Professional Documents
Culture Documents
1. Name:
First name Sri Middle name balaji
Surname Ponraj
2. Male/Female: Male
6. Address:
E-mail bathani.rajbt@gmail.com
Skype id bathani01
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11. Academic Record:
12. Research interests, possible project ideas and what you hope to gain from this
experience.
Research interests:
Title: 8-OHdG – a novel Biomarker to evaluate Oxidative DNA damage in Micro
vascular Complications.
Description: Vascular complications are the leading cause of morbidity and mortality in
patients with diabetes. In nuclear and mitochondrial DNA, 8-hydroxydeoxyguanosine (8-
OHdG), an oxidized nucleoside of DNA, is the most frequently detected and studied
DNA lesion. Upon DNA repair, 8-OHdG is excreted in the urine. Numerous studies have
shown that oxidative DNA damage links pathogenically to a variety of aging-associated
degenerative diseases such as cancer, coronary heart disease and diabetes. Quantification
of urinary 8-OHdG, a specific DNA repair products in the urine, can be made with a
simple ELISA. Finally, the study of Urinary 8-OHdG can lead to predict the earlier onset
of vascular complications.
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Project ideas:
Title: Synthesis and Characterization of Cerium oxide Nanoparticle to study the
hyperglycemia induced Endothelial Dysfunction in Cultured Bovine Retinal Endothelial
Cells.
Description: In order to combat the hyperglycemia induced Endothelial Dysfunction in
humans, I have proposed that rare-earth cerium oxide (CeO2) nanoparticles (free-radical
scavengers) protect normal tissue from hyperglycemia induced damage. Earlier studies
and reports suggest that these nanoparticles may be a therapeutic regenerative
nanomedicine that will scavenge reactive oxygen species, which are responsible for such
induced cell damage. In the end, CeO2 nanoparticles provide a tremendous potential for
endothelial cell protection and can lead to significant benefits for the preservation of
human health and the quality of life for humans having Diabetes Mellitus.
Technical background:
Familiarized with the theoretical concepts and the practical applications of various
subjects like Bio-Nanotechnology, Nanolithography, Molecular Biology, Microbiology,
Animal Biotechnology, Plant Biotechnology and Immunology.
Internships:
Completed a project entitled “Strain improvement of Streptomyces.sp to
increase production of small molecules- Immunomycin” at Research and
Development Department, BIOCON LIMITED, Bangalore, India, from May 15th 2008
to August 16th 2008.
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Courses:
1. Undergone a training programme entitled “Maintenance of Industrially
important cells and their Molecular Characterization” organized by PSG
College of Technology Coimbatore and Supported by Department of
Biotechnology(Ministry of Science and Technology) from November 9th to
November 21st 2009.
2. Undergone an Inplant training programme at Quality Control and Production
Department, PHARMAFABRIKON Madurai, Tamil Nadu, India, from June
21st to June 27th 2006.
3. International Seminar and Workshop on Medical and Pharmaceutical
Nanotechnology held at Anna University Tiruchirappalli, Tamil Nadu, India
from September 25th to September 26th 2008.
4. National Workshop on MEMS in Biomedical Applications held at SSN College
of Engineering Chennai, Tamil Nadu, India from September 17th to September
18th 2009 .
Lab work:
PCR-RFLP, RAPD, Multiplex-PCR, Western Blotting, HPLC, Gel
Electrophoresis, Atomic Force microscopy, Scanning Tunneling Microscopy, Laser
Raman Spectro Photometer, Particle size Analyzer and Particle Spin coater.
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16. Supporting Documentation check-list:
Statement from Parent Institution (in the format provided in S.No. 14)