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SAFC PHARMA INSTALLS THE INDUSTRY’S FIRST COMMERCIAL

DUAL WAVELENGTH X-RAY DIFFRACTOMETER
Allows Increased Throughput for Challenging Single Crystal Analyses

ST. LOUIS, MO. and CPhI, MADRID, Spain, October 13, 2009 – SAFC Pharma®, a business
segment of SAFC®, a member of the Sigma-Aldrich® Group (NASDAQ: SIAL), today
announced that its Pharmorphix® Solid State Research Laboratories in Cambridge, UK, have
installed a new single crystal X-ray diffraction system. The Oxford Diffraction SuperNovaTM
system, which can determine the crystal structures from the most challenging crystal samples,
is the first industrial installation of this state-of-the-art instrumentation anywhere in the world.

Equipped with a powerful high flux dual wavelength microsource X-ray generator, the
SuperNova instrument is capable of performing single crystal X-ray analyses on small
microcrystalline fragments with dimensions of down to 30 to 50 microns. The dual wavelength
capability will allow the rigorous determination of absolute stereochemistry of chemical entities
which contain first row elements only.

Solid-form characterization and research is an essential part of the drug development process.
A fundamental understanding of the physical properties of active pharmaceutical ingredients
(APIs) allows for the selection of the optimal solid-form to ensure patient benefit such as
efficacy and safety, and protect intellectual property.
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Professor Chris Frampton, Chief Scientific Officer for SAFC Pharma’s Pharmorphix Solid State
Research Technology, commented: “The installation of the Oxford Diffraction SuperNova
instrument underlines our commitment to providing the highest quality data and service to our
clients in the area of single crystal X-ray diffraction. The technique of single crystal X-ray
diffraction is used extensively throughout all our projects and provides a fundamental
understanding of solid state processes.”

About SAFC Pharma's Pharmorphix Solid State Research Technology:

(www.safcpharma.com/pharmorphix) is well-recognized for its solid form research studies and is used
by pharmaceutical customers around the globe to enhance their development programs. Often used in
the early to mid stages of drug development, Pharmorphix’s solid-state services complement SAFC
Pharma’s expertise in the manufacture and supply of Active Pharmaceutical Ingredients (APIs) and
intermediates, providing customers with collaborative support through every stage of the clinical
development process and enabling greater speed to market.

About SAFC: SAFC® is the custom manufacturing and services group within Sigma-Aldrich that focuses
on high-purity inorganics for high technology applications, cell culture products and services for
biopharmaceutical manufacturing, biochemical production and the manufacturing of complex, multi-step
organic synthesis of APIs and key intermediates. SAFC has manufacturing facilities around the world
dedicated to providing manufacturing services for companies requiring a reliable partner to produce their
custom manufactured materials. SAFC has four focus areas – SAFC Pharma®, SAFC Supply
SolutionsC, SAFC Biosciences®, and SAFC Hitech® – and had annual sales of over $600 million in
2008. SAFC is one of the world’s 10 largest fine chemical businesses. For more information about
SAFC, visit www.safcglobal.com.

About SAFC Pharma®: SAFC Pharma is a complete pipeline partner for the development and cGMP
custom manufacturing of complex small-molecule APIs and biologic drug products. It combines world-
class project management and chemistry support for all stages of the drug discovery and development
process from research and discovery, through pre-clinical and clinical development to
commercialization, with a focus on reducing the drug development time-line. SAFC has the widest range
of raw materials, highly qualified and experienced staff, state-of-the-art facilities and an integrated
portfolio of services, including full analytical and regulatory support and is a leader in emerging
technologies, including high-potency APIs, solid-state chemistry, viral products and chemical-biologic
API conjugates. For more information visit www.safcpharma.com.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its
biochemical and organic chemical products and kits are used in scientific research, including genomic
and proteomic research, biotechnology, pharmaceutical development and as key components in
pharmaceutical, diagnostic and other high technology manufacturing. The Company has customers in
life science companies, university and government institutions, hospitals, and in industry. Over one
million scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has
7,800 employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating
Customer Success through Innovation and Leadership in Life Science, High Technology and Service.
For more information about Sigma-Aldrich, please visit its award-winning Web site at http://www.sigma-
aldrich.com.
®
Sigma-Aldrich®, SAFC®, SAFC Pharma, SAFC Biosciences, SAFC Supply Solutions, SAFC Hitech and Pharmorphix are
registered trademarks of Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.
SuperNova is a trademark of Oxford Diffraction Ltd.
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