LacNoir2012

Content:
Softwareapplicationforenvironmentalassessmentof

bioprocesses
Introduction DesignoptimizationTraditionalApproach Proposedstrategy Casestudy Conclusions Furtherperspectives

Shortdescriptionofthemethod

ImpactCategories RawMaterialAvailability LandUse Complexityofsynthesis ThermalRisks AcuteToxicity ChronicToxicity Ecotoxicity GlobalWarmingPotential OzoneDepletionPotential AcidificationPotential

=EIBioprocess

PhotochemicalOzoneCreation Potential Odor EutrophicationPotential OrganicCarbon PollutionPotential

Descriptionoftheapplication:
Substancedatabase: properties ABCClassification Graphicalinterfaces: visualization environmentalassessmentofaplant additionofnewsubstancestothedatabase

 Introduction:
optimization: Theactofobtainingthebestresultsundergiven circumstances.

design variables

function

result

Introduction:

o Multiobjectiveoptimization:
operating cost

ParetoFront

capital investment

Introduction

o Interactiveoptimization:

Computationally efficient Flexible Intuitive More close to real world applications

operating cost

1 capital investment

o Designoptimization:

traditionalapproach: manually,trialanderror timeconsuming concentratedonauniqueobjective(usuallyeconomic objectivelikeoperatingcost)

SuperPro Designer

o Proposedstrategy

data transfer

Matlab

SuperProDesigner - toolboxes : - optimization - statistics - advanced visualization tools - advanced computational tools

data transfer

Proposedstrategy

MatlabGUIusedforgeneration ofenvironmentaland economicalcomponentsofthe objectivefunction

Casestudy:interactivemultiobjectiveoptimizationofa bioprocess

CaseStudy

minimize { f1(x), f2(x), f3(x), f4(x), f5(x)}

f1(x) unitproductioncost($/kgmainproduct), f2(x) totalcapitalinvestment($) f3(x) EIBioprocess, f4(x) LlysineconcentrationinstreamS117(finalstream)(g/L) f5(x) biomassconcentrationinstreamS117(finalstream)(g/L) x1 glucoseinitialconcentrationinfermenterP20(g/L) x2 threonineinitialconcentrationinfermenterP20(g/L) x3 glucosefeedflowrate (m3/h) x4 Llysinefeedflowrate instreamS127(kg/batch) x5 biomasssplittingfractioninP14(%) x6 glucoseconcentrationinfeedstream(g/L)

Results

Initialsolution x x1 x2 I<={1,2,3,4,5} x3 x4 x5 x6 Values 60 1.4243 800 100 0.9823 1350 f(x) f1(x) f2(x) f3(x) f4(x) f5(x) Values 12.4414 1.1438*108 0.3095 0.4028 0.1056 I<={1,4} I=={3,5} I0={2} Preferences x x1 x2 x3 x4 x5 x6

Iteration1 Values 60 0.8 800 100 0.8 1350 f(x) f1(x) f2(x) f3(x) f4(x) f5(x) Values 4.4725 1.1546*108 0.1508 0.6221 0.0838

Iteration2 Preferences x x1 I<={1} I=={4,5} I0={2,3} x2 x3 x4 x5 x6 Values 78.5556 1.0273 962.315 190.5411 0.8222 1548.7 f(x) f1(x) f2(x) f3(x) f4(x) f5(x) Values 4.1153 1.1763*108 0.1613 0.6196 0.0956 I<={1,4} I=={5} I={2} I0={3} Preferences x x1 x2 x3 x4 x5 x6

Iteration3 Values 82.334 1.0024 975.57 306.81 0.8751 1560.2 f(x) f1(x) f2(x) f3(x) f4(x) f5(x) Values 4.4727 1.1546*108 0.1508 0.622 0.0840

Conclusions:
Theproposedmethodisaviablealternativetothetraditionally approach,beingeasytouseandsystematic.Canprovidean accuratesolution. Themainadvantagesare:
donotrequireadvancedprogrammingknowledge. canbeusedinbothdesignandoperationphaseofaplant.Inthe

designphasecanbeusedtorenderasustainabledesign.Inthe operationphasecanbeusedtodeterminebesteconomicand environmentalconditionstorenderaproduct,everytimethefinal productchangesorqualityparameterschangesduetodifferent clientspecifications. wecanusethisstrategywithmodernoptimizationalgorithms implementedinMatlab. offersthepossibilityofconsideringmultipleobjectivesand contributestothesustainabilityofthefinaldesignandoperation.

 FurtherPerspectives:
analysisoftheproposedstrategy
Optimizationalgorithm Improvings :

surrogateassistedevolutionaryalgorithms adaptforparallelanddistributedcomputing replacementforOLE