Professional Documents
Culture Documents
1. Smidt CR, Seidehamel RJ, Devaraj S, Jialal I. The effects of a nutritionally complete
dietary supplement (LifePak) on antioxidant status and LDL-oxidation in healthy
non-smokers. FASEB J 1999; 13:A546. (Abstract)
2. Smidt CR, Shieh D. Non-invasive, biophotonic assessment of skin carotenoids as a
biomarker of human antioxidant status. FASEB J 2003; 17: A1115. (Abstract)
3. Smidt, C. R. and Burke, D. S. Nutritional significance and measurement of
carotenoids. Current Topics in Nutraceutical Research. 2004; 2(2): 79-91.
4. C. R. Smidt, W. R. Gellermann and J. R. Zidichouski. Non-invasive Raman
spectroscopy measurement of human carotenoid status. FASEB 2004; 18(4): A480.
5. Kaats GR, Wise JA, Morin R, Pullin D, Squires W, Murrieta TG, Hesslink R.
Reductions in DEXA measurements of body fat with different levels of involvement
in a weight loss program using dietary supplements. Journal of the American
Nutraceutical Association 1 (2): 19 26, 1998.
6. Hata TR, et al. Non-invasive Raman spectroscopic detection of carotenoids in human
skin. J Invest Dermatology 2000; 115:441.
7. Ermakov et al. Resonance Raman detection of carotenoid antioxidants in living
human tissues. Optics Letters. 2001; 26(15): 1179-1181.
8. Ermakov IV, Ermakova MR, Gellermann W, Lademann J. Noninvasive selective
detection of lycopene and beta-carotene in human skin using Raman spectroscopy. J
Biomed Opt. 2004 Mar-Apr; 9(2):332-8.
9. Bhosale P, Ermakov IV, Ermakova MR, Gellermann W, Bernstein PS. Resonance
Raman Quantification of Nutritionally Important Carotenoids in Fruits, Vegetables,
and Their Juices in Comparison to High-Pressure Liquid Chromatography Analysis. J
Agric Food Chem. 2004 Jun 2; 52(11):3281-3285.
General Raman Spectroscopy Studies
10. Ermakov IG, McClane RW, Gellermann W. Resonant Raman detection of macular
pigments in the living human retina. Optics Letters. 2001; 26(4): 202-204.
11. Gellermann et al. In vivo resonant Raman measurement of macular carotenoid
pigments in the young and the aging human retina. J Opt Soc Am A. 2002; 19(6):
1172-1186.
12. Gellermann et al. Raman imaging of human macular pigments. Optics Letters 2002;
27(1): 833-835.
CordyMax
15. Cao, Z. and Wen, Y. Therapeutic effect analysis of JinShuiBao capsule in treatment of
33 elderly senescent Xu-Zheng (Asthenia syndrome) patients. Journal of Applied
TCM 1, 32-33. 1993.
16. Chen D-G. Effects of Cs-4, Jinshuibao Capsules on quality of life of patients with
chronic heart failure. J of Administration of Traditional Chinese Medicine 1995; 5:403.
17. Han S-R. Experiences in treating patients of chronic bronchitis and pulmonary
diseases with Cs-4 capsules. (Jinshuibao). J Administration of Traditional Chinese
Med 1995; 33-4.
18. Xiao Y, Huang XZ, Chen G, Et Al. Increased aerobic capacity in healthy elderly
humans given a fermentation product of cordyceps Cs-4. Medicine and Science in
Sports and Exercise 1999; 31:S174 (Abstract).
19. Nicodemus KJ, Hagan RD, Zhu J, Baker C. Supplementation with Cordyceps Cs-4
fermentation product promotes fat metabolism during prolonged exercise. Medicine
and Science in Sports and Exercise 2001; 33:S 164 (Abstract).
20. Talbott SM, Zhu JS, Rippe JM. CordyMax Cs-4 enhances endurance in sedentary
individuals. Med Sci Sports Exerc 2001; 33 (Abstract).
21. Zhu J, Yin W, Nicodemus K, et al. CordyMax Cs-4 improves glucose metabolism.
FASEB J 2001; 15.
22. Zhu, J. S., Pei, Y., Xu, Z., Wang, B., and Rippe, J. CordyMax reduces serum oxidized
LDL-cholesterol and increases HDL-cholesterol in humans with reduced HDLcholesterol. 4-10-2003.
23. Zhu, JS, Rippe, JM. CordyMax Enhances Aerobic Capability, Endurance
Performance, and Exercise Metabolism in Healthy, Mid-age to Elderly Sedentary
Humans. FASEB J 2004; 18(5): A931.
24. Chen YP, et al. Comparison of treatment chronic renal failure 30 cases by hypha of
culture and natural cordyceps sinensis. Chinese Traditional and Herbal Drugs 1986;
17:256-258.
25. Guo Y-Z. Pharmaceutical Chemistry, Pharmacology and Clinical effects of
Cordyceps Fungus and its preparation Jin Shui Bao. J Modern Diagnostics
Therapeutics 1986; 1:60-65
37. Zhong Yi Yao Guan li Za Zhi, Wang Wei-Quan. Observations of effects of Jin Shui
Bao on SOD activity in COED patients. Journal of Administration of TCM 1995;5:
24-24.
In association with: Wu-Han General Hospital of War Industry.
38. Yang Q-Z. Clinical observation of treating advanced stage schistosomiasis
accompanying hemorrhage of upper digestive tract with tablet of Jin Shui Bao. J
Admin TCM 1995;5: 48-49.
39. Zhen L-H, Dan W-W. The Clinical Efficacy of Cordyceps sinensis Cs-4 Capsule in
Treating Chronic Bronchitis and its Effect on Pulmonary Function. J Management
Traditional Chinese Medicine 1995; 5:9-11.
40. Zheng X., et. al. Observation on the therapeutic effects of artificial Cordyceps in the
treatment of Chronic Bronchitis and its effects on Pulmonary Function. In:
Anonymous Collection of the basic medical and clinical studies of submerged culture
Cordyceps sinensis. 1995; [2]: 95-99.
In association with: Department of Traditional Chinese Medicine Second Affiliated
Hospital of Jiangxi Medical College.
41. Zhang Z., et. al. Clinical and Laboratory Studies of Jin Shui Bao in eliminating
oxygen free radicals in elderly senescent Xu-Zheng patientsJournal of Management
of Traditional Chinese Medicine 5 (supplement), 14-18. 1995.
In association with: Jiangxi Medical College affiliated The Second Hospital.
Department of Biochemistry, Jiangxi Medical College.
Supported by: National Nature Science Research Award.
42. Zhou D., et. al. Effect of Jin Shui Bao capsule on the immunological Function of 36
patients with advanced Cancer. <None Specified> 1995; 15:476-478.
In association with: The First Affiliated Hospital, Guangzhou University of TCM,
Guangzhou.
43. Bao T-T. Further study of pharmacological functions on JinShuiBao. J Admin of
TCM 1995; 5:6-6.
44. Li L, Zheng F, Xiao S, Tan B. Effects of cordyceps sinensis (CS) in real damage of
hemorrhagic fever with renal syndrome (HFRS). J Am Soc Nephrol. 1995; 6:469
(abst).
45. Tao A-H. From Cordyceps sinensis and better than Cordyceps sinensis. J Admin of
TCM. 1995; 5:20-21
46. Xu F. Amelioration of cyclosporin nephrotoxicity by cordyceps sinensis in kidneytransplanted recipients. Nephrol Dial Transplant: Letters. 1995;142-143.
47. Che YS, Lin LZ. Clinical Observation on Therapeutic effects of JinShuiBao on
coronary heart disease, hyperlipidemia, and blood rheology. Chinese Traditional
Herbal Drugs 1996; 27:9:552-553.
48. Guo Qingchang, et. al. Clinical observation of Jin Shui Bao capsule adjunctive
treatment of 20 diabetic patients. Journal of Management of Traditional Chinese
Medicine 5 (supplement): 22.
In association with: Dept. of Medicine, First Affiliated Hospital of the Tianjing
College of Traditional Chinese Medicine.
ANIMAL STUDIES
49. Dai GW, Bao.T.T., Xu CF, Cooper R, Et Al. Enhanced hepatic energy state in mice
after administration of a fermentation product of cordyceps Cs-4. Medicine and
Science in Sports and Exercise 1999; 31:S120 (Abstract).
50. Balon TW, Jasman AP, Zhu JS. A fermentation product of Cordyceps sinensis
increases whole-body insulin sensitivity in rats. J Altern Comp Med 2002; 8:315-23.
51. Zhao CS, Yin WT, Wang JY et al. CordyMax Cs-4 improves glucose metabolism and
increases insulin sensitivity in normal rats. J Altern Complement Med 2002; 8:30914.
REVIEW ARTICLES
52. Zhang H., et. al. Immunopharmacology of Cordyceps sinensis. Department of
Immunology, Anhwai Chinese Medicine University. A Review Journal of
TCM/Western Medicine Relationship.
53. Xu Fei. Artificially Cultured Mycelia of Cordyceps sinensis in Medical Use in China.
China Journal of Chinese Materia Medica, 1992; 27(4), 195-198.
In association with: Naval Medical Institute
54. Clinical Study of Cordyceps Sinensis capsules on the treatment of Chronic
Bronchitis. Jiang-Xi TCM Drugs Factory. Original application material. 1997; 1-6.
In association with: Department of Clinical Pharmacology, Institute of Materia
Medica, Beijing
55. Ding F., et. al. Current Situation of the Researches on Cordyceps Sinensis. Chinese
Journal of Biochemical Pharmaceutics, 1994; 15(4), 297-299.
In association with: Nanjing Biochemical Pharmaceutical Institute
56. Yang Z-H. Clinical Validity of Cordyceps Capsules in the Treatment of Chronic
Bronchitis: A summary. Collection on the basic medicinal and Clinical Studies of
Submerged Culture Cordyceps sinensis 1985:114-117.
57. Zhu, J. S., Halpern, G. M., and Jones, K. The scientific rediscovery of an ancient
Chinese herbal medicine:Cordyceps sinensis. Part I. J Altern.Complement Med. 1998;
4(3): 289-303.
58. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient
Chinese herbal regimen: Cordyceps sinensis: part II. J Altern.Complement Med
1998;4: 429-57.
67. M. Warny, A. Fatimi, E.F. Bostwick, D.C. Laine, F. Lebel, J.T. LaMont, C.
Pothoulakis, C.P. Kelly. Bovine immunoglobulin concentrate-Clostridium difficile
retains C. difficile toxin neutralizing activity after passage through the human
stomach and small intestine. Gut 1999; 44:212-217.
68. J. Tollemar, N. Gross, N. Dolgiras, C. Jarstrand, O. Ringdn and L. Hammarstrm.
Fungal prophylaxis by reduction of fungal colonization by oral administration of
bovine anti-Candida antibodies in bone marrow transplant recipients. Bone Marrow
Transpl. 1999; 23:283-290.
69. T.K. Graczyk, M.R. Cranfield, and E.F. Bostwick. Hyperimmune bovine colostrum
treatment of moribund Leopard geckos (Eublepharis macularius) infected with
Cryptosporidium sp Vet Res 1999; 30:377-382.
70. R. A. Hoerr and E.F. Bostwick. Bioactive Proteins and Probiotic Bacteria: Modulators
of Nutritional Health. Nutrition 2000; 16:7-8.
ProBio PCC
71. Charteris WP, Kelly PM, Morelli L, Collins JK. Development and application of an
in vitro methodology to determine the transit tolerance of potentially probiotic
Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract.
J Appl Microbiol. 1998 May; 84(5):759-68.
72. Plant L, Conway PL. Association of Lactobacillus spp with Peyers Patches in mice.
Clinical and Diagnostic Immunology. 2002; 8(2): 320-324.
73. Plant L, C Lam, PL Conway, and K O'Riordan. Gastrointestinal microbial community
shifts observed following oral administration of a Lactobacillus fermentum strain to
mice. FEMS Microbiology Ecology. 2003; 43:133-140.
74. Gibson SAW, Conway PL. Recovery of a probiotic organism from human faeces after
oral dosing. In Human Health: The contribution of microorganisms in Springer Series
in Applied Biology, 1994, pp. 119143.
PUBLICATION PENDING
75. Conway PL, Blomberg L. Reduction in incidence and severity of diarrhea in soldiers
consuming Lactobacillus fermentum KLD. 2002. (Publication pending)
76. Li P, Conway PL. Effects of administration of Lactobacillus fermentum on faecal
microbes and symptoms in patients with irritable bowel syndrome. 2002.
(Publication pending)
77. Weilin A, Farthing M, Conway PL. Colonization of ileal mucosa by Lactobacillus
fermentum KLD in pouchitis patients after oral dosage. 2002. (Publication pending)
78. Conway PL. Effects Of Oral Administration Of The Probiotic Lactobacillus
Fermentum Vri-002 On The Immune System Of Endurance Athletes. (Publication
pending).
Presented at the Australian Conference of Science and Medicine in Sport October 79, 2004.
ReishiMax
79. Lua QY, Jin YS, Zhang QF, Zhang ZF, Heber D, Go VL, Li FP, Rao JY. Ganoderma
lucidum extracts inhibit growth and induce actin polymerization in bladder cancer
cells in vitro. Cancer Letters 2004; 216:920.
80. Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva D. Ganoderma lucidum
suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB
signaling.Nutr Cancer. 2004;49(2):209-16.
81. Daniel Sliva, Ph.D., Miroslav Sedlak, Ph.D. et al. Biologic Activity of Spores and
Dried Powder from Ganoderma lucidum for the Inhibition of Highly Invasive Human
Breast and Prostate Cancer Cells. The Journal of Alternative and Complementary
Medicine. 2003; 9(4): 491-497.
82. Veronika Slivova, BS; Tatiana Valachovicova, BS; Jia-Hua Jiang, PhD; Daniel Sliva,
PhD. Ganoderma lucidum inhibits invasiveness of breast cancer cells. Journal of
Cancer Integrative Medicine. 2004; 2(1): 25-30.
83. Ma, J., Ye, Q., Hua, Y., Decheng, Z., Cooper, R., Chang, M., Chang, J. Y., and Sun, H.
H. New lanostanoids from the mushroom Ganoderma lucidum. Journal of Natural
Products 2002; 65(1):72-75.
84. Yuan-Yuan Wang, Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey
Wong and Chun-Hung Lin. Studies on the Immuno-Modulating and Antitumor
Activities of Ganoderma lucidum (Reishi) Polysaccharides: Functional and Proteomic
Analyses of a Fucose-Containing Glycoprotein Fraction Responsible for the
Activities. Bioorganic & Medicinal Chemistry. 2002; 10:10571062.
85. Wen-Chuan Lin, Yue-Wen Wu, Ming-Chun Xie, Jia-Shi Zhu. ReishiMax protects the
liver and improves liver functions in an experimental hepatitis model. FASEB J
2004; 18(5): A999.
86. Jia-Hua Jiang, Veronika Slivova, et al. Ganoderma lucidum inhibits proliferation and
induces apoptosis in human prostate cancer cells PC-3. International Journal of
Oncology. 2004; 24:1093-1099.
87. C. Li, J. Yin, F. Guo, D. Zhang & H. Sun. Ganoderic Acid SZ, a New Lanostanoid
from the Mushroom Ganoderma Lucidum. Natural Product Research. 2004.
(Publication pending).
Cholestin
PHARMANEX SCIENTISTS
88. Heber,D.; Yip,I.; Ashley,J.; et al. A Chinese red yeast rice dietary supplement
significantly reduces cholesterol levels FASEB J 1998; 12:A206.
89. Rippe J, Bonovich K, Colfer H et al. A multi-center, self-controlled study of
Cholestin in subjects with elevated cholesterol. Circulation 1999; 99:1123.
90. Ma JY, Li YG, Ye Q, et al. Constituents of red yeast rice, a traditional Chinese food
and medicine. J Agric Food Chem. 2000; 48:5220-5.
91. Heber D, Lembertas A, Lu QY, Bowerman S, Go VL. An analysis of nine proprietary
Chinese red yeast rice dietary supplements: implications of variability in chemical
profile and contents. J Altern Complement Med. 2001; 7:133-9.
92. Heber D, Yip I, Ahsley JM, Elashoff DA, Elashoff RM, Go VL. Cholesterol-lowering
effects of a proprietary Chinese red-yeast rice dietary supplement (83 subjects). Am J
Clin Nutr 1999; 69:231-236.
93. Brown,D. Lipid-lowering Effects of Monascus Purpureus (Red Yeast) Rice.
Quarterly Review of Natural Medicine. 1993; pp. 103-104.
94. Li C, Li Y, Zhonglin H. Experimental studies on the toxicity of Xuezhikang.
Information of the Chinese Pharmacology Society 1995; 12:12-5.
95. Su MZ, et al. Clinical trial of Xue Zhi Kang capsules for treating hyperlipidemia
(116 subjects). New Traditional Chinese Medicines and Clinical Pharmacology 1995;
6(4):16-19.
96. Wang J, Lu Z, Chi J, Wang W. Clinical trial of extract of Monascus purpureus (red
yeast) in the treatment of hyperlipidemia. Chinese Journal of Experimental
Therapuetics for Prepared Chinese Medicine 1995; 1:1-5.
97. Liu ZM. The clinical observation of the medical treatment for hyperlipidemia with
Xue Zhi Kang (50 subjects)
Chinese Medical Information Guide Paper May
1996; 9: 12. In association with: Sino-Japanese United Hospital
98. Shen ZW. A prospective study on Zhitai capsule in the treatment of primary
hyperlipidemia (152 subjects). National Medical J China 1996; 76(2):156-157.
In association with: Beijing University Hospital
99. Chen,Q.S.; Qiang,Z.W.; Peng,Q.; et al. Clinical efficacy observation on a doubleblind, randomized controlled trial of Xue Zhi Kang for the treatment of patients with
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Kou,W-R.; Shi,X.; Lu,Z. The Therapeutic Effects of Xue Zhi Kang over 6
months and the Observation of its Safety. Chinese Journal of Internal Medicine
1998; 37(6): 406-407.
In association with: China Academy of Medical Science and Xie-He Medical University
103.
Lu GP. The comparison of the blood lipids lowering effects of Xue Zhi Kang and
Simvastatin on hypercholesterolemic patients (28 subjects).
Chinese J of
Internal Medicine June 1998; 37(6):371-373.
In association with: Rui-Jin Hospital, Shanghai Second Medical University
104.
Lu, Guoping, et al. Comparison of the effects of Xue Zhi Kang with simvastatin
on lipid profile modifications in patients with hypercholesterolemia. Chinese
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Ping, K.L.; Yu, J.S.; Yun, S.X.; et al. Clinical observation on lipid long-term
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107.
Pulin,Y.; Zhiwei,S.; Meizhen,S.; et al. A Clinical Study of Xue Zhi Kang on the
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Rong,K.W.; Yan,F. General review for basic and clinical researches on "Xue Zhi
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Li, WH.; He, DL.; Li, LH.; et al. Effects of Xue Zhi Kang on lipid profile
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Keithley, JK.; Swanson B.; Sha, BE.; Zeller, JM.; Kessler, HA,; Smith KY. A
Pilot Study of the safety and efficacy of cholestin in treating HIV-related
dyslipidemia. Nutrition 2002 Feb; 18(2):201-204.
ANIMAL STUDIES
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Li C, Zhu Y, Wang Y, Zhu J-S, Chang J, Kritchevsky D. Monascus purpureusfermented rice (red yeast rice): A natural food product that lowers blood
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REVIEW ARTICLES
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1999; 69:175-176.
Venix
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Wan FC, Guo YZ, Deng XA. Sex Hormone-like Effects of JinShuiBao
[Cordyceps sinsensis Cs-4] Capsule: Phamacologic and Clinical Studies. ZhongCheng Drugs. 1988; 9: 29-31.
131.
Li CL, Wu ER, Zhu J-S, Chang J. A mixture of CordyMax and Ginkgo biloba
extract enhances erectile function in orchiectomized male rats. FASEB J 2001;15
(Abstract).
132.
Li CL, Wu ER, Zhu J-S, Chang J. Venix improves cognitive function in memoryimpaired and normal animal models. FASEB J 2001;15 (Abstract).