Tesamorelin Shown to Improve Liver Health in HIV Patients

Human Growth Hormone and Synthetic GH-RH have been used for many years as a treatment for
HIV/AIDS-Related Cacheia! a medical condition that causes "atients to build fat and lose muscle
mass as a result of their medical affliction# $io-Identical HGH and Synthetic GH-RH have the
ca"ability to reverse this catabolic "rocess! hel"in% "atients maintain a healthier body com"osition and
hel"in% them retain muscle stren%th#
&ow it a""ears that $io-Identical Hormone 'hera"y has another use for "atients that are sufferin% from
HIV and AIDS# 'here is "owerful new evidence that 'esamorelin In(ection 'hera"y has the ability to
"revent the accumulation of fat on the liver which is often a sym"tom of HIV Retroviral 'hera"y#
Tesamorelin Safely Helps Metabolize Liver Fat
In a recent article "ublished by the (ournal of the American )edical Association! Harvard )ed School
researchers assessed the benefits of In(ectable 'esamorelin 'hera"y on HIV/AIDS "atients! and
discovered that! in addition to hel"in% burn fat and maintain muscle! 'esamorelin GH-RH was also
effective at reducin% liver fat without havin% a ne%ative im"act on the body*s ability to "rocess %lucose#

'he lead investi%ator for this Harvard 'esamorelin Study is Steven Grins"oon! a medical "rofessor at
Harvard# He e"lains that 'esamorelin HGH has a statistically si%nificant ability to hel" HIV "atients
im"rove liver health and "revent bodyfat accumulation#
What is Fatty Liver Disease?
+atty ,iver Disease is a com"licated condition that ne%atively im"acts the health of many "atients as
they ta-e retroviral medications# In some circumstances! this condition doesn*t lead to any sym"toms!
but there is always a ris- that liver fat can lead to fibrosis! cell dama%e! and inflammation of the liver# If
this condition is left untreated! it can lead to liver cancer! liver disease! and cirrhosis#
+atty ,iver Disease does not affect all HIV "atients! but it is very common! im"actin% from thirty to
forty "ercent of "atients# 'his condition is fre.uently related to the develo"ment of a disorder -nown as
li"odystro"hy! but the the two conditions can a""ear inde"endently of one another# ,y"odystro"hy is a
medical condition in which fat accumulates ra"idly around the midsection! si%nificantly im"actin% the
health of the "atient#
Lypoystrophy is !nother "ommon Symptom of HIV Treatment
,y"odystro"hy is another common condition related to HIV 'reatment! affectin% twenty to thirty
"ercent of "atients treated for the virus# 'esamorelin is a GH-RH analo%ue which simulates the effects
of the hormone! increasin% the "roduction of natural HGH by the "ituitary# Human Growth Hormone
enhances cellular metabolism and restorative "rocesses! and this new evidence su""orts the hy"othesis
that Human Growth Hormone can miti%ate the side-effects of "owerful anti-viral dru%s! "reservin% the
health of the liver#

'esamorelin was a""roved in /010 to hel" HIV "atients treat bodyfat accumulation resultin% from
treatment! and this new study "roves that 'esamorelin "rovides even %reater benefits to these already
at-ris- "atients#
St#y So#$ht to !ssess the %enefits of Tesamorelin Therapy
'he %oal of this 'esamorelin AIDS study was to analy2e the benefits of 'esamorelin beyond those
benefits which have already been established# 'he researchers intended both to "rovide further
evidence of 'esamorelin*s ability to burn adi"ose fat tissue while also investi%atin% how the treatment
affected lean muscle mass! liver health! heart health! and inflammation#
3ri%inally! the researchers did not intend to analy2e the benefits of 'esamorelin with re%ard to +atty
,iver Disease! but because the body of research indicated that fatty liver disease is a ma(or health issue
amon% AIDS "atients! the study increased its sco"e#
Tesamorelin HIV St#y Information
A total of forty-ei%ht "atients "artici"ated in this study! all of which were bein% treated for HIV and
e"erienced bodyfat buildu" as a result of treatment# 'he sub(ects were divided into two %rou"s4 one
%rou" received "lacebo! and the other %rou" received In(ectable 'esamorelin on a daily schedule#
$ecause clinical evidence indicated that some "atients e"erience elevated %lucose levels as a result of
HGH 'hera"y! half the "artici"ants were also analy2ed with re%ard to their insulin levels and any si%ns
of insulin resistance#
'he study lasted for si months! and the "atients were assessed for chan%es every three months! after
their ori%inal consultation at the start of the study# Amon% the data collected at these (unctures were fat
metabolism! su%ar metabolism! and bodyfat "ercenta%e! as well as an analysis of liver fat#
Tesamorelin HIV St#y &es#lts
After si months of treatment! "atients that were selected for 'esamorelin In(ection e"erienced a loss
of bodyfat as well as a si%nificant yet relatively small reduction in liver fat# 3n the other hand! "atients
that too- "lacebo continued to deteriorate "hysically on both fronts#
Analysis of blood su%ar su%%ested that the body at first reacted to chan%es in HGH ,evels with a
reduction in insulin sensitivity! but after si months of treatment! the body fully acclimated to the
chan%e in Growth Hormone ,evels! meanin% that the ris- of insulin resistance was low! althou%h the
treatment did tem"orarily ne%atively im"act blood su%ar metabolism sli%htly#
Why Is It Important that Tesamorelin 'ot Impa(t Ins#lin Sensitivity?
'he lead researcher e"lains that 'esamorelin*s im"act on $lood Su%ar and Insulin is vital to assess!
because individuals with HIV and increased bodyfat are very li-ely to e"erience insulin resistance
already! so for 'esamorelin to be a worthwhile treatment! it needs to have a neutral im"act on %lucose
and insulin#
Dr# Grins"oon continued! e"lainin% that because liver inflammation is often caused by or eacerbated
by the accumulation of liver fat! it would be safe to assume that miti%atin% the volume of liver fat
would im"rove health outcomes for "atients ta-in% retroviral treatments for HIV# 5reliminary results
su%%est that 'esamorelin In(ection 'hera"y indeed had the ability to reduce liver inflammation! as
noted by diminished AS' levels which are indicative of the condition#
Possible F#t#re Tesamorelin St#ies
'he net ste" with re%ard to 'esamorelin HIV Research is to see how the Hormone 'hera"y im"acts
individuals sufferin% from steatohe"atitis! a dan%erous form of inflammation which -ills or severely
interferes with the health of liver cells# $eyond that! it will be im"ortant to assess the %eneral effect that
'esamorelin has on metabolism# )ore study needs to be conducted! but 'esamorelin GH-RH may also
be useful for "atients with fatty liver disease not caused by alcohol or HIV#