Professional Documents
Culture Documents
Newsletter
Of
NORTH EAST INDIA RESEARCH
FORUM
http://tech.groups.yahoo.com/group/northeast_india_research/
www.neindiaresearch.org
If we want to see a developed north east India in very near future, it is the right
time to work together dedicatedly. To initialize it, the senior personalities of well
established organizations of north east might forward their hands together for better
development of the region. As an example, persons from academia/ research
organization as well as industry might work together along with government for the
development of newer industries/organizations in the region. As north east region of
India has most of the natural resources which can prosper it if the resources available
could be properly utilized and exploited. Just to mention, it has huge bank of
petroleum oil, coal, platinum, and many medicinally important plants. As a beginning,
if north east could work for setting up organizations/industries mainly based on
information technology and pharmaceuticals, it might bring back numerous brains of
this region who are working presently in different parts of the globe. The recently
established Biotech Park at Guwahati will definitely boost the region and serve as a
pathfinder. We hope many more such organizations will flourish the north east in the
near future. The improvement of any region is only possible if the people take utmost
care to industrially develop such areas.
At last I wish North East India Research Forum a grand success and become
platform for such healthy scientific discussion in the days to come. I thank Dr. A.
Adhikari for his great idea of creation of such a nice forum. Recently we have started
forum cells in various universities and colleges of north east. Let us hope and wish
that our forum be a platform for excellent scientific discussion and popularization of
science among common peoples. Also I would like to thank all the members and
editorial board members for their dedication to work together for the newsletter. We
would specially like to thank Mr. Anirban (Panacea Studio, Pune) who has been
designing the cover page of NE Quest from the inception of the newsletter. Many
greetings to all!!
Pankaj Bharali
CONTENTS
1. THE FORUM 5
2. SHORT BIOGRAPHY (P.C. Ray and S.S. Bhatnagar) 8
3. SCIENCE NEWS 10
4. NORTH EAST INDIANS MADE US PROUD 22
5. MEMBERS IN NEWS / FELLOWSHIP 23
6. INSTRUMENT OF THE ISSUE (Raman Spectrometer) 24
7. ARTICLES SECTION
8. THESIS ABSTRACT
9. MEMBER’S FACE 68
10. READER`S PAGE 71
11. HIGHER STUDY ABROAD 72
12. OPPORTUNITIES /ADVERTISEMENTS/CONFERENCES 73
13. THROUGH THE LENSE OF THE MEMBERS 76
1. THE FORUM
3. Lack of work culture = 36%
North East India Research Forum was 4. Corruption = 18%
th
created on 13 November 2004. 5. Apathy from Central Govt. = 4%
200
1. Research articles = 33%
150 2. Information about
100 vacancy/positions available = 10%
50 3. Way to have a contact with all
0 members = 29%
0 20 40 60 80
4. Scientific discussions = 14%
Months
5. Others = 2%
Graph of no of members w.r.t. months
• Selection of name for Newsletter
2. Discussions held in the forum There were total 36 proposals submitted by
members of the forum for the Newsletter.
• Necessity of directory of all the The name proposed by Mr. Abhishek
members of the forum. Choudhury, N.E. QUEST received the
• Possibility of organising conference maximum number of votes and hence it is
in the N. E. India. accepted as the name of the Newsletter.
• Taking initiation on setting up of
South East Asian Scientific Institute. • How often should we publish our
• On selection of Best paper award. newsletter '' N. E. Quest’’?
• Let us introspect. 1. Every 3 months = 61%
2. Every 6 months = 38%
3. Poll conducted and results 3. Once a year = 0%
• North East India is lacking behind the 4. Editors of Previous NE-Quest Issues
rest of the country due to-
1. Vol 1 Issue 1 April, 2007
Editor: Dr. Arindam Adhikari
1. Geographical constrain = 0% 2. Vol 1 Issue 2 July 2007
2. Bad leadership = 40% Editor: Dr. Tankeswar Nath
5. A domain in the name of www. • North East India Research Forum cells
neindiaresearch.org is booked. have been started in the following
universities and colleges,
6. Future activities
Cell in the Dibrugarh University
Proper planning and consequent
Contact: Dr. Jitu Ranjan Chetia
implementation always play an important role
in every aspect. Some of the topics / activities Dept. of Chemistry
/ suggestions which were being discussed, Email: jituranjan@yahoo.co.in
time to time in the forum will get top priorities
in our future activities. Those are mentioned Cell in Tezpur University
here, Contact: Dr. Ashim J. Thakur
Dept. of Chemistry
• Preparing complete online database of Email: ajtthax@yahoo.com
N.E. researchers with details. Phone: +91 (3712) 267008/9/10 extn 5059
1. Anybody in the forum can start a While sending request or while fulfilling
meaningful and constructive discussion request for articles please follow the
after discussion with moderators. following points.
2. Comments from the individual
members do not necessarily reflect the • The forum has been formed to help
view of the forum. each other. When a member requests
3. No single moderator can take a articles/literature to forum, members of
crucial decision. All decision would be the forum are always happy to help the
taken by the moderators unanimously or person by supplying the articles. But at
together with the group as majority. this stage we have to keep in mind that
4. One should not write any massage the article should be sent to the person
to the forum addressing some particular who requested it, not to the whole
members. It should always start with Dear forum as it creates lots of unnecessary
all / Dear esteemed members etc. mails in the message box of the
3. SCIENCE NEWS
Nobel Prize in Science, 2009 passive. If there was nothing else, there
would be no life.
The Nobel Prize in Chemistry for The blueprints become transformed
2009 awards studies of one of life's into living matter through the work of
core processes: the ribosome's ribosomes. Based upon the information
translation of DNA information into in DNA, ribosomes make proteins:
life. Ribosomes produce proteins, oxygen-transporting haemoglobin,
which in turn control the chemistry in antibodies of the immune system,
all living organisms. As ribosomes are hormones such as insulin, the collagen
crucial to life, they are also a major of the skin, or enzymes that break
target for new antibiotics. down sugar. There are tens of
thousands of proteins in the body and
they all have different forms and
functions. They build and control life
at the chemical level.
An understanding of the ribosome's
innermost workings is important for a
scientific understanding of life. This
knowledge can be put to a practical
and immediate use; many of today's
antibiotics cure various diseases by
blocking the function of bacterial
ribosomes. Without functional
ribosomes, bacteria cannot survive.
This is why ribosomes are such an
important target for new antibiotics.
This year's three Laureates have all
generated 3D models that show how
different antibiotics bind to the
ribosome. These models are now used
This year's Nobel Prize in Chemistry by scientists in order to develop new
awards Venkatraman Ramakrishnan, antibiotics, directly assisting the saving
Thomas A. Steitz and Ada E. Yonath of lives and decreasing humanity's
(view clockwise in photograph) for suffering.
having showed what the ribosome
looks like and how it functions at the This year's Nobel Prize in Physics is
atomic level. All three have used a awarded for two scientific
method called X-ray crystallography to achievements that have helped to shape
map the position for each and every the foundations of today’s networked
one of the hundreds of thousands of societies. They have created many
atoms that make up the ribosome. practical innovations for everyday life
Inside every cell in all organisms, there and provided new tools for scientific
are DNA molecules. They contain the exploration. In 1966, Charles K. Kao
blueprints for how a human being, a (extreme left in photograph, view
plant or a bacterium, looks and clockwise) made a discovery that led
functions. But the DNA molecule is to a breakthrough in fiber optics. He
carefully calculated how to transmit
light over long distances via optical second part of the award. In 1969
glass fibers. With a fiber of purest Willard S. Boyle and George E.
glass it would be possible to transmit Smith (extreme right and down in
light signals over 100 kilometers, photograph, view clockwise) invented
compared to only 20 meters for the the first successful imaging technology
fibers available in the 1960s. Kao's using a digital sensor, a CCD (Charge-
enthusiasm inspired other researchers Coupled Device). The CCD
to share his vision of the future technology makes use of the
potential of fiber optics. The first photoelectric effect, as theorized by
ultrapure fiber was successfully Albert Einstein and for which he was
fabricated just four years later, in 1970. awarded the 1921 year's Nobel Prize.
Today optical fibers make up the By this effect, light is transformed into
circulatory system that nourishes our electric signals. The challenge when
communication society. These low- designing an image sensor was to
loss glass fibers facilitate global gather and read out the signals in a
broadband communication such as the large number of image points, pixels,
Internet. Light flows in thin threads of in a short time. The CCD is the digital
glass, and it carries almost all of the camera's electronic eye. It
telephony and data traffic in each and revolutionized photography, as light
every direction. Text, music, images could now be captured electronically
and video can be transferred around instead of on film. The digital form
the globe in a split second. If we were facilitates the processing and
to unravel all of the glass fibers that distribution of these images. CCD
wind around the globe, we would get a technology is also used in many
single thread over one billion medical applications, e.g. imaging the
kilometers long – which is enough to inside of the human body, both for
encircle the globe more than 25 000 diagnostics and for microsurgery.
times – and is increasing by thousands Digital photography has become an
of kilometers every hour. irreplaceable tool in many fields of
research. The CCD has provided new
possibilities to visualize the previously
unseen. It has given us crystal clear
images of distant places in our
universe as well as the depths of the
oceans.
forms them – telomerase. The long, Capturing sun rays in space to light
thread-like DNA molecules that carry up Japan
our genes are packed into
chromosomes, the telomeres being the AFP, 2009, Tokyo (Source: Times of
caps on their ends. Elizabeth India)
Blackburn and Jack Szostak
discovered that a unique DNA It may sound like a sci-fi vision, but
sequence in the telomeres protects the Japan’s space agency is dead serious:
chromosomes from degradation. Carol by 2030 it wants to collect solar power
Greider and Elizabeth Blackburn in space and zap it down to Earth,
identified telomerase, the enzyme that using laser beams or microwaves. The
makes telomere DNA. These government has just picked a group of
discoveries explained how the ends of firms and a team of researchers tasked
the chromosomes are protected by the with turning the ambitious, multi-
telomeres and that they are built by billion-dollar dream of unlimited clean
telomerase. energy into reality in coming decades.
Japan has long been a leader in solar
and other renewable energies and this
year set ambitious greenhouse gas
reduction targets.
If the telomeres are shortened, cells The solar cells would capture the solar
age. Conversely, if telomerase activity energy, which is at least five times
is high, telomere length is maintained, stronger in space than on Earth, and
and cellular senescence is delayed. beam it down to the ground through
This is the case in cancer cells, which clusters of lasers or microwaves. These
can be considered to have eternal life. would be collected by gigantic
Certain inherited diseases, in contrast, parabolic antennae, likely to be located
are characterized by a defective in restricted areas at sea or on dam
telomerase, resulting in damaged cells. reservoirs, said Tadashige Takiya, a
The award of the Nobel Prize spokesman at the Japan Aerospace
recognizes the discovery of a Exploration Agency (JAXA).
fundamental mechanism in the cell, a
discovery that has stimulated the The researchers are targeting a one
development of new therapeutic gigawatt system, equivalent to a
strategies. medium-sized atomic power plant that
onto rabbits that had their penises The findings of the study, led by Robin
removed. Choudhury of the department of
cardiovascular medicine at Oxford
The animals seemed to realize they had University, are published in this
working organs again — the 12 with week’s issue of the Journal of the
the grafts tried to mate with female American College of Cardiology.
rabbits within one minute of being put
into cages with them, and four of the This is an exciting find because it gives
female rabbits became pregnant. Those a new opportunity to treat
with the scaffolding alone and no cardiovascular patients, Choudhury
working tissue did not even try. told IANS. This is the first clear
evidence that a therapy to raise levels
Atala is hoping the procedure will of good cholesterol when taken
work with people, perhaps starting alongside statins can have a beneficial
with adult men who have had damage effect.
to their organs. “Patients with
congenital anomalies, penile cancer, The researchers used MRI scans to
traumatic penile injury, and some types show a reduction in the clogging of
of organic erectile dysfunction could artery walls in patients after a year of
benefit from this technology in the treatment with niacin, a B vitamin
future,” the team wrote in the report. commonly used to raise levels of high-
density lipoprotein (HDL) or ’good’
The process takes six weeks from cholesterol. Choudhury, whose father
beginning to end, he said, and there is is a retired surgeon at Nilratan Sircar
reason to believe a penis grafted onto a Hospital in Kolkata, said if the findings
baby would grow with the child. are borne out in ongoing larger studies,
this could benefit large numbers of
Atala hopes the approach will work people worldwide. A third to a quarter
with other organs. “We have made of all heart patients have low levels of
clitoral tissue in the past,” he said. good cholesterol, but niacin fell out of
Atala’s team started their experiments favour after being shown to be useful
with replacement bladders grown from in the early days of heart treatment, as
patients' cells. Patients fitted with statin became more common. Heart
artificial bladders have been enjoying disease is the biggest killer in the
good function for 10 years now, Atala Western world, and atherosclerosis the
said. ‘furring up’ or hardening of arteries is
closely linked to later heart attacks and
Drug with dual benefits for heart strokes.
niacin therapy the size of clogged mold, as well as bacteria, yeast and
artery walls in heart patients thinned other living organisms."
down by an average of 1.1 sq mm,
while those receiving a placebo saw an Garrett pointed to dust mites and mold
average increase of 1.2 sq mm. as particularly worrisome. A damp
building with high humidity may lead
Patients on niacin showed an average to increased levels of dust mites and
23 per cent increase in levels of good mold, leading to increased allergic
cholesterol and a reduction in bad respiratory symptoms, as well as the
cholesterol of 19 per cent. Our results worsening of asthma. And even if
are very encouraging in that they have someone is not allergic, molds may
shown a very definite potential benefit, produce mycotoxins and volatile
and will certainly increase the great organic chemicals (VOCs) that smell
interest in the large outcome studies bad and may cause respiratory
that are due to report in the next couple irritation, he said.
of years, he added. Two such studies
will report their results in the next few Dust mites are microscopic arachnids
years. that thrive in humidity. They cause
allergic reactions and trigger asthma
Heating, Air-Conditioning and symptoms. Nearly half of all young
Carpets May Be Hazardous To Your people with asthma are allergic to dust
Health mites; about 10 percent of the
population is allergic to dust mites.
(Source: ScienceDaily, 2009) Mold requires moisture to grow.
Indoor environments house many
Damp environments, poorly sources of moisture including
maintained heating and air- condensation and leaky pipes.
conditioning systems and carpeting
may contribute to poor indoor air Indoor Breathing Environment
quality, according to experts at the
annual meeting of the American Although there are many culprits that
College of Allergy, Asthma and negatively affect indoor air quality,
Immunology (ACAAI) in Miami poorly maintained air-conditioning and
Beach, Fla. Americans spend about 90 carpeting are among the most
percent of their time indoors, where problematic. "A home's heating and
they are repeatedly exposed to indoor air-conditioning (HVAC) system, if
allergens and airborne particles that poorly maintained, can become a
can lead to respiratory symptoms and major source of microbial allergens,"
conditions. said Garrett. According to Garrett, up
to 30 percent of the air inside a home
Damp Buildings can come from the attic, parking
garage or basement. One study
"If there was just one thing I could do supported by the EPA found that 75
to fix buildings, it would be to change percent of homes had carbon monoxide
the relative humidity," said Doug from the garage inside of the home.
Garrett, CEM, CDSM, building Like air conditioning systems,
scientist and president of Building carpeting often harbors allergens,
Performance and Comfort, Leander, including dust mites and molds said
Texas. "Moisture leads to conditions Jeffrey May, M.A., principal scientist
that are conducive to dust mites and of May Indoor Air Investigations LLC,
Tyngsborough, Mass. Organisms and there" said May. "And 'exhaust only'
particles that become airborne systems are not effective."
eventually settle in carpeting. In damp
environments, carpeting provides an Nanoparticles' indirect threat to
ideal environment for mold growth. DNA
"Many schools shampoo their By Janet Raloff (Source:
carpeting right before school starts at www.scincenews.org, 2009)
the end of summer when it's humid
outside," said May. "There couldn't be Tiny metal nanoparticles can damage
a worse time." DNA, essentially by triggering toxic
gossip. Researchers from throughout
Making a Healthier Indoor the United Kingdom took part in a
Environment series of tests in which they separated
toxic metal nanoparticles from
To improve indoor air quality, Garrett potentially vulnerable test cells —
lists several construction practices that, what I’ll refer to as cellular guinea pigs.
when done right, can make a In some cases the barrier was a piece
significant difference. These include of plastic, other times a four-cell-thick,
installing tight ductwork, achieving intact wall of tissue.
airtight construction, using a correctly
sized HVAC (heating, ventilation and Although the plastic wall protected the
air conditioning) system and making guinea pigs, “We found there was as
sure there is fresh air ventilation. much damage on the [far] side of the
Proper ventilation involves introducing cellular barrier as there was if a barrier
air from a known source and then hadn’t been there in the first place,”
filtering, dehumidifying and pre- observes C. Patrick Case, a researcher
cooling or heating it. "You can't build and pathologist at Southmead Hospital
houses too airtight," said Garrett. "But in Bristol, England. The finding, he
you can under ventilate them." admits, was “a huge surprise.”
Once built, maintenance becomes key. Particularly since the billionth-of-a-
May offers the following advice for meter-scale particles appear to have
home owners on making their indoor wreaked their havoc indirectly.
environments healthier: • Keep the air When tests indicated the nanoparticles
conditioner clean. Use a filter with an were not breaching the cellular wall,
American Society of Heating and Air- Case’s team began probing for
Conditioning Engineers (AHRAE) evidence of some type of cellular
Standard MERV (Minimum Efficiency signaling that might relay a damaging
Reporting Value) of at least 8. • Do not message to the DNA of cells on the
have carpeting in any buildings or opposite side. And indeed, the
homes where humidity can't be researchers report today in Nature
controlled. If you cannot replace carpet, Nanotechnology, the metal
vacuum thoroughly, carefully and nanoparticles triggered the generation
methodically so you don't stir dust into of ATP, a known signaling molecule,
the air. Use a vacuum with a HEPA within cells of the barrier wall. ATP —
filter or cyclonic vacuum. • Prevent and perhaps a chorus of related, but as
mold by dehumidifying the basement. yet unrecognized signaling molecules
In unfinished basements, humidity — whispered their chemical vitriol to
should be kept lower than 50 percent. neighboring cells.
Do research before buying a The final layer of that wall then spit
dehumidifier. "There are scams out out its toxic message, which triggered
improve the brain's ability to form been obtained. While M3 has covered
long-term memories. The studies were nearly 97 per cent of the lunar surface,
conducted in collaboration with some of the other instruments have
American researchers at the National covered more than 90 per cent, added
Institute on Drug Abuse (NIDA), NIH. ISRO.
5. MEMBERS IN NEWS/FELLOWSHIPS
Md. Harunar Rashid has recently Indian Institute of Technology
joined KAUST-Cornell Center for Bombay, India working under the
Energy and Sustainability, Cornell guidance of Prof. R. Murugavel.
University, USA as Postdoctoral
Visiting Scientist. Before his Dr. Bipul Sarma will be joining as a
postdoctoral assignment he was a Post Doctoral Fellow in the Chemical
senior research fellow at Materials and Biological Engineering
Science Division, Indian Association Department, Illinois Institute of
for the Cultivation of Science, Kolkata. Technology, Chicago, USA, under the
He submitted his thesis to Jadavpur direction of Prof. Allan Myerson w.e.f.
University, Kolkata working under the January 2010. He completed his Ph.D.
guidance of Dr. T. K. Mandal. thesis entitled "Structural and Thermal
Analysis of Organic Solids" from
Dr. Diganta Sarma recently joined University of Hyderabad, working
the Department of Medicinal under the guidance of Prof. A. Nangia.
Chemistry, University of Kansas, USA
as a postdoctoral research associate. Dr. Suranjana V. Mayani and Dr.
Prior to this postdoctorate assignment Vishal J. Mayani recently joined the
he worked in the Department of Department of Chemical Engineering,
Medicinal Chemistry, Kyoto Hoseo University, 165 Sechulri,
Pharmaceutical University, Japan as a Baebangmyun, Asan-sity, Choongnam
JSPS postdoctoral fellow w.e.f. 2007. (336-795) Korea as postdoctoral
Dr. Sarma was a PhD scholar of research associates. Dr. Suranjana
National Chemical Laboratory, Pune completed her Ph.D. thesis entitled
before joining as JSPS postdoctoral "Catalytic wet oxidation of phenol and
fellow. its analogues" from Gauhati University,
Guwahati, working under the guidance
Dr. Pranjal Kumar Kalita will be of Prof. K. G. Bhattacharyya. Dr.
joining as a Post Doctoral Fellow in Vishal completed his Ph.D. thesis
January 2010 at Iowa State University, entitles "Chirally modified silicas for
USA. He was a postdoctoral research separation and asymmetric catalysis"
scientist at National Institute for from Central Salt and Marine
Material Science, Tsukuba, Japan prior Chemical Research Institute (CSIR),
to this engagement. Dr. Kalita was a Bhavnagar, working under the
PhD scholar of National Chemical guidance of Dr. S.H.R. Abdi.
Laboratory, Pune before joining NIMS,
Japan. Mr. Kula Kamal Senapati visited
Taiwan in October to participate an
Dr. Nayanmoni Gogoi has recently international conference on Instrument
joined Laboratoire de Chimie de Technology for Application and
Coordination du CNRS, Toulouse, Development of Nanobiology and
France as a post doctoral researcher. Biosensors at ITRC, Hsinchu Science
He completed his Ph.D. thesis entitled Park, Taiwan. He has been selected
“Studies on Discrete Iron Phosphates along with other four Indians.
and Phosphonates, Layered Alkaline Presently, he is working as Scientific
Earth Metal Phosphonates and Officer at Indian Institute of
Polyhedral Tin Carboxylates” from Technology Guwahati.
A concave holographic-grating
spectrograph can also be used. This is
a single element spectrograph. A
reflective grating is formed on a
curved focusing surface to yield an off-
axis spectrograph. The grating is
Fig.2: QE curves relevant to Raman typically a holographic surface relief
Spectroscopy pattern with a reflective overcoat.
Due to the fact that Raman requires a Andor Mechelle: The Echelle grating
spectrograph, long and thin in the Mechelle Spectrograph is a very
spectroscopic chips are typically used, low-frequency reflective grating. The
(except when using an Echelle advantage of this type of spectrometer
z No moving parts
z Wide spectral coverage and high
resolution, simultaneously
z Large reduction in time when
collecting a complete spectrum
z Compact, rugged design
z Improved imaging performance
due to refractive optics
z Efficient coupling with fiber-optic
devices due to fast refractive
optics
Rayleigh Filters
z Subtractive Double
Spectrographs: a double spectrograph
functioning in subtractive mode is
often used as a Rayleigh filter. This is
typically followed by a single
dispersive spectrograph. A "triple"
spectrograph is very light-hungry and
has very poor throughput (~10%). It's
advantage is that it is almost infinitely
tunable.
----xxxx----
7. ARTICLE SECTION
(INVITED ARTICLE) the vice chancellor of the university
initiated electrochemistry research in
Two decades of electrochemistry the department two decades back
research in the Department of which is being continued in his and
Chemistry, Gauhati University, this authors laboratory.
India As research facility the
department now has – UV/Visible
Diganta Kumar Das spectrophotometers, FTIR
Reader, Department of Chemistry spectrophotometers, Atomic absorption
Gauhati University, Guwahati, India spectrophotometer, HPLC, GC-MS,
digkdas@yahoo.com GC, Fluorescence spectrophotometer,
Thermal Analyser, Elemental Analyser,
The department of chemistry Surface Area Analyser,
Gauhati University was established in Electrophoresis, 300 MHz H NMR (to
the year 1955 and earned the be installed) etc. Access to ACS
distinction of being the first publications through UGC-INFIBNET
department for post graduate studies in and Scifinder Scholar facilities are also
Chemistry and research in entire north available.
east India. The department attracted
international attention when a group of Electrochemistry research facilities
researcher discovered water soluble in the department:
vitamin A under the guidance of late The department owns one BAS
Prof R K Barua. The research on 100 B electrochemical work station
vitamin A is still going on in the and one CHI 600 C electrochemical
laboratory of Prof B C Goswami in analyzer. The later was purchased
collaboration with Iowa State under Fast Track scheme of
University, USA. The faculty members Department of Science and
since then did not left any stone Technology by this author. The
unturned to keep the status of research spectroelectrochemistry set up and
in the department at highest possible impidence spectroctroscopy are also
level. The department now has strong available in the laboratory of this
group of researcher in the field of – author. The electrodes the department
Environmental pollution and remedies have includes Glassy Carbon, Platinum,
(Prof K G Bhattacharyya and Prof A K Gold, Silver, Ag-AgCl and Calomel as
Misra), Inorganic synthesis and crystal reference besides Gold and Platinum
engineering (Prof B K Das), Organic ultramicroelectrodes. The Farady case
synthesis and Natural Products (Prof S with cell stand coupled with nitrogen
K Bhattacharyya, Prof P J Das, Dr P gas pursing lines and magnetic stirring
Phukan), Catalysis by zeolites and facilities are also available. Although
Clay (Prof J N Ganguli and Dr A K cyclic voltammetry is mostly used
Talukdar), Computational Chemistry technique, other techniques which are
(Dr C Medhi), Conducting Polymer also quite often considered are Square
(Prof D K Kakati) and Supra Wave Voltammetry (SWV), Chrono
Molecular Chemistry (Dr R J Sarma). Coulometry and Chrono Amperometry
New incumbent S K Gogoi is creating (CA).
facilities for research on
nanotechnology. Prof O K Medhi, now
reserves, will likely cover all but a few to most microorganisms. In these
specialized environments, so it should techniques, cryoprotectants and growth
not establish special reserves for conditions are also important for
maintaining microbial diversity. successful preservation. The
However, we also need to preserve conservation results could be affected
microorganisms off site. The by lots of factors during the
techniques to maintain microbial (virus, preliminary culture preparation, by the
bacteria, fungus) diversity include: choice of protectants, preservation and
regeneration methods with minimum
(i)Isolating and sampling: These consequences for the strains. With the
methods are used to obtain pure strain development of microbiology the
microorganisms for special needs and requirements for the culture
keep them in a suitable medium, which preservation increase. It is not enough
contains the nutrition, as the to perform a successful conservation; it
microorganisms need. is also necessary to keep the strain for
a long–term period.
(ii)Microbial identification: The
procedure of the identification involves 1.1. Some Microbial culture
staining standard and microscopic collections in India
examination, and also includes
biochemical analysis of proteins and • Biodiversity Documentation Centre,
DNA. Jawaharlal Nehru –
• Centre for Advanced Scientific
(iii)Storage of microorganisms. To Research, Jakkur, Bangalore
preserve microorganisms is to maintain • Centre for Cellular and Molecular
a strain for an indefinite period or Biology, Hyderabad –
continuous culture. • College of Agriculture, Maharana
Pratap Agricultural University,
It is important that Udaipur
microorganism resources are preserved • Defence Material and Stores
in a physiologically and genetically Research and Development
stable state. Therefore, frequent Establishment Culture Collection
subculturing on a slant is not • Defence Research and
recommended. Subculturing may also Development Organization, New
lead to contamination. A variety of Delhi
methods are available for strain
• Delhi University Mycological
preservation, which keep their vitality
Herbarium
and authenticity. The major methods
• Department of Microbiology, Bose
that give stable preservation are freeze-
Institute
drying, L-drying (drying from the
• Division of Standardization, Indian
liquid state), cryopreservation (in the
Veterinary Research Institute,
vapor phase of liquid nitrogen or in a
Izatnagar, Bareilley, UP
deep freezer) and subculture under
mineral oil (Mikata 2002; Smith and • Fungal Culture Collection,
Onions 1994). The methods used for University of Delhi, New Delhi 70
preservation depend on the microbial strains of fungi
species. Freeze-drying is suitable for • Indian Institute of Science,
preservation of bacteria, Bangalore http://www.iisc.ernet.in
Actinomycetes, yeasts, and spores of • Indian Type Culture Collection
fungi. Cryopreservation is applicable
Data exist that some bacteria are years (Arkadieva and Pimenova, 1985;
conserved for 5 to 12 months and Kupletskaya and Arkadieva, 1997).
microscopic fungi over 5 years. Fungi
are the longest preserved by 2.3. Water or water–salt solutions:
subcultivation strains and have been There are data for
kept since 1895 (Novik et al., 1998; microbiological objects preserving in
Valagurova et al., 2000). water or water–salt solutions. The cells
are placed in indifferent liquid medium
and they approach a hypobiotic state.
The suspension density, the presence
of Ca2+ ions in the medium, the
solution composition and pH, the
preservation temperature influences the
quantity and protection of the cells at
rest. For example, it is determined that
direct cause for the accelerated death
of Escherichia coli with population
number over 109 cells/ml is the
Figure shows a part of Streptomyces cultures accumulation of lethal metabolites in
producing bioactive metabolite maintained in the intercellular medium. Their
slants at TRA, Jorhat
concentration grows with the cell
density increasing. The optimal pH for
2.2. Mineral oils:
1 month preservation of E. coli is pH 8
Other cultures preservation
and for S. cerevisiae - pH 5.5. This
method is under mineral oil. It was
method is recommended for short term
applied for the first time in 1914 by A.
storage at 4-8 °C for 1 week to 12
Limier to keep the gonorrhea agent
months (Claudia et al., 2002; Vachitov
(Neisseria gonorrhoeae). In 1921 by
and Petrov, 1992).
this way M. Michelle preserved in
broth gonococci, meningococci and
2.4. Drying:
pneumococci (Krasilnikov, 1967). The
The cultures conservation
method essence is covering the well
method that imitates the natural
grown culture on liquid or agar
conditions is drying preservation. It is
nutrient medium with sterile non-toxic
based on the natural microorganism
mineral oil. The most common used oil
properties to fall into anabiosis. Sand,
is paraffin or vaseline with layer
soil, mud, active carbon, saw-dust,
thickness 1 to 2 cm. The aim is to limit
synthetic balls and tablets, polymer
the oxygen access that reduces the
matrixes, high disperse materials, filter
microorganisms’ metabolism and
paper etc are used as microbic material
growth, as well as to restrict the cell
carrier. The large carrier surface
drying during preservation in freezing
adsorbs part of the moisture. The
conditions. According to some
drying is performed at room
investigations the microorganisms
temperature or by heating up at 36-
conservation period under Vaseline oil
40°C. In 1966 Coe and Clark applied
without subcultivation is 1 to 12 years
the method for strains Staphylococcus
depending on their properties. Optimal
aureus, announcing preservation date 6
and utmost time limits are established
months (Norris and Ribbons, 1970).
for cultivation of different taxonomical
There are references for
groups. Different genera yeasts are
stability investigations after
studied and it is determined that the
conservation on different carriers and
conservation period varied from 1 to 7
N. E. Quest; Volume 3, Issue 3, October 2009 39
Newsletter of North East India Research Forum
3. Protectants
Protective compounds- cryoprotectants, 5. Example of data sheet to create
are found to eliminate most of the industrially important microbial
multiple destructive factors during database:
freezing of biological structures. Name of the Microorganisms :
According to the location of their
action the cryoprotectants are divided Collection Details: Biochemical Tests:
in two groups:
Collection No: Urea Hydrolysis:
• endocellular cryoprotectants – media, Collected By: Catalase Test:
penetrating cells;
Date of collection: Citrate Utilization Test:
• extracellular cryoprotectants – media,
connecting with the extracellular water. Season (Weather): Methyl Red Test:
Locality: Gelatin Liquification Test:
Endocellular protectants: The
application of protective media with Site : Nitrate Reduction Test:
endocellular mechanism presents a cell
District: Starch Hydrolysis Test:
penetration. The media overcooling
before the freezing contribute to small State : Test for Indole Production:
crystal formation, which restricts the
Altitude: H2S Production Ability:
mechanical disturbing action during
the cryogenic treatment. The main Habitat: Ammonia Reduction Test:
endocellular protective media are
Soil (type, pH): Endospore Formation:
glycerol (glycerin, 1, 2, 3 propantriol,
C3H8O3) and dimethylsulphoxid Substrate: Special Characteristics:
(DMSO, C2H6SO).
Temperature:
Extracellular protectants: Some of Morphology:
the extracellular protectants applied to
preservation 16S rRNA sequence data:
of the biological objects in frozen state Similarity with other organisms (With
are polyvinylpyrrolidone, hydroxyethyl the help of Blast)
starch and dextran.
6. Conclusion:
4. Quality control after preservation: For all biological materials
After preservation of a preservation, cryopreservation and
microbial strain controls are freeze-drying are the preferred
necessary. At least viability and techniques for long-term storage. The
purity, and where appropriate, the potential of storing lives is extended to
identity of the preserved culture have many thousands of organelle, cell,
to be checked immediately after tissue, organ, and body types including
preservation. A registration form for microorganisms, plants and animals.
the freeze-drying process per batch More recently, cryopreservation has
(e.g. vacuum, product temperature, been used as an appropriate technique
shelf temperature, condenser to preserve plants and animal species.
temperature, time) should be filed. However, many cells and tissues,
Any remark on the viability or which need for long-term bio-storage
properties of a batch has to be await suitable methodologies. As
archived and remain available to different biologies of organisms make
compare with future controls. different responses to cryoprotectants
----xxxx----
WHAT IS SCIENCE?
cut and thrust differ from the manner Cancer Drug Delivery and
in which a savage wields his club. Challenges
Thomas Henry Huxley (1825-95)
English biologist. "The Method of Manashjit Gogoi
Zadig" in Collected Essays IV. Indian Institute of Technology,
Bombay
Science is nothing but developed
perception, interpreted intent, common Cancer represents perhaps two hundred
sense rounded out and minutely diseases that cause abnormal and
articulated. uncontrolled growth of malignant cells.
George Santayana (1863-1952) U. Cancerous cells are highly unorganized
S. philosopher and writer. The Life and irregular in shape and size. The
of Reason. internal structures of cancerous cells
are inconsistent and misshapen. It is a
Science is facts; just as houses are life threatening disease that has been
made of stone, so is science made of affecting mankind since ancient times.
facts; but a pile of stones is not a house, Bone cancer has been discovered in the
and a collection of facts is not mummies of Egyptian and Peruvian
necessarily science. civilizations. Symptoms of cancer and
Jules Henri Poincaré (1854-1912) primitive ways of treatment were
French mathematician. documented in papyruses of different
ages such as Edwin papyrus (2500BC),
Science is the great antidote to the Leyde papyrus (1500BC), and Ebers
poison of enthusiasm and superstition. (1500BC) etc. Hindu epic the
Adam Smith (1723-90) Scottish Ramayana (500BC) too describes the
economist. The Wealth of Nations, use of arsenic paste for cancer
1776. treatment. Around 400BC, the term
“carcinoma” was coined to represent
Science is what you know. Philosophy cancer by Hippocrates- father of
is what you don't know. medicine. Carcinoma comes from
Bertrand Russell (1872-1970) Greek “Karkinoma” meaning
English philosopher, “Crab”[1]
mathematician.
The exact causes and the ways of
It requires a very unusual mind to initiation and spreading of cancer are
undertake the analysis of the obvious. still not well understood, but both
Alfred North Whitehead (1861- external factors (e.g. tobacco smoking,
1947) English philosopher and infections, exposure to retroviruses,
mathematician. chemicals and radiations) as well as
internal factors (e.g. inherited
[Science is] the labor and handicraft of metabolism mutations, hormones and
the mind. immune conditions) are believed to be
Francis Bacon (1561-1626) the reasons for cancer formation and
English essayist, philosopher, growth. These factors may act together
statesman. or in sequential manners to initiate and
promote cancer. Till date, no complete
[Science is] the literature of truth. curing procedure for cancer is
Josh Billings (Henry Wheeler available, only remission or palliation
Shaw) (1818-85) U. S. humorist. is possible with the current treatment
----xxxx---- procedures. A cancer is said to be in
remission state when all clinical dose of anticancer drug could not
evidence of cancer has been administered to the patient(s). So,
disappeared and the microscopic foci treatments become futile. One more
of cancer cells may still remain. problem associated with the
Effective treatment modalities include chemotherapeutic drug is that the
surgery, radiotherapy, chemotherapy, tumor cells become resistant to
hormone therapy, immunotherapy and multiple drugs i.e. development of
hyperthermia. Each of these modalities multiple drug resistance (MDR) cells.
has their own advantages as well as Exposure to drug results in over
disadvantages and usually combination expression of certain proteins like P-
of two or more modalities give the best glycoprotein (P-gp), Multidrug
result. Early detection, regular Resistance-associated Protein (MRP),
screening, examinations and then Lung Resistance related Protein (LRP)
application combination therapy play etc. in tumour cells. These P-gp and
an important role in cancer prevention MRP are expressed in cell membrane
and treatment. It is evident that the risk and they pump out the drug from the
of developing cancer can be reduced cancer cells and hence responsible for
by controlling tobacco and alcohol, substantial reduction of effect of drug.
obesity and sun exposure, having LRPs are present in cytoplasm of cell.
healthy diet and physical activity. There exist few other groups of
Routine cancer screening is also a proteins which are responsible for
necessary to prevent cancer [2,3]. development of MDR cells by altering
the drug target through gene mutation.
Chemotherapy is the treatment Therefore, people are looking for more
procedure of any disease using a advanced drug delivery systems [2, 4].
specific drug. Chemotherapy for
cancer is used in a narrower sense of
treating cancer with the aim to kill or
control cancerous cells. The
chemotherapeutic drug is highly toxic
or even life threatening. More toxic
drugs are more effective. They kill
both malignant and normal cells. So,
due to the application of
chemotherapeutic drug (s), patients Nano-carrier Drug Tumour cell Endothelial Cell
have to tolerate lot of side effects and Figure: EPR effect where nano-carriers reaches the tumour cell through the
sustain in blood for long time, (ii) acid tagged nanoparticles can be used
sufficient tumor accumulation and (iii) for active targeting of this kind of
controlled drug release. cancer cells. Similarly, anti-HER2
(Human Epidermal growth factor
It is well established that nanoparticles Receptor 2) antibody can be
are often engulfed and cleared by conjugated to target some of the breast
reticuloendothelial system (RES). RES cancer cells having higher expression
is a part of our immune system (body’s of HER-2. There exists a host of
defence system) and it clears the proteins/ receptors in different cancer
foreign materials from our body. The cells to target drug delivery [5].
nanoparticles could be made to escape
from RES system and long circulating Once the drug loaded nanoparticles
in the blood by modulating the size, reach the tumor sites the next objective
surface size and composition. Often is to effectively release the drug there.
these nanoparticles are coated with Different triggered release mechanisms
polyethylene glycol (PEG) to make like acid triggering, light triggering,
long circulating. PEGylation of heat triggering and enzyme triggering
nanoparticles inhibits the adsorption of are being tried to release the
protein on the nanoparticles surface chemotherapeutic drug at the tumor
makes them stealth nanoparticles and site.
hence protects it from being opsonized.
Although application nanomedicine, is
The microvasculature of tumor tissue able to address lot of problems raised
is not uniform and the lymphatic in convention chemotherapy, lot more
drainage system that removed the problems are still there to be answered.
body’s waste is also not well organized. Introduction of pegylated/stealth
As shown in figure, the portion of the nanoparticles, increase the efficacy of
blood vessels that supplies nutrients to anticancer drug but it has some side
the tumor becomes leaky and effects like skin toxicity, hand–foot
unorganized. Normal drug present the syndrome also. Passive targeting via
blood can reach different parts of the EPR effect reduces the toxicity of
body even through the well organized anticancer drug. Nanoparticles are
endothelial cells, but nanoparticles supposed to get accumulated in tumor
cannot go through the well organized tissues only, but they accumulate in
endothelial cell due to their size. But it lung, liver, spleen and kidney due to
can reach the tumor sites through leaky porous microstructure of these organs.
vasculature and get accumulated there Active targeting process has also some
because of the poor lymphatic drainage problems like: (i) antibody tagged
system. This process is called nanoparticles bind to their targets so
Enhanced Permeability and Retention strongly that they make a barrier that
(EPR) effect. It is passive targeting of won’t allow other nanoparticles to
the cancer cells. The other way of enter into the tumor sites and (ii) they
targeted drug delivery is active are very rapidly cleared by RES
targeting. Cancer cells over express system. Since there is lot of challenges
some of proteins or receptors e.g. folic in cancer drug delivery, it bears lots of
acid is required to cell proliferation. potentials also. So, extensive research
Due to higher proliferation rate cancers is going on world-wide on cancer drug
cell need folic acid and folic acid delivery to solve these issues and
receptor are being over expressed on significant mile-stone yet to be
the surface of tumor cells. So, folic achieved. We hope with rapid
Further reading:
Anchoring of dopamine
molecules on the surface of NiFe2O4
has been achieved via refluxing.
N a 2 P d C l4
D A in H 2 O Pd
R eflux/ S on ication D il N H 2 N H 2
pH -9
enzymes that catalyze the oxidation of and titania. Solid acid catalysts are
halides by H2O2. VHPO possesses found to replace not only mineral acids
trigonal bipyramidal geometry around but also catalyze the organic reactions.
vanadium in the native site and a After laying the foundation as
distorted tetragonal structure in the indicated above, the scope of work in
active form (peroxo-intermediate). the present Ph. D research have been
Structural characterization has revealed brought out very clearly.
that vanadate is covalently linked to
the Nε of the imidazolyl moiety of a
Chapter 2: Materials and Methods
histidine amino acid, and further
through hydrogen bonds to a variety of
amino acid side chains (e.g. Arg, His, The sources of chemicals and
Ser, Lys) and interstitial water in the solvents, methods for quantitative
proximity of the active center. Special chemical estimations, determination of
emphasis has been put on to the elements and particulars of all
understanding of chemistry of equipment used for physico-chemical
bromoperoxidase activity because of studies are provided in this Chapter.
its remifications on the synthetic The characterization was done using a
applications to bromo-organic variety of physico-chemical techniques,
compounds having commercial for example, elemental analysis, IR,
importance. Quite apart from the UV-Visible, Raman, GC-MS, NMR,
activity highlighted above, SEM, XRD.
peroxovanadium complexes are also
found to be potential clinical Chapter 3: Synthesis,
alternatives of insulin for the treatment Characterization of newer
of diabetes. Hence, insulin-mimetic Peroxovanadates and Study of their
action of peroxovanadium complexes Reactivity
is briefly reviewed in this Chapter.
Besides bio or abiomimetic catalysis, With the increased interest as
development of abio catalytic systems (i) model for vanadium haloperoxidase,
is yet another domain of contemporary (ii) compounds with insulin mimetic or
importance. This aspect, with reference antitumor activity and (iii)
to heterogeneous catalysis and its stoichiometric or catalytic oxidants of
direct bearing with Green Chemistry organic compounds, a myriad of
and Green Technology has been dully peroxovanadium compounds has been
projected in this Chapter. The potential studied in the last two and a half
advantages of heterogeneous catalyst decades. In continuation to our interest
in organic reactions are (a) good in the chemistry of peroxo and
dispersion of active sites, (b) heteroligand peroxo compounds, the
constraints of the pores, (c) easier and following work has been done as a part
safer to handle, d) easier to remove of the present Ph.D. research.
from the reaction mixture and (e)
reusability. Among various Accordingly, this Chapter
heterogeneous catalysts, the focuses on the synthesis and
importance of solid acid catalyst has characterization of newer peroxo-
been emphasized in this Chapter. The vanadium complexes with
effects of supported material in heteroligands such as 3,5-dimethyl
reactivity of solid acid catalysts have pyrazole and citric acid, at or near
physiological pH. Interestingly, while
been also discussed, synthesizing the abovementioned
highlighting the importance of alumina
Scheme -1
from the basal plane is 0.687 Å. The
V=O, V-O (peroxo) and V-N bond
lengths are 1.59 Å, 1.85-1.91 Å, 2.10
Å, respectively similar to those
sulfide, alcohol and also bromination extract bromide from “bittern” (Sea
of chalcones. water), the natural source of bromide
and also demonstrate a catalytic
An internal comparison of the
protocol for bromination of phenol
results has been made to enable us
with sea water without external
comment on their relative efficiency.
addition of Br -.
The reactivity order of the catalysts is
found to be as follows: In order to make the
presentation more articulate, this
Chapter has been divided into two
Na2[V2O2(O2)4(dmpz)] (3) >
DmpzH[VO(O2)2(dmpz)] (1) > sections. While Section 4.1 includes
K[VO(O2)2(dmpz)] the extraction of bromide from sea
(2) >
water as quaternary ammonium
Na3[VO(O2)2(C6H6O7)].4H2O (10) >
A2[V2O4(C6H6O7)2].2H2O [A = Na(4), tribromides followed by their
K(5), NH4(6)] characterization, the methodology for
>
A2[V2O2(O2)2(C6H6O7)2].2H2O (A = oxidative organic bromination of
Na(7), K(8), NH4(9) phenol without isolating the active
>
brominating species from sea water is
A3[VO(O2)2(OH)(O2)2OV], [A =
Na(11), K(12), NH4(13)] > incorporated in Section 4.2 of Chapter
A3[VO(O2)2(F)(O2)2OV], [A = Na(14), 4.
K(15), NH4(16)].
Section 4.1 Extraction of Bromide
from Sea bittern: An Eco-friendly
Chapter 4: Oxidative Extraction of Bio-mimetic Process
Bromide from ‘Sea Bittern’ and
Bromination of phenol directly with The detailed experimental
sea bittern by bio-mimicking procedure for extraction of bromide
catalysis has been laid out in this section.
It is now well established that Tetrabutyl ammonium tribromide
the naturally occurring bromoorganic (TBATB), benzyltrimethyl ammonium
compounds in marine aquatics are tribromide (BTMATB),
catalyzed by VBrPO enzymes in cetyltrimethylammonium tribromide
presence of H2O2 followed by (CTMATB), tetraethyl-ammonium
bromination of the organic substrates. tribromide (TEATB), and
However, synthetically bromoaromatic tetramethylammonium tribromide
compounds are prepared by (TMATB) have all been prepared from
bromination with molecular bromine sea water and characterized.
which has been a cause of great
environmental concern. Taking cues
from the bromoperoxidase activity and Catalyst, H2O2 , H+
keeping environmental safety in mind 3-4 hrs
in conjunction with knowledge and
experience that we gained in the
peroxovanadium chemistry, it was Figure 5 Pictorial representation of
possible to develop newer and eco- extraction of bromide from sea water
friendly brominating agents i.e.
tribromides, “the store house of A set of catalysts has been separately
bromine” and bromination protocols used to extract bromide from sea
from a solution of KBr or NH4Br. In bittern. Bromide (present as MgBr2)
the present Ph.D. work, like my was oxidized by H2O2 in presence of
predecessor, it has been possible to
each catalyst and very dilute H2SO4. catalyzed by solid acids, nitration and
The efficacy of the catalysts was sufoxidation cannot be ignored.
assayed by the isolation of TBATB, Nitration of organic compounds
and then the best catalyst was occupies an important position in the
identified. chemical industries because
nitroaromatic compounds are
extensively utilized as chemical
Section 4.2. Direct Bromination of
feedstocks for a wide range of useful
Phenol with Sea bittern
materials. Likewise, sulfoxides are
This section is to demonstrate synthetically useful intermediates for
the bromination of phenol directly by the construction of various chemically
sea bittern as a representative example. and biologically active molecules
Several test runs have been carried out including therapeutic agents such as
and the reactions were monitored by anti-ulcer, antibacterial, antifungal,
GC to calculate the yield of the anti-athrosclertic and antihypertensive,
reaction. Generally, bromination of for instance. Hence selective oxidation
phenol results in mono-, di- as well as of organic sulfides to sulfoxides is a
tri- bromo phenol. However, pivotal reaction in the sphere of
controlling the experimental conditions, organic synthesis.
we have been able to obtain p-
This Chapter describes
bromophenol selectively with 70%
preparation and characterization of two
conversion. This appears to be a useful
newer solid acid catalysts followed by
observation.
their application in selected organic
transformations, viz. nitration of
Chapter 5: Development of Solid
organic compounds and oxidation of
acid Catalysts for Organic
thioethers.
Transformations
(a) Preparation and Characterization of
Heterogeneous catalysis is a rapidly Newer Solid Acid Catalysts
growing area as it assists in controlling
the environmental pollution. It has Two solid acid catalysts have been
many advantages like easy operation, developed by control heating and
separation, reusability and hence kneading of alumina or titania with
widely used in petrochemical phosphoric acid at a range of
industries. Among heterogeneous temperature 200-2200C. With the
catalysts, solid acids have been the specified molar ratio, this process
subject of most detailed and extensive resulted in the formation of Al(H-
studies. They have been introduced 2PO4)3, (A-cat) and
mainly to replace highly corrosive (TiO2)5.45[Ti4H11(PO4)9].4 H2O, (T-
mineral acids in reaction medium. cat) with alumina and titania,
Hence, they are the beginners to play a respectively. The catalysts were
significant role in the greening of fine characterized by chemical analysis as
and pharmaceutical chemical well as IR, powder XRD, SEM/EDAX,
manufacturing processes. In this regard, TG/DTG analysis.
several solid acid catalysts have been
developed for some organic (b) Nitration of Organic Compounds
transformations. While discussing with Nitric Acid
industrially important organic reactions
Both A-cat and T-cat serve as
efficient solid acid catalysts for
Ce3+/Ce4+ with the ability of ceria to release of oxygen i.e., the oxygen
shift between CeO2 and Ce2O3. Despite mobility was proposed to be due to the
widespread applications, pure ceria is presence of O vacancies associated
poorly thermostable and undergoes with terbium incorporation to ceria
rapid sintering under high temperature lattice. The Tb takes part in the crystal
conditions, which leads to loss of defect generation and thereby O
oxygen buffer capacity and vacancies in ceria host by generating
deactivation of the catalysts. Therefore, strain in the lattice. The nature of
several attempts to overcome the support imposes a huge influence on
problem were made in the literature the physicochemical and catalytic
and are still a matter of interest. One properties of the oxide catalysts.
such approach is the substitution of Unsupported oxides are susceptible to
another metal or metal oxide into the a fall in the surface area and a decrease
ceria lattice, thereby facilitating the in the stability during high temperature
formation of mixed oxides. The applications. Therefore, investigation
combination of two metals in an oxide of CeO2-TbO2 mixed oxides on various
can lead to novel structural and supports is highly essential for better
electronic properties of the final oxide, catalytic evaluation. Motivated by
consequently favouring its catalytic these facts, preparation of various
activity and selectivity. Particle size, unsupported and supported CeO2-TbO2
phase modification, structural defects catalysts [CeO2-TbO2/M (M= Al2O3,
and chemical non-stoichiometry also SiO2, and TiO2)] was planned for the
influence the redox and catalytic present investigation. Modified
properties of the ceria and its aqueous coprecipitation and deposition
composite oxides. As a result, interest coprecipitation methods have been
to make nanosized materials other than utilised for the preparation of the
conventional ones is going on aforementioned catalysts. To study the
increasingly. Though several supported effect of the supports on sintering
and unsupported ceria-based mixed behaviour of the catalysts, prepared
metal oxides have been investigated, catalysts were subjected to different
the search for the second metal/metal calcination temperatures.
oxide to improve both the stability at Characterization of the catalysts has
high temperature and the chemical been carried out using various
activity, by introducing oxygen (O) techniques like thermal analysis (TG-
vacancies in the ceria is still a topic of DTA), X-ray diffraction (XRD),
intensive research. Considering this Raman spectroscopy (RS),
fact, the effect of a lanthanum like Tb transmission and high resolution
on the properties of Ce-based oxide is electron microscopy (TEM-HREM),
worth studying. It is already reported UVvisible diffuse reflectance
in the literature that incorporation of spectroscopy (UV-DRS), X-ray
terbium as promoter allows for an photoelectron spectroscopy (XPS), Ion
improvement of the redox performance scattering spectroscopy (ISS),
of M/CeO2-based catalysts. Regarding temperature programmed reduction-
oxidation-reduction, oxygen storage oxidation (TPR-TPO), and BET
capacity and a high ability to attenuate surface area (SA). All the synthesized
oscillations of oxygen partial pressure catalysts were evaluated for the
in the reacting environment, terbia potential oxygen storage capacity
modified ceria has been found to (OSC), and CO oxidation. Thus, the
posses better catalytic properties. The thesis primarily deals with the
enhanced capacity for storage and synthesis, characterization and activity
9. MEMBER’S FACE
1. Dr. Bipul Ch. Sarma, 2. Ms. Bulumoni Kalita
Technology (NEIST), Jorhat and not worth knowing, life would not be
started her Ph.D. work as CSIR-JRF worth living.
(2005) under the guidance of Dr. Jules Henri Poincaré (1854-1912)
Romesh Chandra Boruah, Sc-G, Head French mathematician.
of Medicinal Chemistry Division. She
has completed her thesis work on Science is not formal logic–it needs the
“Studies on Conjugated Carbonyl free play of the mind in as great a
Compounds and Related Systems. degree as any other creative art. It is
Synthesis of Some Steroidal Aza true that this is a gift which can hardly
Heterocycles.” Her research work was be taught, but its growth can be
designed to utilize conjugated carbonyl encouraged in those who already
compounds for the synthesis of some posses it.
novel steroidal and non-steroidal aza Max Born (1882-1970) German
heterocycles using newer Physicist. Nobel Prize, 1954.
methodologies. Her work was further
extended towards the bioreduction of ... they are ill discoverers that think
organic compounds. She has published there is no land when they can see
several papers in international referred nothing but sea.
journals along with some Indian Francis Bacon (1561-1626)
Patents being filed. She has attended English essayist, philosopher.
and presented at many places in India
on her work at many national and One thing that makes the adventure of
international conferences. She was working in our field particularly
awarded the Best Performing SRF of rewarding, especially in attempting to
NEIST, Jorhat for the year 2008-09. improve the theory, is that... a chief
Very soon, she will be joining as a criterion for the selection of a correct
Research Scientist at Jubilant Chemsys, hypothesis... seems to be the criterion
Noida. of beauty, simplicity, or elegance.
----xxxx---- Murray Gell-Mann (1929- ) U. S.
Physicist (Nobel Prize, 1969).
BEAUTY IN SCIENCE
All of physics is either impossible or
I do not know what I may appear to the trivial. It is impossible until you
world; but to myself I seem to have understand it, and then it becomes
been only like a boy playing on the trivial.
seashore, and diverting myself in now Ernest Rutherford (1871- 1937)
and then finding of a smoother pebble English physicist, born in New
or a prettier shell than ordinary, whilst Zealand. Nobel prize for chemistry
the great ocean of truth lay all 1908.
undiscovered before me.
Sir Isaac Newton (1642-1727) The aim of science is to seek the
English physicist, mathematician. simplest explanation of complex facts.
We are apt to fall into the error of
The scientist does not study nature thinking that the facts are simple
because it is useful; he studies it because simplicity is the goal of our
because he delights in it, and he quest. The guiding motto in the life of
delights in it because it is beautiful. If every natural philosopher should be
nature were not beautiful, it would not ``Seek simplicity and distrust it.''
be worth knowing, and if nature were Alfred North Whitehead (1861-
1947) English mathematician.
Editorial Addition
Qualification Requirement : Hold by 1st October 2010, a first degree of upper second
class Honours standard (or above) or a second class degree and a relevant
postgraduate qualification which will normally be a Master’s degree AND in the
fields of medicine and dentistry, have qualified between 1 October 2000 and 1
October 2005.
Duration: 12 months period of study or two six months periods.
Please follow the link below: http://www.ugc.ac.in/more/splitedoctoralship.pdf