S.G. Chap 11\
What is the difference between an “exocrine gland.” and an “endocrine gland”? endocrine glands lack the ducts exocrine glands posses, thus secreting their chemicals into the blood.
S.G. Chap 11\
What is the difference between an “exocrine gland.” and an “endocrine gland”? endocrine glands lack the ducts exocrine glands posses, thus secreting their chemicals into the blood.
S.G. Chap 11\
What is the difference between an “exocrine gland.” and an “endocrine gland”? endocrine glands lack the ducts exocrine glands posses, thus secreting their chemicals into the blood.
I suggested that you make up 3 x 5 index cards. Put the name of
a hormone on one side and put 4 things on the other side: Tissue of origin, stimulus for release, target tissue, Response of target tissue to hormone. What is the defnition of a hormone (H)? biologically active molecule, secreted by organs and glands into the blood. What is a target tissue (TT)? cell containing the receptor protein for a particular hormone. What does the TT do that makes it a TT for a hormone? receptor proteins. What is the diference between an eocrine g!and. and an endocrine g!and? endocrine glands lack the ducts exocrine glands posses, thus secreting their chemicals into the blood. What are some of the c!assic endocrine g!ands? ("ig ##.#) thyroid gland, pituitary gland, pineal gland, testes. Toda$ we know that most tissues produce __hormones_s. What are neurohormones? neurons which deposit their neurotransmitters into the blood instead of a synaptic cleft, thus acting as hormones. Hormones afect the %%%%%%%%% of their TT metabolism. We can c!assif$ hormones (H) in & wa$s' b$ their chemica! structure and b$ their actions in TT What are the & t$pes of !ipid so!ub!e Hormones? What g!ands produce them? steroids androgenous steroids testosterone,!, corticosteroids aldosterone, cortisone!" testes, adrenal cortex. When !ooking at "ig. ##.&( understand wh$ diferent tissues re!ease diferent steroids e)en though the metabo!ic pathwa$ cou!d go a!! the wa$ from cho!estero! to estradio!*#+,. ,e ab!e to discuss the structure of th$roine and what its parent mo!ecu!e is. When we use the terms -ro* or -re*hormone what is meant? Wh$ are on!$ some tissues the TT for a particu!ar hormone? What do the terms s$nergistic( permissi)e and antagonistic mean with respect to H interactions? #ynergistic$ two hormones works cooperatively, with additive e%ects. &ermissive$ 1 st hormone allows a ' nd hormone to have an e%ect. (ntagonistic$ )wo hormones have opposite e%ects. When we sa$ a H has a . !ife of / da$s( what do we mean? 0n what wa$s did 0 te!! $ou H are remo)ed from the b!ood? )he active concentration of the hormone in the plasma has been reduced by half. *emoved by liver en+ymes and excretion via kidneys, feces.! What is the -riming 1fect (upregu!ation)? Cells increase the number of receptor proteins to increase stimulation from a hormone. What is desensiti2ation or downregu!ation? ,ue to overstimulation from a hormone- compound, cells reduce the number of protein receptors available. 3ead the "itness bo concerning 4nabo!ic 5teroids. 6echanics of H action' The & mechanisms of 7on*po!ar (!ipophi!ic) H. Wh$ do steroids and th$roine need a carrier protein in the p!asma? #teroids and thyroxine are non.polar, and thus insoluble in water, therefore re/uire the attachment to a carrier protein for transportation. ,e ab!e to understand and describe what is shown in fgures' ##.8( ##.9( ##.:( ; ##.+ Where are the receptor proteins for steroids !ocated? "or Th$roine? 0ntrace!!u!ar!$. "or steroids( in the c$top!asm and nuc!eus. "or Th$roine in the nuc!eus. What does dimeri2ation mean? When two hormone receptor proteins bind to the hormone*re!ease e!ement of the <74( acti)ating transcription into m374. What are &nd messengers? i.e. What do the$ do? Where are the$ formed? ' nd messengers relay the information from 1 st messengers hormones, neurotransmitters! to produce the hormonal e%ects. )here are formed within the cytoplasm. What are the #st messengers? 1 st messengers include hormones and neurotransmitters, outside of the cell, which attach to receptor proteins in the membrane. 3e*stud$ the aden$!ate c$c!ase =c46- s$stem( especia!!$ as shown in "ig ##.> This s$stem is the same as the %beta. adrenergic % receptor s$stem (?h +) What is phosphodiesterase. 1n2$me which inacti)ates c46-. @earn the -hospho!ipase ?*?aAA s$stem( especia!!$ as shown in "ig. ##.B. This is a!so known as the %%%% %%%%%%%%%%%% receptor s$stem. The membrane phospho!ipids are sp!it into %,iacylglycogen% ; %inositro! triphosphate (0-/)%%% 5tud$ "ig ##.#C What Hormone binds to the T$rosine Dinase receptor? 0nsu!in What are the responses of tissues to insu!in? i.e. what does insu!in cause to happen? @owers b!ood sugar b$ triggering its uptake. 4fter insu!in binds to its receptor protein( tiros$ne kinase autophs What is autophosphor$!ation? self.phosphorylation, such as in the )yrosine 0inase receptor-en+yme, after the attachment of two insulin hormones to the beta subunits. 5tud$ "ig ##.## and "ig.##.#&(not in Bth ed.) -ituitar$ E!and "ig. ##.#/ ("ig. ##.#& in Bth ed.) This g!and 0s a!so ca!!ed the %%h$poph$sis%%%% 0t has & parts the #st is %anterior pituitar$%% or %%%%pars dista!is%%%% and the &nd is %posterior pituitar$%% or %%pars ner)osa%%%% @earn both of the names and the actions of the : 4nterior -it. Hormones. What are their TT and the response of the TT to these :? What is 65H? What does it do? 6e!anoc$te*stimu!ating hormoneF re!ease of me!anin What is -ituitar$ <warfsm? Eigantism? What is the cause of both? <warfsm caused b$ inadeGuate secretion of Erowth Hormone. Eigantism is abnorma! growth = o)ersecretion of Erowth Hormone. What are the & H from the -ost. -it.? Where are the$ produced? 1xytocin" (nti.diuretic 2ormone. (,2! What causes their re!ease? 1smoreceptors in the hypothalamus for (,2" stimulation of3 Wh$ is the -ituitar$ no !onger ca!!ed the 6aster E!and of the bod$? 0tHs actions are contro!!ed b$ the h$potha!amus( and negati)e feedback !oops( thus no g!and tru!$ in comp!ete contro!. The 4drena! E!. What are the / !a$ers of the adrena! corte? Iona g!omeru!osa( 2ona fascicu!ata( 2ona reticu!aris What are the names of the / t$pes of H produced b$ the 4d. ?orte. 6inera!ocorticoids( E!ucocorticoids( se cortcicoids. Dnow a specifc name for each t$pe. 4!dosterone( cortiso!( How does ?ushing 5$ndrome difer from 4ddisonHs <? cushing from abnorma!!$ high secretion of 4?TH( and thus high !e)e!s of corticosteroids. 4ddisons resu!ts from !ow secretion of minera!corticoids Who was Hans 5e!$e and what did he disco)er about stress? Jnder stress( there is a production of 4?TH( and Th$roid and -arath$roid E!ands What are the names of the & t$pes of ce!!s that make up most of the Th$roid? "o!!icu!ar ce!!s( parafo!!icu!ar ce!!s. The maKor structures found in the Th$roid are ca!!ed %%th$roid fo!!ic!es. What is found in the !umen of these structures? ?o!!oid = protein*rich Luid. What are the & maKor actions that Th$roine causes in its TT? 0ncrease rate of ce!! respiration( s$nthesis of protein. What minera! is important for th$roine? 0odine. What happens if a person has too !itt!e of this minera! in their diet? Jnab!e to s$nthesi2e th$roid hormones (th$roine( triiodoth$ronine( 60T( <0T.) 4 person who has this condition is said to be %%h$poth$roid%% What is ?a!citonin? Where does it come from? What does it do? Hormone which decreases ca!cium !e)e!s in the b!ood stream b$ ecreting in urine( and bone uptake?. 0t comes from the parafo!!icu!ar ce!!s. What is Era)es <isease? 4 person who has it is said to be %%%%%%%%% What is a Toic goiter? What are some of its s$mptoms? What is ?retinism? What causes it? Where are the -arath$roid E!ands !ocated? What do the$ produce? 0n response to what? What action does -TH ha)e in our bod$? The -ancreas and Mthers The pancreas is both a %%%%%%%%%g!. 4nd a %%%%%%%%%%%%%g!. The endocrine portion is !ocated in the %%%%%%%%%s of %%%%%%%%%%%%%% What are the & maKor t$pes of ce!!s found in this portion? 4!pha ce!!s( which produce g!ucagon( and beta ce!!s( which produce insu!in. What H does each ce!! t$pe produce? What is the stimu!us for re!ease of each? What is the TT for E!ucagon and what action does it ha)e on its TT? What are some of the TT for insu!in? What is its maKor action on them? What are some of the characteristics of <. 6e!!itus? Dnow a !itt!e about the -inea! E!. 4nd the ## E!. Mf what importance is each to us? 5tud$ the section on the Eonads and -!acenta. @earn the information in the ita!ici2ed print. What is h?E? What is important about it (& things)? What is an autocrine? (<efnition). Ei)e the name of a specifc one. What is a paracrine? (<efnition). Ei)e the name of a specifc one. What are 1icosanoids? What are -rostag!andins? "rom what mo!ecu!e are the$ made? arachidonic acid, which derives from phospholipds. What is the abbre)iated name for c$c!oo$genase'? ?MN 4hat are 5#(6,#7 non.steroidal anti.in8ammatory drugs