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Bonifacio
Medicine III-A
CASE DISCUSSION
This is a case of B.F., a 62 year old female, who came in due throbbing pain of the right foot.
History revealed that the patient experienced fever, chills, profuse sweating, body malaise and anorexia
hence decided to skip dinner 3 days prior to admission. Oral diabetic medications were however taken
as scheduled in the morning. She subsequently had dizziness and near-syncope but was able to hold a
chair to stop her fall. Cola and a chocolate bar provided relief of symptoms. One day prior to admission,
she accidentally scraped her right middle toe which produced local redness which progressively spread
to the toe, the forefoot, and then the entire foot. On the day of admission, there was purplish
discoloration and throbbing pain of the right middle toe. The patient is a known diabetic of 17 years
duration, maintained on unrecalled oral medications. In 2012, debridement of the right foot was done
secondary to an infected wound. She was admitted last May to June 2014 due to chest pain and was
diagnosed with pneumonia and cardiomegaly. She takes atorvastatin daily. There is history of DM in and
hypertension in both parents as well as in 5 of 6 siblings. At the ER, the folks reported that the patient
had another episode of near-syncope as well as chest pain. The patient was admitted to the ICU.
Patient was seen and examined at the ICU on the 3rd hospital day with the following vital signs: CR of 73
bpm, RR of 25 cpm, and Temperature of 36.6C. Examination findings revealed disorientation to time
and place, poor recent memory, occasional incoherence and disorganization of thought, and GCS 14.
There is increased prominence of tactile fremitus over the left lung field. Fine crackles were noted over
both lung bases and over the left lung apex. Jugular venous pressure is at 7cm over the sternal angle
with head of bed elevated 70, apical pulse is discrete and tapping, localized at the 6 th ICS, left
midclavicular line, loud and distinct S1 and S2 sounds with splitting noted. Significant anterior abdominal
fat deposition was noted. Distal phalanges of the right foot are gangrenous, muscle strength is 4/5 in
both upper extremities and in the left lower extremity, popliteal, dorsal pedal and posterior tibial pulse
are diminished (1), skin of lower extremities and toes are dry with scaling noted.
Working diagnoses for this patient are (1) diabetic foot ulcer, right, Wagner type IV, (2) type 2 diabetes
mellitus, (3) acute coronary syndrome, and (4) community acquired pneumonia moderate risk.
Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of
hyperglycemia. Several distinct types of DM are caused by a complex interaction of genetics and
environmental factors. DM is classified on the basis of the pathogenic process that leads to
hyperglycemia. The two broad categories of DM are designated type 1 and type 2. Type 1 DM is the
result of complete or near-total insulin deficiency. Type 2 DM is a heterogeneous group of disorders
characterized by variable degrees of insulin resistance, impaired insulin secretion, and increased glucose
production. Insulin resistance and abnormal insulin secretion are primary factors. According to
Harrisons, most studies support the view that insulin resistance precedes an insulin secretory defect but
that diabetes develops only when insulin secretion becomes inadequate. Type 2 DM likely encompasses
a range of disorders with common phenotype of hyperglycemia. According to Khardori and Griffing
(2014), Type 2 DM is said to have a strong genetic component. Individuals with a parent with type 2 DM
have an increased risk of diabetes; if both parents have type 2 DM, the risk approaches 40%. Insulin
resistance, as demonstrated by reduced glucose utilization in skeletal muscle, is present in many
nondiabetic, first-degree relatives of individuals with type 2 DM. The disease is polygenic and
multifactorial, since in addition to genetic susceptibility, environmental factors (such as obesity,
nutrition, and physical activity) modulate the phenotype. If we go back to the history, the patient has a
very strong familial predisposition to the development of type 2 DM with both parents and 5 of 6
siblings having the condition. The patient was also noted to be fond of candies, chocolates and
carbonated drinks before diagnosis. Her level of physical activity at home is also quite low as family
members take over the chores and she is proscribed from working much. Harrisons describes the
pathophysiology of Type 2 DM as characterized by impaired insulin secretion, insulin resistance,
excessive hepatic glucose production, and abnormal fat metabolism. Obesity, particularly visceral or
central (as evidenced by the hip-waist ratio), is very common in type 2 DM (80% or more are obese). In
the early stages of the disorder, glucose tolerance remains near-normal, despite insulin resistance,
because the pancreatic beta cells compensate by increasing insulin output. As insulin resistance and
compensatory hyperinsulinemia progress, the pancreatic islets in certain individuals are unable to
sustain the hyperinsulinemic state. IGT, characterized by elevations in postprandial glucose, then
develops. A further decline in insulin secretion and an increase in hepatic glucose production lead to
overt diabetes with fasting hyperglycemia. Ultimately, beta cell failure ensues. Khardori and Griffing
states that Type 2 diabetes mellitus occurs most commonly in adults aged 40 years or older, and the
prevalence of the disease increases with advancing age. Indeed, the aging of the population is one
reason that type 2 diabetes mellitus is becoming increasingly common. Virtually all cases of diabetes
mellitus in older individuals are type 2. Type 2 diabetes mellitus is more prevalent among Hispanics,
Native Americans, African Americans, and Asians/Pacific Islanders than in non-Hispanic whites. Type 2
diabetes mellitus is less common in non-Western countries where the diet contains fewer calories and
daily caloric expenditure is higher. However, as people in these countries adopt Western lifestyles,
weight gain and type 2 diabetes mellitus are becoming virtually epidemic.
DM type 2 may present with classic symptoms of polyuria, polydipsia, polyphagia, weight loss). Polyuria
and polydipsia are not noted in the patient as probably due to poor water intake. Other symptoms that
may suggest hyperglycemia include blurred vision, lower extremity paresthesias, or yeast infections,
particularly balanitis in men. However, many patients with type 2 diabetes are asymptomatic, and their
disease remains undiagnosed for many years. In patients with known type 2 diabetes, the duration of
the patient's diabetes and the care the patient is currently receiving for the disease is noted. The
duration of diabetes is significant because the chronic complications of diabetes are related to the
length of time the patient has had the disease. The patient has diabetes for 17 years, religiously takes
medications but may have a problem with dietary and medication control. Typical physical findings are
central obesity due to the deposition of excess unutilized glucose as triglycerides, hypertension,
decreased light touch, temperature sensation and proprioception and dryness and ulcers of the feet
noted in the patient. Other findings are eye hemorrhages, exudates, neovascularization, and acanthosis
nigricans. Diagnostic criteria by the American Diabetes Association (ADA) include the following: a fasting
plasma glucose (FPG) level of 126 mg/dL (7.0 mmol/L) or higher, or, 2-hour plasma glucose level of 200
mg/dL (11.1 mmol/L) or higher during a 75-g oral glucose tolerance test (OGTT), or random plasma
glucose of 200 mg/dL (11.1 mmol/L) or higher in a patient with classic symptoms of hyperglycemia or
hyperglycemic crisis.
Individuals with DM have a greater frequency and severity of infection. As explained in Harrisons, the
reasons for this include incompletely defined abnormalities in cell-mediated immunity and phagocyte
function associated with hyperglycemia, as well as diminished vascularization. Hyperglycemia aids the
colonization and growth of a variety of organisms (Candida and other fungal species). Many common
infections are more frequent and severe in the diabetic population, whereas several rare infections are
seen almost exclusively in the diabetic population. Pneumonias are more common in the diabetic
population. In general, the organisms that cause pulmonary infections are similar to those found in the
chest pain and cardiomegaly after 17 years of having diabetes. She was prescribed atorvastatin once
daily after being discharged last month, which may be indicative of increased serum lipid levels which is
a major contributory factor to the development of coronary artery disease in DM patients.
Goals of treatment for DM type 2 are classified into (1) microvascular (ie, eye and kidney disease) risk
reduction through control of glycemia and blood pressure; (2) macrovascular (ie, coronary,
cerebrovascular, peripheral vascular) risk reduction through control of lipids and hypertension, smoking
cessation; and (3) metabolic and neurologic risk reduction through control of glycemia.