I. Mediastinum is an interpleural space (area between the
pleural cavities) in the thorax and is bounded laterally by the pleural cavities, anteriorly by the sternum, and posteriorly by the vertebral column (does not contain the lungs). It extends from superior thoracic aperture to diaphragm inferiorly. It contains all the thoracic viscera and structures except lungs. Consists of the superior mediastinum above the pericardium and the three lower divisions: anterior, middle, and posterior. . !uperior mediastinum ". nterior mediastinum (in front of pericardium) C. Middle mediastinum (#he middle mediastinum includes the pericardium, heart, and roots of its great vessels (ascending aorta, pulmonary trun$, and !%C) passing to and from the heart). &. 'osterior mediastinum (posterior to pericardium) Contents of mediastinum: (eart, the great vessels of the heart, esophagus, trachea, phrenic nerve, cardiac nerve, thoracic duct, thymus, and lymph nodes of the central chest. Pericardium and Heart I. 'ericardium Is a )broserous sac that encloses the heart * beginning of great vessels Is composed of the )brous pericardium and serous pericardium. . +ibrous pericardium ,,, the outer most layer, its internal surface of it is lined by glistering serous memebrane, the parietal layer of serous pericardium. #his layer is re-ected onto the heart at the great vessels (aorta, pulmonary trun$ and veins, and superior and inferior venae cavae) as the visceral layer of serous pericardium. #he serous pericardium is composed mainly of mesothelium (that.s secrets the pericardial -uid), a single layer of -attened cells forming an epithelium that lines both the internal surface of the )brous pericardium and the external surface of the heart. #he )brous pericardium protects the heart against sudden over )lling because it is so unyielding. C. 'ericardial cavity Is a potential space between the visceral layer of the serous pericardium (epicardium) and the parietal layer of the serous pericardium. It contains thin )lm of -uid that enables the heart to move and beat in a frictionless environment. /erve supply to pericardium: 'hrenic nerves (C01C2), primary source of sensory )bers3 pain sensations conveyed by these nerves are commonly referred to the s$in (C01 C2 dermatomes) of the Ipsilateral supraclavicular region (top of the shoulder of the same side). !ympathetic trun$s are vasomotor. pplied natomy: Pericarditis, Pericardial Rub, and Pericardial Efusion #he pericardium may be involved in several disease processes. In-ammation of the pericardium (peri,carditis) usually causes chest pain. It may also ma$e the serous pericardium rough. 4sually the smooth opposing layers of serous pericardium ma$e no detectable sound during auscultation. If there is pericarditis, friction of the roughened surfaces may sound li$e the rustle of sil$ when listening with a stethoscope over the left sternal border and upper ribs (pericardial friction rub). !ome in-ammatory diseases produce pericardial e5usion (passage of -uid from pericardial capillaries into the pericardial cavity, or an accumulation of pus). s a result, the heart becomes compressed (unable to expand and )ll fully) and ine5ective. Cardiac Tamponade #he )brous pericardium is a tough, inelastic, closed sac that contains the heart, normally the only occupant other than a thin lubricating layer of pericardial-uid. If extensive pericardial e5usion exists, the compromised volume of the sac does not allow full expansion of the heart, limiting the amount of blood the heart can receive, which in turn reduces cardiac output, which is a potentially lethal condition. Pericardiocentesis: sternal approach or subxiphoid approach &rainage of excess -uid from the pericardial cavity, pericardiocentesis, is usually necessary to relieve cardiac tamponade. &uring pericardiocentesis needle is passed through the left 2 th intercostal space immediately ad6acent to the sternum, because the cardiac notch of the left lung leaves the pericardial sac exposed at this site. (ence, there is no danger of entering into the pleural cavity. #he needle should be $ept close to the sternal margin to avoid danger to the internal thoracic vessels, which lie 7cm or more lateral to the sternal margin or more lateral to sternal margin. #he edge of the sternum is located with the tip of the needle before plunging into the pericardial sac. (#he parasternal route is commonly used for intracardiac in6ections also) In subxiphoid approach: the needle is passed superoposteriorly through the left cost,xiphoid angle because the parietal pleura does not extend beyond the costal margin at this site. If the needle is not angled properly, the diaphragm and liver might be punctured.
Heart: #he wall of each chamber of the heart consists of three layers from super)cial to deep 8picardium, a thin external layer (mesothelium) formed by the visceral layer of serous pericardium. Myocardium, a thic$ middle layer composed of cardiac muscle. 8ndocardium, a thin internal layer (endothelium and subendothelial connective tissue) or lining membrane of the heart that also covers its valves. #he muscle )bers are anchored to the )brous s$eleton of the heart ( #he )brous framewor$ of dense collagen forms four )brous rings, which surround the ori)ces of the valves, right and left )brous trigones (formed by connecting the rings, and the membranous parts of the interatrial and interventricular septa). #he )brous s$eleton of the heart: 9eep the ori)ces of the % and semilunar valves patent and from being overly distended by the volume of blood pumping through them. 'rovides attachments for the lea-ets and cusps of the valves. 'rovides attachment for the myocardium, +orms an electrical :insulator; by separating the myenterically conducted impulses of the atria and ventricles so that they contract independently and by surrounding and providing passage for the initial part of the % bundle (part of the conducting system of the heart). Orientation of the Heart #he heart is related anteriorly to the sternum, costal cartilages, and the medial ends of the 0rd12th ribs on the left side. #he heart and pericardial sac are situated obli<uely, about two thirds to the left and one third to the right of the median plane. #he heart is shaped li$e a tipped,over, three,sided pyramid with an apex, base, four surfaces * four borders. The apex of the heart Is directed anteriorly and to the left and is formed by the inferolateral part of the left ventricle. Is located at left 2th intercostal space in adults, usually = cm from the median plane. Is where the sounds of mitral valve closure are maximal (apex beat)3 the apex underlies the site where the heartbeat may be auscultated on the thoracic wall. uscultation #he process of listening to sounds that are produced by internal organs in the body. &irect auscultation uses the ear alone, such as when listening to the grating of a moving 6oint. Indirect auscultation involves the use of a stethoscope to amplify the sounds from within the body, li$e a heartbeat or lung sounds. The base of the heart Is the heart>s posterior aspect. Is formed mainly by the left atrium, with a lesser contribution by the right atrium. +aces posteriorly toward the bodies of vertebrae #?1#=, and is separated from them by, esophagus, and aorta. @eceives the pulmonary veins on the right and left sides of its left atrial portion and the superior and inferior venae cavae at the superior and inferior ends of its right atrial portion. The four surfaces of the heart are the nterior (sternocostal) surface, formed mainly by the right ventricle. &iaphragmatic (inferior) surface, formed mainly by the left ventricle and partly by the right ventricle. Aeft pulmonary surface, formed mainly by the left ventricle3 it forms the cardiac impression of the left lung. @ight pulmonary surface, formed mainly by the right atrium. #he four borders of the heart are the @ight border (slightly convex), formed by the right atrium and extending between the !%C and the I%C. Inferior border (nearly horiBontal), formed mainly by the right ventricle and only slightly by the left ventricle. Aeft border (obli<ue), formed mainly by the left ventricle and slightly by the left auricle. !uperior border, formed by the right and left atria and auricles Chambers of the Heart Right trium! #he right atrium forms the right border of the heart and receives venous blood from the !%C, I%C, and coronary sinus #he ear,li$e right auricle is a small, conical muscular pouch that pro6ects from the right atrium, increasing the capacity of the atrium as it overlaps the ascending aorta. #he coronary sinus lies in the posterior part of the coronary groove and receives blood from the cardiac veins.). smooth, thin,walled posterior part, on which the !%C, I%C, and coronary sinus open, bringing poorly oxygenated blood into the heart. rough, muscular anterior wall composed of pectinate muscles (A. musculi pectinati). right % ori)ce through which the right atrium discharges the poorly oxygenated blood into the right ventricle. #he interatrial septum, separating the atria, has an oval, thumbprint,siBe depression, the oval fossa (A. fossa ovalis), a remnant of the oval foramen and its valve in the fetus trial "eptal #efects Congenital anomalies of the interatrial septumCusually related to incomplete closure of the oval foramenCare atrial septal defects (!&s). Right $entricle! #he right ventricle forms the largest part of the anterior surface of the heart, a small part of the diaphragmatic surface, and almost the entire inferior border of the heart).#he interior of the right ventricle has irregular muscular elevations called trabeculae carneae. #he right % ori)ce is surrounded by a )brous ring (part of the )brous s$eleton of heart) that resists the dilation that might otherwise result from blood being forced through it at varying pressures #he tricuspid valve guards the right % ori)ce. #he bases of the valve cusps are attached to the )brous ring around the ori)ce. #endinous cords (A. chordae tendineae) attach to the free edges of valve cuspsCmuch li$e the cords attached to a parachute. "ecause the cords are attached to ad6acent sides of two cusps, they prevent separation of the cusps and their inversion when tension is applied to the cords throughout ventricular contraction (systole)Cthat is, the cusps of the tricuspid valve are prevented from prolapsing (being driven into right atrium) as ventricular pressure rises. #hus regurgitation of blood (bac$ward -ow of blood) from the right ventricle into the right atrium is bloc$ed by the valve cusps. #he papillary muscles form conical pro6ections with their bases attached to the ventricular wall and tendinous cords arising from their apices. #he papillary muscles begin to contract before contraction of the right ventricle, tightening the tendinous cords and drawing the cusps together. Contraction is maintained throughout systole. #he interventricular septum, composed of membranous and muscular parts, is a strong, placed partition between the right and the left ventricles. Aeft trium: #he left atrium forms most of the base of the heart). #he pairs of valveless right and left pulmonary veins enter the left atrium. #he left auricle forms the superior part of the left border of the heart. #he interior of the left atrium has +our pulmonary veins (two superior and two inferior) entering its posterior wall. slightly thic$er wall than that of the right atrium. left % ori)ce through which the left atrium discharges the oxygenated blood it receives from the pulmonary veins into the left ventricle. Aeft %entricle. #he left ventricle forms the apex of the heart, nearly all of its left (pulmonary) surface and border, and most of the diaphragmatic surface . "ecause arterial pressure is much higher in the systemic than in the pulmonary circulation, the left ventricle performs more wor$ than the right ventricle, so the #he interior of the left ventricle has ( double,lea-et mitral valve that guards the Dalls are two to three times as thic$ as that of the right ventricle left % ori)ce. Dalls that are covered with thic$ muscular ridges, trabeculae carneae, that are )ner and more numerous than those in the right ventricle. nterior and posterior papillary muscles that are larger than those in the right ventricle. n aortic ori)ce that lies in its right posterosuperior part and is surrounded by a )brous ring to which the right, posterior, and left cusps of the aortic valve are attached. Mitral %al%e. #he mitral valve closes the ori)ce between the left atrium and the left ventricle. ortic %al%e. #he aortic valve is shown spread out. It is between the left ventricle and the ascending aorta. (eart sounds: are produced by closure of valves and by turbulence of blood. #wo heart sounds are lub and dub. #he )rst is due to contraction of ventricles that causes closure of tricuspid and mitral valves (atrioventricular valves) and second is due to relaxation of ventricles that causes closure of pulmonary and aortic valves (semilunar valves). rterial "uppl& of Heart #he coronary arteries supply the myocardium and epicardium and course 6ust deep to the epicardium, normally embedded in fat. #he right and left coronary arteries arise from the corresponding aortic sinuses at the proximal part of the ascending aorta, 6ust superior to the aortic %al%e! #he endocardium receives oxygen and nutrients directly from the chambers of the heart. The right coronar& arter& 'RC) arises from the right aortic sinus of the ascending aorta and runs in the coronary groove (sulcus). /ear its origin, the @C usually gives o5 an ascending sinuatrial '"( nodal branch that supplies the SA node, (part of the cardiac conducting system). #he @C then descends in the coronary groove and gives o5 the right marginal branch, which supplies the right border of the heart as it runs toward (but does not reach) the apex of the heart. fter giving o5 this branch, the @C turns to the left and continues in the coronary groove on the posterior aspect of the heart here its gives rise to the $ nodal branch, which supplies the AV node (part of the cardiac conducting system). #he @C then gives o5 the large posterior I% branch that descends in the posterior I% groove toward the apex of the heart. #he posterior )$ branch supplies both ventricles and sends perforating inter%entricular septal branches to the I% septum. #he terminal (left ventricular) branch of the @C then continues for a short distance in the coronary groove. #ypically, the @C supplies: ! node (?EF) % node (GEF) @# atrium Most of @# ventricle !mall part of A# ventricle The left coronar& arter& (AC) arises from the left aortic sinus of the ascending aorta and passes between the left auricle and the left side of the pulmonary trun$ in the coronary groove. In approximately HEF of people, the " nodal branch arises from the circum-ex branch of the AC and ascends on the posterior surface of the left atrium to the !node. t the left end of the coronary groove, located 6ust left of the pulmonary trun$, the AC divides into two branches, an anterior )$ branch (left anterior descending IA&J branch) and a circum*ex branch! #he anterior I% branch passes along the I% groove to the apex of the heart. (ere it turns around the inferior border of the heart and anastomoses with the posterior I% branch of the right coronary artery. #he anterior I% branch supplies both ventricles and the I% septum In many people, the anterior I% artery gives rise to a lateral 'diagonal( branch, which descends on the anterior surface of the heart. #he smaller circum*ex branch of the +C follows the coronary groove around the left border of the heart to the posterior surface of the heart. #he left marginal arter&, a branch of the circum-ex branch, follows the left margin of the heart and supplies the left ventricle. #he circum-ex branch of the AC terminates in the coronary groove on the posterior aspect of the heart before reaching the crux, but in about one third of hearts it continues as the posterior I% branch. T&picall&, the +C supplies #he left atrium. Most of left ventricle. 'art of right ventricle. Most of I% septum (usually its anterior two thirds), including the % bundle of conducting tissue, through its perforating I% septal branches. #he ! node (in approximately HEF of people). $enous #rainage of Heart Most of the cardiac veins carrying deoxygenated blood from heart drain into coronary sinus and few directly open into right atrium. #he coronary sinus in turn opens into the right atrium Conducting "&stem of the Heart #he conducting system consists of nodal tissue that initiates the heart beat and coordinates contractions of the four heart chambers, and highly specialiBed conducting )bers for conducting them rapidly to the di5erent areas of the heart. #he impulses are then propagated by the cardiac striated muscle cells so that the chamber walls contract simultaneously. #he sinuatrial '"( node is located anterolaterally at the 6unction of the !%C and right atrium. #he atrioventricular (%) node is a smaller collection of nodal tissue than the ! node. #he $ node is located in the posteroinferior region of the interatrial septum near the opening of the coronary sinus .#he signal generated by the ! node passes through the walls of the right atrium, propagated by the cardiac muscle (myogenic conduction), which transmits the signal rapidly from the ! node to the % node. #he % node then distributes the signal to the ventricles through the % bundle. !ympathetic stimulation speeds up conduction, and parasympathetic stimulation slows it down. #he % bundle, the only bridge between the atrial and ventricular myocardium, passes from the % node through the )brous s$eleton of the heart and along the membranous part of the I%!. t the 6unction of the membranous and muscular parts of the I%!, the % bundle divides into right and left bundles. #hese branches proceed on each side of the muscular I%! deep to the endocardium and then ramify into subendocardial branches ('ur$in6e )bers), which extendinto the walls of the respective ventricles. )nner%ation of the Heart #he heart is supplied by autonomic nerve )bers from super)cial and deep cardiac plexuses. #he parasympathetic supply of the heart is from presynaptic )bers of the vagus nerves (C/ K). 'arasympathetic stimulation slows the heart rate, reduces the force of the contraction. "&mpathetic stimulation increases the heart rate and force of contraction. It also causes dilatation of cardiac arterioles. Positional Abnormalities of the Heart: bnormal folding of the embryonic heart may cause the position of the heart to be completely reversed so that the apex is misplaced to the right instead of the leftCdextrocardia. #his congenital anomaly is the most common positional abnormality of the heart, but it is still relatively uncommon. &extrocardia is associated with mirror image positioning of the great vessels and arch of the aorta. #his anomaly may be part of a general transposition of the thoracic and abdominal viscera (situs inversus), or the trans,position may a5ect only the heart (isolated dextrocardia). In dextrocardia with situs inversus, the incidence of accompanying cardiac defects is low, and the heart usually functions normally. Coronar& rter& #isease or Coronar& Heart #isease Coronary artery disease (C&) is one of the leading causes of death. It has many causes, all of which result in a reduced blood supply to the vital myocardial tissue. M,OCR#)+ )-.RCT)O- Dith sudden occlusion of a ma6or artery by an embolus, the region of myocardium supplied by the occluded vessel becomes infracted (rendered virtually blood,less) and undergoes necrosis and this part of the heart stop functioning called heart attac$ (pathological tissue death). #he three most common sites of coronary artery occlusion and the percentage of occlusions involving each artery are the: 7.the most common is nterior I% (A&) branch of the AC (HE12EF)).n area of myocardium that has undergone necrosis constitutes a myocardial infarction (MI). #he most common cause of ischemic heart disease is coronary artery insuLciency resulting from atherosclerosis (process, characteriBed by lipid deposits in the intima (lining layer) of the coronary arteries). #he clinical features of MI include: 7. sensation of pressure or burning in the chest that last longer than 0o minutes. M. 'ain referred to the left arm. 0. /ausea or vomiting, sweating, shortness of breath, and tachycardia. Coronar& ngiograph& 4sing coronary angiography, the coronary arteries can be visualiBed with coronary arteriograms. long, narrow catheter is passed into the ascending aorta via the femoral artery in the inguinal region. 4nder -uoroscopic control, the tip of the catheter is placed 6ust inside the opening of a coronary artery. small in6ection of radiopa<ue contrast material is made, and cine, radiographs are ta$en to show the lumen of the artery and its branches, as well as any stenotic areas that may be present. Coronar& ngioplast& In selected patients, surgeons use percutaneous transluminal coronary angioplasty in which they pass a catheter with a small in-atable bal,loon attached to its tip into the obstructed coronary artery. Dhen the catheter reaches the obstruction, the balloon is in-ated, -attening the atherosclerotic pla<ue against the vessel.s wall. #he vessel is stretched to increase the siBe of the lumen, thus improving blood -ow. Coronar& /&pass 0raft 'atients with obstruction of their coronary circulation and severe angina (chest pain) may undergo a coronary bypass graft operation. segment of an artery or vein is connected to the ascending aorta or to the proximal part of a coronary artery and then to the coronary artery distal to the stenosis. #he great saphenous vein is commonly harvested for coronary bypass surgery. Cardiac Catheteri1ation In cardiac catheteriBation, a radiopa<ue catheter is inserted into a peripheral vein (e.g., the femoralvein) and passed under -uoroscopic control into the right atrium, right ventricle, pulmonary trun$, and pulmonary arteries, respectively. 4sing this techni<ue, intra cardiac pressures can be recorded and blood samples may be removed. If a radiopa<ue contrast medium is in6ected, it can be followed through the heart and great vessels using serially exposed K,ray )lms. "TRO2E, previously $nown medically as a Cerebro%ascular accident 'C$(, is the rapidly developing loss of brain function(s) due to disturbance in the blood supply to the brain. #hrombi (clots) form on the walls of the left atrium in certain types of heart disease. If these thrombi detach, or pieces brea$ o5 from them, they pass into the systemic circulation and occlude peripheral arteries. Ncclusion of an artery supplying the brain results in a stro$e which may a5ect vision, cognition, or the motor function of parts of the body previously controlled by the now, damaged (ischemic) area of the brain. $al%ular Heart #isease &isorders involving the valves of the heart disturb the pumping eLciency of the heart. %alvular heart disease produces either stenosis (narrowing) or insuf)ciency. !tenosis is the failure of a valve to open fully, slowing blood -ow from a chamber. Insuf)ciency or regurgitation, non the other hand, is failure of the valve to close completely, usually owing to nodule formation on (or scarring and contraction of) the cusps so that the edges do not meet or align. #his allows a variable amount of blood (depending on the severity) to -ow bac$ into the chamber it was 6ust e6ected from. "oth stenosis and insuf)ciency result in an increased wor$load for the heart. @estriction of high,pressure blood -ow (stenosis) or passage of blood through a narrow opening into a larger vessel or chamber (stenosis and regurgitation) produces turbulence. #urbulence sets up eddies (small whirlpools) that produce vibrations that are audible as murmurs (on auscultation). 0reat %essels: #he superior %ena ca%a (!%C) returns blood from all structures superior to the diaphragm, except the lungs and heart. It passes inferiorly and ends at the level of the 0rdcostal cartilage, where it enters the right atrium of the heart. #he !%C lies in the right side of the superior mediastinum, anterolateral to the trachea and posterolateral to the ascending aorta. #he ascending aorta, approximately M.2 cm in diameter, begins at the aortic ori)ce. Its only branches are the coronaryarteries, arising from the aortic sinuses. #he ascending aorta is intrapericardial. #he arch of the aorta (aortic arch), the curved continuation of the ascending aorta begins posterior to the Mnd right sternocostal (!C) 6oint at the level of the sternal angle. It arches superiorly, pos,teriorly and to the left, and then inferiorly. #he arch ascends anterior to the right pulmonary artery and the bifurcation of the trachea, reaching its apex at the left side of the trachea and esophagus as it passes over the root of the left lung. #he arch descends posterior to the left root of the lung beside the #H vertebra. #he arch ends by becoming the thoracic (descending) aorta posterior to the Mnd left sternocostal 6oint. #he usual branches of the arch are the brachiocephalic trun$, left common carotid artery, and left subclavian artery. #he brachiocephalic trun$, the )rst and largest branch of the arch of the aorta, it divides into the right common carotid and right subclavian arteries. /ranches of thoracic aorta: named branches to respecti%e thoracic %iscera Th&mus #he thymus, a lymphoid organ, is located in the lower part of the nec$ and the anterior part of the superior mediastinum. It lies posterior to the manubrium of the sternum and extends into the anterior mediastinum. -er%es of the Thorax -er%e Origin #istribution %agus (C/ K) from medulla of brainstem 'ulmonary plexus, esophageal plexus, and cardiac plexus 'hrenic C01C2 Central portion of diaphragm Intercostal s (7177) #71#77 Muscles in and s$in over intercostal space3 lower nerves supply muscles and s$in of anterolateral abdominal wall !ubcostal #7M nerve bdominal wall and s$in of gluteal region @ecurrent laryngeal %agus nerve Intrinsic muscles of larynx)3 Cardiac plexus Cervical and cardiac branches of vagus nerve and sympathetic trun$ Impulses pass to ! node3 parasympathetic )bers slow rate3 reduce force of heartbeat, and constrict coronary arteries3 sympathetic )bers have opposite e5ect 'ulmonary plexus %agus nerve and sympathetic trun$ 'arasympathetic )bers constrict bronchioles3 sympathetic )bers dilate them 8sophage al plexus %agus nerve, sympathetic ganglia and greater splanchnic nerve %agal and sympathetic )bers to smooth muscle and glands of inferior two thirds of esophagus Trachea In tetrapod anatomy the trachea, or 3indpipe, is a tube that connects the pharynx or larynx to the lungs, allowing the passage of air. It is lined with columnar epithelium cells with goblet cells which produce mucus. #his mucus lines the cells of the trachea to trap inhaled foreign particles which the cilia then waft upwards towards the larynx and then the pharynx where it can either be swallowed into the stomach or expelled as phlegm. #he length is about 7E to 7? centimetres (0.= to ?.0 in). It commences at the larynx, level with the sixth cervical vertebrae, and bifurcates into the primary bronchi at the vertebral level of #HO#2. #here are about )fteen to twenty incomplete C, shaped cartilaginous rings which reinforce the anterior and lateral sides of the trachea to protect and maintain the airway. #he trachealis muscle connects the ends of the incomplete rings, and contracts during coughing, reducing the siBe of the lumen of the trachea to increase the air -ow rate. #he esophagus lies posteriorly to the trachea. #he cartilaginous rings are incomplete to allow the trachea to collapse slightly so that food can pass down the esophagus. -ap,li$e epiglottis closes the opening to the larynx during swallowing to prevent swallowed matter from entering the trachea. #horacic orta natomy Nf Carina: it is a cartilaginous ridge within the trachea that runs anteroposteriorly between the two primary bronchi at the site of the tracheal bifurcation at the lower end of the trachea (usually at the level of the Hth to 2th thoracic vertebrae, which is in line with the ngle of Aouis). #he mucous membrane of the carina is the most sensitive area of the trachea and larynx for triggering a cough re-ex. Esophagus #he esophagus is a )bromuscular tube that extends from the pharynx to the stomach. It is usually -attened anteroposteriorly #he esophagus enters the superior mediastinum between the trachea and the vertebral column, where it lies anterior to the bodies of vertebrae #71#H. #he thoracic duct usually lies on the left side of the esophagus). 8sophagus inclines to the left as it approaches and passes through the esophageal hiatus in the diaphragm. Thoracic duct Aocation In the posterior mediastinum, the thoracic duct lies on the bodies of the inferior seven thoracic vertebrae. #he thoracic duct conveys most lymph of the body to the venous system In human anatomy, the thoracic duct (a$a left lymphatic duct) is an important part of the lymphatic systemCit is the largest lymphatic vessel in the body. It collects most of the lymph in the body (except that from the right arm and the right side of the chest, nec$ and head, and lower left lobe of the lung, which is collected by the right lymphatic duct) and drains into the systemic (blood) circulation at the left brachiocephalic vein, right between where the left subclavian vein and left internal 6ugular connection. IIn adults, the thoracic duct is typically 0G,H2cm in length and an average diameter of about 2mm. It usually starts from the level of the second lumbar vertebra and extends to the root of the nec$. It originates in the abdomen from the con-uence of the right and left lumbar trun$ and the intestinal trun$, forming a signi)cant pathway upward called the cisterna chyli, from here the duct courses vertically along the aortic ori)ce of diaphragm to enter the thoracic cavity and furthers ascends behind the esophagus, then crosses behind the esophagus from right to left side at the level of #2 vertebrae, thereafter it ascends up along the left border of the esophagus until it reaches the level of the transverse processes of CP vertebrae. t the root of the nec$ it empties into the 6unction of the left subclavian vein and left 6ugular vein, (called venous angle) below the clavicle, near the shoulders. #iaphragm #he diaphragm functions in breathing. &uring inhalation, the diaphragm contracts, thus enlarging the thoracic cavity (the external intercostal muscles also participate in this enlargement). #his reduces intra,thoracic pressure: In other words, enlarging the cavity creates suction that draws air into the lungs. Dhen the diaphragm relaxes, air is exhaled by elastic recoil of the lung and the tissues lining the thoracic cavity in con6unction with the abdominal muscles, which act as an antagonist paired with the diaphragm>s contraction. #he diaphragm is also involved in non,respiratory functions, helping to expel vomit, faeces, and urine from the body by increasing intra,abdominal pressure, and preventing acid re-ux by exerting pressure on the esophagus as it passes through the esophageal hiatus. In some non,human animals, the diaphragm is not crucial for breathing3 a cow, for instance, can survive fairly asymptomatically with diaphragmatic paralysis as long as no massive aerobic metabolic demands are made of her. natom& #he diaphragm is a dome,shaped musculo)brous septum that separates the thoracic from the abdominal cavity, its convex upper surface forming the -oor of the thorax, and its concave under surface the roof of the abdomen .Its peripheral part consists of muscular )bers that ta$e origin from the circumference of the inferior thoracic aperture and converge to be inserted into a central tendon. #he muscular )bers may be grouped according to their origins into three parts: Part Origin stern al #wo muscular slips from the bac$ of the xiphoid process. costal #he inner surfaces of the cartilages and ad6acent portions of the lower six ribs on either side, lumb ar lumbar vertebrae. )nner%ation #he diaphragm is innervated by the phrenic nerve. )-"ERT)O- ll the )bers of diaphragm is converted into a common central tendon #he central tendon of the diaphragm is a thin but strong aponeurosis situated near the center of the vault formed by the muscle, but somewhat closer to the front than to the bac$ of the thorax, Openings in the #iaphragm Inferior view of the human diaphragm, showing openings #he diaphragm is pierced by a series of apertures to permit of the passage of structures between the thorax and abdomen. #hree large openings C the aortic, the esophageal, and the vena cava C and a series of smaller ones are described. opening le% el structures caval opening #G inferior vena cava, esophageal hiatus #7E esophagus, aortic hiatus #7M the aorta, the aBygos vein, and the thoracic duct commonly used mnemonic to remember the level of the diaphragmatic apertures is this: Mnemonic ortic hiatus Q 7M letters Q #7M Nesophagus Q 7E letters Q #7E %ena cava Q G letters Q #G (iccups are involuntary intermittent sudden contractions of the diaphragm.