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Anterior Pituitary
Prolactin (High)
Breast
4. Haane has to use the bathroom constantly. Blood and urine samples were taken and gave
the following results:
• Plasma osmolarity: increased
• Urine osmolarity: decreased
• Urine osmolarity after water deprivation: no change
• Plasma ADH: high
Haane’s laboratory results are consistent with nephrogenic diabetes insipidus. Her kidneys are
unresponsive to ADH.
• Her plasma osmolarity is increased because she is excreting excess water in her urine
which concentrates her plasma
• Her urine osmolarity is decreased even after water deprivation (which normally would
concentrate the urine) because her kidneys are unresponsive to ADH and therefore cannot
concentrate urine.
• Her plasma ADH is high because her high plasma osmolarity stimulates the posterior
pituitary to secrete ADH despite the unresponsive nature of her kidneys.
5. Millie’s neural stalk was severed during surgery. She soon notices a milky discharge
from her nipples.
1
Hypothalamus
Dopamine (-)
Anterior Pituitary
Prolactin
Breast
The production of milk is a positive feedback loop is inhibited by dopamine. If Millie’s neural
stalk was injured, then she no longer has the dopamine suppression of milk production; hence the
discharge from her nipples.
6. If a person was given glucocorticoid drugs, which zones of the adrenal gland would
atrophy?
Zona fasciculata and zona reticularis.
The thicker middle zona fasciculata and the compact innermost zona reticularis produce
cortisol and androgens. They are regulated by ACTH. (Endocrine pathophysiology, p. 85)
9. Timmy the turtle moves slowly because of his hypothyroidism, how will his condition
affect his calcitonin levels?
His condition will probably not affect his calcitonin levels. Even though calcitonin is
regulated by the thyroid gland, its release is governed by the level of extracellular calcium
levels.
2
10. E
11. C
12. A
13. D
14. E