Professional Documents
Culture Documents
& Answers
about . . .
Autoimmunity
You can also find this booklet on the NIAMS Web site at
www.niams.nih.gov.
Autoimmunity
Table of Contents
What Is Autoimmunity? . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Autoimmunity? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
Autoimmune Diseases? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Autoimmunity? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Autoimmunity
What Is Autoimmunity?
But when the system doesn’t work right, this process can
cause harm. Immune cells can mistake your body’s own
cells as invaders and attack them. This “friendly fire”
can affect almost any part of the body. It can sometimes
affect many parts of the body at once. This is called
autoimmunity (meaning self-immunity).
Most scientists think that our genes and things in the envi
ronment are involved. If you have a certain gene or combi
nation of genes, you may be at higher risk for autoimmune
disease. But you won’t get the disease until something
around you turns on your immune system. This may
1
include the sun, infections, drugs, or, in some women,
pregnancy.
If the skin is the target, you may have skin rashes, blisters,
or color changes. If it’s the thyroid gland, you may be tired,
gain weight, be more sensitive to cold, and have muscle
aches. If it’s the joints, you may have joint pain, stiffness,
and loss of function.
2
Autoimmunity
Eyes
• Sjögren’s syndrome
• Type 1 diabetes mellitus
• Uveitis
Glands
• Graves’ disease
• Thyroiditis
• Type 1 diabetes mellitus
Heart
• Myocarditis
• Rheumatic fever
• Scleroderma
• Systemic lupus erythematosus
3
Joints
• Ankylosing spondylitis
• Rheumatoid arthritis
• Systemic lupus erythematosus
Kidneys
• Glomerulonephritis
• Systemic lupus erythematosus
• Type 1 diabetes mellitus
Lungs
• Rheumatoid arthritis
• Sarcoidosis
• Scleroderma
• Systemic lupus erythematosus
Muscles
• Dermatomyositis
• Myasthenia gravis
• Polymyositis
Skin
• Alopecia areata
• Pemphigus/pemphigoid
• Psoriasis
• Scleroderma
• Systemic lupus erythematosus
• Vitiligo
4
Autoimmunity
5
and autoantibodies, the doctor can be more sure of
a diagnosis.
6
Autoimmunity
* Brand names included in this booklet are provided as examples only, and their
inclusion does not mean that these products are endorsed by the National Institutes
of Health or any other Government agency. Also, if a particular brand name is not
mentioned, this does not mean or imply that the product is unsatisfactory.
7
also see a nephrologist for related kidney problems and a
dermatologist for skin problems.
8
Autoimmunity
9
and eager to help you. They may not let you do the
things you can do. They may even give up their own
interests to be with you. Learn as much as you can
about your disease. Share what you learn with your
family. Involve them in counseling or a support
group. It may help them better understand the dis
ease and how they can help.
10
Autoimmunity
11
pigmentation disorder. They hope to find genes that
may cause vitiligo and learn how they affect the skin.
12
Autoimmunity
13
■ National Institute of Diabetes and Digestive and
Kidney Diseases (NIDDK)
National Diabetes Information Clearinghouse (NDIC)
1 Information Way
Bethesda, MD 20892–3560
Phone: 301–654–3327 or 800–860–8747 (free of charge)
E-mail: ndic@info.niddk.nih.gov
www.niddk.nih.gov
■ National Institute of Neurological Disorders and Stroke
Office of Communication and Public Liaison
P.O. Box 5801
Bethesda, MD 20824
Phone: 301–496–5751 or 800–352–9424 (free of charge)
E-mail: braininfo@ninds.nih.gov
www.ninds.nih.gov
■ NIH Clinical Center
Patient Recruitment Office
TTY: 866–411–1010
E-mail: prpl@mail.cc.nih.gov
http://clinicalstudies.info.nih.gov/
Bethesda, MD 20892–7518
Phone: 301–402–4336
http://rarediseases.info.nih.gov
14
Autoimmunity
Other Organizations
Schaumburg, IL 60168–4014
Phone: 847–330–0230 or
Fax: 847–330–0050
www.aad.org
or
Washington, DC 20005–4355
Phone: 202–842–3555
Fax: 202–842–4355
www.aaos.org
15
■ American College of Rheumatology
1800 Century Place, Suite 250
Atlanta, GA 30345
Phone: 404–633–3777
Fax: 404–633–1870
E-mail: acr@rheumatology.org
www.rheumatology.org
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Autoimmunity
www.ccfa.org
Wynnewood, PA 19096
Phone: 610–667–0131
Fax: 610–667–7036
E-mail: info@gbsfi.com
www.guillain-barre.com
17
■ Juvenile Diabetes Research Foundation International
120 Wall Street
Phone: 212–785–9500 or
Fax: 212–785–9595
E-mail: info@jdrf.org
www.jdf.org
Phone: 202–887–0088
Fax: 202–466–8940
E-mail: tma@myositis.org
www.myositis.org
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Autoimmunity
Phone: 516–487–4992
E-mail: nadfmail@aol.com
www.medhelp.org/nadf
or
Phone: 415–472–3780
Fax: 415–472–5343
E-mail: info@naaf.org
www.naaf.org
19
■ International Pemphigus Foundation
1540 River Park Drive, Suite 208
Sacramento, CA 95815
Phone: 916–922–1298
Fax: 510–527–8497
E-mail: pemphigus@pemphigus.org
www.pemphigus.org
Tyler, TX 75701
Phone: 903–595–3713
Fax: 903–593–1545
E-mail: info@nvfi.org
www.nvfi.org
■ Scleroderma Foundation
300 Rosewood Drive, Suite 105
Danvers, MA 01923
Phone: 978–463–5843
Fax: 978–463–5809
E-mail: sfinfo@scleroderma.org
www.scleroderma.org
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Autoimmunity
Phone: 415–834–9444 or
Fax: 415–834–9177
E-mail: info@sclerodermaresearch.org
www.sclerodermaresearch.org
Bethesda, MD 20817
Phone: 301–530–4420 or
Fax: 301–530–4415
www.sjogrens.org
E-mail: info@spondylitis.org
www.spondylitis.org
21
■ Thyroid Foundation of America, Inc.
One Longfellow Place, Suite 1518
Boston, MA 02114
Phone: 800–832–8321 (free of charge)
Fax: 617–534–1515
E-mail: info@allthyroid.org
www.allthyroid.org
■ Vasculitis Foundation
P.O. Box 28660
Phone/Fax: 816–436–8211
E-mail: vf@vasculitisfoundation.org
www.vasculitisfoundation.org
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23
Appendix II: Glossary of Diseases
24
Autoimmunity
25
Graves’ disease—An autoimmune disease of the thyroid
gland that results in the overproduction of thyroid hormone.
This causes such symptoms as nervousness, heat intoler
ance, heart palpitations, and unexplained weight loss.
26
Autoimmunity
27
Rheumatic fever—A disease that can occur following
untreated streptococcus (strep) infection. It most often
affects children, causing painful, inflamed joints and, in
some cases, permanent damage to heart valves.
28
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29
Acknowledgments
The NIAMS gratefully acknowledges the assistance of Jill Buyon, M.D., of New
York University Medical Center, New York, NY; Elaine Collier, M.D., of the
National Institute of Allergy and Infectious Diseases, NIH; Elizabeth Gretz, M.D.,
of NIAMS, NIH; Peter Lipsky, M.D., of NIAMS, NIH; Michael Lockshin, M.D.,
of the Hospital for Special Surgery, New York, NY; Barbara Mittleman, M.D., of
NIAMS, NIH; Alan Moshell, M.D., of NIAMS, NIH; and Noel Rose, M.D.,
Ph.D., of the Johns Hopkins University School of Hygiene and Public Health,
Baltimore, MD, in the preparation and review of this booklet. Mary Anne Dunkin
was the primary author of this booklet.
30
The mission of the National Institute of Arthritis and
Musculoskeletal and Skin Diseases (NIAMS), a part of the
Department of Health and Human Services’ National Insti
tutes of Health (NIH), is to support research into the causes,
treatment, and prevention of arthritis and musculoskeletal
and skin diseases; the training of basic and clinical scientists
to carry out this research; and the dissemination of informa
tion on research progress in these diseases. The National
Institute of Arthritis and Musculoskeletal and Skin Diseases
Information Clearinghouse is a public service sponsored by
the NIAMS that provides health information and information
sources. Additional information can be found on the NIAMS
Web site at www.niams.nih.gov.
U.S. Department of Health and Human Services
Public Health Service
National Institutes of Health
National Institute of Arthritis and
Musculoskeletal and Skin Diseases