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NISSO HPC SSL SL L M H SFP

mPas @20C/2%aq 2.0 ~ 2.9 3.0 ~ 5.9 6.0 ~ 10.0 150 ~ 400 1,000 ~ 4,000
Molecular Weight/GPC method 40,000 100,000 140,000 620,000 910,000
A
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b
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Regular type 99% passes
through 40 mesh (350m)

Fine Powder type 99% passes
through 100 mesh (150m)

Super Fine Powder type
(D50 < 20m)

A
p
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l
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Film coating
Binding
Sustained release
Thickening
Solubility
HPC is soluble in water, water-free lower alcohols and
polar solvents. Solutions are transparent and have a smooth
feel. Solubility in organic solvents is limited only by the
viscosity increase.
Soluble
Water, Methyl alcohol, Ethyl alcohol, Isopropyl
alcohol, Pyridine, Cyclohexanone, Cellosolve,
Acetic acid
Hazy
Acetone, Tertiary butanol , Dioxane, Cyclohexanol,
Cyclohexanol, Lactic acid, Methyl ethyl ketone
Insoluble
Aliphatic hydrocarbons, Benzene, Xylene,
Glycerin, Toluene, Gasoline
TECHNICAL DATA SHEET
DATASHEET #: TDS-01
HPC Grades
OR
Hydroxypropyl Cellulose
(cellulose, 2-hydroxypropyl ether)
H
OR
CH
2
OR
CH
2
OR
O
O
O
O
H H
OR
OR H
H
H H
H H
R : -H CH
3
H
m CH
2
CH 0
or
CAS No. 9004-64-2
Chemical Structure
Aqueous Solution Dispersion
HEATING >>
<< COOLING
LCST = Lower Critical Solution Temperature
LCST
44~46 C
HPC-L at 20 C HPC-L at 50 C
Fig 3: Viscosity change vs. Temperature, Aqueous solution
Fig 6: Viscosity change vs. pH
Fig 4: Viscosity change vs. Temperature, Ethanol solution
Fig 7: Viscosity change vs. Days lapsed under UV radiation
Fig 5: Phase transition effect is completely reversible upon cooling
1
10 20 30 40
10
100
V
i
s
c
o
s
i
t
y

(
m
P
a

s
)
Temperature (C)
1000
1 60 50
HPC-M
HPC-L
HPC-SL
1
5 10 15 20 25
100
10
1000
V
i
s
c
o
s
i
t
y

(
m
P
a

s
)
pH value
10,000
0 30
HPC-H
HPC-M
HPC-L
1
10 20 30 40
10
100
V
i
s
c
o
s
i
t
y

(
m
P
a

s
)
Temperature (C)
1000
1 60 50
HPC-H
HPC-M
HPC-L & SL
0
1 4 7 11
20
10
30
V
i
s
c
o
s
i
t
y

(
m
P
a

s
)
pH value
40
0 14
HPC-H
HPC-M
HPC-L
HPC-SL
1
2 3 4 5 6
10
100
1000
V
i
s
c
o
s
i
t
y

(
m
P
a

s
)
Concentration (%)
100,000
10,000
1 10 8 9 7
H
M
L
SL
SSL
1
2 3 4 5 6
10
100
1000
V
i
s
c
o
s
i
t
y

(
m
P
a

s
)
Concentration (%)
100,000
10,000
1 10 8 9 7
H
M
L
SL
SSL
Fig 1: Viscosity change vs. Concentration, Aqueous solution Fig 2: Viscosity change vs. Concentration, Ethanol solution
Viscosity Change
Viscosity of HPC in aqueous solution is virtually unchanged in pH range from 1-12. HPC viscosity is also unaffected by UV
irradiation. Viscosity change caused by change in HPC concentration or change in temperature are shown in fgures below.
TDS-01
Version 1.0
Copyright 2011 Nisso HPC
Notice
The information described in this sheet is believed to be accurate and are presented in good faith
with no guarantee or obligation as to accuracy and no assumption of liability. Users should make
their own tests to determine the suitability of products for their own particular use. NISSO makes no
warranty of any kind, express or implied, including those of merchantability and ftness for particular
purpose other than the material conforms to its applicable current standard specifcations.
U.S./Canada
Nisso America Inc.
45 Broadway, Suite 2120
New York, New York 10006
(T) 212-490-3050
(F) 212-972-9361
www.nissoamerica.com
info@nissoamerica.com
Europe
Nisso Chemical Europe, GmbH
Berliner Allee 42, 40212
Duesseldorf, Germany
(T) +49-(0)-211-1306686-0
(F) +49-(0)-211-328231
www.nisso-chem.de
Head Ofce
Nippon Soda Co., Ltd
2-1 2-Chome, Ohtemachi
Chiyoda-ku, Tokyo 100-8165 Japan
(T) 81-3-3245-6159
(F) 81-3-3245-6059
info@nippon-soda.co.jp
Additives
Nisso HPC contains no silica or
other additives.
Compendial Status
USP/NF, EP, JP compliant; Food
use approved 21 CFR 172.870,
E463
Expiration
Expiration date is (3) years
from date of manufacture.
Physical and Chemical Properties Softening Temperature
Specifc gravity (particles) 1.2224
Coloring temperature 195-210C
Charring temperature 260-275C
Softening temperature (C)
1st transition 2nd transition
HPC-H 73 164
HPC-M 68 178
HPC-L 60 185
HPC-SL 68 192
HPC-SSL 75 183
HPC-SSL HPC-SL HPC-L HPC-M HPC-H
Bulk density loose (g/cc) 0.37 0.39 0.37 0.44 0.44
Bulk density tapped (g/cc) 0.55 0.51 0.48 0.54 0.53
Compressibility (%) 32.7 23.5 22.9 18.5 17.0
Angle of repose (Degree) 49 46 45 42 40
Particle size (D
50
) (m) 50-70 70-90 100-120 130-150 130
HPC-SFP HPC-SL (FP) HPC-L (FP) HPC-M (FP) HPC-H (FP)
Bulk density loose (g/cc) 0.24 0.32 0.33 0.37 0.33
Bulk density tapped (g/cc) 0.41 0.49 0.48 0.50 0.48
Compressibility (%) 41.5 34.7 31.3 26.0 22.3
Angle of repose (Degree) 50 47 47 46 44
Particle size (D
50
) (m) < 20 60-80 60-80 60-80 50-70
Powder Characteristics
Moisture Uptake
Fig 8: Moisture uptake at 50% and 80% relative humidity
0
1 2 3 4
6
2
8
4
10
12
14
16
M
o
i
s
t
u
r
e

c
o
n
t
e
n
t

(
%
)
Days elapsed (days)
18
0 6 5
HPC-L, SL
HPC-M
80% RH
50% RH
Packaging
Nisso HPC is available in a
10kg box.
Site of Manufacture
Nippon Soda Co., Ltd.
Nihongi Plant
350 Fujjisawa, Joetsu city
Niigata prefecture, Japan