Professional Documents
Culture Documents
Imaging of Intrauterine
Contraceptive Devices
Nagamani Peri, MD, David Graham, MD, Deborah Levine, MD
Objective. Intrauterine contraceptive devices (IUDs) are reemerging as common methods of birth control in the United States. Imaging, especially sonography, has an important role in their evaluation. This
review illustrates the normal and abnormal imaging appearances of IUDs. Methods. We describe and
illustrate the appearance of different types of IUDs on different imaging modalities as well as radiologically relevant complications associated with IUDs. Results. On sonography, the IUD should be visualized as centrally located within the endometrial cavity, with the crossbar (if present) in the fundal
portion of the endometrial cavity. Some older patients have IUDs in place that are no longer commonly
used, such as the Lippes Loop (Ortho Pharmaceutical, Raritan, NJ) and Saf-T-Coil (Julius Schmid
Laboratories, Little Falls, NJ), which have a pathognomonic appearance. Newer IUDs, such as the early
version of the Mirena IUD (Leiras Oy, Turku, Finland), may be difficult to visualize on sonography.
Patients from China frequently have a ring-shaped IUD. Sonography is important in assessing the complications of IUDs, including a low position, associated infection, myometrial migration, uterine
perforation, intrauterine or extrauterine pregnancy associated with the IUD, and retention and fragmentation of the IUD. If an IUD is known to be present but not visualized sonographically, plain radiography is helpful in assessing the location. Computed tomography and magnetic resonance imaging
are not typically used to assess IUDs, but the appearances of IUDs should be recognized with these
modalities. Conclusions. Imaging, specifically sonography, has a crucial role in the evaluation and management of IUDs and associated complications. Key words: contraceptive device; intrauterine contraceptive device, sonography.
Abbreviations
CT, computed tomography; IUD, intrauterine contraceptive device; MRI, magnetic resonance imaging; 3D,
3-dimensional
2007 by the American Institute of Ultrasound in Medicine J Ultrasound Med 2007; 26:13891401 0278-4297/07/$3.50
Types of IUDs
Inert IUDs
To our knowledge, the first IUD used in humans
was a ring-shaped device, developed in the early
1900s by Ernst Grafenberg.7 However, this was
not widely used because of fear of infection and
difficulty of removal. The first American IUD
was the Margulies spiral (Gynecoil; Ortho
Pharmaceutical, Raritan, NJ), which frequently
caused bleeding and cramping and had a hard,
uncomfortable tail. It was modified by Jack
Lippes, who created the Lippes Loop IUD (Ortho
Pharmaceutical), changed the ring to a loop for
easy removal, and also attached a softer string for
checking its position. This IUD is curved back and
Figure 2. Intrauterine contraceptive device in the peritoneal
cavity of a patient with a nonvisualized IUD on sonography. Plain
radiograph shows a Mirena IUD in the left hemipelvis. This was
confirmed to have perforated into the cul-de-sac at laparoscopy.
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Copper-Containing IUDs
Copper-containing IUDs are of several different
types and consist of first generation-models developed in early 1970s, such as the Copper 7 (G. D. Searle
& Company, High Wycombe, England), secondgeneration types such as the Nova T (Leiras Oy,
Turku, Finland), and third-generation types
such as the T Cu380A (ParaGard; GynoPharma,
Summerville, NJ). The various types of copper IUDs
release varying amounts of elemental copper and
have different effective periods. The local increase
in copper levels leads to decreased sperm motility and irritation of the endometrium and is
possibly ovicidal. These IUDs typically have a
straight shaft and crossbars that form the shape
of a 7 or a T (Figures 1 and 10). Because of the
dense composition of the straight shaft, a ringFigure 4. Magnetic resonance imaging appearance of an IUD.
Sagittal T2-weighted (A) and coronal short tau inversion recovery (B) views show linear signal voids (arrows) in the endometrium from the IUD.
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Figure 7. Lippes Loop on multiple modalities. A, Pelvic radiograph shows the curved appearance. B and C, Sagittal CT reconstruction (B) and transvaginal sonogram (C) show 5 intermittent
echogenic shadowing foci.
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B
Figure 11. Progestasert IUD. Sagittal sonographic image of the
uterus shows the echogenic proximal and distal ends (arrows)
and shadowing in between.
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Figure 12. Mirena IUD. Sagittal (A) and coronal (B) transvaginal
sonograms show the echogenic T-shaped Mirena IUD with the
crossbars in the expected location in the endometrium, just
below the fundus.
A
B
B
C
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sonography, the Essure device appears as a curvilinear, dense, uniformly echogenic structure with
shadowing in the region of the fallopian tube, with
the proximal tip at the uterine cornu (Figure 14).
Complications of IUDs
The radiologically relevant complications of IUDs
include malposition, uterine perforation, pelvic
inflammatory disease, and pregnancy. These
issues are discussed in the following sections.
Figure 14. Essure device. A, Transverse transabdominal sonogram shows the curvilinear, uniformly echogenic Essure device
(arrows) extending from the uterine fundus to the fallopian
tubes bilaterally. B, In a different patient, scout radiograph with
the hysterosalpingographic catheter in place shows the
radiopaque Essure device bilaterally.
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Figure 16. Intrauterine contraceptive device in a cesarean delivery scar in a patient with pelvic pain. Sagittal transvaginal sonogram shows the lower portion of a Mirena IUD (arrow) extending into the defect of the cesarean delivery scar.
Uterine Expulsion
When the string of the IUD cannot be felt on
physical examination, the possibilities are as
follows: (1) the IUD has been ejected from the
uterus; (2) the IUD is in the uterus (in either a
normal or an abnormal location), but the string
is broken or misplaced; and (3) the uterus has
perforated, and the IUD is no longer in the
endometrial cavity. The expulsion rate is highest
when the IUD is placed in the immediate postpartum period after a vaginal delivery.22
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Uterine Perforation
The perforation rate for IUDs is quoted as 1 to 2
per 1000 and is increased in the following
instances: (1) with placement by inexperienced
operators; (2) when the IUD is placed less than
6 months postpartum; (3) in women with fewer
prior pregnancies; and (4) in women with an
increased number of miscarriages.23 When the
IUD migrates outside the uterus, it can lead to
additional complications, such as bowel or
bladder perforation.24 In addition, in a hormone-containing IUD, the serum hormone
levels can be up to 10 times higher when the
IUD is in a peritoneal location than when it is
intrauterine. When an IUD cannot be visualized sonographically, a plain radiograph of the
abdomen can help in localizing the IUD (Figure
2). A CT scan of the abdomen can help in more
accurate localization of an IUD for appropriate
management.
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Conclusions
Imaging, especially sonography, has a crucial role
in evaluation IUD locations as well as management of associated complications. Knowledge of
the various types of IUDs and their appearances
will aid the imager in accurate assessment of the
various types of IUDs.
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5.
6.
7.
8.
9.
10.
11.
Sivin I, Stern J. Health during prolonged use of levonorgestrel 20 micrograms/d and the copper TCu 380Ag
intrauterine contraceptive devices: a multicenter study.
International Committee for Contraception Research
(ICCR). Fertil Steril 1994; 61:7077.
12.
13.
14.
15.
16.
17.
18.
B
Figure 22. Fragmented ring IUD in a patient who had pelvic
pain and bleeding. A, Sagittal sonogram shows a discontinuous
echogenic foreign body in the uterus. B, Frontal pelvic radiograph shows a fragmented IUD.
References
1400
1.
19.
2.
Mbabajende V. Historical survey of modern reversible contraceptive methods. Imbonezamuryango 1986; 5:1417.
20.
3.
Tyrrel T, Murphy FB, Bernardino ME. Tubo-ovarian abscesses: CT-guided percutaneous drainage. Radiology 1990;
175:8789.
21.
4.
Kim SH, Kim SH, Yang DM, Kim KA. Unusual causes of
tubo-ovarian abscess: CT and MR imaging findings.
Radiographics 2004; 24:15751589.
Peri et al
22.
23.
Caliskan E, Ozturk N, Dilbaz BO, Dilbaz S. Analysis of risk factors associated with uterine perforation by intrauterine
devices. Eur J Contracept Reprod Health Care 2003; 8:150
155.
24.
25.
26.
27.
28.
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