RESEARCH PROPOSAL

THE RELATIONSHIP BETWEEN

CAFFEINE CONSUMPTION
AND OSTEOPOROSIS
Arranged by:
TIA MONITA
540!00!0!0
MEDICAL FACULT"
SRIWI#A"A UNI$ERSIT"
%00&%00'
i
APPRO$AL LETTER
Re(ear)* Pr+,+(a-
THE RELATIONSHIP BETWEEN
CAFFEINE CONSUMPTION
AND OSTEOPOROSIS
Arranged by:
T.a M+n./a
540!00!0!0
Ha( been e0)e,/ed and ()+red a( an a((.gn1en/ +2 ,r+,+(a- 1a3.ng
MEDICAL FACULT"
SRIWI#A"A UNI$ERSIT"
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Pa-e1bang4 De)e1ber %00
ii
PREFACE
Praise and thanks are submitted to the mighty God, because
of His blesses that is given to me so that I can fnish this proposal.
This proposal talks about the relationship between caeine
consumption and osteoporosis.
This proposal is made in order to achieve permission to
conduct research about the eect of caeine consumption to
osteoporosis .
It would be impossible to fnish writing this proposal without
the helps, supports, insight, patience, and perseverance of many
people. !irst, I would like to thank our lecturers who taught and led
us.
!inally, I would like to thank to everyone who cooperated and
give contributions in the process of this research.
Palembang, December 2008

Tia Monita
iii
i.
CONTENT
Page(
Preface i
Content ii
Chapter I Introduction 1
A. ac!ground 1
. Problem" 1
C. #e"earch $b%ecti&e 1
D. enefit" of #e"earch 1
Chapter II 'iterature #e&ie( 2
A. Theor) *rame" 2
. Concept *rame" +
C. ,)pothe"i" +
D. $perational Confine -
Chapter III #e"earch Method" .
A. T)pe of re"earch .
. Time and Place .
C. Population and "ample /
D. Data Collection /
0. Data Collecting /
*. 1ariable" 8
2. Data anal)"i" 8
,. 0thic problem" 3
I. Acti&it) Plan 3
4. #e"earch organi5ation 3
6. #e"earch co"t planning 10
i&
#eference
C,APT0# I
I7T#$D8CTI$7
A. AC62#$87D
,igh caffeine con"umption ha" been propo"ed a" a ri"! factor for o"teoporo"i".
ecau"e caffeine increa"e" urine production, calcium, (hich i" a component of the
fluid, i" lo"t. Therefore, (e de"ign a re"earch to find the a""ociation bet(een high
caffeine con"umption and o"teoporo"i".
. P#$'0M
The e&idence a""ociating high caffeine con"umption (ith the decrea"e of bone
den"it) i" incon"i"tent.
C. $40CTI10
The aim of thi" re"earch i" to in&e"tigate the a""ociation bet(een caffeine
con"umption and o"teoporo"i".

D. 070*IT9
&
1. The re"ult of thi" re"earch hopefull) (ill gi&e more information about
a""ociation bet(een chocolate con"umption and o"teoporo"i".
2. Thi" re"earch (ill enhance the !no(ledge of the re"earcher.
C,APT0# II
'IT0#AT8#0 #01I0:
A. T,0$#; *#AM09
R.(3 Fa)/+r(
In)rea(e

$"teoporo"i" i" a condition in (hich bone" become (ea! and fragile. The area"
(here thi" condition u"uall) occur" are hip", (ri"t" or "pine, although all bone" are
affected and can be bro!en. In the earl) "tage" of o"teoporo"i" there are no "ign" or
")mptom", it i" called <"ilent di"ea"e=. There i" no different feeling in an) (a) until a
bone brea!". It i" more common in (omen. The fre>uenc) of o"teoporo"i" in men i"
&i
$9T0$P$#$9I9
*amil)
,i"tor)
,ormone" 0ating
,abit
Medication" Acti&it) 9mo!ing
Caffeinated
be&erage"
1?@ of (omen. $&er half of the (omen older than .- )ear" of age (ill ha&e "ome
o"teoporo"i".
The ri"! factor for getting o"teoporo"i" include, famil) hi"tor), "mo!ing,
medication, acti&it), hormone", hi"tor) of "!ipping men"trual period" from eAce""i&e
eAerci"e in )oung (oman or eating di"order", and eating habit. *or eating habit, the
o"teoporo"i" ri"! i" higher if )ou do not eat enough dair) food" li!e mil!, )ogurt, and
chee"e from (hich )ou get calciumB or if )ou drin! a lot of caffeinated be&erage"
Ccoffee, cola "odaD or alcohol, or eat a lot of animal protein C"uch a" chic!en, beef,
fi"h or egg"D.
Caffeine i" an al!aloid compound that "timulate" cardiac mu"cle and the central
ner&ou" ")"tem and i" ab"orbed and di"tributed throughout the bod) &er) rapidl).
People commonl) percei&e caffeine to ha&e de"irable effect" "uch a" increa"ed
alertne"" and energ), enhanced mood, le"" fatigue and a boo"t in athletic
performance. ,o(e&er, there are "ome dra(bac!" related to con"uming eAce""
amount", including up"et "tomach, in"omnia, ner&ou"ne"", headache", caffeine
dependence, deh)dration and bone lo"".
ecau"e caffeine increa"e" urine production, calcium, (hich i" a component of
the fluid, i" lo"t. Calcium pla)" a critical role in maintaining bone den"it) and in
pre&enting the de&elopment of o"teoporo"i", a condition in (hich the bone" (ea!en
and become "u"ceptible to fracture".
&ii
,igh con"umption of caffeine i" indicated for more than @00 mg or three cup" of
coffee per da).
. C$7C0PT *#AM09
$ne point of time
C. ,;P$T,0909
:$M07 :IT,$8T
$9T0$P$#$9I9
CA**0I70
C$798MPTI$7
C E D
:$M07 :IT,
$9T0$P$#$9I9
CA**0I70
C$798MPTI$7
C F D
CA**0I70
C$798MPTI$7
C F D
CA**0I70
C$798MPTI$7
C E D
9AMP'0
&iii
Caffeine Con"umption
$"teoporo"i"
There i" an a""ociation bet(een caffeinated be&erage" con"umption and
o"teoporo"i".
D. $P0#ATI$7A' C$7*I70
$"teoporo"i" i" a condition in (hich bone" become (ea! and fragile. The area"
(here thi" condition u"uall) occur" are hip", (ri"t" or "pine, although all bone" are
affected and can be bro!en.
Caffeine i" an al!aloid compound that "timulate" cardiac mu"cle and the central
ner&ou" ")"tem and i" ab"orbed and di"tributed throughout the bod) &er) rapidl).
,igh con"umption of caffeine i" indicated for more than @00 mg or three cup" of
coffee per da).
iA
C,APT0# III
M0T,$D
A. T;P0 $* #090A#C,
Cro""F9ectional 9tud)
The benefit" of cro""F"ectional "tud) G
F Conducted o&er "hort period of time
F 2enerall) ea") and economical
F Conducted to find the relation"hip bet(een pre&alent di"ea"e and the ri"!
factor CeApo"ureD.
The lo"" of cro""F"ectional "tud) G
F Difficult) for "tud)ing rare di"ea"e
F Difficult to "eparate cau"e from effect
F Potential bia".
. TIM0 and P'AC0
TIM0 G December 22
nd
until 2+
th
,2008
A
P'AC0 G Moh. ,u"ein ,o"pital, Palembang
C. P$P8'ATI$7 and 9AMP'0
8"e random "ampling
P$P8'ATI$7 G Patient" in Moh. ,u"ein Palembang
9AMP'0 G .0F/0 )ear" old (omen (ith the po""ibilit) of
con"uming caffeine.
9AMP'0 9IH0 G 200 repre"entati&e "ample" that fulfill inclu"ion
criteria.
Criteria Inclu"ion G
o .0F/0 )ear" old (omen (ith the po""ibilit) of con"uming caffeine.
Criteria 0Aclu"ion G
o .0F/0 )ear" old (omen (ith the po""ibilit) of con"uming caffeine,
but (ith "ome confounding factor" or contradicti&e di"ea"e.
o The "ample (ho refu"e to participate in the re"earch
D. DATA C$''0CTI$7
P#IMA#; DATA G The data from >ue"tioner
90C$7DA#; DATA G Medical record in Moh. ,u"ein ,o"pital.
Ai
0. DATA C$''0CTI72 T$$'
Iue"tioner
Medical #ecord
*. 1A#IA'09
I7D0P07D07T 1A#IA'0 G Caffeine con"umption
D0P07D07T 1A#IA'0 G $"teoporo"i"
C$7*$87DI72 *ACT$#9 G 1. Age
2. 9eA
@. Diet high in "aturated fat cancer
+. $be"it)
-. Moderate alcohol inta!e
2. DATA A7A';9I9
Caffeine
con"umption
$"teoporo"i"
Total
E F
E a b CaEbD
F c d CcEdD
Total CaEcD CbEdD
#atio Pre&alence G a ? CaEbD G c ? CcEdD
If #atio Pre&alenceG
J1, ha&e a""ociation a" a protecti&e factor
Aii
K1, ha&e no a""ociation
L1, ha&e a""ociation a" a ri"! factor
,. 0T,IC9 P#$'0M
There i" no ethical problem in thi" "tud) de"ign, becau"e (e %u"t do the
ob"er&ational from >ue"tionnaire and from medical record.
I. ACTI1IT; P'A7

A)/.5./y Day(
1 2 @ + - . /
1. Preparation
2. Implementation
@. Arranged a report
" "
" " "
" "
4. #090A#C, $#2A7I9ATI$7
6etua G Tia Monita
:a!il G 9hella Indah 'e"tari
9e!retari" G Te""a #uliant)
endahara G 7abila 9indami
Anggota G
1. 2inda Chitra Pu"pita
Aiii
2. Putri Prapita 9ari
@. *eblin 1er"iliant)
+. 4oande 7eci""a
-. I"ti Aprillani
.. $!tari Angelina
6. #090A#C, C$9T P'A77I72
1. ,onorarium G #p 10.000.000,00
2. *or tool" that (e need G #p .00.000,00
@. *or material that (e need G #p -00.000,00
+. Tran"portation G #p 800.000,00
-. 9tationer) G #p +00.000,00
.. Co"t for anal)5e data G #p 1.-00.000,00
/. Co"t for cop) report G #p /00.000,00
Total G #p 1+.-00.000,00
Ai&
REFERENCE
1. udiarto, 0!o. 200@. Metodologi Penelitian Kedokteran. 02C, 4a!arta,
Indone"ia
2. :i!ipedia Indone"ia. 2008. Osteoporosis. 2@G18, December 20
th
,2008
ChttpG??id.(i!ipedia.org?(i!i? o"teoporo"i", acce""ed on Dec 20
th
D
@. Cooper C, At!in"on 04, :ahner ,:, $=*allon :M, #igg" ', 4udd ,',
Melton '4. Is caffeine consumption a risk factor for osteoporosis. Dec 2008
ChttpG??(((.ncbi.nlm.nih.go&?pubmed?D
+. 2oogle. 2008. Caffeine. December 20
th
,2008,ChttpG??(((.google.co.id?,
acce""ed on December 20
th
2008D
A&