4141

20097

1,060,560
1,065 (2011)

1993 - ,
1994
1996

1999

2000

BASF, Nihon Nohyaku and Nippon Soda

2003

2004

1950s
1960s
1987
1991
1992

2006
2007

2008
2010

2011

CNAS

GLP
GLP
GLP

PCG

1.

2.

3.,

4.

0.5

10

0.4

0.3

0.2

0.1

0
1960 1970 1980 1990 2000 2010 2020
Hectares per person (LHS)
Population (bn) (RHS)

Source: The Contribution of Crop Protection Products to the United States Economy, Mark Goodwin Consulting Ltd.

(,,,)

Product life cycle

2009 Sales breakdown

~20-25 yrs

Molecule

~$9bn

Patent

~$44bn

~25 yrs

Post-patent
~$35bn

Generic

Proprietary post-patent

$11bn of sales

$24bn of sales

Source: Rotam estimates, PhillipsMcDougall

10


Leading crop protection companies (2009)

Source: PhillipsMcDougall

Other includes Arysta Life Sciences, United Phosphorous, FMC, Cheminova,

Sumitomo Chemical, Isagro, Chemtura, Sipcam, ISK, Summit Agro Intl and Rotam

Nufarm and MAI 2010 2224

11

Rotam

12

13

14

:
:
:
, , ,

,
,

15

:
2005

2008

2005

2009

1995

1993

2011

2002

2003

2011

2001

2005

1985

2003
2003

2003

2004

60

16

23%

Source: Rotam internal information

17

Source: Rotam internal information

18

19

Source: Individual companys financial statement

Note:: Syngenta, Makteshim Agan Nufarm
: ,

20

(Buying Group)

21

22

Mark Lu

Tony Damaceno

James Bristow

Tom Chavez

C.Y. Lo

Jack Tseng

William Yuen

Yifan Wu

Subu

UPL

Jean Michel

Dr. S.C. Tewari

UPL

Andy Qu

Duhamel

Paul Savage

Ben Niu

Marc Lore

Garth Drury

Alok Kumar

Alvaro Canizares

UPL

Ezio Da Silva Costa

23

2008 2009 2010

4
5
7
42
58
63
56
62
76
47
53
54
149
178
200

2011
10
67
90
61
228

2011
2011

73%

24

Source: Rotam internal information

25

Source: Rotam internal information

26

(American
Appraisal),
20113
USD238m,

27

:
()

Source: Rotam internal information

28

:
GLP

GLP(Good Laboratory
Practice)

(Time to market)

2009
2010
2011

GLP
8%
17%
28%

29

:
7GLP*

1)Daphnia similis acute immobilization test for Grimectrin

2)Avian dietary toxicity test in Japanese quails
3)An extended laboratory and aged residue study to determine the effects of
Abamectin 18g/l EC on the non-target Arthropods aphidius Rhopalosiphi
(Hymenoptera: Braconidae) and typhlodromus pyri (ACARI: Phytoseiidae)
4)Honeybees, acute oral toxicity test (Apis mellifera)
5)Earthworm, acute toxicity test with metsulfuron methyl technical
6)Alga growth inhibition test (Pseudokirchneriella subcapitata) for FH 040-001
7)Soil Microorganism: Carbon Transformation Test for Toledo 250EC
8)Acute toxicity study of Clomazone 480 g/l EC to fish Danio rerio

1)[14C]-Avermectin B1a: Aqueous photolysis in steril buffer at pH 7

2)[14C]-Avermectin B1a: Rate of degradation in 3 soils at 20C
3)[14C]- Nicosulfuron: adsorption to the desorption from four soils.
4)[14C]- CGA71019; anaerobic soil degradation
5)Clomazone: assessment of ready biodegradability closed bottle test.
6)[14C]- Dicamba: Aqueous photolysis and quantum Yield Determination in Buffer
at pH 7.

30

71:
(daphnia),
(Japanese quail), (soil
microorganism), (aphidius
rhopalosiphi)(earthworm)
(honeybee), (midge), (rainbow
trout), (predatory mite),
(green algae).
,

14:
14
,,,

1)Evaluation of the mutagenic potential by

micronucleus assay in mice
2)Evaluation of the Mutagenic potential by
reverse mutation assay in Salmonella typhimurium
(Ames test)
3)Metabolism of 14C-metsulfuron methyl in goat
4)In vitro Mammalian Chromosome Aberration test
in human lymphocytes with 2-(3trifluorometyl)phenoxy) nicotinic acid
5)Evaluation of the mutagenic activity of 5hydroxydicamba in an in vitro mammalian cell
gene mutation test with L5178Y mouse lymphoma
cells (with independent repeat)
6)Salmonella typhimurium Reverse Mutation Assay
with Dicamba Technical

37:

(Salmonella typhimurium)
,
(micronucleus),
(in vitro
mammalian lymphoma
cells),

,
,

(aberration)
(aberration),

:
:
database
database
database

31

:
2012311,

GLP9986
9986
9986
2571

2571
2571

(35)

,,,
269
269
269

32

:
()

34

: 23%
: 23%

()

2008
3,207
1,306
152

2009
3,951
1,683
435

2010
4,897
2,073
478

35

Source: Individual companys financial statement

Note:: Syngenta, Makteshim Agan Nufarm
: ,

36

Source: Individual companys financial statement

Note:: Syngenta, Makteshim Agan Nufarm
: ,

37

38


1.
1.
2.
2.GLP
GLP
GLP,
,
3.
3.
(Rapid Trait Development System)

39

:
1
2
3
4
5
6
7
8
9
10
10
11
11
12
12

40

41