DISEASE DESTROYS MANIFESTATIONS

Brown-Squard Sd

Dorsal columns (DC)

CorticoSpinal Tract (CST)
Descending Hypothalamics
SpinoThalamic Tract (STT)

LMN
Cause: spinal cord hemisection
Ipsilateral loss of propioception, vibration, pressure, fine
touch below lesion
Ipsilateral paresis below lesion
Ipsilateral Horners Sd
Contralateral loss of pain & T 2 segments below lesion.
Ipsilateral at level of lesion
Flacid paralysis at level of lesion

CST
STT
Spares DC

Cause: ASA occlusion
Bilateral spastic paresis
Bilateral loss of pain & T

UMN
LMN

Cause: nobody fucking knows,
some say is a defective SOD1
Bilateral spastic weakness of lower limbs
Bilateral flaccid weakness of upper limbs
Spinal muscular atrophy
Hyperreflexia, hypertonic

Demyelination of white
matter, random and
asymmetric
Cause: autoimmune, HLA-DR2
association
Motor & senstitive deficits. Scanning speech, intention
tremors, nystagmus, optic neuritis, internuclear
ophtalmoplegia, vertigo
Subacute combined
degeneration
Also: pernicious anemia
DC

Lateral CST
SpinoCerebellar Tracts


Cause: VitB12 def, pernicious
anemia
Bilateral loss of vibration, pressure, fine touch below
lesion
Bilateral spastic paresis below lesion.

Youve seen this! pt with megaloblastic anemia, weaker and
weaker until she couldnt walk nor feel her legs. Started
walking a little and with help after first complex B shot! She
was D/C when she totally recoverd motor fx.
Tabes Dorsalis

Dorsal roots
DC

Cause: 3 syphilis, use a
condom please
Loss of propioception high-step stride
Impaired vibration, pressure, fine touch, asterognosis,
paroxysmal pain, ataxia.
(+) Romber sign (with eyes close)
Argyll-Robertson pupils (ojos de puta: se acomoda pero no reacciona)

LMN

Cause: poliovirus (dsDNA,
icosahedral, naked, circular
virus)
Flacid paralysis
Hyporreflexia
Hypotonia, muscle atrophy
Fasciculations
Also: Werdnig-Hoffman disease (Infantile Spinal Muscular
Atrophy) destruction of ventral horn cells (LMN only)
Syringomyelia

STT crossing anterior White
commisure
LMN (ventral horns)
Descending hypothalamics.
Cause: progressive cavitation
of central canal
First Bilateral loss of pain & T sensation (hands,
forearms)
Then, bilateral flaccid paralysis (upper limb muscles)
Horners Sd: late manifestation