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Mallory bodies. Hyaline (eosinophilic) inclusions (arrow) are present in the cytosol of hepatocytes.
A and B, Right-sided Bell's palsy showing inability to fully close the eye and drooping of the corner of the mouth
Acid-fast stain of a lung biopsy in a patient with reactivation tuberculosis due to Mycobacterium tuberculosis
Acoustic neuroma showing spindleshaped cells with alternating dark and light areas
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Cerebellum in a patient with rabies showing Purkinje cells with intracytoplasmic, eosinophilic inclusions (arrows) called Negri bodies
Common systemic fungal infections. The yeast form of Cryptococcus neoformans (A) produces a narrow-based bud (arrow). Coccidioides immitis (B) has spherules containing endospores (arrows). Multinucleated giant cells
Dependent pitting edema showing depressions in the skin around the ankle. Pitting edema is due to an increase in vascular hydrostatic pressure or a decrease in vascular oncotic pressure (hypoalbuminemia)
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Dermatographism
Diffuse membranous glomerulonephritis. The H[amp ]E (hematoxylin [amp ] eosin)-stained biopsy (A) shows glomerular basement membranes that are uniformly thickened. There is no proliferative component. The silver stain
Electron micrograph of a type II pneumocyte showing lamellar body (arrow) containing surfactant
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Metastatic renal cell carcinoma showing multiple nodular lesions scattered throughout the lung parenchyma
Fibroadenoma
Mallory bodies. Hyaline (eosinophilic) inclusions (arrow) are present in the cytosol of hepatocytes
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Hydronephrosis of the kidney. There is marked dilation of the renal pelvis and calyces with thinning of the overlying cortex and medulla due to compression atrophy
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Acute myocardial infarction (MI) showing a pale infarction of the posterior wall of the left ventricle (bottom left)
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Caseous granuloma showing a central area of acellular, necrotic material surrounded by activated macrophages (epithelioid cells), lymphocytes, and multiple multinucleated Langhans-type giant cells
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Apoptosis in the epidermis. The arrow shows a clear space in the epidermis containing an intensely eosinophilic staining cell with a small, dense nucleus.
Signs of acute inflammation. The patient has erysipelas of the face due to group A streptococcus. Signs of acute inflammation that are present in the photograph include redness (rubor) and swelling (tumor)
Acute inflammation. Histologic section of lung in bronchopneumonia showing sheets of neutrophils with multilobed nuclei.
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Purulent (suppurative) inflammation. The photograph shows a skin abscess (furuncle) due to Staphylococcus aureus. Abscesses are pus-filled nodules located in the dermis.
Fibrinous inflammation. The epicardial surface of the heart is covered by a shaggy layer of fibrin material
Pseudomembranous inflammation. There is necrosis and a yellow-colored exudate covering the mucosal surface of the colon due to a toxin produced by Clostridium difficile.
Chronic inflammation. This tissue shows an infiltrate of predominantly plasma cells (cells with eccentric nucleus and perinuclear clearing) and lymphocytes
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Ehlers-Danlos syndrome
Keloid formation
Absolute leukocytosis with left shift. Arrows point to band (stab) neutrophils, which exhibit prominence of the azurophilic granules (toxic granulation). Vacuoles in the cytoplasm represent phagolysosomes
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Systemic sclerosis. The tightening of the skin around the mouth is caused by excess collagen.
Kaposi's sarcoma in HIV. Skin lesions are raised, red, and nonpruritic
Patient with signs of volume the mucosal surface of the tongue is dry. Additional findings on examination were hypotension, tachycardia, and decreased skin turgor. (From Forbes C, depletion
Electrocardiogram showing hyperkalemia. Arrows show peaked T waves, which are a sign of hyperkalemia.
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Coronary artery thrombosis. In this specially stained cross-section of a coronary artery, collagen is blue and the thrombus is red
Pulmonary embolus. The main branches of the pulmonary artery are occluded with large-caliber thromboemboli (saddle emboli)
Down syndrome. The facial profile (A) shows a short stature, small head with small nose and ears. The hand (B) shows a single palmar (simian) crease
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Klinefelter's syndrome
Prader-Willi syndrome
Angelman syndrome
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Kwashiorkor and marasmus. Left, Child with kwashiorkor, showing dependent pitting edema involving the lower legs. Right, Child with marasmus, showing broomstick extremities with loss of muscle mass and sub
Anorexia nervosa
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Lipoma showing a wellcircumscribed yellow tumor (A) containing benign adipose cells (B)
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.Figure 8-4 Squamous cell carcinoma. The many well-differentiated foci of eosinophilic-staining neoplastic cells produce keratin in layers (keratin pearls)..jpg
Osteogenic sarcoma of the distal femur. The light-colored mass of tumor in the metaphysis abuts the epiphyseal plate (arrow)
Metastasis to the liver. The liver contains multiple nodules that have a depressed central area (umbilicated)
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Malignant melanoma. The lesion on the patient's forearm is black, is multinodular, and has an irregular border with areas of pale-gray discoloration
Xanthelasma. Yellow, raised lesions are noted on the eyelids in both eyes
Hyaline arteriolosclerosis
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Henoch-Schnlein purpura
Acute myocardial infarction (day 7) in the posterior wall of the left ventricle
Fibrinous pericarditis. The surface of the heart is covered by a shaggy, fibrinous exudate
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Left ventricular aneurysm. The bulging aneurysm has a thin wall of scar tissue
Acute rheumatic fever. Uniform, verrucoid-appearing sterile vegetations appear along the line of closure of the mitral valve
Mitral valve prolapse. The arrow shows prolapse of the posterior mitral leaflet into the left atrium
Aortic stenosis
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Myocarditis. The biopsy shows a lymphocytic infiltrate with dissolution of myocardial fibers
Peripheral blood reticulocytes with supravital stain (new methylene blueView drug information). Red blood cells with thread-like material in the cytosol represent residual RNA filaments and protein (arrow
Peripheral blood smear in iron deficiency anemia. The enlarged central area of pallor in the red blood cell (arrow) indicates a decrease in hemoglobin synthesis,
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Ringed sideroblasts in a bone marrow aspirate. Dark blue iron granules around the nucleus of developing normoblasts (arrows) represent iron trapped within mitochondria and indicate a defect in mitochondri
Peripheral blood with coarse basophilic stippling of RBCs in lead poisoning. Note the mature RBC containing numerous dots representing ribosomes (arrow)
Peripheral blood in megaloblastic anemia showing the hypersegmented neutrophil (arrow) with nine lobes
Peripheral blood with spherocytes in hereditary spherocytosis. Numerous, round, dense red blood cells (RBCs) without central areas of pallor represent spherocytes (arrows). The mean corpuscular hemoglobi
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Peripheral blood with sickle cells and target cells, showing the dense, boat-shaped sickle cells. Cells with a bull's-eye appearance are target cells (arrows), which have excess RBC membrane that bulges
Peripheral blood with sickle cells and HowellJolly bodies. The three dense boat-shaped sickle cells and the two cells containing a single dark, round inclusion (arrows) represent nuclear remnants. Howel
Peripheral blood with schistocytes. The fragmented red blood cells (RBCs) with absence of central pallor, schistocytes, are produced when RBCs are mechanically injured by calcium deposits in an aortic valve
Plasmodium falciparum ring forms in red blood cells (RBCs). This RBC has two ring forms. Multiple infestation of an RBC is characteristic of P. falciparum malaria
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Peripheral blood with atypical lymphocyte. The cell shows prominent nucleoli and coarse nuclear chromatin. The cytoplasm is abundant and is indented by adjacent red blood cells
Peripheral blood in chronic myelogenous leukemia. Marked leukocytosis shows neutrophils at different stages of development (segmented and band neutrophils, metamyelocytes and myelocytes)
Peripheral blood with promyelocyte filled with Auer rods in acute promyelocytic leukemia
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Gaucher disease
Niemann-Pick disease
Senile purpura
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Asbestos body
Malignant mesothelioma
Sarcoid granuloma
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Oral thrush
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.Barrett's esophagus
. Esophageal varices
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. Gastric adenocarcinoma
. Celiac disease
.Dermatitis herpetiformis
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Hemorrhagic infarction
. Meckel diverticulum
. Sigmoid diverticulosis
. Ulcerative colitis.
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. Crohn's disease
Tubular adenoma
. Familial polyposis
. Acute appendicitis
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Alcoholic cirrhosis
.Kayser-Fleischer ring.
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.Hepatocellular carcinoma
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Normal glomerulus
.Subepithelial immunocomplex
. Crescentic glomerulonephritis
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. Diabetic glomerulosclerosis
.Acute pyelonephritis.
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. Benign nephrosclerosis
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A, Candida. B, Chlamydia trachomatis. C, Gardnerella vaginalis. D, Herpes type E, Herpes type 2. F, Human papillomavirus.
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. Endometrial carcinoma
.Leiomyomas.
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. Primary hypothyroidism
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Graves' disease
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.Rheumatoid arthritis
.Tophi (arrows)
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.Molluscum contagiosum
.Erythema infectiosum
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.Acne rosacea
. Tinea versicolor.
. Lymphocutaneous sporotrichosis
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.Contact dermatitis.
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. Pityriasis rosea
. Erythema multiforme
. Erythema nodosum
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. Granuloma annulare.
. Acanthosis nigricans
.Solar lentigo
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. Compound nevus
.Anencephaly
. Neurofibromatosis
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.Epidural hematoma
.Subdural hematoma
.Atherosclerotic stroke.
.Embolic stroke
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. Intracerebral hemorrhage
.Bacterial meningitis
. Cerebral abscess
.Fusion of the podocytes. Arrowheads show fusion of the podocytes, which should be separated by slit pores. This finding occurs in all glomerular diseases that present with the nephrotic syndrome (e.g., minimal change
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.Gram stain of Streptococcus pneumoniae. The sputum stain shows numerous lancet-shaped diplococci
.Granular immunofluorescence. Granular irregular deposits in the capillaries are caused by immunocomplex deposition (e.g., poststreptococcal glomerulonephritis
. brain of a newborn with kernicterus. Arrows depict yellow bilirubin pigment deposited in the basal ganglia
.Herpes zoster
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.Huntington disease. Coronal section (A) shows a dilated lateral ventricle and atrophy of the caudate, putamen, and globus pallidus when compared with a normal coronal section (B)
.If the crystal is blue when parallel to the slow ray, the crystal demonstrates positive birefringence.
.Normal peripheral blood smear showing RBCs. The RBCs are uniform in size, and the central areas of pallor are slightly less than half the total diameter of an RBC. The four dark objects (arrows) outside
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.Keratoacanthoma
classic Reed-Sternberg (RS) cell. The large, multilobed cell with prominent nucleoli is surrounded by a halo of clear nucleoplasm. Classic RS cells are more easily found in mixedcellularity Hodgkin's lymphoma
.Linear immunofluorescence. The uninterrupted smooth immunofluorescence along the glomerular basement membrane is caused by deposition of IgG antibodies directed against the membrane (e.g., Goodpasture syndrome)
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.Liver biopsy stained with Prussian blue in a patient with hereditary hemochromatosis
.Lung biopsy stained with Gomori methenamine-silver showing septated hyphae and fruiting body (inset) of Aspergillus fumigatus
.Malignant plasma cells in multiple myeloma. The majority of malignant plasma cells show a gray-blue cytoplasm, peripherally located nuclei, and perinuclear clearing
.Multiple sclerosis showing multiple areas of demyelinated white matter (arrows pointing to brown plaques)
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.Neurocysticercosis showing multiple cysts between the gray and white matter
.Optic disk with papilledema showing loss of the disk margin and hard exudates (white streaks
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.Patient with myasthenia gravis showing ptosis of the left eye (A) followed by opening of the eye (B) after intravenous injection of Tensilon.
.Petechiae in idiopathic thrombocytopenic purpura showing pinpoint hemorrhages, a sign of platelet dysfunction
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.Prostate cancer metastatic to the vertebral column. Multiple white foci of metastatic prostate cancer produce an osteoblastic response in the bone.
.Radiograph of a skull showing multiple punched out lytic lesions in multiple myeloma
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.Senile plaque (arrow) shows an eosinophilic center with peripherally located distended neuronal processes (neurites).
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.Spongiform encephalopathy in Creutzfeldt-Jakob disease showing classic bubbles and holes of the neuropil cell bodies
.Substantia nigra in a patient with Parkinson disease (A) and a normal individual (B)
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.Tinea corporis showing annular lesions with erythematous margins and clear centers
.subnuclear vacuoles (arrows) containing mucin push the nuclei of the endometrial cells toward the apex of the cell
Wernicke's encephalopathy showing hemorrhage and discoloration of mamillary bodies and the wall of the third ventricle
Wilson's disease showing cavitary necrosis of the putamen on both sides of the brain
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cytomegalovirus. The enlarged nuclei of many of the type I pneumocytes contain large inclusions
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