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KERACUNAN DEXTROMETHORPHAN

PENDAHULUAN
Dextromethorphan (DM) merupakan obat yang bekerja sentral dengan
meningkatkan ambang sentral batuk digunakan di Amerika sejak tahun 1954. Namun
keracunan dengan obat ini dapat terjadi secara tidak sengaja atau penggunaan kronik
diatas dosis terapi. Sumber dari Drug Abuse Warning Network dari bagian emergensi di
Amerika menyebutkan 12.584 orang pada tahun 2004 mencari pertolongan akibat
masalah pemakaian obat DM ke unit gawat darurat. (Chyka, 2007).

FARMAKODINAMIK
FARMAKOKINETIK
RECREATIONAL DRUG
SINDROMA SEROTONIN
INTOKSIKASI
PENATALAKSANAAN
KESIMPULAN
DAFTAR PUSTAKA
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evidence-based consensus guideline for out-of hospital management. Clinical
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Intoxication Associated with Interaction with Amitriptilin in a Poor CYPD2D6
Metabolizer: A Single Case Re-Exposure Study. Journal Of Pain and Symptoms
Management, 36, 92-96
4. Gutstein H.B, Akil H (2001). Opioid Analgesics. In Goodman & Gilmans, The
Pharmacological Basis of Therapeutics. 10th Edition. Editors: Hardman J.G, Limbird
L.E.Chapter 23,pp 569-619
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The Journal of Emergency Medicine, 22, 393-396
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Metabolite Dextrophan Block 34 Neuronal Nicotinic Receptors. The journal of
Pharmacology and Experimental Theurapeutics, 293, 962-968
8. Kompas (2009). Awasi Penyalahgunaan Obat DMP. Terbitan 14 April 2009
9. Mayhew M (2007). Dextromethorphan Abuse. Available at http://www.npjournal.org.
Accessed 06/29/2009
10. National Drug Intelligence Center (NDIC) (2004). Dextromethorphan. In Intelligence
Bulletin, October 2004. Available from http://ndic.riss.net.. Accessed 6/11/2009
11. Pikiran Rakyat (2009).
12. Schumacher M.A, Basbaum A.I, Way W.L (2007). Opioid Analgesics and
Antagonists. In Basic & Clinical Pharmacology. 10 th edition. Edited by Katzung B.G.
Chapter 31, pp 489-510
13. Shin E.J, Lee P H, Kim H J, Nabeshima T (2008). Potential of Dextromethorphan and
Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles
in Terms of Abuse and Neuroprotective Effects. J Pharmacol Sci 106, 22-27
14. Siu A, Drachtman R (2007). Dextromethorphan: A Review of Nmethyl-D-aspartate
Receptor Antagonist in the Management of Pain. CNS Drug Reviews, 13, 96-106
15. Wolfe T.R, Caravati E.M (1995). Massive Dextromethorphan Ingestion and Abuse.
Am J Emerg Med, 13, 174-176

16. Wikipedia (2009). Recreational use of dextromethorphan. Available from: Accessed


6/11/2009
17. Ziaee V, Hamed E.A, Hosmand A, Amini H et al (2005). Side Effect of
Dextromethorphan Abuse, A Case Series. Addictive Behaviors, 30, 1607-1613

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