MOLUSCUM CONTAGIOSUM

Histopathology:
At low magnification the "domed
papule" is divided into pear
shaped nodules of proliferating
epidermis which on the surface
appear as volcanic micro craters
(arrow 2) separated by the
epidermal lips of the crater (arrow
1).
The characteristic and key
feature is the presence of
molluscum bodies also known as
Henderson-Patterson bodies in
the depths of the "volcanos".
These bodies appear about 1-2
layers above the basal cell layer
(arrow 5) of the epidermis as pink
to red inclusions (arrow 3) and
progress to become large bright
red inclusions in the upper layers
of the epidermis.
Finally, they may exceed the size
of the original cell (arrows 3 in
high mag images). The inclusions
displace the nucleus and leave
only a thin crescent of basophilic
material. In the granular layer the
inclusions at first are surrounded
by blue granules (arrow 4) and
eventually may even appear
slightly basophilic in the upper
layers.


The stratum corneum or cornified
layer is oftendisintegrated as the
inclusions enlarge (arrow 2). At
the peak the molluscum bodies
may reach a diameter of 35
microns. Ultrastructure shows
each inclusion is composed of
brick shaped viruses with
dumbbell shaped nucleoids
surrounded by the amorphous
layer of capsids












CARCINOMA PLANOCELLULARE


Keratinized squamous stratified epithelium Basement membrane of the stratified squamous
epthelium is penetrated by atypical cells with
invasion to the underlying connective tissue

1. Islands of neoplastic squamous cells
2. Keratinous pearls
3. Stroma with immune cells












CARCINOMA BASOCELLULARE

















NEVUS PIGMENTOSUS


Micro Findings
1. Small nests or bundles of nevus
cells in dermis with thinned
overlying epidermis.
2. Nevus cells: (no necessarity to
differentiate these cells described
below).
3. Cuboidal cells with regular,
spheroid, moderately
hyperchromatic nuclei.
Upper: larger cells (type A)
with some multinucleated
giant melanocytes.
Middle: smaller cells (type
B) like lymphocytes.
Lower: spindle shaped
(type C) in neuroid bundles
(presumed schwannian
derivation)
4. No cellular atypia nor junctional
activity.
Junctional activity:
melanocytes proliferation
or dropping off restricted
to basal portion.
















MELANOMA MALIGNA