Professional Documents
Culture Documents
A Molecular Approach
Sixth Edition
Brief Contents
PART I
PART III
Introduction
PART II
343
PART IV
Cell Regulation
587
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
Contents
Preface xix
Organization and Features of The Cell xxi
Media and Supplements to Accompany The Cell xxiii
Part I
Introduction
CHAPTER 1
17
CHAPTER 2
The Composition of
Cells 43
The Molecules of Cells 43
Carbohydrates 44
Lipids 46
Nucleic acids 49
Proteins 52
Cell Membranes 58
Membrane lipids 58
Membrane proteins 59
Transport across cell membranes 62
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
Contents
KEY EXPERIMENT
ix
CHAPTER 4
CHAPTER 3
Cell Metabolism
73
Metabolic Energy 81
Free energy and ATP 81
The generation of ATP from glucose 84
The derivation of energy from other organic
molecules 89
Photosynthesis 90
Phenylketonuria 98
Fundamentals of
Molecular Biology
103
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
Contents
151
CHAPTER 5
CHAPTER 6
Replication, Maintenance,
and Rearrangements
of Genomic DNA 191
DNA Replication 191
DNA polymerases 192
The replication fork 193
The fidelity of replication 200
Origins and the initiation of replication 201
Telomeres and telomerase: maintaining the
ends of chromosomes 205
DNA Rearrangements
219
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
Contents
KEY EXPERIMENT
CHAPTER 7
Regulation of Transcription in
Eukaryotes 251
cis-acting regulatory sequences: promoters and
enhancers 251
Transcription factor binding sites 255
Transcriptional regulatory proteins 258
Structure and function of transcriptional
activators 260
Eukaryotic repressors 263
Regulation of elongation 264
Relationship of chromatin structure to
transcription 266
Regulation of transcription by noncoding RNAs 271
DNA methylation 273
xi
CHAPTER 8
Protein Synthesis,
Processing, and
Regulation 297
Translation of mRNA 297
Transfer RNAs 298
The ribosome 299
The organization of mRNAs and the initiation of
translation 305
The process of translation 307
Regulation of translation 313
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
xii
Contents
The Nucleus
345
CHAPTER 10
Lysosomes 412
Lysosomal acid hydrolases 412
Endocytosis and lysosome formation 414
Phagocytosis and autophagy 416
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
Contents
KEY EXPERIMENT
Questions 457
References and Further Reading 458
CHAPTER 12
CHAPTER 11
Bioenergetics and
Metabolism 421
Mitochondria 421
Organization and function of mitochondria 422
The genetic system of mitochondria 424
Protein import and mitochondrial assembly 425
Photosynthesis 446
Electron transport 446
ATP synthesis 449
Peroxisomes 450
Functions of peroxisomes 451
Peroxisome assembly 453
MOLECULAR MEDICINE
Diseases of Mitochondria:
Lebers Hereditary Optic Neuropathy 426
KEY EXPERIMENT
xiii
472
Microtubules 482
Structure and dynamic organization of
microtubules 482
Assembly of microtubules 485
Organization of microtubules within cells 488
490
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
xiv
Contents
KEY EXPERIMENT
CHAPTER 14
CHAPTER 13
515
Endocytosis 544
Phagocytosis 544
Receptor-mediated endocytosis 545
Protein trafficking in endocytosis 550
MOLECULAR MEDICINE
MOLECULAR MEDICINE
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
587
Contents
xv
Part IV Cell
Regulation 587
CHAPTER 15
Cell Signaling
589
CHAPTER 16
641
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
xvi
Contents
Cytokinesis 667
KEY EXPERIMENT
KEY EXPERIMENT
CHAPTER 17
CHAPTER 18
Cancer
713
Oncogenes 727
Retroviral oncogenes 727
Proto-oncogenes 728
Oncogenes in human cancer 731
Functions of oncogene products 735
KEY EXPERIMENT
MOLECULAR MEDICINE
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
Contents
Glossary 773
Illustration Credits 797
Index 799
2013 Sinauer Associates, Inc. This material cannot be copied, reproduced, manufactured
or disseminated in any form without express written permission from the publisher.
xvii