debate. &he proposed model used contains a second order unstable, linear, dynamical system, in a negati$e feedback loop with a nonlinearity which comprising a linear gain in parallel with a signed s.uare. Describing function analysis is used to gi$e a $ery close estimate of inherent, almost sinusoidal oscillation, which is .uenched by deep brain stimulation. &he relationship between the critical amplitude of deep brain stimulation *expressed either in $olts or milliamps+ and the fractional pulse width needed for .uenching the oscillation is deri$ed.