Abstract

Methods of identifying immune response modulators are disclosed. Some methods

comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or
fragments thereof comprising the Zinc-LeuZip domains. Some methods comprise
identifying chemical candidates that modulate the hetero-oligomerization of FOXP1 with
FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Some methods
comprise identifying chemical candidates that modulate interaction of IL-2 promoter with
FOXP3 and/or fragments thereof comprising the Zinc-LeuZip domains. Method of treating
individuals who have or are suspected of having autoimmune disease, inflammatory
disease, cell, tissue or organ transplantation, or coronary artery disease, and methods of
treating individuals who have or are suspected of having infectious disease, cancer, or who
are immunocompromised or undergoing vaccination

Other References

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