Not meant to condone or advocate illegal activity. Check the laws in your state or country.An educational resource of an alternative form of methamphetamine production. The "P2P"method popularized on the "Breaking Bad" series.
Not meant to condone or advocate illegal activity. Check the laws in your state or country.An educational resource of an alternative form of methamphetamine production. The "P2P"method popularized on the "Breaking Bad" series.
Not meant to condone or advocate illegal activity. Check the laws in your state or country.An educational resource of an alternative form of methamphetamine production. The "P2P"method popularized on the "Breaking Bad" series.
Methamphetamine via Reductive Amination of Phenyl-2-
Propanone Using Aluminum Amalgam and Methylamine in wet Isopropanol Procedure adapted from the synthesis of MDMA from MDP2P in Pihkal #109 Procedure 1: Using Methylamine ydrochloride In a 1000ml wide-mouthed rlenmeyer flask! 19 "rams of aluminum foil cut to #$#cm pieces was amal"amated in a solution of %00m" mercuric chloride &'"(l2) in *00ml warm water until the solution +ecame "reyish! and hydro"en +u++les was e,ol,ed in a steady rate from the aluminum surface- .he water was decanted off! and the aluminum amal"am was washed with 2$%00ml cold water- .o the aluminum amal"am there was added 29-%" methylamine hydrochloride &0-// mol! # e0,) dissol,ed in #0ml hot water! *% ml isopropanol! *0ml 2%1 a0ueous 2a3' &0-// mol)! 19-*%" &0-1/* mol) phenyl-2-propanone &P2P) and finally 1*%ml isopropanol- 'ydro"en was ,i"orously e,ol,ed from the aluminum amal"am! and the temperature of the solution rose 0uickly- .he reaction rate was controlled +y immersin" the reaction flask in cold water durin" 2h! whereafter it was allowed to stand at room temperature with ma"netic stirrin" o,erni"ht! with attention +ein" "i,en to the reaction mi$ture durin" the first hour so that the temperature did not rise o,er %04(- .o the reaction mi$ture there was added another %0ml 2%1 2a3'! and the reaction mi$ture was stirred for #0min and then allowed to settle- .he clear supernatant was decanted! and 100ml isopropanol was added to the "rey slud"e! and it was stirred for 1%min! and the supernatant a"ain decanted- .he aluminum slud"e at the +ottom of the flask was now filtered throu"h celite in a +uchner funnel and washed with 2$%0ml .'5 &methanol can also +e used)- All the decantations and washes were com+ined! and the solution concentrated under ,acuum- .he residue was taken up in 1000ml water! acidified +y the addition of conc '(l! and washed with #$%0ml D(M! +asified with 2%1 2a3'! and e$tracted with #$100ml D(M- .he com+ined D(M e$tracts were dried o,er M"63/! filtered and the sol,ent distilled off- .he residue was distilled twice under aspirator ,acuum at 100-1104( to "i,e 1/-7%" &7*1) of methamphetamine P a g e | 2 free+ase as a water-white oil- .he hydrochloride salt can +e prepared +y dissol,in" the oil in 10$ the ,olume of diethyl ether and "assin" the solution with dry '(l "as until no more precipitate forms- .he methamphetamine hydrochloride is filtered off with suction and washed with diethyl ether and air dried- Procedure 2: Using !"# A$ueous Methylamine %ree&ase In a %00ml wide-mouthed rlenmeyer flask! aluminum foil &10"! 0-#* mol) cut to #$#cm pieces was amal"amated in a solution of 200 m" '"(l 2 in /00 ml warm water until the solution +ecame "reyish! and hydro"en +u++les was e,ol,ed in a steady rate from the aluminum surface- .he water was decanted! and the amal"amated aluminum pieces were washed twice with 2%0ml cold water- .o the aluminum amal"am &still in the a+o,e flask) there was added! 0uickly! a /01 Methylamine solution &/# m8! 0-%0 mol)! isopropanol &100 m8)! Phenyl-2-Propanone &1#-/2"! 0-10 mol)! and finally another 100 m8 isopropanol &which was used to rinse the +eaker the P2P had +een in)- .he aluminum pieces were poked with a "lass rod so that all of them were +elow the surface of the li0uid- 'ydro"en +e"an to e,ol,e ,i"orously from the aluminum surface! and the temperature &which was measured +y a small thermometer inserted into the flask) rose 0uickly- .he e,aporation of methylamine was attenuated +y co,erin" the mouth of the flask with some Al foil &do not plu" it ti"ht! or it may e$plode)! and the reaction rate was controlled +y immersin" the reaction flask in cold water from time to time durin" the first hour so that the temperature did not rise o,er %04(- At the 2 hour point most of the aluminum was consumed! and 20 m8 2%1 a0ueous 2a3' was added to the solution and ma"netic stirrin" was initiated &keep an eye on the temperature a"ain! and keep it +elow %04()- At the # hour point another 20 m8 2%1 2a3' was added &no si"nificant temp rise)! whereafter it was allowed to stir at room temp o,erni"ht and then allowed to settle- .he clear supernatant was decanted! 100ml isopropanol was added to the "rey slud"e! it was stirred for another hour! and the supernatant a"ain decanted after the particle suspension had settled- .he aluminum slud"e at the +ottom of the flask was now ,acuum filtered throu"h an inch of (elite in a +uchner funnel and washed with 2 $ %0 m8 methanol- All the decantations and washes were com+ined! and the solution concentrated under ,acuum- .he residue was taken up in #00 m8 water! acidified with conc- '(l! washed with #$%0ml methylene chloride! +asified with 2%1 2a3'! and e$tracted with #$100ml ethyl acetate- .he com+ined or"anic e$tracts were washed with *%ml +rine! followed +y dryin" o,er anhydrous sodium sulfate with "ood ma"netic stirrin" for 1% min- .he dryin" a"ent was remo,ed +y filtration from the crystal-clear solution and the sol,ent distilled off on an oil-+ath heated to no more than 1104( &as to not risk any e,aporation of the free+ase)- .he residue was taken up in 1%0 m8 diethyl ether and with "ood stirrin" a solution of %M '(l in isopropanol was added until the solution was acid to dampened uni,ersal p' paper- .he precipitate was filtered off with suction usin" a fritted "lass funnel and the filter cake was washed with 2 $ %0 m8 ether and sucked dry- After air-dryin" o,erni"ht on a plate! the crude product &1#-7 ") still had a stron" sol,ent smell! and was recrystalli9ed +y dissol,in" it in 7% m8 acetonitrile &% m8:"ram)! and 0uickly ,acuum filterin" the hot solution throu"h a fritted "lass funnel to remo,e a sli"ht P a g e | 3 tur+idity! and the solution was then left at room temp to crystalli9e! and after a+out an hour the white crystalline precipitate was filtered with suction! washed with 2 $ 2% m8 ether and air dried- .he filtrate and ether washes &collected separately) were +oth cooled to -204( in the free9er! and from the acetonitrile a second crop was collected! while nothin" came out of the ether- .he first and second crop wei"hed 12-0 " and 0-/% "! respecti,ely! makin" the total yield of Methamphetamine 'ydrochloride 12-/% "rams! or 7*1 of theory