GENERIC NAME: Clarithromycin

BRAND NAME: Klaricid

Drug class: Antibiotic/macrolide
DRUG MECHANISM: semisynthetic macrolide antibiotic derived from erythromycin that is active against
a variety of microorganisms. It can inhibit protein synthesis in bacteria by reversibly binding to the 50S
ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain
elongation.
Indications: Lower respiratory tract infections; Upper respiratory tract infections; Skin and skin structure
infections; Acute otitis media.
Contraindications: hypersensitivity to macrolide antibiotic drugs, history of QT prolongation or ventricular
cardiac arrhythmia, should not be used concomitantly with HMG-CoA reductase inhibitors (statins),
lovastatin or simvastatin, due to the risk of rhabdomyolysis, should not be given to patients with
hypokalaemia (risk of prolongation of QT-time), should not be used in patients who suffer from severe
hepatic failure in combination with renal impairment.
DOSAGE: Klaricid Paediatric Suspension 250mg/5ml or Clarithromycin 250mg/5ml Granules for Oral
Suspension is indicated in children 6 months to 12 years.
ADVERSE EFFECTS: abdominal pain, diarrhoea, nausea, vomiting and taste perversion.
NURSING RESPONSIBILITIES:
1. Consider cross-sensitivity with other macrolides
2. Monitor serum levels of theophyline and carbamazepine
3. Instruct client not to take antijistamines


GENERIC NAME: fluticasone furoate
BRAND NAME: Avamys
Drug class: steroids/corticosteroids
DRUG MECHANISM: Avamys works by reducing the inflammation in the nasal passages. This helps to
relieve or prevent symptoms of rhinitis.
Indications: helps to reduce the symptoms of seasonal allergic rhinitis such as stuffy, runny, or itchy nose;
sneezing; and red, itchy, or watery eyes. This medication may start to work 8 to 24 hours after the first dose, but it
may take several days to reach its full effect.
Contraindications:
1. should not be used by anyone who is allergic to fluticasone furoate or to any of the ingredients of the
medication
DOSAGE: For children 2 to less than 12 years of age, the recommended starting dose is 1 spray in each nostril once
daily. The doctor may suggest increasing the dose to 2 sprays in each nostril once daily until symptoms are
controlled. Once the symptoms are under control, the doctor may suggest reducing the dose to 1 spray in each nostril
once daily.
ADVERSE EFFECTS: . nose bleed, headaches, dryness in the nose, hypersensitivity reactions including anaphylaxis,
angioedema, rash, and urticarial, fever, sore throat
NURSING RESPONSIBILITIES:
1. Do not double a dose to make up for a missed dose.
2. Do not get any spray in your eyes. If you do, rinse your eyes well with water
3. Take the nozzle out of your nose. Breathe out through your mouth