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FOOD ENERGY 1
METABOLISM
Anabolism:
building up of larger molecules
(eg. ‘anabolic steroids’)
Catabolism:
breakdown into smaller molecules
(eg. digestion)
2
ENERGY ‘CURRENCY’ = ATP
The body is continually creating energy
Spending it on cellular processes
Saving it for later use
Similar to people working to make money only
3
ENERGY USES:
Muscle activity (movement)
Food absorption in the gut (tef)
Basal metabolism:
synthesis of cellular substances
secretion by glands
maintenance of membrane potentials (nerve
and muscle)
etc…
4
IN A NUTSHELL
We eat a meal
Food is broken down into smaller and smaller
components
The smallest components are absorbed into our
bloodstream
Absorbed components are transported into the cells
(with occasional stops along the way)
Once inside the cell,
may be used for energy
building blocks
organized into storage for later use
5
FROM THE GUT...
Macronutrients
Carbohydrates / sugars
monosaccharides:
glucose (appx. 80%), fructose, galactose
fats
glycerol and fatty acids
proteins
amino acids
6
...TO THE CELL.
ENERGY PRODUCTION
=
CELLULAR RESPIRATION
Process of oxidizing food ‘stuff’ into water and co2
Capturing the energy released into ATP
7
GLUCOSE
Glucose is the body’s main energy
source.
Most fructose and galactose is rapidly converted to
glucose in the liver
Fats and proteins may also be used in energy
production, though this occurs to a lesser extent and
will be discussed later
Most of our discussion on energy production in the
cell will focus on glucose as the energy source.
8
Cellular uptake of glucose
9
Facilitated diffusion
Glucose is carried into the cell by proteins in the
cell membrane
high concentration to low concentration (from
blood into cell)
10
Facilitated diffusion
Glucose uptake by the cell is limited by the number of
protiens located on the membrane
Normally not enough glucose would be transported
across the cell to accomplish minimal energy needs
11
Inside the cell
1. Glucose can immediately be used for energy
production in the cell (glycolysis)
15
3 PHASES
1: Glycolysis
2: Kreb’s cycle
(citric acid cycle)
3: Electron
Transport
Chain (ETC)
16
GLYCOLYSIS
In cell cytoplasm
Anaerobic
Rapid production of ATP
net yield: 2 ATP per
glucose
17
Glycolysis
Without oxygen
Short lived… (several
minutes worth of
energy)
Inefficient (one mole of
glucose has 686 kcal,
in glycolysis, only 24
captured by ATP)
Lactic acid production
With oxygen
First step of ATP
production 18
GLYCOLYSIS
6 CO2 + 8 NADH+H+
+ 2 FADH2 + 2 ATP
21
23
NADH AND FADH2
Though glycolysis and the kreb's cycle both create
ATP, the main purpose of both of these steps in the
breakdown of glucose for energy is to make the H2 of
glucose available in forms which will be usable in
oxidation.
24
Electron transport chain and oxidative
phosphorylation
In mitochondria
Aerobic: only time o2
is used directly
Most ATP produced
here
Energy converter
25
Electron transport chain
28
30
38% Efficient
31
BOOK KEEPING
Glycolysis (-2 ATP in process) 2 ATP
KREB’S (citric acid) CYCLE 2 ATP
ELECTRON TRANSPORT CHAIN 34 ATP
38 ATP
32
FATS
Triglycerides are broken down to form
glycerol and fatty acids
glycerol enters glycolysis at the c3 level
(pyruvate)
fatty acids are broken down to form acetyl co-
a and enter the krebs cycle
33
PROTIEN
Amino acids are broken down into ammonia
(lost in urine) and C3 (4), (5) carboxylic acids
of the Kreb's cycle.
34
35
DIABETES MELLITUS
Insulin is not available, either due to lack of
production by pancreas, or lack of activity
Problems:
Blood sugar levels are high
Body cannot use glucose for energy (except
brain and liver)
Cannot store glucose as glycogen
36
DIABETES MELLITIS
Results… the 3 P’s
High blood sugar leads to high osmotic pressure
in blood and extracellular fluid… this sucks water
out of cells and dehydrates them
38
DIABETES MELLITIS
ENERGY PRODUCTION
Uncontrolled diabetics use fats and proteins for
their energy production.
When using mainly fats and proteins for energy,
and not supplying any glucose to the cells,
‘ketones’ build up in the blood, and make the
blood acidic… this leads to a state called
ketosis... this can lead to loss of massive
amounts of electrolytes in the urine, nausea,
vomiting, and eventually coma
As large amounts of fats are mobilized for use as
energy, blood triglyceride levels increase
(basically, ‘fatty blood’) leading to increased
atherosclerosis and vascular diseases. 39
FOSSIL FUEL OF THE FUTURE?
– In this proposal, a green algal system that uses solar energy to split water (H2O) into Hydrogen
(H2) and oxygen (O2), will be refined for large scale H2 production. Subsequent combustion of
H2 yields only H2O, eliminating both net H2O use and the production of harmful greenhouse 40
gases, associated with the burning of fossil fuels.