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PHARMACEUTICAL
S
TORRENT PHARMA
Torrent Pharmaceuticals is a flagship company located at Ahmedabad
(India). It produces Bulk drugs and compounds in the therapeutic areas of
cardiovascular and central nervous system. Torrent Pharma has also entered
areas like gastro-intestinal, diabetology, anti-infective and pain management
systems.
Torrent Pharmaceuticals was set up in the year 1959 and was initially
headquartered in Ahmedabad (India). Torrent Pharmaceuticals was derived
from the name Trinity Laboratories Ltd. which was promoted by U. N. Mehta
and now trades in 50 countries with more than 1000 product registration
across the globe. Torrent Pharma has drawn a revenue of 13.3 billion for the
year 2007 and its net income for the same is 0.9 billion. TORRENTPH is a
flagship company which manufactures Bulk drugs and compounds in the
therapeutic areas with main concentration on cardiovascular and central
nervous system.
Torrent Pharmaceuticals Limited has six divisions for marketing and each
division succumbs to the defined therapeutic areas. Torrent Pharma has
established 22 new conceptualizations in the Indian market and 14 for the
international market that includes Europe, Russia and Brazil. TORRENTPH has
also launched a subordinate in Brazil and has stretched its focus on Russia
and CIS countries during 2004-2005. Five fully owned subordinates of
Torrent Pharmaceuticals are:
PRODUCTS
Highlights :
• Nicorandil
• Risperidone
• Venlafaxine Hydrochloride
• Ropinarole Hydrochloride
• Duloxetine Hydrochloride
• Ormeloxifen Hydrochloride
• Nebivolol Hydrochloride
• Lamotrigine
• Sertraline Hydrochloride
• Clopidogrel bisulphate
MANUFACTURING:
INDRAD PLANT
Torrent’s manufacturing facility at Indrad, Gujarat, was set up in 1989.
Today, the Indrad facility is at par with international standards. It complies
with WHO, cGMP, MHRA and TGA norms and has received ISO 9001, ISO
14001 and OHSAS 18001 (Occupational Health and Safety Management
System) certifications; adequately reflecting Torrent’s commitment towards
quality and safety. Attainment of such standards have also opened the key to
gaining footholds in regulated, lucrative markets like the US and EU for
Torrent Pharma.
Infrastructure ::
Baddi Plant ::
Set up with an investment of over Rs. 130 crores, the Baddi Plant is a most
modern, state-of-the-art facility that will cater to the requirements of
domestic markets. The Plant commenced operations in November 2005 and
has a capacity to manufacture 3600 million tablets, 400 million capsules and
18 million Oral Liquid bottles, per annum. Other operations at the Plant have
been streamlined, with the critical machines and operations already
functional at the Plant. Production of most of the domestic products has
already been shifted to Baddi.
Infrastructure :
Highlights ::
• First Indian pharmaceutical plant to get ISO 9001, ISO 14001 &
OHSAS 18001certification.
• Quality Assurance is independence of Manufacturing.
• In-Process quality is checked during manufacturing.
• Validation of facilities, equipments, process, products & cleaning as per
Master Plan.
• Complaint Handling.
• Storage of quality record and control samples.
• Stability Studies.
• Registration Documents (DMF)
Technology Transfer :
Validation :
Documentation Control :
• cGMP training
• SOP compliance
• Audit of facility for compliance
• Line clearance
• In-process counter checks
• Critical sampling
• Record verification
• Release of batch for marketing
• Investigation of market complaints
• Stability of products
QUALITY CONTROL
Quality Control for API / PM, Finished Products & In-Process Control
is as follows :
2) Capsule Facility ::
• ENCAPSULATION
• Hard Gelatin
o Pellet Filling
o Tablet Filling
o Combination of Powder/Pellet & Powder / Tablet Filling
• Soft Gelatin
3) Parentals Facility ::
Facility has been designed under technical guidance of M/s. Novo Nordisk,
Denmark which complies International Regulations.
• VIAL : INSULIN
• AMPOULE
• FREEZE DRYING
• AREA
4) Packaging Facility ::
Area Design ::
API production plant is divided in two part, Technical plant and Pharma area.
Technical plant is provided with once through filtered air while Pharma area
is provided with once through filtered air-conditioned air.
Activities include -
• Production Planning
• Indent of raw material and packaging material.
• Inventory monitoring to meet with marketing requirements
The department works as a support function for the entire plant activity,
including new project, formulation and API production, administration, estate
upkeep, environmental controls and ensures compliance of all statutory as
well as regulatory directives. This calls for multi disciplinarily technical
expertise and constant knowledge update to keep pace with changing trends
in the industry.
Major Instruments ::
• TOC Analyzer
• Gas Liquid Chromatograph with Head Space with Auto Sampler
attachment to estimate very trace level (ppm) of organic volatile /toxic
solvents to meet ICH guidelines
• Total Organic Carbon analyzer with SSM for Cleaning Validation of
manufacturing equipment to ensure that product is practically free
(ppb level) from previous product.
• Ultra Pure Water Purification system for HPLC grade water (TOC<
10 ppb and particles < 0.22 micron, Endotoxin < 0.001 cfu/ml.)
• Video Microscope for monitoring the crystallinity of Insulin products.
• Fourier Transform Infra Red Spectrophotometer to ensure total
identity/ genuineness of the product.
• Slit to Agar to monitor Viable Count / Area monitoring to ensure that
the Production, QC and Stores areas are meeting international
standards.
• Steri Test, a closed concept membrane filtration system for sterility
testing to reduce the rate of false positive results.
• Automatic Glass Ware Washing and Drying Machine to ensure
right quality of cleanliness of the glass wares.
• High Performance Liquid Chromatographs
DOMESTIC OPERATIONS
Torrent has to its credit, leading brands in various therapeutic segments. It
is a dominant player in the therapeutic areas of Cardiovascular (CV), Central
Nervous System (CNS), Gastro-Intestinal, Diabetology, Anti-infectives and
Pain Management. Efforts are on to increase its salience in other therapeutic
areas as well. In the domestic market, the focus is exclusively on ethical
allopathic market and the higher end of the institutional market in urban and
semi-urban areas.
To sharpen its focus and enhance its customer reach in the domestic market,
Torrent operates through sales and marketing divisions structured on specific
Therapeutic areas. Currently, it has 11 sales and marketing divisions- Vista,
Prima, Delta, Psycan, Azuca, Mind, Axon, Neuron, Omega, Sensa and Alfa,
each of which have a clear therapeutic focus.Torrent Pharma promotes
various platforms for knowledge sharing including conferences for doctors. It
continues its efforts towards customer education on various diseases and
their symptoms and cures, thereby increasing customer awareness.
» Latin America
» Europe
» Japan
MARKETING DIVISIONS
Prima ::
Vista ::
Omega ::
Psycan ::
Delta ::
The newly formed Delta division provides drugs for the lifestyle diseases and
operates in Cardiology and Diabetology therapeutic segments. This division is
a leading player in Hypertension management and Diabetology segment in
the domestic pharmaceuticals market.
Azuca ::
Mind ::
Neuron::
Some of the brands, earlier under Mind division but catering to neurology,
have now been brought under Neuron. Neuron would mainly cater to Anti-
epileptic, Anti-parkinsons, Alzheimer, Neurotonics and Anti-depressant
segments.
Axon ::
Sensa ::
The new CNS division, Sensa, focuses exclusively on the ailments inflicting
the geriatric population. This includes Parkinsons’, Alzheimers’s and
depression that are some of the most prevalent ailments in this segment.
Alfa ::
The third new division, Alfa is in the mass products segment and focuses on
Gastro, Ortho, and Anti Infectives segments. The gastro-intestinal market is
worth around Rs. 3000 crores and is growing at 19%.
Customer perspective
Torrent has at all times provided dependable products for its customers,
as a good reputation is a brand in itself.
Torrent donated Rs. 1 crore to the Prime Minister’s National Relief Fund to
rebuild the lives of Tsunami victims.
Realizing the need for specialized hospitals, Torrent has established and
manages medical institutions
It is among the largest spenders on R&D and has set up one of the
most advanced research centers in the country at an investment of Rs.
200 crores so far
FAILURES
2) En.wikipedia.org/wiki/Torrent_Pharmaceutica
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3) Business.mapsofindia.com