14/07/2014 06:22 Myoglobinuria - Wikipedia, the free encyclopedia

Page 1 of 2 http://en.wikipedia.org/wiki/Myoglobinuria
Myoglobinuria
Classification and external resources
Urine from a person with rhabdomyolysis showing the characteristic brown
discoloration as a result of myoglobinuria
ICD-10 R82.1
(http://apps.who.int/classifications/icd10/browse/2010/en#/R82.1)
ICD-9 791.3 (http://www.icd9data.com/getICD9Code.ashx?icd9=791.3)
DiseasesDB 23059 (http://www.diseasesdatabase.com/ddb23059.htm)
eMedicine ped/1535 (http://www.emedicine.com/ped/topic1535.htm)
MeSH D009212 (http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?
field=uid&term=D009212)
Model of helical domains in
myoglobin.
Myoglobinuria
From Wikipedia, the free encyclopedia
Myoglobinuria is the presence of
myoglobin in the urine, usually
associated with rhabdomyolysis or
muscle destruction. Myoglobin is
present in muscle cells as a reserve
of oxygen.
Contents
1 Causes
2 Diagnosis
3 Treatment
4 External links
5 References
Causes
Trauma, vascular problems,
venoms, malignant hyperthermia,
certain drugs and other situations
can destroy or damage the muscle,
releasing myoglobin to the
circulation and thus to the kidneys.
Under ideal situations myoglobin will be filtered and excreted with
the urine, but if too much myoglobin is released into the circulation
or in case of renal problems, it can occlude the renal filtration system
leading to acute tubular necrosis and acute renal insufficiency.
Other causes of myoglobinuria include:
McArdle's disease
Phosphofructokinase deficiency
[1]
Carnitine palmitoyltransferase II deficiency
malignant hyperthermia
Polymyositis
Diagnosis
14/07/2014 06:22 Myoglobinuria - Wikipedia, the free encyclopedia
Page 2 of 2 http://en.wikipedia.org/wiki/Myoglobinuria
Diagnosis
After centrifuging, the urine of myoglobinuria is clear, where the serum of hemoglobinuria after centrifuge
is pink to red.
Treatment
Hospitalization and IV hydration should be the first step in any patient suspected of having myoglobinuria or
rhabdomyolysis. The goal is to induce a brisk diuresis to prevent myoglobin precipitation and deposition,
which can cause acute kidney injury. Mannitol can be added to assist with diuresis. Adding sodium
bicarbonate to the IV fluids will cause alkalinzation of the urine, believed to reduce the breakdown of
myoglobin into its nephrotoxic metabolites, thus preventing renal damage. Often, IV normal saline is all that
is needed to induce diuresis and alkalinize the urine.
External links
Overview (http://neuromuscular.wustl.edu/msys/myoglob.html) on the Neuromuscular disease center
website.
References
1. ^ Toscano A, Musumeci O (October 2007). "Tarui disease and distal glycogenoses: clinical and genetic update"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949577). Acta Myol 26 (2): 1057. PMC 2949577
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949577). PMID 18421897
(https://www.ncbi.nlm.nih.gov/pubmed/18421897).
Retrieved from "http://en.wikipedia.org/w/index.php?title=Myoglobinuria&oldid=607028642"
Categories: Abnormal clinical and laboratory findings for urine Medical sign stubs
This page was last modified on 4 May 2014 at 14:18.
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